CoChat
Sign Up
Cited by 155

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR‐124 and reduced AMPA receptors

Dutta, Ranjan, Chomyk, Anthony M., Chang, Ansi, Ribaudo, Michael V., Deckard, Sadie A., Doud, Mary K., Edberg, Dale D., Bai, Brian, Li, Michael, Baranzini, Sergio E., Fox, Robert J., Staugaitis, Susan M., Macklin, Wendy B., Trapp, Bruce D.·2013·Annals of Neurology
DOI 10.1002/ana.23860PMC PMC3679350
Open this paper in CoChat — free account

Abstract

Objective: Hippocampal demyelination, a common feature of postmortem multiple sclerosis (MS) brains, reduces neuronal gene expression and is a likely contributor to the memory impairment that is found in >40% of individuals with MS. How demyelination alters neuronal gene expression is unknown. Methods: To explore whether loss of hippocampal myelin alters expression of neuronal microRNAs (miRNAs), we compared miRNA profiles from myelinated and demyelinated hippocampi from postmortem MS brains and performed validation studies. Results: A network‐based interaction analysis depicts a correlation between increased neuronal miRNAs and decreased neuronal genes identified in our previous study. The neuronal miRNA miR‐124 was increased in demyelinated MS hippocampi and targets mRNAs encoding 26 neuronal proteins that were decreased in demyelinated hippocampus, including the ionotrophic glutamate receptors AMPA2 and AMPA3. Hippocampal demyelination in mice also increased miR‐124, reduced expression of AMPA receptors, and decreased memory performance in water maze tests. Remyelination of the mouse hippocampus reversed these changes. Interpretation: We establish here that myelin alters neuronal gene expression and function by modulating the levels of the neuronal miRNA miR‐124. Inhibition of miR‐124 in hippocampal neurons may provide a therapeutic approach to improve memory performance in MS patients. Ann Neurol 2013;73:637–645

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/ana.23860

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Upregulation of miR-124 levels in the hippocampus was associated with reduction of GRIA2 and decrease in synaptic plasticity.

    “In contrast, upregulation of miR-124 levels in the hippocampus was associated with reduction of glutamate ionotropic receptor AMPA type subunit 2 (GRIA2, excitatory neurotransmitter receptors) and decrease in synaptic plasticity (Dutta et al. 2013).”

    From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Dutta et al. 2013

  • Demyelination could increase miR-124 expression and decrease memory performance, and remyelination of the mouse hippocampus reversed these changes.

    “Their results showed that demyelination could increase miR-124 expression and decrease memory performance. However, remyelination of the mouse hippocampus reversed these changes (Dutta et al. 2013).”

    From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Dutta et al. 2013

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 28

  1. 10.1016/j.neuron.2006.09.011 · DOI
  2. 10.1002/ana.410360704 · DOI
  3. 10.1097/00019052-200306000-00006 · DOI
  4. 10.1016/S1474-4422(08)70259-X · DOI · Paper page
  5. 10.1002/ana.22337 · DOI
  6. 10.1186/1471-2377-11-153 · DOI
  7. 10.1093/brain/awn030 · DOI
  8. 10.1016/j.cell.2009.01.002 · DOI · Paper page
  9. 10.1016/j.brainres.2010.04.002 · DOI · Paper page
  10. 10.1016/j.neuron.2010.02.018 · DOI · Paper page
  11. 10.1016/j.neuron.2010.01.027 · DOI · Paper page
  12. 10.1093/hmg/ddn005 · DOI
  13. 10.1073/pnas.0710263105 · DOI · Paper page
  14. 10.1126/science.1140481 · DOI · Paper page
  15. 10.1038/nn1174 · DOI
  16. 10.1093/brain/awp300 · DOI · Paper page
  17. 10.1038/nrneurol.2010.179 · DOI · Paper page
  18. 10.1016/j.neuron.2009.09.007 · DOI
  19. 10.1016/j.neuron.2009.05.029 · DOI · Paper page
  20. 10.1038/nrn2763 · DOI · Paper page
  21. 10.1038/nrn2037 · DOI
  22. 10.1111/j.1750-3639.2007.00120.x · DOI
  23. 10.1186/1471-2105-12-380 · DOI
  24. 10.1146/annurev.neuro.30.051606.094309 · DOI
  25. 10.1038/nrn2797 · DOI · Paper page
  26. 10.1146/annurev.neuro.30.051606.094313 · DOI · Paper page
  27. 10.1016/S1474-4422(09)70043-2 · DOI · Paper page
  28. 10.1523/JNEUROSCI.3030-10.2010 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Dutta, R., Chomyk, A. M., Chang, A., Ribaudo, M. V., Deckard, S. A., Doud, M. K., Edberg, D. D., Bai, B., Li, M., Baranzini, S. E., Fox, R. J., Staugaitis, S. M., Macklin, W. B., & Trapp, B. D.
Venue
Annals of Neurology
Publisher
Wiley
Published
2013-04-17
Volume
73
Issue
5
Pages
637-645
ISSN
  • 0364-5134
  • 1531-8249
DOI
10.1002/ana.23860
PMC
PMC3679350
Cited by
155
References
5
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review