The known unknowns of T cell immunity to COVID-19
Abstract
Tremendous progress has been made in understanding the role of T cell immunity in acute and convalescent COVID-19 infection. Here we shed light on the "known unknowns" of pre-existing and acquired T cell responses in relation to acute and convalescent SARS-CoV-2 infection.
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The COVID-19 mRNA vaccines are primarily focused on triggering B cells to promote induction of neutralizing antibodies, but there are also good reasons to believe that CD8+ T cell and CD4+ T cell responses may contribute to protection against SARS-CoV-2.
“The COVID-19 mRNA vaccines are primarily focused on triggering B cells to promote the induction of neutralizing antibodies, but there are also good reasons to believe that CD8+ T cell and CD4+ T cell responses may contribute to the protection against SARS-CoV-2 [66]”
From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [66]
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Human mucosal tissue-resident memory T cells in health and disease
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Self-citationOral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects
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- Authors
- Karlsson, A. C., Humbert, M., & Buggert, M.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Karlsson, Annika C.
- Buggert, Marcus
- Venue
- Science Immunology
- Published
- 2020-11-13
- Volume
- 5
- Issue
- 53
- ISSN
- 2470-9468 (ISSN-L)
- OpenAlex
- W3104569809
- Cited by
- 165
- References
- 58
- Citations by year
- 2025: 9 · 2024: 33 · 2023: 25 · 2022: 38 · 2021: 59 · 2020: 1
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- T cell immunity, COVID-19 pandemic, SARS-CoV-2, acute infection, T cell memory
- MeSH terms
- COVID-19, SARS-CoV-2, Antibodies, Viral, Humans, Immunity, Cellular, Immunologic Memory, T-Lymphocytes, Host-Pathogen Interactions, Immunity, Humoral, Pandemics
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