Cited by 165SARS-CoV-2 and COVID-19 ResearchT-cell and B-cell ImmunologyCOVID-19 Clinical Research Studies

The known unknowns of T cell immunity to COVID-19

Karlsson, Annika C., Humbert, Marion, Buggert, Marcus·2020·Science Immunology

Abstract

Tremendous progress has been made in understanding the role of T cell immunity in acute and convalescent COVID-19 infection. Here we shed light on the "known unknowns" of pre-existing and acquired T cell responses in relation to acute and convalescent SARS-CoV-2 infection.

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Registry

Crossref · 10.1126/sciimmunol.abe8063

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59 of 59 references verified0 citation errors · 0 not checkable

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  • The COVID-19 mRNA vaccines are primarily focused on triggering B cells to promote induction of neutralizing antibodies, but there are also good reasons to believe that CD8+ T cell and CD4+ T cell responses may contribute to protection against SARS-CoV-2.

    “The COVID-19 mRNA vaccines are primarily focused on triggering B cells to promote the induction of neutralizing antibodies, but there are also good reasons to believe that CD8+ T cell and CD4+ T cell responses may contribute to the protection against SARS-CoV-2 [66]”

    From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [66]

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Authors
Karlsson, A. C., Humbert, M., & Buggert, M.
Affiliations
Karolinska Institutet (SE)
Corresponding author
  • Karlsson, Annika C.
  • Buggert, Marcus
Venue
Science Immunology
Published
2020-11-13
Volume
5
Issue
53
ISSN
2470-9468 (ISSN-L)
OpenAlex
W3104569809
Cited by
165
References
58
Citations by year
2025: 9 · 2024: 33 · 2023: 25 · 2022: 38 · 2021: 59 · 2020: 1
FWCI
4.03
Type
journal article
Language
en
Open access
closed
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
T cell immunity, COVID-19 pandemic, SARS-CoV-2, acute infection, T cell memory
MeSH terms
COVID-19, SARS-CoV-2, Antibodies, Viral, Humans, Immunity, Cellular, Immunologic Memory, T-Lymphocytes, Host-Pathogen Interactions, Immunity, Humoral, Pandemics

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