The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Drug Repurposing Approaches for the Treatment of Influenza Viral Infection: Reviving Old Drugs to Fight Against a Long-Lived Enemy
Open accessAbstract
Influenza viruses still constitute a real public health problem today. To cope with the emergence of new circulating strains, but also the emergence of resistant strains to classic antivirals, it is necessary to develop new antiviral approaches. This review summarizes the state-of-the-art of current antiviral options against influenza infection, with particular focus on the recent advances of anti-influenza drug repurposing strategies and their potential therapeutic, regulatory and economic benefits. The review will illustrate the multiple ways to reposition molecules for the treatment of influenza, from adventitious discovery to in silico-based screening. These novel antiviral molecules, many of which targeting the host cell, in combination with conventional antiviral agents targeting the virus, will ideally enter the clinics and reinforce the therapeutic arsenal to combat influenza virus infections.
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“Historically, drug combinations have been utilized efficiently to treat various bacterial and viral infections and to fight cancer [18–21].”
From Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs (2020) · cites this paper as [20]
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Envisaging the Future of Long-Acting Injectables and Implants
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Metadata
- Authors
- Pizzorno, A., Padey, B., Terrier, O., & Rosa-Calatrava, M.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Terrier, Olivier
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-03-19
- Volume
- 10
- Pages
- 531-531
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6434107
- OpenAlex
- W2923800168
- Cited by
- 122
- References
- 117
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 17 · 2021: 24 · 2020: 38 · 2019: 5
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Région Auvergne-Rhône-Alpes
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Keywords
- drug repurposing, influenza virus, antiviral agents, host-targeted antivirals, antiviral resistance, virtual screening, antiviral drug discovery
- MeSH terms
- Animals, Antiviral Agents, Humans, Influenza, Human, Orthomyxoviridae, Orthomyxoviridae Infections, Drug Repositioning
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