Cited by 245Gut microbiota and healthImmune Response and InflammationProbiotics and Fermented Foods

The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.

Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens

Open access

Cheng, Hong-Yu, Ning, Meng-Xia, Chen, De-Kun, Ma, Wen-Tao·2019·Frontiers in Immunology

DOI 10.3389/fimmu.2019.00607PMC PMC6449424

Open this paper in CoChat — free account Open PDF

Abstract

The mammalian intestine is colonized by over a trillion microbes that comprise the "gut microbiota," a microbial community which has co-evolved with the host to form a mutually beneficial relationship. Accumulating evidence indicates that the gut microbiota participates in immune system maturation and also plays a central role in host defense against pathogens. Here we review some of the mechanisms employed by the gut microbiota to boost the innate immune response against pathogens present on epithelial mucosal surfaces. Antimicrobial peptide secretion, inflammasome activation and induction of host IL-22, IL-17, and IL-10 production are the most commonly observed strategies employed by the gut microbiota for host anti-pathogen defense. Taken together, the body of evidence suggests that the host gut microbiota can elicit innate immunity against pathogens.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2019.00607

Cites

150 of 150 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Gut microbiota plays an important role in the induction of antimicrobial peptides expression against pathogens. Antimicrobial peptides are key components of innate immunity to control pathogen growth within the intestine. Accumulated evidence identified that gut microbiota can contribute to the expression of antimicrobial peptides and play a central role in host defense against pathogens. Paneth cells could directly sense gut microbiota through cell-autonomous myeloid differentiation primary response 88 (MyD88)-dependent toll-like receptor (TLR) activation, triggering expression of α-defensins and C-type lectins. With regard to β-defensin, gut microbiota induce β-defensin expression in cell culture mediated by NF-κB- and MAPK/AP-1-dependent pathways in vitro. Then β-defensin interacts with intestinal epithelial cell (IEC) through CCR6 to activate epithelial restitution and barrier repair.CC BY · PubMed Central

Figure 2 Gut microbiota enhance the expression of IL-22 against invading pathogens. IL-22 is important in maintaining the integrity of mucosal barriers and can be produced by many different types innate immune cells, which induce the expression of various antimicrobial proteins, including lipocalin-2, calprotectin, C-type lectins, S100A8, S100A9, and so on to clear pathogens. Increasing evidence identified that gut microbiota enhances the expression of IL-22 to protect the host against pathogens. The results show that gut microbiota utilize tryptophan as an energy source and produce a metabolite, indole-3-aldehyde (IAld), which in turns activated Ahr on innate immune cells. Once activated, innate immune cells will secrete IL-22, which protects the host against opportunistic pathogens by reducing their colonization.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
Role of the normal gut microbiota
Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Mechanism and Regulation of NLRP3 Inflammasome Activation
He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
IL-10: The Master Regulator of Immunity to Infection
Couper, K. N., Blount, D. G., & Riley, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5771 · Cited by 2,288
Microbial tryptophan catabolites in health and disease
Roager, H. M., & Licht, T. R. (2018) · Nature Communications · doi:10.1038/s41467-018-05470-4 · Cited by 2,236

Show all 150 references

Sorted by citations

Items 101–200 of 245

Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study
Wang, Q., Gao, T., Zhang, W., Liu, D., Li, X., Chen, F., & Mei, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1279218 · Cited by 20
Mutual interaction of microbiota and host immunity during health and diseases
Wu, D., Zhang, Y., Dong, S., & Zhong, C. (2021) · Biophysics Reports · doi:10.52601/bpr.2021.200045 · Cited by 16
Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome
Mancabelli, L., Milani, C., Fontana, F., Lugli, G. A., Tarracchini, C., Turroni, F., van Sinderen, D., & Ventura, M. (2022) · Journal of Oral Microbiology · doi:10.1080/20002297.2022.2051336 · Cited by 14
Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics
Marißen, J., Reichert, L., Härtel, C., Fortmann, M. I., Faust, K., Msanga, D. R., Harder, J., Zemlin, M., de Agüero, M. G., Masjosthusmann, K., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126684 · Cited by 19
Indole intercepts the communication between enteropathogenic E. coli and Vibrio cholerae
Gorelik, O., Rogad, A., Holoidovsky, L., Meijler, M. M., & Sal‐Man, N. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2138677 · Cited by 14
The Effect of Cross-Sex Fecal Microbiota Transplantation on Metabolism and Hormonal Status in Adult Rats
Feješ, A., Belvončíková, P., Sanchis, D. P., Borbélyová, V., Celec, P., Džunková, M., & Gardlík, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010601 · Cited by 14
Forging a New Frontier: Antimicrobial Peptides and Nanotechnology Converging to Conquer Gastrointestinal Pathogens
Canales, C. S. C., Roque‐Borda, C. A., Cazorla, J. I. M., Cazorla, R. M. M., Apaza, U. J. P., Silva, V. D. J., Primo, L. M. D. G., Martínez‐Morales, M. J., Sábio, R. M., Santos, H. A., et al. (2025) · Small · doi:10.1002/smll.202501431 · Cited by 15
Microbiota-Derived Extracellular Vesicles as Potential Mediators of Gut–Brain Communication in Traumatic Brain Injury: Mechanisms, Biomarkers, and Therapeutic Implications
Benameur, T., Hasan, A., Toufig, H., Panaro, M. A., Filannino, F. M., & Porro, C. (2025) · Biomolecules · doi:10.3390/biom15101398 · Cited by 16
Functional role of thioester-containing proteins in the Drosophila anti-pathogen immune response
Tafesh‐Edwards, G., & Eleftherianos, I. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104578 · Cited by 13
High Cellular Internalization of Virus-Like Mesoporous Silica Nanoparticles Enhances Adaptive Antigen-Specific Immune Responses against Cancer
Phan, N. M., Nguyen, T. L., Choi, Y.-J., Mo, X. W., Trinh, T. A., Yi, G., & Kim, J. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c07106 · Cited by 13
Structural characterization of polysaccharide isolated from Inonotus hispidus and its anti-obesity effect based on regulation of the interleukin-17-mediated inflammatory response
Zhang, Y., Zhang, X., Jin, X., Li, Z., Li, L., Zhu, Y., Kong, F., & Wang, D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138975 · Cited by 14
Gut microbiota and microbiota-derived metabolites in colorectal cancer: enemy or friend
Wang, X., Sun, X., Chu, J., Sun, W., Yan, S., & Wang, Y. (2023) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-023-03742-w · Cited by 13
Interactions between microsporidia and other members of the microbiome
Tersigni, J., Jarkass, H. T. E., James, E. B., & Reinke, A. W. (2024) · Journal of Eukaryotic Microbiology · doi:10.1111/jeu.13025 · Cited by 12
A long journey to treat epilepsy with the gut microbiota
Li, Q., Gu, Y., Liang, J., Yang, Z., & Qin, J. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1386205 · Cited by 13
Harmony Within: Unravelling the Microbiome–Immune System Symbiosis for Health
Suchiita, A., Gupta, N., Nandi, K., Sonkar, S. C., & Chandra, L. (2025) · Advanced Gut & Microbiome Research · doi:10.1155/agm3/9927379 · Cited by 13
Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection
Stolzer, I., Ruder, B., Neurath, M. F., & Günther, C. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151491 · Cited by 12
Phyllanthus emblica (Amla) Fruit Powder as a Supplement to Improve Preweaning Dairy Calves’ Health: Effect on Antioxidant Capacity, Immune Response, and Gut Bacterial Diversity
Nguse, M., Yang, Y. M., Fu, Z., Xu, J., Ma, L., & Bu, D. (2022) · Biology · doi:10.3390/biology11121753 · Cited by 12
Research progress of the avian coccidiosis vaccine
Cai, H., Qi, N., Li, J., Lv, M., Lin, X., Hu, J., Zhang, J., Liao, S., & Sun, M. (2022) · Veterinary Vaccine · doi:10.1016/j.vetvac.2022.100002 · Cited by 11
Synergism of Diet, Genetics, and Microbiome on Health
Das, P., Banka, R., Ghosh, J., Singh, K., Choudhury, S. R., & Koner, S. (2024) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-5528-2.ch006 · Cited by 11
Effect of diet on the microbiota and immune system in patients with systemic lupus erythematosus
Ruiz‐Pozo, V. A., Paz‐Cruz, E., Cadena-Ullauri, S., Tamayo‐Trujillo, R., Guevara‐Ramírez, P., Simancas‐Racines, D., Frías-Toral, E., & Zambrano, A. K. (2024) · Food and Agricultural Immunology · doi:10.1080/09540105.2024.2434475 · Cited by 11
The Role of Vitamin D in Gastrointestinal Homeostasis and Gut Inflammation
Vemulapalli, V., & Thomas, A. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073020 · Cited by 15
Effects of dietary lysozyme supplementation on growth performance, intestinal morphology, immune function, antioxidant capacity, and gut microbiota in broilers
Chen, L., Peng, W., Wang, T., Ma, S., Wang, X., Dai, B., Zhang, R., Yang, C., & Wu, Y. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105741 · Cited by 11
Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health
Nausch, B., Bittner, C. B., Höller, M., Abramov-Sommariva, D., Hiergeist, A., & Gessner, A. (2022) · Antibiotics · doi:10.3390/antibiotics11101331 · Cited by 14
Viral infectious diseases severity: co-presence of transcriptionally active microbes (TAMs) can play an integral role for disease severity
Yadav, A., & Pandey, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1056036 · Cited by 11
Effects of Dietary Bacillus coagulans and Tributyrin on Growth Performance, Serum Antioxidants, Intestinal Morphology, and Cecal Microbiota of Growing Yellow-Feathered Broilers
Hou, J., Lian, L., Lu, L., Gu, T., Zeng, T., Chen, L., Xu, W., Li, G., Wu, H., & Tian, Y. (2023) · Animals · doi:10.3390/ani13223534 · Cited by 11
Host-microbe interactions at barrier tissues and immunomodulation: a scoping review
Chigozie, V. U., Enyi, E. O., Akwari, A. A., & Esimone, C. O. (2025) · Discover Bacteria. · doi:10.1007/s44351-025-00037-3 · Cited by 14
Association of microbial community structure with gill disease in marine-stage farmed Atlantic salmon (Salmo salar); a yearlong study
Clinton, M., Wyness, A. J., Martín, S., Brierley, A. S., & Ferrier, D. E. K. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-04125-5 · Cited by 13
Gut bacteria affect the tumoral immune milieu: distorting the efficacy of immunotherapy or not？
Pu, X., Chao, G., Dong, L., & Chang, P. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1739794 · Cited by 11
Immunomodulatory effect of two hydrolysates of chitin on cyclophosphamide-induced mice via immune response enhancement and gut microbiota modulation
Zhang, Q., Tang, X., Zhang, X., He, Y., & Li, Y. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105799 · Cited by 10
Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders
Song, J. G., Yu, M., Lee, B., Lee, J., Hwang, S.-H., Na, D., & Kim, H. W. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.02.024 · Cited by 10
Antibiotic use but not gastrointestinal infection frequently precedes first diagnosis of functional gastrointestinal disorders
Jones, M., Shah, A., Walker, M. M., Koloski, N. A., Holtmann, G., & Talley, N. J. (2021) · United European Gastroenterology Journal · doi:10.1002/ueg2.12164 · Cited by 10
Macrogenomic and Metabolomic Analyses Reveal Mechanisms of Gut Microbiota and Microbial Metabolites in Diarrhea of Weaned Piglets
Xie, F., Zhou, M., Li, X., Li, S., Ren, M., & Wang, C. (2024) · Animals · doi:10.3390/ani14162327 · Cited by 9
The gut immune axis in ulcerative colitis: insights from microbiome research
Wasim, R. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11124-8 · Cited by 10
Human microbiome and cardiovascular diseases
Alam, J., Puppala, V., Uppulapu, S. K., Das, B., & Banerjee, S. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.07.012 · Cited by 11
Dietary fungi in cancer immunotherapy: From the perspective of gut microbiota
Wei, Y., Song, D., Wang, R., Li, T., Wang, H., & Li, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1038710 · Cited by 9
Recent advances in roles of G-protein coupled receptors in intestinal intraepithelial lymphocytes
Sumida, H. (2020) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2019-053 · Cited by 9
Infants’ gut microbiome data: A Bayesian Marginal Zero-inflated Negative Binomial regression model for multivariate analyses of count data
Hajihosseini, M., Amini, P., Saidi‐Mehrabad, A., & Dinu, I. A. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.02.027 · Cited by 8
Influence of microbiota-driven natural antibodies on dengue transmission
Wu‐Chuang, A., Rojas, A., Bernal, C., Cardozo, F., Valenzuela, A., Romero, C., Mateos‐Hernández, L., & Cabezas‐Cruz, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1368599 · Cited by 9
Thallium(III) exposure alters diversity and co-occurrence networks of bacterial and fungal communities and intestinal immune response along the digestive tract in mice
Li, D., Yao, H., Li, Y., Li, Z., Yang, X., Zhu, X., & Zeng, X. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-24994-3 · Cited by 8
Immunoglobulin secretion influences the composition of chicken caecal microbiota
Volf, J., Kaspers, B., Schusser, B., Crhánová, M., Karasová, D., Štěpánová, H., Babák, V., & Rychlı́k, I. (2024) · Scientific Reports · doi:10.1038/s41598-024-76856-2 · Cited by 9
The Gut–Heart Axis and Its Role in Doxorubicin-Induced Cardiotoxicity: A Narrative Review
Tonon, C. R., Pereira, A. G., Ferreira, N. F., Monte, M. G., Vieira, N. M., Fujimori, A. S. S., Balin, P. D. S., de Paiva, S. A. R., Zornoff, L. A. M., Minicucci, M. F., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13040855 · Cited by 8
The Human Gut Microbiota: A Dynamic Biologic Factory
Minagar, A., & Jabbour, R. (2024) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2023_243 · Cited by 8
From sugar binders to diabetes fighters: the lectin saga of antihyperglycemic activity through systematic review and meta-analysis
Akshaya Simha, N., Patil, S. M., Jayanthi, M. K., Chaitra, N., Wong, L. S., Kijsomporn, J., Raj, R., & Ramu, R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1382876 · Cited by 10
Plant- and Nutraceutical-based Approach for the Management of Diabetes and its Neurological Complications: A Narrative Review
Öztürk, Y., & Öztürk, N. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191014165633 · Cited by 8
Primary immunodeficiency and the microbiome
Al‐Nesf, M. A., Morgan, D., & Mohamed‐Ali, V. (2021) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001067 · Cited by 11
Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses
Lan, Y., Li, Y., & Wang, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1562482 · Cited by 7
The Role of Farm Environment and Management in Shaping the Gut Microbiota of Poultry
Carrasco, J. M. D., Redondo, L. M., Casanova, N. A., & Fernández-Miyakawa, M. E. (2022) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-90303-9_10 · Cited by 8
The gastrointestinal antibiotic resistome in pediatric leukemia and lymphoma patients
MacDonald, T., Dunn, K. A., MacDonald, J., Langille, M. G. I., Limbergen, J. V., Bielawski, J. P., & Kulkarni, K. P. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1102501 · Cited by 7
Effects of Dietary Glucose Oxidase Supplementation on the Performance, Apparent Ileal Amino Acids Digestibility, and Ileal Microbiota of Broiler Chickens
Meng, Y., Huo, H., Zhang, Y., Bai, S., Wang, R., Zhang, K., Ding, X., Wang, J., Zeng, Q., Peng, H., et al. (2021) · Animals · doi:10.3390/ani11102909 · Cited by 7
Intestinal Microbiota Correction in the Treatment and Prevention of Urinary Tract Infection
Стуров, Н. В., Popov, S. V., Zhukov, V. A., Владимировна, Л. Т., Ивановна, Р. Е., & Николаевич, К. Г. (2022) · Urology Research and Practice · doi:10.5152/tud.2022.22119 · Cited by 7
Microbiome of athletes: Its features and diversity: A literature review
Палладіна, О. Л., & Kaliga, A. M. (2024) · International Journal of Medicine and Medical Research · doi:10.61751/ijmmr/1.2024.56 · Cited by 6
Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria
Mousa, W. K., Shaikh, A. Y., Ghemrawi, R., Aldulaimi, M., Ali, A., Sammani, N., Khair, M., Helal, M. I. D., Al-Marzooq, F. I., & Oueis, E. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00383g · Cited by 7
Physicochemical and microstructural characteristics of canola meal fermented by autonomously screened Bacillus licheniformis DY145 and its immunomodulatory effects on gut microbiota
Wang, Y., Cao, K., Zhang, X., Li, C., Wang, X., Liu, X., Ren, J., & Chen, L. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144291 · Cited by 7
Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology
Beniuk, V. O., Goncharenko, V. M., Курченко, А. И., Tatskyy, O. F., Konovalenko, S. V., Vintoniuk, S., Melnikov, S., Нуріманов, К. Р., & Подпрятов, С. С. (2020) · International Journal of Immunology · doi:10.11648/j.iji.20200801.11 · Cited by 6
Microbiota and their Influence in the Human Body
Al-Judaibi, A. A. (2021) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.15.1.27 · Cited by 8
Gut Microbiota and Inflammatory Disorders
Krishna, V., Kumar, N., & Banerjee, S. (2021) · Current Drug Targets · doi:10.2174/1389450122666210623125603 · Cited by 6
Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome
He, J., Tang, Q., Liu, Y., Wang, L., & Chai, Y. (2025) · Antioxidants · doi:10.3390/antiox14060721 · Cited by 6
Rape bee pollen outperforms camellia bee pollen in enhancing gut health and antioxidant capacity of wanxi white goose
Ren, M., Ji, C., Jiang, C., Zhang, F., Yu, Q., Hu, Q., Zhao, C., Ghonaim, A. H., & Li, S. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105688 · Cited by 5
Oral Administration of the Antimicrobial Peptide Mastoparan X Alleviates Enterohemorrhagic Escherichia coli–Induced Intestinal Inflammation and Regulates the Gut Microbiota
Zhao, X. Q., Wang, L., Zhu, C. L., Xue, X. H., Xia, X. J., Wu, X. L., Wu, Y. D., Liu, S. Q., Zhang, G. P., Bai, Y. Y., et al. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-10013-x · Cited by 5
Evidence on the importance of gut microbiota for the immune system
Surapsari, J., Oktarina, M. D., Sundjaya, T., & Wasito, E. (2023) · World Nutrition Journal · doi:10.25220/wnj.v06.s2.0002 · Cited by 5
Biochemical characterization of bifunctional enzymatic activity of a recombinant protein (Bp0469) from Blautia producta ATCC 27340 and its role in the utilization of arabinogalactan oligosaccharides
Bhaiyya, R., Sharma, S. C., & Singh, R. P. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126736 · Cited by 5
Scope of bacterial surface effector molecules beyond probiotics
Bhawal, S., Kumari, A., Rana, S., Kapila, S., & Kapila, R. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103180 · Cited by 7
Meta-analyses of host metagenomes from colorectal cancer patients reveal strong relationship between colorectal cancer-associated species
Escalona, M. A. R., Poloni, J. D. F., Krause, M. J., & Dorn, M. (2023) · Molecular Omics · doi:10.1039/d3mo00021d · Cited by 5
Antagonistic effect of gut microbiota of the Egyptian honeybees, Apis mellifera L. against the etiological agent of Stonebrood disease
Shehabeldine, A. M., Hashem, A. H., & Hasaballah, A. I. (2021) · International Journal of Tropical Insect Science · doi:10.1007/s42690-021-00654-w · Cited by 5
Unraveling the role of discoidin domain receptors as an anti-fibrotic target in various organs: A comprehensive review
Gong, H., Zhong, H., Ma, Y., Li, X., & Zhang, D. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146739 · Cited by 4
The barrier and protective functions of intestinal mucin in defense against Candida albicans
Liu, Y., Li, D., Ma, L., Wen, Y., & Shi, D. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1561004 · Cited by 6
Ophiocordyceps sinensis-induced changes in Thitarodes xiaojinensis: from intestinal barrier destruction, microbiome dysbiosis to immune responses at the molecular level
Bao, X.-W., Wang, Q.-H., Li, T., Li, Y., Bian, Z.-Y., Liu, S., He, L., Niu, S., & Guo, J. (2025) · BMC Biology · doi:10.1186/s12915-025-02277-w · Cited by 4
The Immunomodulatory Role of Probiotics
Siddique, F., Akram, K., Al-Ghamdi, E. S., Arshad, Q., & Siddique, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.98839 · Cited by 4
Early-life antibiotic exposures: Paving the pathway for dysbiosis-induced disorders
Attiq, A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177298 · Cited by 5
Increased pathogens and reduced intestinal immune genes associated with fish diseases during the winter-spring transition
Yuan, R., Jin, X., Liu, X., Hao, K., Shi, Y., Yang, Z., Zhang, L., Chen, J., Guo, C., Wu, Y., et al. (2025) · International Microbiology · doi:10.1007/s10123-025-00693-0 · Cited by 4
Evaluation of host and bacterial gene modulation during Lawsonia intracellularis infection in immunocompetent C57BL/6 mouse model
Kirthika, P., Park, S.-W., Jawalagatti, V., & Lee, J. H. (2022) · Journal of Veterinary Science · doi:10.4142/jvs.21274 · Cited by 4
Role of gut microbiota in food safety
So, S. Y., Wu, Q., & Savidge, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819470-6.00012-3 · Cited by 5
Asexual reproduction of Aurelia aurita depends on the presence of a balanced microbiome at polyp stagePreprint
Jensen, N., Weiland‐Bräuer, N., Joel, S., Chibani, C. M., & Schmitz, R. A. (2023) · Research Square · doi:10.21203/rs.3.rs-2637771/v1 · Cited by 4
What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease?
Brutkiewicz, R. R., Cao, W., Morgan, D., Reis, R. S. D., Suryadevara, V., Willette, A. A., Willette, S. A., Wyatt-Johnson, S. K., & Duggan, M. R. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.05.009 · Cited by 3
The hidden piece in inflammatory bowel diseases: The significance of intestinal mucus in mediating the bacteria-cells crosstalk
Guagliano, G., Boeri, L., Merli, M., Yan, H., Vangosa, F. B., Visai, L., Visentin, S., Petrini, P., & Sardelli, L. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101937 · Cited by 4
The Evolution, Oligomerization, Function, and Action Mechanism of α2-Macroglobulin
Xie, W., Gao, L., Deng, H., Liu, D., & Pang, Q. (2026) · Cells · doi:10.3390/cells15040353 · Cited by 3
Immunomodulatory effect of fermented Benincasa hispida cong. extracts on BALB/c mice
Choi, S., Men, X., Oh, G., Im, J., Choi, Y., Yang, J.-M., Hur, H.-S., Kim, S., Cho, J., & Lee, O. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105942 · Cited by 3
Antimicrobial Resistance in Escherichia coli Isolates Collected from Poultry Meat: An Epidemiological Surveillance Study from Guwahati City
Deka, J., & Ahmed, G. (2021) · Proceedings of the Zoological Society · doi:10.1007/s12595-021-00384-4 · Cited by 3
Investigating the Influence of Gut Microbiota-related Metabolites in Gastrointestinal Cancer
Marzhoseyni, Z., Shaghaghi, Z., Alvandi, M., & Shirvani, M. (2024) · Current Cancer Drug Targets · doi:10.2174/0115680096274860231111210214 · Cited by 3
Climate Changes and COVID-19
Shousha, H. I., Ayman, H., & Hashem, M. B. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-61943-4_14 · Cited by 3
Editorial: Lactic acid bacteria and their bioactive compounds: key regulators of gut microbiota and immune function
Fijan, S., Connil, N., Matijašić, B. B., Sreenivasa, M. Y., & Anandharaj, M. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1720803 · Cited by 3
Sex-specific disease resistance and gut microbiota dynamics in juvenile common carp (Cyprinus carpio) following viral infection
Yang, P., Cai, C., Shi, Y., Chen, G., Zhang, Q., Cheng, G., Zhai, G., YIN, Z., Kong, W., & Xu, Z. (2025) · Water Biology and Security · doi:10.1016/j.watbs.2025.100410 · Cited by 2
Effect of lysozyme supplementation on growth performance, immune status, antioxidant function and intestinal microbiota in broilers
Wang, T., Xu, H., Zhang, S., Hu, Y., Wu, Y., Zhang, R., Xiao, X., & Yang, C. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105829 · Cited by 2
Dysbiosis and Dyslipidemia: Unraveling the Microbiome's Role in Lipid Metabolism and Therapeutic Potential
Sharma, N., & Roy, S. (2025) · Apmis · doi:10.1111/apm.70100 · Cited by 4
Aspartate aminotransferase is required for Salmonella expansion in the inflamed gut via TCA anaplerosis
Shealy, N. G., Baltagulov, M., Avalos, H. F., Olivas, J., Jones, K. M., & Byndloss, M. X. (2026) · Infection and Immunity · doi:10.1128/iai.00161-26 · Cited by 2
Symbiotic Synergy from Sponges to Humans: Microflora–Host Harmony Is Crucial for Ensuring Survival and Shielding against Invading Pathogens
Hajra, D., Kirthivasan, N., & Chakravortty, D. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00554 · Cited by 2
Unveiling microbial dynamics: a review of health and immune enhancement in school settings
Asumang, P., Ntumi, R., & Dwomoh, F. (2024) · Frontiers in Microbiomes · doi:10.3389/frmbi.2024.1488702 · Cited by 4
Antimicrobial peptides in the gut–brain axis: A straightforward review to unravel some missing links
da Silva, F. P., Bruzaferro, E. V. M., & Câmara, N. O. S. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24729 · Cited by 2
SPORCULARDA PROBİYOTİK TAKVİYESİ VE MİKROBİYATANIN PERFORMANSA ETKİSİ
Bozdoğan, F. B. K., & Tazeoğlu, A. (2022) · Spor ve Performans Araştırmaları Dergisi · doi:10.17155/omuspd.1077375 · Cited by 1
The Role of the Gut Microbiome and the Hepatic Axis in the Pathogenesis of Metabolic Syndrome and Therapeutics
Divya, K. P., Hari, P., Kanwar, N., Aggarwal, N., Dhoat, P. S., Liu, L., Kanwal, A., & Singh, S. P. (2023) · Advanced Gut & Microbiome Research · doi:10.1155/2023/5431615 · Cited by 1
Associations and interactions between prokaryotes and other gut biota in non-human primates
Bambi, M., Hauffe, H. C., & Barelli, C. (2025) · Primates · doi:10.1007/s10329-025-01224-1 · Cited by 1
Deciphering the Post-Operative Dynamics of Opportunistic Gut Microbiota in Colorectal Cancer Patients
Kenneth, M. J., Fang, C., Wu, C., Hsieh, M.-C., Lai, M.-L., & Hsu, B. (2025) · Microorganisms · doi:10.3390/microorganisms13122818 · Cited by 2
Effects of Replacing Soybean Meal with Different Proportions of Black Soldier Fly Larvae Meal on Antioxidant Indicators, Immune System, and Gut Health of Xichuan Black-Bone Chickens
Geng, X., Yang, L., Hou, Y., Zhang, Z., He, F., Xu, R., Zhang, P., Jiang, R., Li, W., Sun, G., et al. (2026) · Antioxidants · doi:10.3390/antiox15040408 · Cited by 1
Effect of dietary supplementation with quercetin or rutin on the growth performance, meat quality and cecal microbiota of broilers under high stocking density
Zhao, Y., Liu, Y., Ning, J., Li, J., & Dong, Y. (2026) · Veterinary and Animal Science · doi:10.1016/j.vas.2026.100669 · Cited by 1
Probiotic modulation of the athletic gut: Implications for intestinal barrier function, immunity and exercise-related stress
Charitos, I. A., Marinelli, G., Inchingolo, A. D., Scacco, A., Calò, F., Ciocia, C., Inchingolo, F., Scacco, S., Palermo, A., Severino, M., et al. (2026) · Advances in Oral and Maxillofacial Surgery · doi:10.1016/j.adoms.2026.100670 · Cited by 1
Pulmonary megakaryocytes orchestrate host defense via PcrV-induced NF-κB signaling in Pseudomonas aeruginosa infection
Guo, X., 代芊, Liao, X., Ma, Y., Liu, H., Xiong, J., Yu, H., Li, Y., Zhang, K., Zhou, J., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03072-y · Cited by 1
Microbiome Insights Into Zoonotic Risk at Wildlife–Human Interfaces in a Transitioning Landscape in Thailand
van Leeuwen, P., Thinphovong, C., Sluydts, V., Nicolas, A., Kritiyakan, A., Kriengudom, A., Soisook, P., Chaisiri, K., Morand, S., & MICHAUX, J. R. (2026) · Integrative Zoology · doi:10.1111/1749-4877.70167 · Cited by 1
The Link Between Gut Microbiota and Autoimmune Diseases
Goyal, D., Dey, M., & Singh, R. K. (2022) · Springer eBooks · doi:10.1007/978-981-19-1946-6_3 · Cited by 1
Gut Microbiota in Elderly Onset Rheumatoid Arthritis
Kushugulova, A. R., Kunz, J., Poddighe, D., & Ainabekova, B. A. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-14023-5_9 · Cited by 1
Mucus Perspective to Conduct the Molecular Concertation in Inflammatory Bowel DiseasesPreprint
Sardelli, L., Boeri, L., Guagliano, G., Merli, M., Vangosa, F. B., & Petrini, P. (2023) · Preprints.org · doi:10.20944/preprints202305.2116.v1

Authors: Cheng, H.-Y., Ning, M.-X., Chen, D.-K., & Ma, W.-T.
Affiliations: Northwest A&F University (CN)
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2019-03-29
Volume: 10
Pages: 607-607
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2019.00607
PMC: PMC6449424
OpenAlex: W2926238016
Cited by: 244
References: 150
Citations by year: 2026: 16 · 2025: 39 · 2024: 51 · 2023: 35 · 2022: 38 · 2021: 38 · 2020: 22 · 2019: 4
FWCI: 2.25
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Northwest Agriculture and Forestry University (00500/Z109021716)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, innate immunity, host-pathogen interaction, intestinal epithelium, antimicrobial peptides, inflammasome activation, IL-22, IL-17, IL-10, mucosal immunity, immune system maturation
MeSH terms: Gastrointestinal Microbiome, Animals, Humans, Immunity, Innate, Intestinal Mucosa, Cytokines, Antimicrobial Cationic Peptides, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks