The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
Open accessAbstract
Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent sources of inflammation inhabit other metabolic regulatory tissues, including liver and gut, and recirculate to promote systemic inflammation and thus obesity comorbidities. Tissue-associated immune cells, especially T cell subpopulations, have become a hotspot of inquiry based on their contributions to obesity, type 2 diabetes, non-alcoholic fatty liver diseases and certain types of cancers. The cell-cell interactions that take place under the stress of obesity are mediated by intracellular contact and cytokine production, and constitute a complicated network that drives the phenotypic alterations of immune cells and perpetuates a feed-forward loop of metabolic decline. Herein we discuss immune cell functions in various tissues and obesity-associated cancers from the viewpoint of inflammation. We also emphasize recent advances in the understanding of crosstalk amongst immune cell subsets under obese conditions, and suggest future directions for focused investigations with clinical relevance.
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Cites
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Cited by
Bajaj, V., Gadi, N., Spihlman, A. P., Wu, S. C., Choi, C. H., & Moulton, V. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.571416 · Cited by 476
Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease
Karl, M., Hasselwander, S., Zhou, Y., Reifenberg, G., Kim, Y. O., Park, K., Ridder, D. A., Wang, X., Seidel, E., Hövelmeyer, N., et al. (2022) · Hepatology · doi:10.1002/hep.32428 · Cited by 44
Implications of inflammatory states on dysfunctional immune responses in aging and obesity
Thomas, A. L., Alarcon, P. C., Divanovic, S., Chougnet, C. A., Hildeman, D. A., & Moreno-Fernandez, M. E. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.732414 · Cited by 35
Cabrera-Reyes, F., Parra-Ruiz, C., Yuseff, M. I., & Zanlungo, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.790568 · Cited by 24
Khajuria, D. K., Reider, I., Kamal, F., Norbury, C. C., & Elbarbary, R. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1250309 · Cited by 15
Metadata
- Authors
- Liu, R., & Nikolajczyk, B. S.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-07-17
- Volume
- 10
- Pages
- 1587-1587
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2962176576
- Cited by
- 303
- References
- 158
- FWCI
- 25.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, R., & Nikolajczyk, B. S. (2019). Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.01587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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