The DOI matches its Crossref record; 252 of the 252 references it cites were found in a registry or an index.
Microglia in Retinal Degeneration
Open accessAbstract
The retina is a complex tissue with multiple cell layers that are highly ordered. Its sophisticated structure makes it especially sensitive to external or internal perturbations that exceed the homeostatic range. This necessitates the continuous surveillance of the retina for the detection of noxious stimuli. This task is mainly performed by microglia cells, the resident tissue macrophages which confer neuroprotection against transient pathophysiological insults. However, under sustained pathological stimuli, microglial inflammatory responses become dysregulated, often worsening disease pathology. In this review, we provide an overview of recent studies that depict microglial responses in diverse retinal pathologies that have degeneration and chronic immune reactions as key pathophysiological components. We also discuss innovative immunomodulatory therapy strategies that dampen the detrimental immunological responses to improve disease outcome.
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Cites
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More than meets the eye: The role of microglia in healthy and diseased retina
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Choi, S., Guo, L., & Cordeiro, M. F. (2021) · Cells · doi:10.3390/cells10061507 · Cited by 63
Chan, Y. K., Dick, A. D., Hall, S. M., Langmann, T., Scribner, C. L., Mansfield, B. C., & for the Ocular Gene Therapy Inflammation Working Group (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.4.3 · Cited by 56
Self-citationIndole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration
Khan, A. S., & Langmann, T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01999-8 · Cited by 44
Self-citationHDAC inhibition ameliorates cone survival in retinitis pigmentosa mice
Samardzija, M., Corna, A., Gomez-Sintes, R., Jarboui, M. A., Armento, A., Roger, J. E., Petridou, E., Haq, W., Paquet-Durand, F., Zrenner, E., et al. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-020-00653-3 · Cited by 48
Metadata
- Authors
- Rashid, K., Akhtar-Schaefer, I., & Langmann, T.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-08-20
- Volume
- 10
- Pages
- 1975-1975
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2965422920
- Cited by
- 355
- References
- 252
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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