CoChat
Sign Up
Cited by 99MicroRNA in disease regulationCancer-related molecular mechanisms researchPlant Molecular Biology Research

A myriad of roles of miR-25 in health and disease

Open access
Sárközy, Márta, Kahán, Zsuzsanna, Csont, Tamás·2018·Oncotarget
DOI 10.18632/oncotarget.24662PMC PMC5940376
Open this paper in CoChat — free accountOpen PDF

Abstract

// Márta Sárközy 1 , Zsuzsanna Kahán 2 and Tamás Csont 1 1 Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary 2 Department of Oncotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary Correspondence to: Márta Sárközy, email: sarkozy.marta@med.u-szeged.hu Keywords: cardiovascular diseases; oncology; p57; SERCA2a; TRAIL Received: August 31, 2017 Accepted: January 30, 2018 Published: April 20, 2018 ABSTRACT Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in different predicted target mRNAs. In this review, we specifically focus on the role of miR-25 in healthy and diseased conditions. Many of miR-25 target mRNAs are involved in biological processes such as cell proliferation, differentiation, and migration, apoptosis, oxidative stress, inflammation, calcium handling, etc. Therefore, it is no surprise that miR-25 has been reported as a key regulator of common cancerous and non-cancerous diseases. MiR-25 plays an important role in the pathogenesis of acute myocardial infarction, left ventricular hypertrophy, heart failure, diabetes mellitus, diabetic nephropathy, tubulointerstitial nephropathy, asthma bronchiale, cerebral ischemia/reperfusion injury, neurodegenerative diseases, schizophrenia, multiple sclerosis, etc. MiR-25 is also a well-described oncogenic miRNA playing a crucial role in the development of many tumor types including brain tumors, lung, breast, ovarian, prostate, thyroid, oesophageal, gastric, colorectal, hepatocellular cancers, etc. In this review, our aim is to discuss the translational therapeutic role of miR-25 in common diseased conditions based on relevant basic research and clinical studies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.18632/oncotarget.24662

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The most abundantly recovered miRNAs likely reflect important functional regulatory RNAs.

    “miR-25 was also proposed to be involved in the regulation of cancer (Sarkozy et al., 2018), suggesting that the most abundantly recovered miRNAs likely reflect important functional regulatory RNAs.”

    From Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP (2022) · cites this paper as Sarkozy et al., 2018

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 150

  1. [3]St Laurent G Wahlestedt C Kapranov P The Landscape of long noncoding RNA classification Trends Genet 2015 31 239 51 https://doi.org/10.1016/j.tig.2015.03.007 25869999 PMC4417002 · DOI
  2. [4]Gurha P MicroRNAs in cardiovascular disease Curr Opin Cardiol 2016 31 249 54 https://doi.org/10.1097/HCO.0000000000000280 26885771 · DOI
  3. [7]Concepcion CP Bonetti C Ventura A The microRNA-17-92 family of microRNA clusters in development and disease Cancer J 2012 18 262 67 https://doi.org/10.1097/PPO.0b013e318258b60a 22647363 PMC3592780 · DOI
  4. [8]Poliseno L Salmena L Riccardi L Fornari A Song MS Hobbs RM Sportoletti P Varmeh S Egia A Fedele G Rameh L Loda M Pandolfi PP Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation Sci Signal 2010 3 ra29 https://doi.org/10.1126/scisignal.2000594 20388916 PMC2982149 · DOI · Paper page
  5. [9]Notari M Pulecio J Raya Á Update on the Pathogenic Implications and Clinical Potential of microRNAs in Cardiac Disease BioMed Res Int 2015 2015 105620 https://doi.org/10.1155/2015/105620 26221581 PMC4499420 · DOI
  6. [10]Ono K Horie T Nishino T Baba O Kuwabara Y Kimura T MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism Int Heart J 2015 56 365 71 https://doi.org/10.1536/ihj.15-019 26084456 · DOI
  7. [11]Lee RC Feinbaum RL Ambros V The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 1993 75 843 54 https://doi.org/10.1016/0092-8674(93)90529-Y 8252621 · DOI · Paper page
  8. [12]Pasquinelli AE Reinhart BJ Slack F Martindale MQ Kuroda MI Maller B Hayward DC Ball EE Degnan B Müller P Spring J Srinivasan A Fishman M Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA Nature 2000 408 86 89 https://doi.org/10.1038/35040556 11081512 · DOI
  9. [13]Reinhart BJ Slack FJ Basson M Pasquinelli AE Bettinger JC Rougvie AE Horvitz HR Ruvkun G The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Nature 2000 403 901 06 https://doi.org/10.1038/35002607 10706289 · DOI
  10. [15]Ambros V The functions of animal microRNAs Nature 2004 431 350 55 https://doi.org/10.1038/nature02871 15372042 · DOI · Paper page
  11. [16]Bartel DP MicroRNAs: target recognition and regulatory functions Cell 2009 136 215 33 https://doi.org/10.1016/j.cell.2009.01.002 19167326 PMC3794896 · DOI · Paper page
  12. [17]He L Hannon GJ MicroRNAs: small RNAs with a big role in gene regulation Nat Rev Genet 2004 5 522 31 https://doi.org/10.1038/nrg1379 15211354 · DOI · Paper page
  13. [18]Caiazza C Mallardo M The Roles of miR-25 and its Targeted Genes in Development of Human Cancer MicroRNA 2016 5 113 19 https://doi.org/10.2174/2211536605666160905093429 27594089 · DOI
  14. [19]Hennessy EJ Moore KJ Using microRNA as an alternative treatment for hyperlipidemia and cardiovascular disease: cardio-miRs in the pipeline J Cardiovasc Pharmacol 2013 62 247 54 https://doi.org/10.1097/FJC.0b013e31829d48bf 23743768 PMC3773000 · DOI
  15. [20]Tang Q Zhong H Xie F Xie J Chen H Yao G Expression of miR-106b-25 induced by salvianolic acid B inhibits epithelial-to-mesenchymal transition in HK-2 cells Eur J Pharmacol 2014 741 97 103 https://doi.org/10.1016/j.ejphar.2014.07.051 25094038 · DOI
  16. [21]Yu D Shin HS Lee YS Lee YC miR-106b modulates cancer stem cell characteristics through TGF-β/Smad signaling in CD44-positive gastric cancer cells Lab Invest 2014 94 1370 81 https://doi.org/10.1038/labinvest.2014.125 25286029 · DOI
  17. [22]Cao L Kong LP Yu ZB Han SP Bai YF Zhu J Hu X Zhu C Zhu S Guo XR microRNA expression profiling of the developing mouse heart Int J Mol Med 2012 30 1095 104 https://doi.org/10.3892/ijmm.2012.1092 22895573 · DOI
  18. [23]Ma H Hostuttler M Wei H Rexroad CE 3rd Yao J Characterization of the rainbow trout egg microRNA transcriptome PLoS One 2012 7 e39649 https://doi.org/10.1371/journal.pone.0039649 22761856 PMC3382587 · DOI
  19. [24]Liu X Trakooljul N Hadlich F Muráni E Wimmers K Ponsuksili S MicroRNA-mRNA regulatory networking fine-tunes the porcine muscle fiber type, muscular mitochondrial respiratory and metabolic enzyme activities BMC Genomics 2016 17 531 https://doi.org/10.1186/s12864-016-2850-8 27485725 PMC4970254 · DOI
  20. [25]Ward JA Esa N Pidikiti R Freedman JE Keaney JF Tanriverdi K Vitseva O Ambros V Lee R McManus DD Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction Fam Med Med Sci Res 2013 2 108 24432306 PMC3890357
  21. [26]Ren J Zhang J Xu N Han G Geng Q Song J Li S Zhao J Chen H Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease PLoS One 2013 8 e80738 https://doi.org/10.1371/journal.pone.0080738 24339880 PMC3855151 · DOI
  22. [27]Varga ZV Zvara A Faragó N Kocsis GF Pipicz M Gáspár R Bencsik P Görbe A Csonka C Puskás LG Thum T Csont T Ferdinandy P MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs Am J Physiol Heart Circ Physiol 2014 307 H216 27 https://doi.org/10.1152/ajpheart.00812.2013 24858849 · DOI
  23. [28]Towbin JA Bowles NE The failing heart Nature 2002 415 227 33 https://doi.org/10.1038/415227a 11805847 · DOI
  24. [29]Heineke J Molkentin JD Regulation of cardiac hypertrophy by intracellular signalling pathways Nat Rev Mol Cell Biol 2006 7 589 600 https://doi.org/10.1038/nrm1983 16936699 · DOI
  25. [30]Dirkx E Gladka MM Philippen LE Armand AS Kinet V Leptidis S El Azzouzi H Salic K Bourajjaj M da Silva GJ Olieslagers S van der Nagel R de Weger R Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure Nat Cell Biol 2013 15 1282 93 https://doi.org/10.1038/ncb2866 24161931 · DOI
  26. [31]Tschöpe C Van Linthout S Kherad B Heart Failure with Preserved Ejection Fraction and Future Pharmacological Strategies: a Glance in the Crystal Ball Curr Cardiol Rep 2017 19 70 https://doi.org/10.1007/s11886-017-0874-6 28656481 · DOI
  27. [32]Divakaran V Adrogue J Ishiyama M Entman ML Haudek S Sivasubramanian N Mann DL Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading Circ Heart Fail 2009 2 633 42 https://doi.org/10.1161/CIRCHEARTFAILURE.108.823070 19919989 PMC3064555 · DOI
  28. [33]Liu Q Wang Y Yang T Wei W Protective effects of miR-25 against hypoxia/reoxygenationinduced fibrosis and apoptosis of H9c2 cells Int J Mol Med 2016 38 1225 34 https://doi.org/10.3892/ijmm.2016.2702 27513215 · DOI
  29. [34]Wahlquist C Jeong D Rojas-Muñoz A Kho C Lee A Mitsuyama S van Mil A Park WJ Sluijter JP Doevendans PA Hajjar RJ Mercola M Inhibition of miR-25 improves cardiac contractility in the failing heart Nature 2014 508 531 35 https://doi.org/10.1038/nature13073 24670661 PMC4131725 · DOI
  30. [35]Bush EW van Rooij E miR-25 in heart failure Circ Res 2014 115 610 12 https://doi.org/10.1161/CIRCRESAHA.114.304909 25214573 · DOI
  31. [36]Amara VR Surapaneni SK Tikoo K Dysregulation of microRNAs and renin-angiotensin system in high salt diet-induced cardiac dysfunction in uninephrectomized rats PLoS One 2017 12 e0180490 https://doi.org/10.1371/journal.pone.0180490 28727756 PMC5519030 · DOI
  32. [37]Chiang DY Kongchan N Beavers DL Alsina KM Voigt N Neilson JR Jakob H Martin JF Dobrev D Wehrens XH Li N Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release Circ Arrhythm Electrophysiol 2014 7 1214 22 https://doi.org/10.1161/CIRCEP.114.001973 25389315 PMC4270890 · DOI
  33. [38]Csonka C Sárközy M Pipicz M Dux L Csont T Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart Oxid Med Cell Longev 2016 2016 3863726 https://doi.org/10.1155/2016/3863726 26788247 PMC4691632 · DOI
  34. [39]Varga ZV Kupai K Szűcs G Gáspár R Pálóczi J Faragó N Zvara A Puskás LG Rázga Z Tiszlavicz L Bencsik P Görbe A Csonka C MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart J Mol Cell Cardiol 2013 62 111 21 https://doi.org/10.1016/j.yjmcc.2013.05.009 23722270 · DOI
  35. [40]Pan L Huang BJ Ma XE Wang SY Feng J Lv F Liu Y Liu Y Li CM Liang DD Li J Xu L Chen YH MiR-25 protects cardiomyocytes against oxidative damage by targeting the mitochondrial calcium uniporter Int J Mol Sci 2015 16 5420 33 https://doi.org/10.3390/ijms16035420 25764156 PMC4394484 · DOI
  36. [41]Maier KG Ruhle B Stein JJ Gentile KL Middleton FA Gahtan V Thrombospondin-1 differentially regulates microRNAs in vascular smooth muscle cells Mol Cell Biochem 2016 412 111 17 https://doi.org/10.1007/s11010-015-2614-9 26728995 · DOI
  37. [42]Li P Zhang Q Wu X Yang X Zhang Y Li Y Jiang F Circulating microRNAs serve as novel biological markers for intracranial aneurysms J Am Heart Assoc 2014 3 e000972 https://doi.org/10.1161/JAHA.114.000972 25249297 PMC4323791 · DOI
  38. [43]Hong Z Chen KH DasGupta A Potus F Dunham-Snary K Bonnet S Tian L Fu J Breuils-Bonnet S Provencher S Wu D Mewburn J Ormiston ML Archer SL MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype Am J Respir Crit Care Med 2017 195 515 29 https://doi.org/10.1164/rccm.201604-0814OC 27648837 PMC5378421 · DOI
  39. [44]Korkmaz-Icöz S Lehner A Li S Vater A Radovits T Hegedűs P Ruppert M Brlecic P Zorn M Karck M Szabó G Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to Ischemia/Reperfusion Injury: Identification of Underlying Gene Expression Changes J Diabetes Res 2015 2015 396414 https://doi.org/10.1155/2015/396414 26229969 PMC4502305 · DOI
  40. [45]Setyowati Karolina D Sepramaniam S Tan HZ Armugam A Jeyaseelan K miR-25 and miR-92a regulate insulin I biosynthesis in rats RNA Biol 2013 10 1365 78 https://doi.org/10.4161/rna.25557 24084692 PMC3817158 · DOI
  41. [46]Nielsen LB Wang C Sørensen K Bang-Berthelsen CH Hansen L Andersen ML Hougaard P Juul A Zhang CY Pociot F Mortensen HB Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression Exp Diabetes Res 2012 2012 896362 22829805 PMC3398606
  42. [47]Padmashree DG Swamy NR Molecular signaling cascade of miRNAs in causing Diabetes Nephropathy Bioinformation 2013 9 401 08 https://doi.org/10.6026/97320630009401 23750089 PMC3670122 · DOI
  43. [48]Fu Y Zhang Y Wang Z Wang L Wei X Zhang B Wen Z Fang H Pang Q Yi F Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy Am J Nephrol 2010 32 581 89 https://doi.org/10.1159/000322105 21071935 · DOI
  44. [50]Zhang JF Shi LL Zhang L Zhao ZH Liang F Xu X Zhao LY Yang PB Zhang JS Tian YF MicroRNA-25 Negatively Regulates Cerebral Ischemia/Reperfusion Injury-Induced Cell Apoptosis Through Fas/FasL Pathway J Mol Neurosci 2016 58 507 16 https://doi.org/10.1007/s12031-016-0712-0 26768135 · DOI
  45. [51]Huang F Zhang L Long Z Chen Z Hou X Wang C Peng H Wang J Li J Duan R Xia K Chuang DM Tang B Jiang H miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3 FEBS Lett 2014 588 4791 98 https://doi.org/10.1016/j.febslet.2014.11.013 25451224 PMC6370487 · DOI
  46. [52]Guo F Han X Zhang J Zhao X Lou J Chen H Huang X Repetitive transcranial magnetic stimulation promotes neural stem cell proliferation via the regulation of MiR-25 in a rat model of focal cerebral ischemia PLoS One 2014 9 e109267 https://doi.org/10.1371/journal.pone.0109267 25302788 PMC4193773 · DOI
  47. [53]Rodríguez-Aznar E Barrallo-Gimeno A Nieto MA Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons J Neurosci 2013 33 5095 105 https://doi.org/10.1523/JNEUROSCI.4459-12.2013 23516276 PMC6704984 · DOI
  48. [54]Shi Y Huang F Tang B Li J Wang J Shen L Xia K Jiang H MicroRNA profiling in the serums of SCA3/MJD patients Int J Neurosci 2014 124 97 101 https://doi.org/10.3109/00207454.2013.827679 23879331 · DOI
  49. [55]Kaunzner UW Al-Kawaz M Gauthier SA Defining Disease Activity and Response to Therapy in MS Curr Treat Options Neurol 2017 19 20 https://doi.org/10.1007/s11940-017-0454-5 28451934 · DOI
  50. [56]De Santis G Ferracin M Biondani A Caniatti L Rosaria Tola M Castellazzi M Zagatti B Battistini L Borsellino G Fainardi E Gavioli R Negrini M Furlan R Granieri E Altered miRNA expression in T regulatory cells in course of multiple sclerosis J Neuroimmunol 2010 226 165 71 https://doi.org/10.1016/j.jneuroim.2010.06.009 20637509 · DOI
  51. [57]Earls LR Fricke RG Yu J Berry RB Baldwin LT Zakharenko SS Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia J Neurosci 2012 32 14132 44 https://doi.org/10.1523/JNEUROSCI.1312-12.2012 23055483 PMC3486522 · DOI
  52. [59]Xie HQ Xu T Chen Y Li Y Xia Y Xu SL Wang L Tsim KW Zhao B New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins Chem Biol Interact 2016 259 286 90 https://doi.org/10.1016/j.cbi.2016.06.030 27374124 · DOI
  53. [60]Kuhn AR Schlauch K Lao R Halayko AJ Gerthoffer WT Singer CA MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype Am J Respir Cell Mol Biol 2010 42 506 13 https://doi.org/10.1165/rcmb.2009-0123OC 19541842 PMC2848741 · DOI
  54. [61]Xue L Xu Z Wang K Wang N Zhang X Wang S Network analysis of microRNAs, transcription factors, target genes and host genes in human anaplastic astrocytoma Exp Ther Med 2016 12 437 44 https://doi.org/10.3892/etm.2016.3272 27347075 PMC4906628 · DOI
  55. [62]Zhang J Gong X Tian K Chen D Sun J Wang G Guo M miR-25 promotes glioma cell proliferation by targeting CDKN1C Biomed Pharmacother 2015 71 7 14 https://doi.org/10.1016/j.biopha.2015.02.005 25960208 · DOI
  56. [63]Xu FX Su YL Zhang H Kong JY Yu H Qian BY Prognostic implications for high expression of MiR-25 in lung adenocarcinomas of female non-smokers Asian Pac J Cancer Prev 2014 15 1197 203 https://doi.org/10.7314/APJCP.2014.15.3.1197 24606441 · DOI
  57. [64]Suh SS Yoo JY Nuovo GJ Jeon YJ Kim S Lee TJ Kim T Bakàcs A Alder H Kaur B Aqeilan RI Pichiorri F Croce CM MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme Proc Natl Acad Sci USA 2012 109 5316 21 https://doi.org/10.1073/pnas.1202465109 22431589 PMC3325690 · DOI
  58. [65]Peng G Yuan X Yuan J Liu Q Dai M Shen C Ma J Liao Y Jiang W miR-25 promotes glioblastoma cell proliferation and invasion by directly targeting NEFL Mol Cell Biochem 2015 409 103 11 https://doi.org/10.1007/s11010-015-2516-x 26209061 · DOI
  59. [66]Birks DK Barton VN Donson AM Handler MH Vibhakar R Foreman NK Survey of MicroRNA expression in pediatric brain tumors Pediatr Blood Cancer 2011 56 211 16 https://doi.org/10.1002/pbc.22723 21157891 · DOI
  60. [67]Yang Y Mei Q miRNA signature identification of retinoblastoma and the correlations between differentially expressed miRNAs during retinoblastoma progression Mol Vis 2015 21 1307 17 https://doi.org/10.3390/molecules21101307 26730174 PMC4688417 · DOI
  61. [68]Xiang J Hang JB Che JM Li HC MiR-25 is up-regulated in non-small cell lung cancer and promotes cell proliferation and motility by targeting FBXW7 Int J Clin Exp Pathol 2015 8 9147 53 26464659 PMC4583891
  62. [69]Savita U Karunagaran D MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (non small cell lung cancer) cells Biochem Biophys Res Commun 2013 434 841 47 https://doi.org/10.1016/j.bbrc.2013.04.025 23611780 · DOI
  63. [70]Barrallo-Gimeno A Nieto MA The Snail genes as inducers of cell movement and survival: implications in development and cancer Development 2005 132 3151 61 https://doi.org/10.1242/dev.01907 15983400 · DOI
  64. [71]Vega S Morales AV Ocaña OH Valdés F Fabregat I Nieto MA Snail blocks the cell cycle and confers resistance to cell death Genes Dev 2004 18 1131 43 https://doi.org/10.1101/gad.294104 15155580 PMC415638 · DOI
  65. [72]Wu C Li M Hu C Duan H Clinical significance of serum miR-223, miR-25 and miR-375 in patients with esophageal squamous cell carcinoma Mol Biol Rep 2014 41 1257 66 https://doi.org/10.1007/s11033-013-2970-z 24390317 · DOI
  66. [73]Chen Z Wu Y Meng Q Xia Z Elevated microRNA-25 inhibits cell apoptosis in lung cancer by targeting RGS3 In Vitro Cell Dev Biol Anim 2016 52 62 67 https://doi.org/10.1007/s11626-015-9947-2 26416661 · DOI
  67. [74]He Z Liu Y Xiao B Qian X miR-25 modulates NSCLC cell radio-sensitivity through directly inhibiting BTG2 expression Biochem Biophys Res Commun 2015 457 235 41 https://doi.org/10.1016/j.bbrc.2014.12.094 25576360 · DOI
  68. [75]Yang T Chen T Li Y Gao L Zhang S Wang T Chen M Downregulation of miR-25 modulates non-small cell lung cancer cells by targeting CDC42 Tumour Biol 2015 36 1903 11 https://doi.org/10.1007/s13277-014-2793-0 25432132 · DOI
  69. [76]Zhang S Chen H Zhao X Cao J Tong J Lu J Wu W Shen H Wei Q Lu D REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility Oncogene 2013 32 242 50 https://doi.org/10.1038/onc.2012.32 22349819 · DOI
  70. [77]Wang C Ding M Xia M Chen S Van Le A Soto-Gil R Shen Y Wang N Wang J Gu W Wang X Zhang Y Zen K A Five-miRNA Panel Identified From a Multicentric Case-control Study Serves as a Novel Diagnostic Tool for Ethnically Diverse Non-small-cell Lung Cancer Patients EBioMedicine 2015 2 1377 85 https://doi.org/10.1016/j.ebiom.2015.07.034 26629532 PMC4634198 · DOI
  71. [78]Ponomaryova AA Morozkin ES Rykova EY Zaporozhchenko IA Skvortsova TE Dobrodeev AY Zavyalov AA Tuzikov SA Vlassov VV Cherdyntseva NV Laktionov PP Choinzonov EL Dynamic changes in circulating miRNA levels in response to antitumor therapy of lung cancer Exp Lung Res 2016 42 95 102 https://doi.org/10.3109/01902148.2016.1155245 26986825 · DOI
  72. [79]Shi SB Wang M Tian J Li R Chang CX Qi JL MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocations Transl Res 2016 170 1 7 https://doi.org/10.1016/j.trsl.2015.11.006 26687391 · DOI
  73. [80]Zhao Z Liu J Wang C Wang Y Jiang Y Guo M MicroRNA-25 regulates small cell lung cancer cell development and cell cycle through cyclin E2 Int J Clin Exp Pathol 2014 7 7726 34 25550809 PMC4270611
  74. [81]Wang Z Wang N Liu P Chen Q Situ H Xie T Zhang J Peng C Lin Y Chen J MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin Oncotarget 2014 5 7013 7026 https://doi.org/10.18632/oncotarget.2192 25026296 PMC4196180 · DOI
  75. [82]Wu Q Wang C Lu Z Guo L Ge Q Analysis of serum genome-wide microRNAs for breast cancer detection Clin Chim Acta 2012 413 1058 65 https://doi.org/10.1016/j.cca.2012.02.016 22387599 · DOI
  76. [83]Cancer Genome Atlas Network Comprehensive molecular portraits of human breast tumours Nature 2012 490 61 70 https://doi.org/10.1038/nature11412 23000897 PMC3465532 · DOI · Paper page
  77. [84]Farazi TA Ten Hoeve JJ Brown M Mihailovic A Horlings HM van de Vijver MJ Tuschl T Wessels LF Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets Genome Biol 2014 15 R9 https://doi.org/10.1186/gb-2014-15-1-r9 24398324 PMC4053773 · DOI
  78. [85]Hu Z Dong J Wang LE Ma H Liu J Zhao Y Tang J Chen X Dai J Wei Q Zhang C Shen H Serum microRNA profiling and breast cancer risk: the use of miR-484/191 as endogenous controls Carcinogenesis 2012 33 828 34 https://doi.org/10.1093/carcin/bgs030 22298638 · DOI
  79. [86]Jonsdottir K Janssen SR Da Rosa FC Gudlaugsson E Skaland I Baak JP Janssen EA Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers PLoS One 2012 7 e48692 https://doi.org/10.1371/journal.pone.0048692 23144930 PMC3492447 · DOI
  80. [87]Gerson KD Maddula VS Seligmann BE Shearstone JR Khan A Mercurio AM Effects of β4 integrin expression on microRNA patterns in breast cancer Biol Open 2012 1 658 66 https://doi.org/10.1242/bio.20121628 23213459 PMC3507297 · DOI
  81. [88]Sakurai M Masuda M Miki Y Hirakawa H Suzuki T Sasano H Correlation of miRNA expression profiling in surgical pathology materials, with Ki-67, HER2, ER and PR in breast cancer patients Int J Biol Markers 2015 30 e190 99 https://doi.org/10.5301/jbm.5000141 25907662 · DOI
  82. [89]Chang JT Wang F Chapin W Huang RS Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas PLoS One 2016 11 e0168284 https://doi.org/10.1371/journal.pone.0168284 27959953 PMC5154569 · DOI
  83. [90]Tanic M Yanowski K Gómez-López G Rodriguez-Pinilla MS Marquez-Rodas I Osorio A Pisano DG Martinez-Delgado B Benítez J MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors Int J Cancer 2015 136 593 602 24917463
  84. [91]Wu X Zeng R Wu S Zhong J Yang L Xu J Comprehensive expression analysis of miRNA in breast cancer at the miRNA and isomiR levels Gene 2015 557 195 200 https://doi.org/10.1016/j.gene.2014.12.030 25523096 · DOI
  85. [92]Langhe R Norris L Saadeh FA Blackshields G Varley R Harrison A Gleeson N Spillane C Martin C O’Donnell DM D’Arcy T O’Leary J O’Toole S A novel serum microRNA panel to discriminate benign from malignant ovarian disease Cancer Lett 2015 356 628 36 https://doi.org/10.1016/j.canlet.2014.10.010 25451316 · DOI
  86. [93]Feng S Pan W Jin Y Zheng J MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2 Tumour Biol 2014 35 12339 44 https://doi.org/10.1007/s13277-014-2546-0 25179841 · DOI
  87. [94]Siegel R Naishadham D Jemal A Cancer statistics, 2013 CA Cancer J Clin 2013 63 11 30 https://doi.org/10.3322/caac.21166 23335087 · DOI · Paper page
  88. [95]Zhang H Zuo Z Lu X Wang L Wang H Zhu Z MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer Oncol Rep 2012 27 594 98 22076535
  89. [96]Wang X Meng X Li H Liu W Shen S Gao Z MicroRNA-25 expression level is an independent prognostic factor in epithelial ovarian cancer Clin Transl Oncol 2014 16 954 58 https://doi.org/10.1007/s12094-014-1178-6 24696291 · DOI
  90. [97]Meng X Joosse SA Müller V Trillsch F Milde-Langosch K Mahner S Geffken M Pantel K Schwarzenbach H Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients Br J Cancer 2015 113 1358 66 https://doi.org/10.1038/bjc.2015.340 26393886 PMC4815782 · DOI
  91. [98]Benson EA Skaar TC Liu Y Nephew KP Matei D Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study PLoS One 2015 10 e0141279 https://doi.org/10.1371/journal.pone.0141279 26485143 PMC4612782 · DOI
  92. [99]Egidi MG Cochetti G Guelfi G Zampini D Diverio S Poli G Mearini E Stability Assessment of Candidate Reference Genes in Urine Sediment of Prostate Cancer Patients for miRNA Applications Dis Markers 2015 2015 973597 https://doi.org/10.1155/2015/973597 26078486 PMC4452852 · DOI
  93. [100]Zoni E Kruithof-de Julio M van der Pluijm G miR-25, integrin and cancer invasiveness Oncoscience 2015 2 663 64 https://doi.org/10.18632/oncoscience.214 26425648 PMC4580050 · DOI
  94. [101]Liang H Studach L Hullinger RL Xie J Andrisani OM Down-regulation of RE-1 silencing transcription factor (REST) in advanced prostate cancer by hypoxia-induced miR-106b~25 Exp Cell Res 2014 320 188 99 https://doi.org/10.1016/j.yexcr.2013.09.020 24135225 PMC3947575 · DOI
  95. [102]McCann MJ Rowland IR Roy NC The anti-proliferative effects of enterolactone in prostate cancer cells: evidence for the role of DNA licencing genes, mi-R106b cluster expression, and PTEN dosage Nutrients 2014 6 4839 55 https://doi.org/10.3390/nu6114839 25372501 PMC4245566 · DOI
  96. [103]Li Z Sun Y Chen X Squires J Nowroozizadeh B Liang C Huang J p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma Mol Cancer Res 2015 13 584 91 https://doi.org/10.1158/1541-7786.MCR-14-0277-T 25512615 PMC4369163 · DOI
  97. [104]Leite KR Tomiyama A Reis ST Sousa-Canavez JM Sañudo A Camara-Lopes LH Srougi M MicroRNA expression profiles in the progression of prostate cancer—from high-grade prostate intraepithelial neoplasia to metastasis Urol Oncol 2013 31 796 801 https://doi.org/10.1016/j.urolonc.2011.07.002 21880514 · DOI
  98. [105]Zoni E van der Horst G van de Merbel AF Chen L Rane JK Pelger RC Collins AT Visakorpi T Snaar-Jagalska BE Maitland NJ van der Pluijm G miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression Cancer Res 2015 75 2326 36 https://doi.org/10.1158/0008-5472.CAN-14-2155 25858144 · DOI
  99. [106]Cochetti G Poli G Guelfi G Boni A Egidi MG Mearini E Different levels of serum microRNAs in prostate cancer and benign prostatic hyperplasia: evaluation of potential diagnostic and prognostic role OncoTargets Ther 2016 9 7545 53 https://doi.org/10.2147/OTT.S119027 PMC5167485 28008272 · DOI
  100. [107]Bryzgunova OE Zaripov MM Skvortsova TE Lekchnov EA Grigor’eva AE Zaporozhchenko IA Morozkin ES Ryabchikova EI Yurchenko YB Voitsitskiy VE Laktionov PP Comparative Study of Extracellular Vesicles from the Urine of Healthy Individuals and Prostate Cancer Patients PLoS One 2016 11 e0157566 https://doi.org/10.1371/journal.pone.0157566 27305142 PMC4909321 · DOI
  101. [108]Li M Song Q Li H Lou Y Wang L Circulating miR-25-3p and miR-451a May Be Potential Biomarkers for the Diagnosis of Papillary Thyroid Carcinoma PLoS One 2015 10 e0132403 https://doi.org/10.1371/journal.pone.0132403 26168287 PMC4500410 · DOI
  102. [109]Mei Z Chen S Chen C Xiao B Li F Wang Y Tao Z Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25 PLoS One 2015 10 e0139456 https://doi.org/10.1371/journal.pone.0139456 26437444 PMC4593557 · DOI
  103. [110]Visone R Pallante P Vecchione A Cirombella R Ferracin M Ferraro A Volinia S Coluzzi S Leone V Borbone E Liu CG Petrocca F Troncone G Specific microRNAs are downregulated in human thyroid anaplastic carcinomas Oncogene 2007 26 7590 95 https://doi.org/10.1038/sj.onc.1210564 17563749 · DOI
  104. [111]Esposito F Tornincasa M Pallante P Federico A Borbone E Pierantoni GM Fusco A Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2 J Clin Endocrinol Metab 2012 97 E710 18 https://doi.org/10.1210/jc.2011-3068 22399519 · DOI
  105. [112]Aherne ST Smyth PC Flavin RJ Russell SM Denning KM Li JH Guenther SM O’Leary JJ Sheils OM Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling Mol Cancer 2008 7 89 https://doi.org/10.1186/1476-4598-7-89 19055826 PMC2612696 · DOI
  106. [113]Aherne ST Smyth P Freeley M Smith L Spillane C O’Leary J Sheils O Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression Int J Mol Med 2016 38 433 45 https://doi.org/10.3892/ijmm.2016.2653 27353001 PMC4935456 · DOI
  107. [114]Xu X Chen Z Zhao X Wang J Ding D Wang Z Tan F Tan X Zhou F Sun J Sun N Gao Y Shao K MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma Biochem Biophys Res Commun 2012 421 640 45 https://doi.org/10.1016/j.bbrc.2012.03.048 22450326 · DOI
  108. [115]Wu X Ajani JA Gu J Chang DW Tan W Hildebrandt MA Huang M Wang KK Hawk E MicroRNA expression signatures during malignant progression from Barrett’s esophagus to esophageal adenocarcinoma Cancer Prev Res (Phila) 2013 6 196 205 https://doi.org/10.1158/1940-6207.CAPR-12-0276 23466817 PMC3608471 · DOI
  109. [116]Kan T Sato F Ito T Matsumura N David S Cheng Y Agarwal R Paun BC Jin Z Olaru AV Selaru FM Hamilton JP Yang J The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim Gastroenterology 2009 136 1689 700 https://doi.org/10.1053/j.gastro.2009.02.002 19422085 PMC2887605 · DOI
  110. [117]Slaby O Srovnal J Radova L Gregar J Juracek J Luzna P Svoboda M Hajduch M Ehrmann J Dynamic changes in microRNA expression profiles reflect progression of Barrett’s esophagus to esophageal adenocarcinoma Carcinogenesis 2015 36 521 27 https://doi.org/10.1093/carcin/bgv023 25784377 · DOI
  111. [118]Chiam K Wang T Watson DI Mayne GC Irvine TS Bright T Smith L White IA Bowen JM Keefe D Thompson SK Jones ME Hussey DJ Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal Adenocarcinoma J Gastrointest Surg 2015 19 1208 15 https://doi.org/10.1007/s11605-015-2829-9 25943911 · DOI
  112. [119]Zhang K Wu X Wang J Lopez J Zhou W Yang L Wang SE Raz DJ Kim JY Circulating miRNA profile in esophageal adenocarcinoma Am J Cancer Res 2016 6 2713 21 27904783 PMC5126285
  113. [120]Komatsu S Ichikawa D Hirajima S Kawaguchi T Miyamae M Okajima W Ohashi T Arita T Konishi H Shiozaki A Fujiwara H Okamoto K Yagi N Otsuji E Plasma microRNA profiles: identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma Br J Cancer 2014 111 1614 24 https://doi.org/10.1038/bjc.2014.451 25117812 PMC4200091 · DOI
  114. [121]Fang WK Liao LD Li LY Xie YM Xu XE Zhao WJ Wu JY Zhu MX Wu ZY Du ZP Wu BL Xie D Guo MZ Down-regulated desmocollin-2 promotes cell aggressiveness through redistributing adherens junctions and activating beta-catenin signalling in oesophageal squamous cell carcinoma J Pathol 2013 231 257 70 https://doi.org/10.1002/path.4236 23836524 · DOI
  115. [122]Zhu L Yan W Rodriguez-Canales J Rosenberg AM Hu N Goldstein AM Taylor PR Erickson HS Emmert-Buck MR Tangrea MA MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells Am J Cancer Res 2011 1 574 84 21796275 PMC3142940
  116. [123]Wu C Wang C Guan X Liu Y Li D Zhou X Zhang Y Chen X Wang J Zen K Zhang CY Zhang C Diagnostic and prognostic implications of a serum miRNA panel in oesophageal squamous cell carcinoma PLoS One 2014 9 e92292 https://doi.org/10.1371/journal.pone.0092292 24651474 PMC3961321 · DOI
  117. [124]Espinosa-Parrilla Y Muñoz X Bonet C Garcia N Venceslá A Yiannakouris N Naccarati A Sieri S Panico S Huerta JM Barricarte A Menéndez V Sánchez-Cantalejo E Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study Int J Cancer 2014 135 2065 76 https://doi.org/10.1002/ijc.28850 24643999 · DOI
  118. [125]Petrocca F Visone R Onelli MR Shah MH Nicoloso MS de Martino I Iliopoulos D Pilozzi E Liu CG Negrini M Cavazzini L Volinia S Alder H E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer Cancer Cell 2008 13 272 86 https://doi.org/10.1016/j.ccr.2008.02.013 18328430 · DOI
  119. [126]Li BS Zuo QF Zhao YL Xiao B Zhuang Y Mao XH Wu C Yang SM Zeng H Zou QM Guo G MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival Oncogene 2015 34 2556 65 https://doi.org/10.1038/onc.2014.214 25043310 · DOI
  120. [127]Tamilzhalagan S Rathinam D Ganesan K Amplified 7q21-22 gene MCM7 and its intronic miR-25 suppress COL1A2 associated genes to sustain intestinal gastric cancer features Mol Carcinog 2017 56 1590 602 https://doi.org/10.1002/mc.22614 28059478 · DOI
  121. [128]Zhou J Zhou J Wang W Li W Wu L Li G Shi J Zhou S The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer Tumour Biol 2016 37 5515 20 https://doi.org/10.1007/s13277-015-4376-0 26572149 · DOI
  122. [129]Gong J Cui Z Li L Ma Q Wang Q Gao Y Sun H MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7 Tumour Biol 2015 36 7831 40 https://doi.org/10.1007/s13277-015-3510-3 25944166 · DOI
  123. [130]Zhang Y Peng Z Zhao Y Chen L microRNA-25 Inhibits Cell Apoptosis of Human Gastric Adenocarcinoma Cell Line AGS via Regulating CCNE1 and MYC Med Sci Monit 2016 22 1415 1420 27120728 PMC4913832
  124. [131]Zhang M Wang X Li W Cui Y miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells Biochem Biophys Res Commun 2015 460 806 12 https://doi.org/10.1016/j.bbrc.2015.03.110 25824045 · DOI
  125. [132]Zhao H Wang Y Yang L Jiang R Li W MiR-25 promotes gastric cancer cells growth and motility by targeting RECK Mol Cell Biochem 2014 385 207 13 https://doi.org/10.1007/s11010-013-1829-x 24078004 · DOI
  126. [133]Zhang R Wang W Li F Zhang H Liu J MicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers Med Oncol 2014 31 243 https://doi.org/10.1007/s12032-014-0243-x 25218271 · DOI
  127. [134]Zhou X Zhu W Li H Wen W Cheng W Wang F Wu Y Qi L Fan Y Chen Y Ding Y Xu J Qian J Diagnostic value of a plasma microRNA signature in gastric cancer: a microRNA expression analysis Sci Rep 2015 5 11251 https://doi.org/10.1038/srep11251 26059512 PMC4462022 · DOI
  128. [135]Zhu C Ren C Han J Ding Y Du J Dai N Dai J Ma H Hu Z Shen H Xu Y Jin G A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer Br J Cancer 2014 110 2291 99 https://doi.org/10.1038/bjc.2014.119 24595006 PMC4007222 · DOI
  129. [136]Li F Guo Y Liu J Zhang R The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer PLoS One 2017 12 e0178427 https://doi.org/10.1371/journal.pone.0178427 28562634 PMC5451054 · DOI
  130. [137]Kim BH Hong SW Kim A Choi SH Yoon SO Prognostic implications for high expression of oncogenic microRNAs in advanced gastric carcinoma J Surg Oncol 2013 107 505 510 22996433
  131. [138]Marchi S Lupini L Patergnani S Rimessi A Missiroli S Bonora M Bononi A Corrà F Giorgi C De Marchi E Poletti F Gafà R Lanza G Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25 Curr Biol 2013 23 58 63 https://doi.org/10.1016/j.cub.2012.11.026 23246404 PMC3540261 · DOI
  132. [139]Niu Y Wu Y Huang J Li Q Kang K Qu J Li F Gou D Identification of reference genes for circulating microRNA analysis in colorectal cancer Sci Rep 2016 6 35611 https://doi.org/10.1038/srep35611 27759076 PMC5069661 · DOI
  133. [140]Li X Yang C Wang X Zhang J Zhang R Liu R The expression of miR-25 is increased in colorectal cancer and is associated with patient prognosis Med Oncol 2014 31 781 https://doi.org/10.1007/s12032-013-0781-7 24293092 · DOI
  134. [141]Nishida N Nagahara M Sato T Mimori K Sudo T Tanaka F Shibata K Ishii H Sugihara K Doki Y Mori M Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters Clin Cancer Res 2012 18 3054 70 https://doi.org/10.1158/1078-0432.CCR-11-1078 22452939 · DOI
  135. [142]Li Q Zou C Zou C Han Z Xiao H Wei H Wang W Zhang L Zhang X Tang Q Zhang C Tao J Wang X Gao X MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7 Cancer Lett 2013 335 168 74 https://doi.org/10.1016/j.canlet.2013.02.029 23435373 · DOI
  136. [143]Clark T Maximin S Meier J Pokharel S Bhargava P Hepatocellular Carcinoma: Review of Epidemiology, Screening, Imaging Diagnosis, Response Assessment, and Treatment Curr Probl Diagn Radiol 2015 44 479 86 25979220
  137. [144]Kishikawa T Otsuka M Yoshikawa T Ohno M Takata A Shibata C Kondo Y Akanuma M Yoshida H Koike K Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs Sci Rep 2013 3 2739 https://doi.org/10.1038/srep02739 24061441 PMC3781398 · DOI
  138. [145]Li Y Tan W Neo TW Aung MO Wasser S Lim SG Tan TM Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma Cancer Sci 2009 100 1234 42 https://doi.org/10.1111/j.1349-7006.2009.01164.x 19486339 · DOI
  139. [146]Feng X Jiang J Shi S Xie H Zhou L Zheng S Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway Int J Oncol 2016 49 2600 10 https://doi.org/10.3892/ijo.2016.3751 27840896 · DOI
  140. [147]Razumilava N Bronk SF Smoot RL Fingas CD Werneburg NW Roberts LR Mott JL miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma Hepatology 2012 55 465 75 https://doi.org/10.1002/hep.24698 21953056 PMC3268937 · DOI
  141. [148]Wang C Wang X Su Z Fei H Liu X Pan Q MiR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1 Oncotarget 2015 6 36231 36244 https://doi.org/10.18632/oncotarget.4740 26460549 PMC4742173 · DOI
  142. [149]Wang Y Gao Y Shi W Zhai D Rao Q Jia X Liu J Jiao X Du Z Profiles of differential expression of circulating microRNAs in hepatitis B virus-positive small hepatocellular carcinoma Cancer Biomark 2015 15 171 80 https://doi.org/10.3233/CBM-140451 25519019 PMC12928525 · DOI
  143. [150]He XX Kuang SZ Liao JZ Xu CR Chang Y Wu YL Gong J Tian DA Guo AY Lin JS The regulation of microRNA expression by DNA methylation in hepatocellular carcinoma Mol Biosyst 2015 11 532 39 https://doi.org/10.1039/C4MB00563E 25424171 · DOI
  144. [151]Xu X Liu Z Wang J Ling Q Xie H Guo H Wei X Zhou L Zheng S miRNA profiles in livers with different mass deficits after partial hepatectomy and miR-106b~25 cluster accelerating hepatocyte proliferation in rats Sci Rep 2016 6 31267 https://doi.org/10.1038/srep31267 27507706 PMC4978973 · DOI
  145. [152]Jin Y Yu D Tolleson WH Knox B Wang Y Chen S Ren Z Deng H Guo Y Ning B MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes Biochem Pharmacol 2016 113 88 96 https://doi.org/10.1016/j.bcp.2016.06.007 27311985 PMC5672627 · DOI
  146. [153]Su ZX Zhao J Rong ZH Geng WM Wu YG Qin CK Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma Diagn Pathol 2014 9 47 https://doi.org/10.1186/1746-1596-9-47 24593846 PMC4016611 · DOI
  147. [154]Li LM Hu ZB Zhou ZX Chen X Liu FY Zhang JF Shen HB Zhang CY Zen K Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma Cancer Res 2010 70 9798 807 https://doi.org/10.1158/0008-5472.CAN-10-1001 21098710 · DOI
  148. [155]Cook NL Pereira TN Lewindon PJ Shepherd RW Ramm GA Circulating microRNAs as noninvasive diagnostic biomarkers of liver disease in children with cystic fibrosis J Pediatr Gastroenterol Nutr 2015 60 247 54 https://doi.org/10.1097/MPG.0000000000000600 25625579 · DOI
  149. [156]Wen Y Han J Chen J Dong J Xia Y Liu J Jiang Y Dai J Lu J Jin G Han J Wei Q Shen H Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma Int J Cancer 2015 137 1679 90 https://doi.org/10.1002/ijc.29544 25845839 · DOI
  150. [157]Yen CS Su ZR Lee YP Liu IT Yen CJ miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma World J Gastroenterol 2016 22 5183 92 https://doi.org/10.3748/wjg.v22.i22.5183 27298561 PMC4893465 · DOI

Cited by

Sorted by citations

Authors
Sárközy, M., Kahán, Z., & Csont, T.
Affiliations
University of Szeged (HU)
Corresponding author
Sárközy, Márta
ORCID
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2018-04-20
Volume
9
Issue
30
Pages
21580-21612
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.24662
PMC
PMC5940376
OpenAlex
W2800069595
Cited by
99
References
7
Citations by year
2026: 7 · 2025: 4 · 2024: 14 · 2023: 14 · 2022: 17 · 2021: 14 · 2020: 12 · 2019: 16 · 2018: 1
FWCI
1.12
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Oncotarget (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
Funders
  • Emberi Eroforrások Minisztériuma (3.6.2‐16‐2017‐00006, K115990, EFOP-3.6.2-16, GINOP-2.3.2-15-2016-00040, EFOP 3.6.2 16 2017 00006, UNKP-17-4)
  • Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (GINOP-2.3.2.-15-2016-00040, GINOP-2, K115990, GINOP-2.3.2, GINOP-2.3.2-15, 3.6.2-16-2017-00006, EFOP 3.6.2-16-2017-00006)
  • Szegedi Tudományegyetem
  • National Research, Development and Innovation Office (GINOP 2.3.2.-15.2016-00040, EFOP-3.6.2–16–2017–00006)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
miR-25, microRNA, miR-106b-25 cluster, miR-106b, miR-93, cardiovascular disease, cancer, p57, SERCA2a, TRAIL, acute myocardial infarction, heart failure, diabetic nephropathy, asthma, cerebral ischemia-reperfusion injury, neurodegenerative diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review