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Cited by 103Nutritional Studies and DietAgriculture Sustainability and Environmental ImpactDietary Effects on Health

Plant-Based Nutrition: Exploring Health Benefits for Atherosclerosis, Chronic Diseases, and Metabolic Syndrome—A Comprehensive Review

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Peña-Jorquera, Humberto, Cid-Jofré, Valeska, Landaeta-Díaz, Leslie, Petermann-Rocha, Fanny, Martorell, Miquel, Zbinden-Foncea, Hermann, Ferrari, Gerson, Jorquera-Aguilera, Carlos +1 more·2023·Nutrients
DOI 10.3390/nu15143244PMC PMC10386413
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Abstract

Atherosclerosis, chronic non-communicable diseases, and metabolic syndrome are highly interconnected and collectively contribute to global health concerns that reduce life expectancy and quality of life. These conditions arise from multiple risk factors, including inflammation, insulin resistance, impaired blood lipid profile, endothelial dysfunction, and increased cardiovascular risk. Adopting a plant-based diet has gained popularity as a viable alternative to promote health and mitigate the incidence of, and risk factors associated with, these three health conditions. Understanding the potential benefits of a plant-based diet for human health is crucial, particularly in the face of the rising prevalence of chronic diseases like diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Thus, this review focused on the plausible advantages of consuming a type of food pattern for the prevention and/or treatment of chronic diseases, emphasizing the dietary aspects that contribute to these conditions and the evidence supporting the benefits of a plant-based diet for human health. To facilitate a more in-depth analysis, we present separate evidence for each of these three concepts, acknowledging their intrinsic connection while providing a specific focus on each one. This review underscores the potential of a plant-based diet to target the underlying causes of these chronic diseases and enhance health outcomes for individuals and populations.

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    From The Effect of Cooking and Cooling Chickpea Pasta on Resistant Starch Content, Glycemic Response, and Glycemic Index in Healthy Adults (2024) · cites this paper as [1]

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  1. [2]Neufingerl N. Eilander A. Nutrient intake and status in adults consuming plant-based diets compared to meat-eaters: A systematic review Nutrients 2022 14 29 10.3390/nu14010029 35010904 PMC8746448 · DOI
  2. [3]Jardine M.A. Kahleova H. Levin S.M. Ali Z. Trapp C.B. Barnard N.D. Perspective: Plant-Based Eating Pattern for Type 2 Diabetes Prevention and Treatment: Efficacy, Mechanisms, and Practical Considerations Adv. Nutr. 2021 12 2045 10.1093/advances/nmab063 34113961 PMC8634508 · DOI
  3. [4]Yang X. Li Y. Wang C. Mao Z. Chen Y. Ren P. Fan M. Cui S. Niu K. Gu R. Association of plant-based diet and type 2 diabetes mellitus in Chinese rural adults: The Henan Rural Cohort Study J. Diabetes Investig. 2021 12 1569 1576 10.1111/jdi.13522 PMC8409831 33559976 · DOI
  4. [5]Joshi S. Ettinger L. Liebman S.E. Plant-Based Diets and Hypertension Am. J. Lifestyle Med. 2020 14 397 10.1177/1559827619875411 33281520 PMC7692016 · DOI
  5. [6]Gibbs J. Gaskin E. Ji C. Miller M.A. Cappuccio F.P. The effect of plant-based dietary patterns on blood pressure: A systematic review and meta-analysis of controlled intervention trials J. Hypertens. 2021 39 23 37 10.1097/HJH.0000000000002604 33275398 · DOI
  6. [7]Butnariu M. Fratantonio D. Herrera-Bravo J. Sukreet S. Martorell M. Ekaterina Robertovna G. Les F. López V. Kumar M. Pentea M. Plant-food-derived bioactives in managing hypertension: From current findings to upcoming effective pharmacotherapies Curr. Top. Med. Chem. 2023 23 589 617 10.2174/1568026623666230106144509 36617707 · DOI
  7. [9]Yokoyama Y. Levin S.M. Barnard N.D. Association between plant-based diets and plasma lipids: A systematic review and meta-analysis Nutr. Rev. 2017 75 683 698 10.1093/nutrit/nux030 28938794 PMC5914369 · DOI
  8. [10]Tantamango-Bartley Y. Jaceldo-Siegl K. Fan J. Fraser G. Vegetarian diets and the incidence of cancer in a low-risk population Cancer Epidemiol. Biomarkers Prev. 2013 22 286 294 10.1158/1055-9965.EPI-12-1060 23169929 PMC3565018 · DOI
  9. [11]Zhao Y. Zhan J. Wang Y. Wang D. The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers: A Meta-Analysis Based on 3,059,009 Subjects Front. Public Health 2022 10 892153 10.3389/fpubh.2022.892153 35719615 PMC9204183 · DOI
  10. [12]Fan F.Y. Sang L.X. Jiang M. McPhee D.J. Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease Molecules 2017 22 484 10.3390/molecules22030484 28335502 PMC6155401 · DOI
  11. [13]Musial C. Kuban-Jankowska A. Gorska-Ponikowska M. Beneficial Properties of Green Tea Catechins Int. J. Mol. Sci. 2020 21 1744 10.3390/ijms21051744 32143309 PMC7084675 · DOI
  12. [14]Wang X. Yang D.Y. Yang L.Q. Zhao W.Z. Cai L.Y. Shi H.P. Anthocyanin Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies J. Am. Coll. Nutr. 2019 38 470 477 10.1080/07315724.2018.1531084 30589398 · DOI
  13. [15]Briata I.M. Paleari L. Rutigliani M. Petrera M. Caviglia S. Romagnoli P. Libera M.D. Oppezzi M. Puntoni M. Siri G. A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps Int. J. Mol. Sci. 2021 22 11024 10.3390/ijms222011024 34681684 PMC8539981 · DOI
  14. [16]Della Pepa G. Vetrani C. Vitale M. Bozzetto L. Costabile G. Cipriano P. Mangione A. Patti L. Riccardi G. Rivellese A.A. Effects of a diet naturally rich in polyphenols on lipid composition of postprandial lipoproteins in high cardiometabolic risk individuals: An ancillary analysis of a randomized controlled trial Eur. J. Clin. Nutr. 2020 74 183 192 10.1038/s41430-019-0459-0 31249395 · DOI
  15. [17]Ghaedi E. Foshati S. Ziaei R. Beigrezaei S. Kord-Varkaneh H. Ghavami A. Miraghajani M. Effects of phytosterols supplementation on blood pressure: A systematic review and meta-analysis Clin. Nutr. 2020 39 2702 2710 10.1016/j.clnu.2019.12.020 31902603 · DOI
  16. [18]Bao X. Zhang Y. Zhang H. Xia L. Molecular Mechanism of β-Sitosterol and its Derivatives in Tumor Progression Front. Oncol. 2022 12 926975 10.3389/fonc.2022.926975 35756648 PMC9213880 · DOI
  17. [19]DAYI T. OZGOREN M. Effects of the Mediterranean diet on the components of metabolic syndrome J. Prev. Med. Hyg. 2022 63 E56 10.15167/2421-4248/JPMH2022.63.2S3.2747 36479500 PMC9710414 · DOI
  18. [20]Huang P.L. A comprehensive definition for metabolic syndrome DMM Dis. Model. Mech. 2009 2 231 237 10.1242/dmm.001180 19407331 PMC2675814 · DOI
  19. [21]Ford E.S. Prevalence of the Metabolic Syndrome Defined by the International Diabetes Federation Among Adults in the U.S Diabetes Care 2005 28 2745 2749 10.2337/diacare.28.11.2745 16249550 · DOI
  20. [22]Rochlani Y. Pothineni N.V. Kovelamudi S. Mehta J.L. Metabolic syndrome: Pathophysiology, management, and modulation by natural compounds Ther. Adv. Cardiovasc. Dis. 2017 11 215 10.1177/1753944717711379 28639538 PMC5933580 · DOI
  21. [23]Hui W.S. Liu Z. Ho S.C. Metabolic syndrome and all-cause mortality: A meta-analysis of prospective cohort studies Eur. J. Epidemiol. 2010 25 375 384 10.1007/s10654-010-9459-z 20425137 · DOI
  22. [24]Jovanovic C.E.S. Hoelscher D.M. Chen B. Ranjit N. van den Berg A.E. The associations of plant-based food and metabolic syndrome using NHANES 2015-16 data J. Public Health 2022 45 e22 e29 10.1093/pubmed/fdab403 35021215 · DOI
  23. [25]Shang P. Shu MPH Z. Wang Y. Li N. Du S. Sun F. Xia Y. Zhan S. Veganism does not reduce the risk of the metabolic syndrome in a Taiwanese cohort Asia Pac. J. Clin. Nutr. 2011 20 404 410 21859659
  24. [26]Noce A. Di Lauro M. Di Daniele F. Zaitseva A.P. Marrone G. Borboni P. Di Daniele N. Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome Nutrients 2021 13 630 10.3390/NU13020630 33669163 PMC7919668 · DOI
  25. [27]McGrath L. Fernandez M.L. Plant-based diets and metabolic syndrome: Evaluating the influence of diet quality J. Agric. Food Res. 2022 9 100322 10.1016/J.JAFR.2022.100322 · DOI
  26. [28]Li H. Zeng X. Wang Y. Zhang Z. Zhu Y. Li X. Hu A. Zhao Q. Yang W. A prospective study of healthful and unhealthful plant-based diet and risk of overall and cause-specific mortality Eur. J. Nutr. 2022 61 387 398 10.1007/S00394-021-02660-7 34379193 · DOI
  27. [29]Petermann-Rocha F. Parra-Soto S. Gray S. Anderson J. Welsh P. Gill J. Sattar N. Ho F.K. Celis-Morales C. Pell J.P. Vegetarians, fish, poultry, and meat-eaters: Who has higher risk of cardiovascular disease incidence and mortality? A prospective study from UK Biobank Eur. Heart J. 2021 42 1136 1143 10.1093/EURHEARTJ/EHAA939 33313747 PMC7982287 · DOI
  28. [30]Storz M.A. What makes a plant-based diet? a review of current concepts and proposal for a standardized plant-based dietary intervention checklist Eur. J. Clin. Nutr. 2022 76 789 10.1038/S41430-021-01023-Z 34675405 PMC9187516 · DOI
  29. [31]Akinyemiju T. Moore J.X. Pisu M. Lakoski S.G. Shikany J. Goodman M. Judd S.E. A prospective study of dietary patterns and cancer mortality among Blacks and Whites in the REGARDS cohort Int. J. cancer 2016 139 2221 10.1002/ijc.30287 27459634 PMC5041524 · DOI
  30. [32]Shikany J.M. Safford M.M. Newby P.K. Durant R.W. Brown T.M. Judd S.E. Southern Dietary Pattern is Associated with Hazard of Acute Coronary Heart Disease in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study Circulation 2015 132 804 10.1161/CIRCULATIONAHA.114.014421 26260732 PMC4558233 · DOI
  31. [33]Wozniak H. Larpin C. De Mestral C. Guessous I. Reny J.L. Stringhini S. Vegetarian, pescatarian and flexitarian diets: Sociodemographic determinants and association with cardiovascular risk factors in a Swiss urban population Br. J. Nutr. 2020 124 844 10.1017/S0007114520001762 32418548 PMC7525113 · DOI
  32. [34]Satija A. Hu F.B. Plant-based diets and cardiovascular health Trends Cardiovasc. Med. 2018 28 437 441 10.1016/j.tcm.2018.02.004 29496410 PMC6089671 · DOI · Paper page
  33. [35]Jebari-Benslaiman S. Galicia-García U. Larrea-Sebal A. Olaetxea J.R. Alloza I. Vandenbroeck K. Benito-Vicente A. Martín C. Pathophysiology of Atherosclerosis Int. J. Mol. Sci. 2022 23 3346 10.3390/ijms23063346 35328769 PMC8954705 · DOI
  34. [36]Bale B.F. Doneen A.L. Leimgruber P.P. Vigerust D.J. The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress Front. Cardiovasc. Med. 2022 9 3281 PMC9682196 36439997
  35. [37]Bergheanu S.C. Bodde M.C. Jukema J.W. Pathophysiology and treatment of atherosclerosis: Current view and future perspective on lipoprotein modification treatment Neth. Heart J. 2017 25 231 10.1007/S12471-017-0959-2 28194698 PMC5355390 · DOI
  36. [38]Basta G. Schmidt A.M. De Caterina R. Advanced glycation end products and vascular inflammation: Implications for accelerated atherosclerosis in diabetes Cardiovasc. Res. 2004 63 582 592 10.1016/j.cardiores.2004.05.001 15306213 · DOI
  37. [40]Cazzaniga A. Scrimieri R. Giani E. Zuccotti G.V. Maier J.A.M. Endothelial Hyper-Permeability Induced by T1D Sera Can be Reversed by iNOS Inactivation Int. J. Mol. Sci. 2020 21 2798 10.3390/ijms21082798 32316573 PMC7215952 · DOI
  38. [41]Matsuura E. Hughes G.R.V. Khamashta M.A. Oxidation of LDL and its clinical implication Autoimmun. Rev. 2008 7 558 566 10.1016/j.autrev.2008.04.018 18625445 · DOI · Paper page
  39. [42]Trompet S. Packard C.J. Jukema J.W. Plasma apolipoprotein-B is an important risk factor for cardiovascular disease, and its assessment should be routine clinical practice Curr. Opin. Lipidol. 2018 29 51 52 10.1097/MOL.0000000000000476 29298274 · DOI
  40. [43]Behbodikhah J. Ahmed S. Elyasi A. Kasselman L.J. De Leon J. Glass A.D. Reiss A.B. Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target Metabolites 2021 11 690 10.3390/metabo11100690 34677405 PMC8540246 · DOI
  41. [44]Fonseca L. Paredes S. Ramos H. Oliveira J.C. Palma I. Apolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol Lipids Health Dis. 2020 19 127 10.1186/s12944-020-01292-w 32505210 PMC7275418 · DOI
  42. [46]Helgadottir A. Thorleifsson G. Snaebjarnarson A. Stefansdottir L. Sveinbjornsson G. Tragante V. Björnsson E. Steinthorsdottir V. Gretarsdottir S. Helgason H. Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles: A Mendelian randomization analysis Eur. J. Prev. Cardiol. 2022 29 2374 2385 10.1093/eurjpc/zwac219 36125206 · DOI · Paper page
  43. [47]Toikka J.O. Niemi P. Ahotupa M. Niinikoski H. Viikari J.S.A. Rönnemaa T. Hartiala J.J. Raitakari O.T. Large-artery elastic properties in young men: Relationships to serum lipoproteins and oxidized low-density lipoproteins Arterioscler. Thromb. Vasc. Biol. 1999 19 436 441 10.1161/01.ATV.19.2.436 9974429 · DOI
  44. [48]Linna M. Ahotupa M. Löppönen M.K. Irjala K. Vasankari T. Circulating oxidised LDL lipids, when proportioned to HDL-c, emerged as a risk factor of all-cause mortality in a population-based survival study Age Ageing 2013 42 110 113 10.1093/ageing/afs074 22693160 · DOI
  45. [49]O’Keefe J.H. Cordain L. Harris W.H. Moe R.M. Vogel R. Optimal low-density lipoprotein is 50 to 70 mg/dL: Lower is better and physiologically normal J. Am. Coll. Cardiol. 2004 43 2142 2146 10.1016/j.jacc.2004.03.046 15172426 · DOI
  46. [50]Ference B.A. Ginsberg H.N. Graham I. Ray K.K. Packard C.J. Bruckert E. Hegele R.A. Krauss R.M. Raal F.J. Schunkert H. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel Eur. Heart J. 2017 38 2459 10.1093/eurheartj/ehx144 28444290 PMC5837225 · DOI · Paper page
  47. [51]Kawamoto R. Kikuchi A. Akase T. Ninomiya D. Kumagi T. Low density lipoprotein cholesterol and all-cause mortality rate: Findings from a study on Japanese community-dwelling persons Lipids Health Dis. 2021 20 105 10.1186/s12944-021-01533-6 34511127 PMC8436563 · DOI
  48. [52]Jacobs D.R. Blackburn H. Higgins M. Reed D. Iso H. McMillan G. Neaton J. Nelson J. Potter J. Rifkind B. Report of the Conference on Low Blood Cholesterol: Mortality Associations Circulation 1992 86 1046 1060 10.1161/01.CIR.86.3.1046 1355411 · DOI
  49. [53]Kritchevsky S.B. Wilcosky T.C. Morris D.L. Truong K.N. Tyroler H.A. Changes in Plasma Lipid and Lipoprotein Cholesterol and Weight Prior to the Diagnosis of Cancer1 | Cancer Research | American Association for Cancer Research Available online: https://aacrjournals.org/cancerres/article/51/12/3198/496777/Changes-in-Plasma-Lipid-and-Lipoprotein (accessed on 1 January 2023) 2039996
  50. [54]Postmus I. Deelen J. Sedaghat S. Trompet S. De Craen A.J.M. Heijmans B.T. Franco O.H. Hofman A. Dehghan A. Slagboom P.E. LDL cholesterol still a problem in old age? A Mendelian randomization study Int. J. Epidemiol. 2015 44 604 612 10.1093/ije/dyv031 25855712 · DOI
  51. [55]Weverling-Rijnsburger A.W.E. Blauw G.J. Lagaay A.M. Knook D.L. Meinders A.E. Westendorp R.G.J. Total cholesterol and risk of mortality in the oldest old Lancet 1997 350 1119 1123 10.1016/S0140-6736(97)04430-9 9343498 · DOI · Paper page
  52. [56]Wang B. Liu J. Chen S. Ying M. Chen G. Liu L. Lun Z. Li H. Huang H. Li Q. Malnutrition affects cholesterol paradox in coronary artery disease: A 41,229 Chinese cohort study Lipids Health Dis. 2021 20 36 10.1186/s12944-021-01460-6 33874960 PMC8056540 · DOI
  53. [57]Tuso P. Stoll S.R. Li W.W. A Plant-Based Diet, Atherogenesis, and Coronary Artery Disease Prevention Perm. J. 2015 19 62 10.7812/TPP/14-036 25431999 PMC4315380 · DOI
  54. [58]Huang W.C. Tung C.L. Yang Y.C.S.H. Lin I.H. Ng X.E. Tung Y.T. Endurance exercise ameliorates Western diet-induced atherosclerosis through modulation of microbiota and its metabolites Sci. Rep. 2022 12 3612 10.1038/s41598-022-07317-x 35256637 PMC8901804 · DOI
  55. [59]Lian Z. Perrard X.Y.D. Peng X. Raya J.L. Hernandez A.A. Johnson C.G. Lagor W.R. Pownall H.J. Hoogeveen R.C. Simon S.I. Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice Arterioscler. Thromb. Vasc. Biol. 2020 40 72 85 10.1161/ATVBAHA.119.313078 31619061 PMC6991890 · DOI
  56. [60]Noakes M. Clifton P.M. Changes in plasma lipids and other cardiovascular risk factors during 3 energy-restricted diets differing in total fat and fatty acid composition Am. J. Clin. Nutr. 2000 71 706 712 10.1093/ajcn/71.3.706 10702163 · DOI
  57. [61]Hooper L. Martin N. Jimoh O.F. Kirk C. Foster E. Abdelhamid A.S. Reduction in saturated fat intake for cardiovascular disease Cochrane Database Syst. Rev. 2020 8 CD011737 10.1002/14651858.CD011737 32827219 PMC8092457 · DOI · Paper page
  58. [62]Maki K.C. Dicklin M.R. Kirkpatrick C.F. Saturated fats and cardiovascular health: Current evidence and controversies J. Clin. Lipidol. 2021 15 765 772 10.1016/j.jacl.2021.09.049 34649831 · DOI
  59. [63]Astrup A. Magkos F. Bier D.M. Brenna J.T. de Oliveira Otto M.C. Hill J.O. King J.C. Mente A. Ordovas J.M. Volek J.S. Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review J. Am. Coll. Cardiol. 2020 76 844 857 10.1016/j.jacc.2020.05.077 32562735 · DOI
  60. [64]Gershuni V.M. Saturated Fat: Part of a Healthy Diet Curr. Nutr. Rep. 2018 7 85 96 10.1007/s13668-018-0238-x 30084105 · DOI
  61. [65]Shen H. Eguchi K. Kono N. Fujiu K. Matsumoto S. Shibata M. Oishi-Tanaka Y. Komuro I. Arai H. Nagai R. Saturated fatty acid palmitate aggravates neointima formation by promoting smooth muscle phenotypic modulation Arterioscler. Thromb. Vasc. Biol. 2013 33 2596 2607 10.1161/ATVBAHA.113.302099 23968977 · DOI
  62. [66]Mills C.E. Harding S.V. Bapir M. Mandalari G. Salt L.J. Gray R. Fielding B.A. Wilde P.J. Hall W.L. Berry S.E. Palmitic acid–rich oils with and without interesterification lower postprandial lipemia and increase atherogenic lipoproteins compared with a MUFA-rich oil: A randomized controlled trial Am. J. Clin. Nutr. 2021 113 1221 10.1093/ajcn/nqaa413 33675343 PMC8106759 · DOI
  63. [67]Afonso M.S. Lavrador M.S.F. Koike M.K. Cintra D.E. Ferreira F.D. Nunes V.S. Castilho G. Gioielli L.A. Paula Bombo R. Catanozi S. Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation J. Nutr. Biochem. 2016 32 91 100 10.1016/j.jnutbio.2016.01.005 27142741 · DOI
  64. [68]Ishiyama J. Taguchi R. Yamamoto A. Murakami K. Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells Atherosclerosis 2010 209 118 124 10.1016/j.atherosclerosis.2009.09.004 19782984 · DOI
  65. [69]Guasch-Ferré M. Liu X. Malik V.S. Sun Q. Willett W.C. Manson J.A.E. Rexrode K.M. Li Y. Hu F.B. Bhupathiraju S.N. Nut Consumption and Risk of Cardiovascular Disease J. Am. Coll. Cardiol. 2017 70 2519 10.1016/j.jacc.2017.09.035 29145952 PMC5762129 · DOI
  66. [70]Riccardi G. Giosuè A. Calabrese I. Vaccaro O. Dietary recommendations for prevention of atherosclerosis Cardiovasc. Res. 2022 118 1188 1204 10.1093/cvr/cvab173 34229346 · DOI
  67. [71]Nergiz-Ünal R. Kuijpers M.J.E. De Witt S.M. Heeneman S. Feijge M.A.H. Garcia Caraballo S.C. Biessen E.A.L. Haenen G.R.M.M. Cosemans J.M.E.M. Heemskerk J.W.M. Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors Thromb. Res. 2013 131 411 417 10.1016/j.thromres.2013.01.003 23347681 · DOI
  68. [72]Urpi-Sarda M. Casas R. Chiva-Blanch G. Romero-Mamani E.S. Valderas-Martínez P. Arranz S. Andres-Lacueva C. Llorach R. Medina-Remón A. Lamuela-Raventos R.M. Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis Pharmacol. Res. 2012 65 577 583 10.1016/j.phrs.2012.03.006 22449789 · DOI
  69. [73]Estruch R. Anti-inflammatory effects of the Mediterranean diet: The experience of the PREDIMED study Proc. Nutr. Soc. 2010 69 333 340 10.1017/S0029665110001539 20515519 · DOI
  70. [75]Sanchez A. Mejia A. Sanchez J. Runte E. Brown-Fraser S. Bivens R.L. Diets with customary levels of fat from plant origin may reverse coronary artery disease Med. Hypotheses 2019 122 103 105 10.1016/j.mehy.2018.10.027 30593389 · DOI
  71. [76]Mensink R.P. Katan M.B. Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials Arterioscler. Thromb. A J. Vasc. Biol. 1992 12 911 919 10.1161/01.ATV.12.8.911 1386252 · DOI · Paper page
  72. [77]Müller H. Lindman A.S. Brantsætert A.L. Pedersen J.I. The Serum LDL/HDL Cholesterol Ratio Is Influenced More Favorably by Exchanging Saturated with Unsaturated Fat Than by Reducing Saturated Fat in the Diet of Women J. Nutr. 2003 133 78 83 10.1093/jn/133.1.78 12514271 · DOI
  73. [78]Sun T. Chen M. Shen H. PingYin Fan L. Chen X. Wu J. Xu Z. Zhang J. Predictive value of LDL/HDL ratio in coronary atherosclerotic heart disease BMC Cardiovasc. Disord. 2022 22 273 10.1186/s12872-022-02706-6 35715736 PMC9206383 · DOI
  74. [79]Toscano L.T. Toscano L.T. Tavares R.L. da Silva C.S.O. Silva A.S. Chia induces clinically discrete weight loss and improves lipid profile only in altered previous values Nutr. Hosp. 2014 31 1176 1182 10.3305/NH.2015.31.3.8242 25726210 · DOI
  75. [80]Pacheco L.S. Li Y. Rimm E.B. Manson J.E. Sun Q. Rexrode K. Hu F.B. Guasch-Ferré M. Avocado Consumption and Risk of Cardiovascular Disease in US Adults J. Am. Heart Assoc. 2018 11 e024014 10.1161/JAHA.121.024014 35352568 PMC9075418 · DOI
  76. [82]Koeth R.A. Wang Z. Levison B.S. Buffa J.A. Org E. Sheehy B.T. Britt E.B. Fu X. Wu Y. Li L. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis Nat. Med. 2013 19 576 10.1038/nm.3145 23563705 PMC3650111 · DOI · Paper page
  77. [83]Andraos S. Lange K. Clifford S.A. Jones B. Thorstensen E.B. Kerr J.A. Wake M. Saffery R. Burgner D.P. O’Sullivan J.M. Plasma Trimethylamine N-Oxide and Its Precursors: Population Epidemiology, Parent–Child Concordance, and Associations with Reported Dietary Intake in 11- to 12-Year-Old Children and Their Parents Curr. Dev. Nutr. 2020 4 nzaa103 10.1093/cdn/nzaa103 32666035 PMC7335361 · DOI
  78. [84]Jia J. Dou P. Gao M. Kong X. Li C. Liu Z. Huang T. Assessment of Causal Direction Between Gut Microbiota-Dependent Metabolites and Cardiometabolic Health: A Bidirectional Mendelian Randomization Analysis Diabetes 2019 68 1747 1755 10.2337/db19-0153 31167879 · DOI
  79. [85]Miller M.J. Bostwick B.L. Kennedy A.D. Donti T.R. Sun Q. Sutton V.R. Elsea S.H. Chronic Oral l-Carnitine Supplementation Drives Marked Plasma TMAO Elevations in Patients with Organic Acidemias Despite Dietary Meat Restrictions JIMD Rep. 2016 30 39 10.1007/8904_2016_539 26936850 PMC5110437 · DOI
  80. [86]Yu Z.L. Zhang L.Y. Jiang X.M. Xue C.H. Chi N. Zhang T.T. Wang Y.M. Effects of dietary choline, betaine, and L-carnitine on the generation of trimethylamine-N-oxide in healthy mice J. Food Sci. 2020 85 2207 2215 10.1111/1750-3841.15186 32572979 · DOI
  81. [88]Ilyas A. Wijayasinghe Y.S. Khan I. El Samaloty N.M. Adnan M. Dar T.A. Poddar N.K. Singh L.R. Sharma H. Khan S. Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds Front. Mol. Biosci. 2022 9 818 10.3389/fmolb.2022.964624 PMC9601739 36310589 · DOI
  82. [89]Meyer K.A. Shea J.W. Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies Nutrients 2017 9 711 10.3390/nu9070711 28686188 PMC5537826 · DOI
  83. [90]Samulak J.J. Sawicka A.K. Hartmane D. Grinberga S. Pugovics O. Lysiak-Szydlowska W. Olek R.A. L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women Ann. Nutr. Metab. 2019 74 11 17 10.1159/000495037 30485835 · DOI
  84. [91]Losasso C. Eckert E.M. Mastrorilli E. Villiger J. Mancin M. Patuzzi I. Di Cesare A. Cibin V. Barrucci F. Pernthaler J. Assessing the influence of vegan, vegetarian and omnivore oriented westernized dietary styles on human gut microbiota: A cross sectional study Front. Microbiol. 2018 9 317 10.3389/fmicb.2018.00317 29556222 PMC5844980 · DOI · Paper page
  85. [92]De Filippo C. Cavalieri D. Di Paola M. Ramazzotti M. Poullet J.B. Massart S. Collini S. Pieraccini G. Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa Proc. Natl. Acad. Sci. USA 2010 107 14691 14696 10.1073/pnas.1005963107 20679230 PMC2930426 · DOI · Paper page
  86. [93]Topping D.L. Clifton P.M. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides Physiol. Rev. 2001 81 1031 1064 10.1152/physrev.2001.81.3.1031 11427691 · DOI · Paper page
  87. [94]Hentges D.J. Maier B.R. Burton G.C. Flynn M.A. Tsutakawa R.K. Effect of a High-Beef Diet on the Fecal Bacterial Flora of Humans1 | Cancer Research | American Association for Cancer Research Available online: https://aacrjournals.org/cancerres/article/37/2/568/481691/Effect-of-a-High-Beef-Diet-on-the-Fecal-Bacterial (accessed on 1 January 2023) 832279
  88. [96]Kim C.H. Park J. Kim M. Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation Immune Netw. 2014 14 277 288 10.4110/in.2014.14.6.277 25550694 PMC4275385 · DOI · Paper page
  89. [97]Willemsen L.E.M. Koetsier M.A. Van Deventer S.J.H. Van Tol E.A.F. Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E1 and E2 production by intestinal myofibroblasts Gut 2003 52 1442 10.1136/gut.52.10.1442 12970137 PMC1773837 · DOI
  90. [99]Grondin J.A. Kwon Y.H. Far P.M. Haq S. Khan W.I. Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies Front. Immunol. 2020 11 2054 10.3389/fimmu.2020.02054 33013869 PMC7500085 · DOI
  91. [100]Yao D. Dai W. Dong M. Dai C. Wu S. MUC2 and related bacterial factors: Therapeutic targets for ulcerative colitis EBioMedicine 2021 74 103751 10.1016/j.ebiom.2021.103751 34902790 PMC8671112 · DOI
  92. [101]Kang Y. Park H. Choe B.H. Kang B. The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease Front. Med. 2022 9 1312 10.3389/fmed.2022.848344 PMC9120656 35602503 · DOI
  93. [102]Costabile G. Vetrani C. Bozzetto L. Giacco R. Bresciani L. Del Rio D. Vitale M. Della Pepa G. Brighenti F. Riccardi G. Plasma TMAO increase after healthy diets: Results from 2 randomized controlled trials with dietary fish, polyphenols, and whole-grain cereals Am. J. Clin. Nutr. 2021 114 1342 1350 10.1093/ajcn/nqab188 34091663 · DOI
  94. [103]Griffin L.E. Djuric Z. Angiletta C.J. Mitchell C.M. Baugh M.E. Davy K.P. Neilson A.P. A Mediterranean diet does not alter plasma trimethylamine N-oxideconcentrations in healthy adults at risk for colon cancer Food Funct. 2019 10 2138 10.1039/C9FO00333A 30938383 PMC6552673 · DOI
  95. [104]Thomas M.S. Puglisi M. Malysheva O. Caudill M.A. Sholola M. Cooperstone J.L. Fernandez M.L. Eggs Improve Plasma Biomarkers in Patients with Metabolic Syndrome Following a Plant-Based Diet—A Randomized Crossover Study Nutrients 2022 14 2138 10.3390/nu14102138 35631279 PMC9147178 · DOI
  96. [105]Zhu C. Sawrey-Kubicek L. Bardagjy A.S. Houts H. Tang X. Sacchi R. Randolph J.M. Steinberg F.M. Zivkovic A.M. Whole egg consumption increases plasma choline and betaine without affecting TMAO levels or gut microbiome in overweight postmenopausal women Nutr. Res. 2020 78 36 41 10.1016/j.nutres.2020.04.002 32464420 · DOI
  97. [106]Greene C.M. Zern T.L. Wood R.J. Shrestha S. Aggarwal D. Sharman M.J. Volek J.S. Fernandez M.L. Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge J. Nutr. 2005 135 2793 2798 10.1093/jn/135.12.2793 16317122 · DOI
  98. [107]Weggemans R.M. Zock P.L. Katan M.B. Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: A meta-analysis Am. J. Clin. Nutr. 2001 73 885 891 10.1093/ajcn/73.5.885 11333841 · DOI · Paper page
  99. [108]Connor W.E. Hodges R.E. Bleiler R.E. The serum lipids in men receiving high cholesterol and cholesterol-free diets J. Clin. Investig. 1961 40 894 10.1172/JCI104324 13695088 PMC290802 · DOI
  100. [109]Wells V.M. Bronte-Stewart B. Egg Yolk and Serum-cholesterol Levels: Importance of Dietary Cholesterol Intake Br. Med. J. 1963 1 577 10.1136/bmj.1.5330.577 13999890 PMC2123481 · DOI
  101. [110]Rouhani M.H. Rashidi-Pourfard N. Salehi-Abargouei A. Karimi M. Haghighatdoost F. Effects of Egg Consumption on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials J. Am. Coll. Nutr. 2018 37 99 110 10.1080/07315724.2017.1366878 29111915 · DOI
  102. [111]Hopkins P.N. Effects of dietary cholesterol on serum cholesterol: A meta-analysis and review Am. J. Clin. Nutr. 1992 55 1060 1070 10.1093/ajcn/55.6.1060 1534437 · DOI
  103. [112]West A.A. Shih Y. Wang W. Oda K. Jaceldo-Siegl K. Sabaté J. Haddad E. Rajaram S. Caudill M.A. Burns-Whitmore B. Egg n-3 fatty acid composition modulates biomarkers of choline metabolism in free-living lacto-ovo-vegetarian women of reproductive age J. Acad. Nutr. Diet. 2014 114 1594 1600 10.1016/j.jand.2014.02.012 24726349 · DOI
  104. [113]Wang Z. Tang W.H.W. Buffa J.A. Fu X. Britt E.B. Koeth R.A. Levison B.S. Fan Y. Wu Y. Hazen S.L. Editor’s choice: Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide Eur. Heart J. 2014 35 904 10.1093/eurheartj/ehu002 24497336 PMC3977137 · DOI · Paper page
  105. [115]Dickinson K.M. Clifton P.M. Keogh J.B. Endothelial function is impaired after a high-salt meal in healthy subjects– Am. J. Clin. Nutr. 2011 93 500 505 10.3945/ajcn.110.006155 21228265 · DOI
  106. [116]Lennon-Edwards S. Ramick M.G. Matthews E.L. Brian M.S. Farquhar W.B. Edwards D.G. Salt loading has a more deleterious effect on flow-mediated dilation in salt-resistant men than women Nutr. Metab. Cardiovasc. Dis. 2014 24 990 995 10.1016/j.numecd.2014.05.004 24989702 PMC4195435 · DOI · Paper page
  107. [117]Kawashima S. Yokoyama M. Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis Arterioscler. Thromb. Vasc. Biol. 2004 24 998 1005 10.1161/01.ATV.0000125114.88079.96 15001455 · DOI
  108. [118]Vogel R.A. Corretti M.C. Plotnick G.D. Effect of a single high-fat meal on endothelial function in healthy subjects Am. J. Cardiol. 1997 79 350 354 10.1016/S0002-9149(96)00760-6 9036757 · DOI · Paper page
  109. [120]Ros E. Núñez I. Pérez-Heras A. Serra M. Gilabert R. Casals E. Deulofeu R. A Walnut Diet Improves Endothelial Function in Hypercholesterolemic Subjects Circulation 2004 109 1609 1614 10.1161/01.CIR.0000124477.91474.FF 15037535 · DOI
  110. [121]Mateos R. Salvador M.D. Fregapane G. Goya L. Why Should Pistachio Be a Regular Food in Our Diet? Nutrients 2022 14 3207 10.3390/nu14153207 35956383 PMC9370095 · DOI
  111. [122]Katz D.L. Davidhi A. Ma Y. Kavak Y. Bifulco L. Njike V.Y. Effects of Walnuts on Endothelial Function in Overweight Adults with Visceral Obesity: A Randomized, Controlled, Crossover Trial J. Am. Coll. Nutr. 2013 31 415 423 10.1080/07315724.2012.10720468 PMC3756625 23756586 · DOI
  112. [124]Heiss C. Finis D. Kleinbongard P. Hoffmann A. Rassaf T. Kelm M. Sies H. Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week J. Cardiovasc. Pharmacol. 2007 49 74 80 10.1097/FJC.0b013e31802d0001 17312446 · DOI
  113. [125]Velmurugan S. Gan J.M. Rathod K.S. Khambata R.S. Ghosh S.M. Hartley A. Van Eijl S. Sagi-Kiss V. Chowdhury T.A. Curtis M. Dietary nitrate improves vascular function in patients with hypercholesterolemia: A randomized, double-blind, placebo-controlled study Am. J. Clin. Nutr. 2016 103 25 10.3945/ajcn.115.116244 26607938 PMC4691670 · DOI · Paper page
  114. [126]Haynes A. Linden M.D. Robey E. Naylor L.H. Cox K.L. Lautenschlager N.T. Green D.J. Relationship between monocyte-platelet aggregation and endothelial function in middle-aged and elderly adults Physiol. Rep. 2017 5 13189 10.14814/phy2.13189 28533260 PMC5449553 · DOI
  115. [127]Burger P.C. Wagner D.D. Platelet P-selectin facilitates atherosclerotic lesion development Blood 2003 101 2661 2666 10.1182/blood-2002-07-2209 12480714 · DOI
  116. [129]Bondonno C.P. Blekkenhorst L.C. Prince R.L. Ivey K.L. Lewis J.R. Devine A. Woodman R.J. Lundberg J.O. Croft K.D. Thompson P.L. Association of Vegetable Nitrate Intake with Carotid Atherosclerosis and Ischemic Cerebrovascular Disease in Older Women Stroke 2017 48 1724 1729 10.1161/STROKEAHA.117.016844 28596448 · DOI · Paper page
  117. [130]Sundqvist M.L. Larsen F.J. Carlström M. Bottai M. Pernow J. Hellénius M.L. Weitzberg E. Lundberg J.O. A randomized clinical trial of the effects of leafy green vegetables and inorganic nitrate on blood pressure Am. J. Clin. Nutr. 2020 111 749 756 10.1093/ajcn/nqaa024 32091599 PMC7338722 · DOI
  118. [131]Tischmann L. Adam T.C. Mensink R.P. Joris P.J. Longer-term soy nut consumption improves vascular function and cardiometabolic risk markers in older adults: Results of a randomized, controlled cross-over trial Clin. Nutr. 2022 41 1052 1058 10.1016/j.clnu.2022.03.014 35395555 · DOI
  119. [132]Tucci M. Marino M. Martini D. Porrini M. Riso P. Del Bo’ C. Plant-Based Foods and Vascular Function: A Systematic Review of Dietary Intervention Trials in Older Subjects and Hypothesized Mechanisms of Action Nutrients 2022 14 2615 10.3390/nu14132615 35807796 PMC9268664 · DOI
  120. [133]Woo K.S. McCrohon J.A. Chook P. Adams M.R. Robinson J.T.C. McCredie R.J. Lam C.W.K. Feng J.Z. Celermajer D.S. Chinese adults are less susceptible than whites to age-related endothelial dysfunction J. Am. Coll. Cardiol. 1997 30 113 118 10.1016/S0735-1097(97)00111-3 9207630 · DOI
  121. [134]Anderson J.S. Nettleton J.A. Herrington D.M. Johnson W.C. Tsai M.Y. Siscovick D. Relation of omega-3 fatty acid and dietary fish intake with brachial artery flow-mediated vasodilation in the Multi-Ethnic Study of Atherosclerosis Am. J. Clin. Nutr. 2010 92 1204 1213 10.3945/ajcn.2010.29494 20826628 PMC2954452 · DOI
  122. [135]Sanders T.A.B. Hall W.L. Maniou Z. Lewis F. Seed P.T. Chowienczyk P.J. Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: A randomized controlled trial Am. J. Clin. Nutr. 2011 94 973 980 10.3945/ajcn.111.018036 21865334 · DOI
  123. [136]Xin W. Wei W. Li X. Effect of Fish Oil Supplementation on Fasting Vascular Endothelial Function in Humans: A Meta-Analysis of Randomized Controlled Trials PLoS ONE 2012 7 46028 10.1371/journal.pone.0046028 23029372 PMC3448723 · DOI
  124. [137]Lin C.L. Fang T.C. Gueng M.K. Vascular dilatory functions of ovo-lactovegetarians compared with omnivores Atherosclerosis 2001 158 247 251 10.1016/S0021-9150(01)00429-4 11500198 · DOI
  125. [138]Lau K. Srivatsav V. Rizwan A. Nashed A. Liu R. Shen R. Akhtar M. Bridging the Gap between Gut Microbial Dysbiosis and Cardiovascular Diseases Nutrition 2017 9 859 10.3390/nu9080859 PMC5579652 28796176 · DOI
  126. [139]Ma J. Li H. The role of gut microbiota in atherosclerosis and hypertension Front. Pharmacol. 2018 9 1082 10.3389/fphar.2018.01082 30319417 PMC6167910 · DOI
  127. [141]Richards L.B. Li M. van Esch B.C.A.M. Garssen J. Folkerts G. The effects of short-chain fatty acids on the cardiovascular system Pharma Nutrition 2016 4 68 111 10.1016/j.phanu.2016.02.001 · DOI
  128. [142]Feng Y. Huang Y. Wang Y. Wang P. Song H. Wang F. Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy PLoS ONE 2019 14 e0218384 10.1371/journal.pone.0218384 31211803 PMC6581431 · DOI
  129. [143]Edelblum K.L. Turner J.R. The Tight Junction in Inflammatory Disease: Communication Breakdown Curr. Opin. Pharmacol. 2009 9 715 10.1016/j.coph.2009.06.022 19632896 PMC2788114 · DOI
  130. [144]Chen W.Y. Wang M. Zhang J. Barve S.S. McClain C.J. Joshi-Barve S. Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability Am. J. Pathol. 2017 187 2686 2697 10.1016/j.ajpath.2017.08.015 28935573 PMC5818631 · DOI
  131. [146]Vinolo M.A.R. Rodrigues H.G. Nachbar R.T. Curi R. Regulation of Inflammation by Short Chain Fatty Acids Nutrients 2011 3 858 10.3390/nu3100858 22254083 PMC3257741 · DOI · Paper page
  132. [147]Li M. van Esch B.C.A.M. Wagenaar G.T.M. Garssen J. Folkerts G. Henricks P.A.J. Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells Eur. J. Pharmacol. 2018 831 52 59 10.1016/j.ejphar.2018.05.003 29750914 · DOI
  133. [148]Yang R. Jia Q. Mehmood S. Ma S. Liu X. Genistein ameliorates inflammation and insulin resistance through mediation of gut microbiota composition in type 2 diabetic mice Eur. J. Nutr. 2021 60 2155 2168 10.1007/s00394-020-02403-0 33068158 · DOI
  134. [149]Cordain L. Eaton S.B. Sebastian A. Mann N. Lindeberg S. Watkins B.A. O’Keefe J.H. Brand-Miller J. Origins and evolution of the Western diet: Health implications for the 21st century Am. J. Clin. Nutr. 2005 81 341 354 10.1093/ajcn.81.2.341 15699220 · DOI · Paper page
  135. [150]Davies G.J. Crowder M. Dickerson J.W.T. Dietary fibre intakes of individuals with different eating patterns Hum. Nutr. Appl. Nutr. 1985 39 139 148 2991173
  136. [151]Park Y. Subar A.F. Hollenbeck A. Schatzkin A. Dietary Fiber Intake and Mortality in the NIH-AARP Diet and Health Study Arch. Intern. Med. 2011 171 1061 1068 10.1001/archinternmed.2011.18 21321288 PMC3513325 · DOI
  137. [152]Zhang S. Tian J. Lei M. Zhong C. Zhang Y. Association between dietary fiber intake and atherosclerotic cardiovascular disease risk in adults: A cross-sectional study of 14,947 population based on the National Health and Nutrition Examination Surveys BMC Public Health 2022 22 1076 10.1186/s12889-022-13419-y 35641963 PMC9158217 · DOI
  138. [153]Daïen C.I. Pinget G.V. Tan J.K. Macia L. Detrimental impact of microbiota-accessible carbohydrate-deprived diet on gut and immune homeostasis: An overview Front. Immunol. 2017 8 12 10.3389/fimmu.2017.00548 28553291 PMC5427073 · DOI
  139. [155]Sonnenburg E.D. Smits S.A. Tikhonov M. Higginbottom S.K. Wingreen N.S. Sonnenburg J.L. Diet-induced extinction in the gut microbiota compounds over generations Nature 2016 529 212 10.1038/nature16504 26762459 PMC4850918 · DOI · Paper page
  140. [157]Soliman G.A. Dietary Fiber, Atherosclerosis, and Cardiovascular Disease Nutrients 2019 11 1155 10.3390/nu11051155 31126110 PMC6566984 · DOI
  141. [158]Nagarajan S. Mechanisms of anti-atherosclerotic functions of soy-based diets J. Nutr. Biochem. 2010 21 255 260 10.1016/j.jnutbio.2009.09.002 19954957 · DOI
  142. [159]Henning A.L. Venable A.S. Vingren J.L. Hill D.W. McFarlin B.K. Consumption of a high-fat meal was associated with an increase in monocyte adhesion molecules, scavenger receptors, and Propensity to Form Foam Cells Cytom. Part B Clin. Cytom. 2018 94 606 612 10.1002/cyto.b.21478 27569052 · DOI
  143. [161]Yun Y.R. Kim H.J. Song Y.O. Kimchi Methanol Extract and the Kimchi Active Compound, 3′-(4′-Hydroxyl-3′,5′-Dimethoxyphenyl)Propionic Acid, Downregulate CD36 in THP-1 Macrophages Stimulated by oxLDL J. Med. Food 2014 17 886 10.1089/jmf.2013.2943 25010893 PMC4126270 · DOI
  144. [162]Vetrani C. Costabile G. Luongo D. Naviglio D. Rivellese A.A. Riccardi G. Giacco R. Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome Nutrition 2016 32 217 221 10.1016/j.nut.2015.08.006 26706023 · DOI
  145. [163]Amato R. Rossino M.G. Cammalleri M. Locri F. Pucci L. Dal Monte M. Casini G. Lisosan G Protects the Retina from Neurovascular Damage in Experimental Diabetic Retinopathy Nutrients 2018 10 1932 10.3390/nu10121932 30563182 PMC6316708 · DOI
  146. [164]Giusti L. Gabriele M. Penno G. Garofolo M. Longo V. Del Prato S. Lucchesi D. Pucci L. A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells Oxid. Med. Cell. Longev. 2017 2017 1026268 10.1155/2017/1026268 28386305 PMC5366772 · DOI
  147. [165]Annunziata G. Arnone A. Ciampaglia R. Tenore G.C. Novellino E. Fermentation of Foods and Beverages as a Tool for Increasing Availability of Bioactive Compounds. Focus on Short-Chain Fatty Acids Foods 2020 9 999 10.3390/foods9080999 32722417 PMC7466228 · DOI
  148. [166]Karki R. Sahi N. Jeon E.R. Park Y.S. Kim D.W. Chungtaejeon, a Korean fermented tea, scavenges oxidation and inhibits cytokine induced proliferation and migration of human aortic smooth muscle cells Plant Foods Hum. Nutr. 2011 66 27 33 10.1007/s11130-011-0211-y 21344199 · DOI
  149. [167]Rahmani P. Melekoglu E. Tavakoli S. Malekpour Alamdari N. Rohani P. Sohouli M.H. Impact of red yeast rice supplementation on lipid profile: A systematic review and meta-analysis of randomized-controlled trials Expert Rev. Clin. Pharmacol. 2023 16 73 81 10.1080/17512433.2023.2138342 36259545 · DOI
  150. [168]Minamizuka T. Koshizaka M. Shoji M. Yamaga M. Hayashi A. Ide K. Ide S. Kitamoto T. Sakamoto K. Hattori A. Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial Asia Pac. J. Clin. Nutr. 2021 30 424 435 10.6133/APJCN.202109_30(3).0009 34587702 · DOI
  151. [169]Hu J. Wang J. Gan Q.X. Ran Q. Lou G.H. Xiong H.J. Peng C.Y. Sun J.L. Yao R.C. Huang Q.W. Impact of Red Yeast Rice on Metabolic Diseases: A Review of Possible Mechanisms of Action J. Agric. Food Chem. 2020 68 10441 10455 10.1021/acs.jafc.0c01893 32854499 · DOI
  152. [170]Samtiya M. Aluko R.E. Dhewa T. Moreno-Rojas J.M. Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview Foods 2021 10 839 10.3390/foods10040839 33921351 PMC8068854 · DOI
  153. [171]Barera A. Buscemi S. Monastero R. Caruso C. Caldarella R. Ciaccio M. Vasto S. β-glucans: Ex vivo inflammatory and oxidative stress results after pasta intake Immun. Ageing 2016 13 14 10.1186/s12979-016-0068-x 27057204 PMC4823838 · DOI
  154. [172]Nakashima A. Yamada K. Iwata O. Sugimoto R. Atsuji K. Ogawa T. Ishibashi-Ohgo N. Suzuki K. β-Glucan in Foods and Its Physiological Functions J. Nutr. Sci. Vitaminol. 2018 64 8 17 10.3177/jnsv.64.8 29491277 · DOI
  155. [173]Ho H.V.T. Sievenpiper J.L. Zurbau A. Mejia S.B. Jovanovski E. Au-Yeung F. Jenkins A.L. Vuksan V. A systematic review and meta-analysis of randomized controlled trials of the effect of barley β-glucan on LDL-C, non-HDL-C and apoB for cardiovascular disease risk reductioni-iv Eur. J. Clin. Nutr. 2016 70 1239 1245 10.1038/ejcn.2016.89 27273067 · DOI
  156. [175]Basu A. Role of Berry Bioactive Compounds on Lipids and Lipoproteins in Diabetes and Metabolic Syndrome Nutrients 2019 11 1983 10.3390/nu11091983 31443489 PMC6770868 · DOI
  157. [176]Huang H. Chen G. Liao D. Zhu Y. Xue X. Effects of Berries Consumption on Cardiovascular Risk Factors: A Meta-analysis with Trial Sequential Analysis of Randomized Controlled Trials Sci. Rep. 2016 6 23625 10.1038/srep23625 27006201 PMC4804301 · DOI
  158. [177]Luís Â. Domingues F. Pereira L. Association between berries intake and cardiovascular diseases risk factors: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials Food Funct. 2018 9 740 757 10.1039/C7FO01551H 29243749 · DOI
  159. [178]Vendrame S. Adekeye T.E. Klimis-Zacas D. The Role of Berry Consumption on Blood Pressure Regulation and Hypertension: An Overview of the Clinical Evidence Nutrients 2022 14 2701 10.3390/nu14132701 35807881 PMC9268395 · DOI
  160. [179]Yamakoshi J. Kataoka S. Koga T. Ariga T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits Atherosclerosis 1999 142 139 149 10.1016/S0021-9150(98)00230-5 9920515 · DOI
  161. [180]Yang M.Y. Huang C.N. Chan K.C. Yang Y.S. Peng C.H. Wang C.J. Mulberry leaf polyphenols possess antiatherogenesis effect via inhibiting LDL oxidation and foam cell formation J. Agric. Food Chem. 2011 59 1985 1995 10.1021/jf103661v 21314155 · DOI
  162. [181]Filosa S. Di Meo F. Crispi S. Polyphenols-gut microbiota interplay and brain neuromodulation Neural Regen. Res. 2018 13 2055 10.4103/1673-5374.241429 30323120 PMC6199944 · DOI
  163. [182]Corrêa T.A.F. Rogero M.M. Hassimotto N.M.A. Lajolo F.M. The Two-Way Polyphenols-Microbiota Interactions and Their Effects on Obesity and Related Metabolic Diseases Front. Nutr. 2019 6 188 10.3389/fnut.2019.00188 31921881 PMC6933685 · DOI
  164. [183]Tang M. Cheng L. Liu Y. Wu Z. Zhang X. Luo S. Plant Polysaccharides Modulate Immune Function via the Gut Microbiome and May Have Potential in COVID-19 Therapy Molecules 2022 27 2773 10.3390/molecules27092773 35566123 PMC9101721 · DOI
  165. [184]Krishna Rao R. Samak G. Protection and Restitution of Gut Barrier by Probiotics: Nutritional and Clinical Implications Curr. Nutr. Food Sci. 2013 9 99 10.2174/1573401311309020004 24353483 PMC3864899 · DOI
  166. [185]Gou H.Z. Zhang Y.L. Ren L.F. Li Z.J. Zhang L. How do intestinal probiotics restore the intestinal barrier? Front. Microbiol. 2022 13 929346 10.3389/fmicb.2022.929346 35910620 PMC9330398 · DOI
  167. [186]Vendrame S. Guglielmetti S. Riso P. Arioli S. Klimis-Zacas D. Porrini M. Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut J. Agric. Food Chem. 2011 59 12815 12820 10.1021/jf2028686 22060186 · DOI
  168. [187]Lara-Guzmán O.J. Medina S. Álvarez R. Oger C. Durand T. Galano J.M. Zuluaga N. Gil-Izquierdo Á. Muñoz-Durango K. Oxylipin regulation by phenolic compounds from coffee beverage: Positive outcomes from a randomized controlled trial in healthy adults and macrophage derived foam cells Free Radic. Biol. Med. 2020 160 604 617 10.1016/j.freeradbiomed.2020.07.020 32745768 · DOI
  169. [188]Al-Ishaq R.K. Abotaleb M. Kubatka P. Kajo K. Büsselberg D. Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels Biomolecules 2019 9 430 10.3390/biom9090430 31480505 PMC6769509 · DOI
  170. [189]Cade W.T. Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting Phys. Ther. 2008 88 1322 10.2522/ptj.20080008 18801863 PMC2579903 · DOI
  171. [190]Huang D. Refaat M. Mohammedi K. Jayyousi A. Al Suwaidi J. Abi Khalil C. Macrovascular Complications in Patients with Diabetes and Prediabetes Biomed Res. Int. 2017 2017 7839101 10.1155/2017/7839101 29238721 PMC5697393 · DOI
  172. [191]Olfert M.D. Wattick R.A. Vegetarian Diets and the Risk of Diabetes Curr. Diab. Rep. 2018 18 101 10.1007/s11892-018-1070-9 30229314 PMC6153574 · DOI
  173. [192]Schiattarella A. Lombardo M. Morlando M. Rizzo G. The Impact of a Plant-Based Diet on Gestational Diabetes: A Review Antioxidants 2021 10 557 10.3390/antiox10040557 33918528 PMC8065523 · DOI
  174. [193]Qian F. Liu G. Hu F.B. Bhupathiraju S.N. Sun Q. Association Between Plant-Based Dietary Patterns and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis JAMA Intern. Med. 2019 179 1335 1344 10.1001/jamainternmed.2019.2195 31329220 PMC6646993 · DOI · Paper page
  175. [194]Chen Z. Drouin-Chartier J.P. Li Y. Baden M.Y. Manson J.E. Willett W.C. Voortman T. Hu F.B. Bhupathiraju S.N. Changes in Plant-Based Diet Indices and Subsequent Risk of Type 2 Diabetes in Women and Men: Three U.S. Prospective Cohorts Diabetes Care 2021 44 663 671 10.2337/dc20-1636 33441419 PMC7896264 · DOI
  176. [195]Vinayagam R. Xu B. Antidiabetic properties of dietary flavonoids: A cellular mechanism review Nutr. Metab. 2015 12 60 10.1186/s12986-015-0057-7 26705405 PMC4690284 · DOI · Paper page
  177. [198]Yan L. Vaghari-Tabari M. Malakoti F. Moein S. Qujeq D. Yousefi B. Asemi Z. Quercetin: An effective polyphenol in alleviating diabetes and diabetic complications Crit. Rev. Food Sci. Nutr. 2022 1 24 10.1080/10408398.2022.2067825 35468007 · DOI
  178. [199]Tsalamandris S. Antonopoulos A.S. Oikonomou E. Papamikroulis G.A. Vogiatzi G. Papaioannou S. Deftereos S. Tousoulis D. The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives Eur. Cardiol. Rev. 2019 14 50 10.15420/ecr.2018.33.1 PMC6523054 31131037 · DOI · Paper page
  179. [200]Sun C. Zhao C. Guven E.C. Paoli P. Simal-Gandara J. Ramkumar K.M. Wang S. Buleu F. Pah A. Turi V. Dietary polyphenols as antidiabetic agents: Advances and opportunities Food Front. 2020 1 18 44 10.1002/fft2.15 · DOI
  180. [201]Tresserra-Rimbau A. Castro-Barquero S. Becerra-Tomás N. Babio N. Martínez-González M.Á. Corella D. Fitó M. Romaguera D. Vioque J. Alonso-Gomez A.M. Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial Antioxidants 2022 11 316 10.3390/antiox11020316 35204199 PMC8868059 · DOI
  181. [202]Aryaeian N. Sedehi S.K. Arablou T. Polyphenols and their effects on diabetes management: A review Med. J. Islam. Repub. Iran 2017 31 134 10.14196/mjiri.31.134 29951434 PMC6014790 · DOI
  182. [203]Gilbert E.R. Liu D. Anti-diabetic functions of soy isoflavone genistein: Mechanisms underlying effects on pancreatic β-cell function Food Funct. 2013 4 200 10.1039/C2FO30199G 23160185 PMC3678366 · DOI
  183. [204]Duru K.C. Kovaleva E.G. Danilova I.G. van der Bijl P. Belousova A.V. The potential beneficial role of isoflavones in type 2 diabetes mellitus Nutr. Res. 2018 59 1 15 10.1016/j.nutres.2018.06.005 30442228 · DOI
  184. [205]Guevara-Cruz M. Godinez-Salas E.T. Sanchez-Tapia M. Torres-Villalobos G. Pichardo-Ontiveros E. Guizar-Heredia R. Arteaga-Sanchez L. Gamba G. Mojica-Espinosa R. Schcolnik-Cabrera A. Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects BMJ Open Diabetes Res. Care 2020 8 e000948 10.1136/bmjdrc-2019-000948 32152146 PMC7064085 · DOI
  185. [207]Jain R. Bolch C. Al-Nakkash L. Sweazea K.L. Systematic review of the impact of genistein on diabetes-related outcomes Am. J. Physiol. Regul. Integr. Comp. Physiol. 2022 323 R279 R288 10.1152/ajpregu.00236.2021 35816719 · DOI
  186. [209]Chen Z. Zuurmond M.G. van der Schaft N. Nano J. Wijnhoven H.A.H. Ikram M.A. Franco O.H. Voortman T. Plant versus animal based diets and insulin resistance, prediabetes and type 2 diabetes: The Rotterdam Study Eur. J. Epidemiol. 2018 33 883 893 10.1007/s10654-018-0414-8 29948369 PMC6133017 · DOI
  187. [210]Toumpanakis A. Turnbull T. Alba-Barba I. Effectiveness of plant-based diets in promoting well-being in the management of type 2 diabetes: A systematic review BMJ Open Diabetes Res. Care 2018 6 534 10.1136/bmjdrc-2018-000534 PMC6235058 30487971 · DOI
  188. [211]Parry S.A. Rosqvist F. Mozes F.E. Cornfield T. Hutchinson M. Piche M.E. Hülsmeier A.J. Hornemann T. Dyson P. Hodson L. Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars Diabetes Care 2020 43 1134 1141 10.2337/dc19-2331 32165444 PMC7171936 · DOI
  189. [212]Kahleova H. Tura A. Hill M. Holubkov R. Barnard N.D. A Plant-Based Dietary Intervention Improves Beta-Cell Function and Insulin Resistance in Overweight Adults: A 16-Week Randomized Clinical Trial Nutrients 2018 10 189 10.3390/nu10020189 29425120 PMC5852765 · DOI
  190. [213]Kouvari M. Tsiampalis T. Kosti R.I. Naumovski N. Chrysohoou C. Skoumas J. Pitsavos C.S. Panagiotakos D.B. Mantzoros C.S. Quality of plant-based diets is associated with liver steatosis, which predicts type 2 diabetes incidence ten years later: Results from the ATTICA prospective epidemiological study Clin. Nutr. 2022 41 2094 2102 10.1016/j.clnu.2022.07.026 36087518 · DOI
  191. [214]Golzarand M. Bahadoran Z. Mirmiran P. Sadeghian-Sharif S. Azizi F. Dietary phytochemical index is inversely associated with the occurrence of hypertension in adults: A 3-year follow-up (the Tehran Lipid and Glucose Study) Eur. J. Clin. Nutr. 2015 69 392 398 10.1038/ejcn.2014.233 25387902 · DOI
  192. [215]Pounis G. Costanzo S. Di Giuseppe R. De Lucia F. Santimone I. Sciarretta A. Barisciano P. Persichillo M. De Curtis A. Zito F. Consumption of healthy foods at different content of antioxidant vitamins and phytochemicals and metabolic risk factors for cardiovascular disease in men and women of the Moli-sani study Eur. J. Clin. Nutr. 2013 67 207 213 10.1038/ejcn.2012.201 23249879 · DOI
  193. [216]Pettersen B.J. Anousheh R. Fan J. Jaceldo-Siegl K. Fraser G.E. Vegetarian diets and blood pressure among white subjects: Results from the Adventist Health Study-2 (AHS-2) Public Health Nutr. 2012 15 1909 10.1017/S1368980011003454 22230619 PMC3443300 · DOI
  194. [217]Fraser G. Katuli S. Anousheh R. Knutsen S. Herring P. Fan J. Vegetarian diets and cardiovascular risk factors in black members of the Adventist Health Study-2 Public Health Nutr. 2015 18 537 10.1017/S1368980014000263 24636393 PMC4167463 · DOI
  195. [218]Najjar R.S. Moore C.E. Montgomery B.D. A defined, plant-based diet utilized in an outpatient cardiovascular clinic effectively treats hypercholesterolemia and hypertension and reduces medications Clin. Cardiol. 2018 41 307 313 10.1002/clc.22863 29575002 PMC6489725 · DOI
  196. [219]Jennings A. Welch A.A. Fairweather-Tait S.J. Kay C. Minihane A.M. Chowienczyk P. Jiang B. Cecelja M. Spector T. Macgregor A. Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women Am. J. Clin. Nutr. 2012 96 781 788 10.3945/ajcn.112.042036 22914551 · DOI
  197. [220]Fairlie-Jones L. Davison K. Fromentin E. Hill A.M. The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Nutrients 2017 9 908 10.3390/nu9080908 28825651 PMC5579701 · DOI
  198. [221]Mozos I. Flangea C. Vlad D.C. Gug C. Mozos C. Stoian D. Luca C.T. Horbańczuk J.O. Horbańczuk O.K. Atanasov A.G. Effects of Anthocyanins on Vascular Health Biomolecules 2021 11 811 10.3390/biom11060811 34070757 PMC8227852 · DOI
  199. [222]Grillo A. Salvi L. Coruzzi P. Salvi P. Parati G. Sodium Intake and Hypertension Nutrients 2019 11 1970 10.3390/nu11091970 31438636 PMC6770596 · DOI
  200. [223]Geleijnse J.M. Kok F.J. Grobbee D.E. Blood pressure response to changes in sodium and potassium intake: A metaregression analysis of randomised trials J. Hum. Hypertens. 2003 17 471 480 10.1038/sj.jhh.1001575 12821954 · DOI

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Authors
Peña-Jorquera, H., Cid-Jofré, V., Landaeta-Díaz, L., Petermann-Rocha, F., Martorell, M., Zbinden-Foncea, H., Ferrari, G., Jorquera-Aguilera, C., & Cristi-Montero, C.
Affiliations
  • IRyS Group, Physical Education School, Pontificia Universidad Católica de Valparaíso, Viña del Mar 2530388, Chile
  • Universidad de Santiago de Chile (CL)
  • Facultad de Salud y Ciencias Sociales, Universidad de las Américas, Santiago 7500975, Chile
  • University of Glasgow (GB)
  • University of Concepción (CL)
  • Laboratorio de Fisiología del Ejercicio y Metabolismo, Escuela de Kinesiología, Facultad de Medicina, Universidad Finis Terrae, Santiago 7500000, Chile
  • Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Av. Pedro de Valdivia 425, Providencia 7500912, Chile
  • Universidad Mayor (CL)
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2023-07-21
Volume
15
Issue
14
Pages
3244
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu15143244
PMC
PMC10386413
OpenAlex
W4385202370
Cited by
103
References
28
Citations by year
2026: 18 · 2025: 34 · 2024: 42 · 2023: 9
FWCI
5.09
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Deposito Digital UFV (Francisco de Vitoria University) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Physical Sciences › Environmental Science › Ecology › Agriculture Sustainability and Environmental Impact
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
plant-based diet, atherosclerosis, non-communicable diseases, metabolic syndrome, diabetes mellitus, hypertension, dyslipidemia, cancer, insulin resistance, inflammation, endothelial dysfunction, cardiovascular risk, disease prevention
MeSH terms
Chronic Disease, Health Promotion, Humans, Quality of Life, Diet, Vegetarian, Metabolic Syndrome, Atherosclerosis

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