Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct
Open accessAbstract
Key Points: Alternatively activated macrophages derived from monocytes and tissue macrophages have distinct transcriptional profiles and phenotypes. Monocyte-derived AAMs are more involved with immune regulation than tissue-derived AAMs.
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Exposure or treatment of monocytes with IL-4 and IL-13 polarizes these cells toward an M2a phenotype.
“In stark contrast, exposure or treatment of monocytes with IL-4 and IL-13 polarizes these cells toward an M2a phenotype (8, 86).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [86]
Infection of inflammatory monocytes may turn them into arginase-expressing alternatively activated macrophages that trigger differentiation of naïve CD4 T cells into FoxP3+ cells, which are immunosuppressive in leishmaniasis.
“Infection of inflammatory monocytes (126) may also turn them into arginase-expressing alternatively activated macrophages that trigger the differentiation of naïve CD4 T cells into FoxP3+ cells (86), which are immunosuppressive in leishmaniasis (127, 128).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [86]
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- Authors
- Gundra, U. M., Girgis, N. M., Ruckerl, D., Jenkins, S., Ward, L. N., Kurtz, Z. D., Wiens, K. E., Tang, M. S., Basu-Roy, U., Mansukhani, A., Allen, J. E., & Loke, P.
- Affiliations
- New York University (US)
- Centre for Immunity, Infection and Evolution, and the Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
- Centre for Immunity, Infection and Evolution (GB)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-05-15
- Volume
- 123
- Issue
- 20
- Pages
- e110-e122
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4023427
- OpenAlex
- W2019954526
- Cited by
- 371
- References
- 8
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 26 · 2023: 27 · 2022: 24 · 2021: 43 · 2020: 48 · 2019: 36 · 2018: 34 · 2017: 26 · 2016: 19 · 2015: 29 · 2014: 12 · 2012: 1
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Wellcome Trust (095831)
- National Institutes of Health
- Medical Research Council (MR/K01207X/1)
- National Cancer Institute (P30CA16087-31, T32CA009161, P30CA016087)
- National Institute of Allergy and Infectious Diseases (R21AI094166, F32AI102502, R01AI093811, T32AI007180, AI093811, AI094166)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- M2 macrophages, monocyte-derived macrophages, tissue-resident macrophages, IL-4 receptor alpha, macrophage lineage, retinoic acid, Raldh2, PD-L2, CD206, CX3CR1, aldehyde dehydrogenase, UCP1, immune regulation, Arg1
- MeSH terms
- Uncoupling Protein 1, Animals, Cells, Cultured, Ion Channels, Macrophage Activation, Macrophages, Mice, Inbred C57BL, Monocytes, CD4 Antigens, Gene Expression, Gene Expression Profiling, Mitochondrial Proteins, Cell Proliferation, Mice, Forkhead Transcription Factors
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