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Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives
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In recent decades, probiotic bacteria have become increasingly popular as a result of mounting scientific evidence to indicate their beneficial role in modulating human health. Although there is strong evidence associating various Lactobacillus probiotics to various health benefits, further research is needed, in particular to determine the various mechanisms by which probiotics may exert these effects and indeed to gauge inter-individual value one can expect from consuming these products. One must take into consideration the differences in individual and combination strains, and conditions which create difficulty in making direct comparisons. The aim of this paper is to review the current understanding of the means by which Lactobacillus species stand to benefit our gastrointestinal health.
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“To exert these beneficial effects, they must withstand the harsh conditions of the gastrointestinal tract, including gastric acidity and bile salts [1].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [1]
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Metadata
- Authors
- Dempsey, E., & Corr, S. C.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Corr, Sinéad C.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2022-04-06
- Volume
- 13
- Pages
- 840245-840245
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC9019120
- OpenAlex
- W4225650845
- Cited by
- 579
- References
- 164
- Citations by year
- 2026: 145 · 2025: 220 · 2024: 139 · 2023: 59 · 2022: 16
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, cc-by-nc-sa)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion, cc-by)
- Funders
- Science Foundation Ireland
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus, probiotics, gut health, probiotic mechanisms of action, interindividual variability, strain differences, gut microbiota, health benefits
- MeSH terms
- Bacteria, Humans, Lactobacillus, Probiotics, Gastrointestinal Tract
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