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Cited by 132Tryptophan and brain disordersAmino Acid Enzymes and MetabolismNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.

Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders

Open access
Li, Dan, Yu, Shuang, Long, Yu, Shi, Ai, Deng, Jie, Ma, Yin, Wen, Jing, Li, Xiaoqiu, Liu, Songyu, Zhang, Yulu, Wan, Jinyan, Li, Nan, Ao, Rui·2022·Frontiers in Immunology
DOI 10.3389/fimmu.2022.985378PMC PMC9496178
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Abstract

Neurological and psychiatric disorders are a category of chronic diseases that are widespread and pose serious mental and physical health problems for patients. The substrates, products, and enzymes of Tryptophan metabolism all contribute to the development of neurological and psychiatric disorders. This paper deals with three metabolic pathways of tryptophan that produce a series of metabolites called tryptophan Catabolics (TRYCATs). These metabolites are involved in pathological processes such as excitotoxicity, neuroinflammation, oxidative stress, and mitochondrial damage and are closely associated with neurological and psychiatric disorders such as Alzheimer’s disease and depression. Here, we review the elements that affect how tryptophan metabolism is regulated, including inflammation and stress, exercise, vitamins, minerals, diet and gut microbes, glucocorticoids, and aging, as well as the downstream regulatory effects of tryptophan metabolism, including the regulation of glutamate (Glu), immunity, G-protein coupled receptor 35 (Gpr35), nicotinic acetylcholine receptor (nAChR), aryl hydrocarbon receptor (AhR), and dopamine (DA). In order to advance the general understanding of tryptophan metabolism in neurological and psychiatric disorders, this paper also summarizes the current situation and effective drugs of tryptophan metabolism in the treatment of neurological and psychiatric disorders and considers its future research prospects.

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Metadata

Authors
Li, D., Yu, S., Long, Y., Shi, A., Deng, J., Ma, Y., Wen, J., Li, X., Liu, S., Zhang, Y., Wan, J., Li, N., & Ao, R.
Affiliations
  • Chengdu University of Traditional Chinese Medicine (CN)
  • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Corresponding author
  • Li, Nan
  • Ao, Rui
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2022-09-08
Volume
13
Pages
985378-985378
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2022.985378
PMC
PMC9496178
OpenAlex
W4295865246
Cited by
129
References
136
Citations by year
2026: 27 · 2025: 52 · 2024: 32 · 2023: 18
FWCI
1.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Jiangxi University of Traditional Chinese Medicine (zdsys-202107)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
tryptophan metabolism, tryptophan catabolites, neurological disorders, mental illness, Alzheimer's disease, depression, excitotoxicity, neuroinflammation, oxidative stress, mitochondrial damage, gut microbiota, glucocorticoids, aging, glutamate, GPR35, nicotinic acetylcholine receptors, aryl hydrocarbon receptor, dopamine
MeSH terms
Mental Disorders, Dopamine, Glucocorticoids, Humans, Receptors, Nicotinic, Tryptophan, Vitamins, Receptors, Aryl Hydrocarbon, Glutamic Acid

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