The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Antibiotic resistance in probiotic bacteria
Open accessAbstract
Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. The main probiotic bacteria are strains belonging to the genera Lactobacillus and Bifidobacterium, although other representatives, such as Bacillus or Escherichia coli strains, have also been used. Lactobacillus and Bifidobacterium are two common inhabitants of the human intestinal microbiota. Also, some species are used in food fermentation processes as starters, or as adjunct cultures in the food industry. With some exceptions, antibiotic resistance in these beneficial microbes does not constitute a safety concern in itself, when mutations or intrinsic resistance mechanisms are responsible for the resistance phenotype. In fact, some probiotic strains with intrinsic antibiotic resistance could be useful for restoring the gut microbiota after antibiotic treatment. However, specific antibiotic resistance determinants carried on mobile genetic elements, such as tetracycline resistance genes, are often detected in the typical probiotic genera, and constitute a reservoir of resistance for potential food or gut pathogens, thus representing a serious safety issue.
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“Though Bacillus species has been shown greater resilience due to spore formation, strain-dependent susceptibility can undermine their efficacy.8”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [8]
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“However, many resistance determinants identified in Bacillus probiotics are considered intrinsic chromosomal traits, and therefore, their presence alone does not necessarily indicate horizontal gene transfer without further analysis of their genomic context.8,28”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [8]
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Cites
The use of bacterial spore formers as probiotics: Table 1
Hong, H. A., Duc, L. H., & Cutting, S. M. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.12.001 · Cited by 980
Antimicrobial Agents and Chemotherapy
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Pathogenic relevance of Lactobacillus: A retrospective review of over 200 cases
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Antibiotic Resistances of Starter and Probiotic Strains of Lactic Acid Bacteria
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(BIOHAZ), E. P. O. B. H. (2013) · EFSA Journal · doi:10.2903/j.efsa.2013.3449 · Cited by 349
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The biosynthesis and functionality of the cell-wall of lactic acid bacteria
Delcour, J., Ferain, T., Deghorain, M., Palumbo, E., & Pascal Hols, A. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002089722581 · Cited by 262
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1 of the 71 references couldn’t be matched to a known paper.
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An omics-based framework for assessing the health risk of antimicrobial resistance genes
Zhang, A., Gaston, J. M., Dai, C. L., Zhao, S., Poyet, M., Groussin, M., Yin, X., Li, L.-G., van Loosdrecht, M. C. M., Topp, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25096-3 · Cited by 977
Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer
Fong, W., Li, Q., & Yu, J. Q. (2020) · Oncogene · doi:10.1038/s41388-020-1341-1 · Cited by 643
How to select a probiotic? A review and update of methods and criteria
Pereira, G. V. D. M., Coelho, B. D. O., Magalhães, A. I., Thomaz‐Soccol, V., & Soccol, C. R. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.09.003 · Cited by 574
Review of alternatives to antibiotic use in aquaculture
Bondad‐Reantaso, M. G., MacKinnon, B., Karunasagar, I., Fridman, S., Alday‐Sanz, V., Brun, E., Groumellec, M. L., Li, A., Surachetpong, W., Karunasagar, I., et al. (2023) · Reviews in Aquaculture · doi:10.1111/raq.12786 · Cited by 445
Lactobacillus species: Taxonomic complexity and controversial susceptibilities
Goldstein, E. J. C., Tyrrell, K. L., & Citron, D. M. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ072 · Cited by 392
Metadata
- Authors
- Gueimonde, M., Sánchez, B., G. de los Reyes-Gavilán, C., & Margolles, A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 202-202
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC3714544
- OpenAlex
- W2163619058
- Cited by
- 691
- References
- 71
- Citations by year
- 2026: 52 · 2025: 71 · 2024: 68 · 2023: 80 · 2022: 98 · 2021: 70 · 2020: 58 · 2019: 52 · 2018: 52 · 2017: 31 · 2016: 27 · 2015: 17 · 2014: 13 · 2013: 1
- FWCI
- 28.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministerio de Ciencia e Innovación
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- antibiotic resistance, probiotic bacteria, Lactobacillus, Bifidobacterium, intrinsic antibiotic resistance, mobile genetic elements, tetracycline resistance genes, gut microbiota restoration, food safety, antibiotic therapy
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