The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Regulation of lung immunity and host defense by the intestinal microbiota
Open accessAbstract
Every year in the United States approximately 200,000 people die from pulmonary infections, such as influenza and pneumonia, or from lung disease that is exacerbated by pulmonary infection. In addition, respiratory diseases such as, asthma, affect 300 million people worldwide. Therefore, understanding the mechanistic basis for host defense against infection and regulation of immune processes involved in asthma are crucial for the development of novel therapeutic strategies. The identification, characterization, and manipulation of immune regulatory networks in the lung represents one of the biggest challenges in treatment of lung associated disease. Recent evidence suggests that the gastrointestinal (GI) microbiota plays a key role in immune adaptation and initiation in the GI tract as well as at other distal mucosal sites, such as the lung. This review explores the current research describing the role of the GI microbiota in the regulation of pulmonary immune responses. Specific focus is given to understanding how intestinal "dysbiosis" affects lung health.
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Cites
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Cited by
Emerging Pathogenic Links Between Microbiota and the Gut-Lung Axis
Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.142 · Cited by 1,606
The gut microbiome as a major regulator of the gut-skin axis
Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01459 · Cited by 707
The gut microbiome’s role in the development, maintenance, and outcomes of sepsis
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Skin Barrier Function and the Microbiome
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Gut-Lung Axis: The Microbial Contributions and Clinical Implications
He, Y., Wen, Q., Yao, F., Xu, D., Huang, Y., & Wang, J. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1176988 · Cited by 301
Metadata
- Authors
- Samuelson, D. R., Welsh, D. A., & Shellito, J. E.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2015-10-07
- Volume
- 6
- Pages
- 1085-1085
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W1893619344
- Cited by
- 433
- References
- 15
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- gold
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- Samuelson, D. R., Welsh, D. A., & Shellito, J. E. (2015). Regulation of lung immunity and host defense by the intestinal microbiota. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2015.01085
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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