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Cited by 310Fungal Infections and StudiesFungal and yeast genetics researchMicrobial Metabolism and Applications

Fungal Melanin: What do We Know About Structure?

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Nosanchuk, Joshua D., Stark, Ruth E., Casadevall, Arturo·2015·Frontiers in Microbiology
DOI 10.3389/fmicb.2015.01463PMC PMC4687393
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Abstract

The production of melanin significantly enhances the virulence of many important human pathogenic fungi. Despite fungal melanin's importance in human disease, as well as melanin's contribution to the ability of fungi to survive in diverse hostile environments, the structure of melanin remains unsolved. Nevertheless, ongoing research efforts have progressively revealed several notable structural characteristics of this enigmatic pigment, which will be the focus of this review. These compositional and organizational insights could further our ability to develop novel therapeutic approaches to combat fungal disease and enhance our understanding of how melanin is inserted into the cell wall.

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  • Fungal melanin has a conserved lamellar stacking structure, but the interlayer spacing varies among species: 4.39 Å for C. neoformans, 4.15 Å for Wangiella dermatitidis, and 4.45 Å for A. niger.

    “Fungal melanin has a conserved lamellar stacking structure, but the interlayer spacing varies among species: 4.39 Å for C. neoformans, 4.15 Å for Wangiella dermatitidis, and 4.45 Å for A. niger [34].”

    From Fungal Melanin in Plant Pathogens: Complex Biosynthesis Pathways and Diverse Biological Functions (2025) · cites this paper as [34]

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Authors
Nosanchuk, J. D., Stark, R. E., & Casadevall, A.
Affiliations
  • Albert Einstein College of Medicine (US)
  • The Graduate Center, CUNY (US)
  • Johns Hopkins University (US)
Corresponding author
Nosanchuk, Joshua D.
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2015-12-22
Volume
6
Pages
1463-1463
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2015.01463
PMC
PMC4687393
OpenAlex
W2243082285
Cited by
310
References
5
Citations by year
2026: 21 · 2025: 32 · 2024: 22 · 2023: 34 · 2022: 40 · 2021: 37 · 2020: 31 · 2019: 32 · 2018: 23 · 2017: 31 · 2016: 7
FWCI
2.58
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CUNY Academic Works (City University of New York) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (AI52733, 8G12MD007603)
Topics
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
Keywords
fungal melanin, melanin structure, fungal virulence, human pathogenic fungi, fungal cell wall, antifungal drug development

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