The DOI matches its Crossref record; 111 of the 112 references it cites were found in a registry or an index.
Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems
Open accessAbstract
Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and intimately linked to diet. The gut microbiota interaction has been pointed out as a hot topic research at treating obesity and related metabolic diseases by influencing energy metabolism and immune system. In terms of the novel identified beneficial microbes, Akkermansia muciniphila (A.muciniphila ) is colonized in the mucosa layer of the gut and modulates basal metabolism. A.muciniphila is consistently correlated with obesity. The causal beneficial impact on A.muciniphila-treated obesity is coming to light, which is proved by a variety of animal models and human studies. A.muciniphila has been characterized as a beneficial player in body metabolism and create a great expectation for treatments of the metabolic disorders associated with obesity, as well as considered as new generation therapeutic agents. This paper aimed to was to investigate the underlying basic mechanism of A.muciniphila-related obesity and host interactions in recent discoveries, facilitating to establish the causal relationship in human and the A.muciniphila-associated therapeutic supplement.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Akkermansia muciniphila is well documented to confer protective effects against metabolic disorders including obesity [54, 55].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518
Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094
Flagged first, then by citations
1 of the 112 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 401–418 of 418
Yuan, H., Chan, Y., Chen, G., Xu, L., Zhang, C., Tang, G., Feng, Y., & Wang, N. (2026) · Food Frontiers · doi:10.1002/fft2.70275
Alzahrani, N. S., Alshammari, G. M., Yagoub, A. E. A., Krishnamoorthy, R., Alshuniaber, M. A., Moubayed, N., & Yahya, M. A. (2026) · Natural Product Communications · doi:10.1177/1934578x261431451
Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up
Ahrens, A. P., Dias, R., Hyötyläinen, T., White, P. A., Orešič, M., Triplett, E. W., & Ludvigsson, J. (2026) · mSystems · doi:10.1128/msystems.01424-25 · Cited by 1
Ji, Y., Zhao, L., Wang, L., Wang, A., Zhang, C., Xie, Y., & Luo, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1840517 · Cited by 1
Zanotto, T. M., Santos, A., Vecina, J. F., Quaresma, P. G. F., Guadagnini, D., Rocha, G. Z., Brambilla, S. R., Carvalho, C. R. D. O., & Saad, M. J. A. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112875
Vahid, F., Stopa, V., Malisoux, L., Devaux, Y., Lamy, E., Silva, F. M. S. C. E., Forberger, S., Magistris, T. D., Sureda, A., Monserrat-Mesquida, M., et al. (2026) · Obesity Reviews · doi:10.1111/obr.70175 · Cited by 1
Alterations in Gut Microbiota and Serum Metabolome Are Associated with Postpartum Depression
Li, S., Pi, M., Yang, Z., Ma, X., Jinjun, Y., & Zhou, Y. (2026) · Nutrients · doi:10.3390/nu18152562
Khalil, M., Vacca, M., Giordano, V., Apa, C. A., Pietragalla, G., Calabrese, F. M., Rubino, D., Celano, G., Casamassima, N., Chiarini, M., et al. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.103224
Peng, J., Gao, X., Chen, G., Yan, A., Yu, Q., Tian, W., & Cai, K. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1898227
The Role of Akkermansia muciniphila in Obesity: Benefit or Harm?
Rojas, O. C., & González, G. M. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11144-1
Liao, A., Niu, Z.-L., Xu, T., Chen, J.-W., Pan, L., Wang, X., Chandrapala, J., Li, P., Zhang, J., & Huang, J. (2026) · Food & Function · doi:10.1039/d6fo00563b
Fassatoui, M., Pédron, T., Kheriji, N., Hechmi, M., Dallali, H., Jmel, H., Henda, J., Abid, A., SANSONETTI, P. J., & Kéfi, R. (2026) · Bioscience Reports · doi:10.1042/bsr20260157
Zhou, G., Chen, M., Zhao, L., Liu, F., Yue, Z., Zhao, J., & Ren, D. (2026) · The FASEB Journal · doi:10.1096/fj.202603191rr
The Skinny on Akkermansia muciniphila
Ross, S. M. (2026) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000810
El‐Sehrawy, A. A. M. A., Gameil, M. A., Nakib, A. M. E., Aseeri, A. A., Alanazi, M. A., Alharbi, S. S., Taki-Eldin, A., Maashi, M. S., Elmazny, G. M., Almansour, H., et al. (2026) · BMC Endocrine Disorders · doi:10.1186/s12902-026-02599-y
Asif, H. M., Fujisaka, S., Zahid, R., Aslam, M. R., Bilal, M., Yokoyama, M., & Tobe, K. (2026) · Natural Product Communications · doi:10.1177/1934578x261499940
Mazloum, A., Batashkov, N., Ledyaeva, V., Khulkhachiev, G., Tabakov, D., Mityaeva, O. N., & Volchkov, P. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1954427
Smith, C., Garza, K., Azari, H., Vellers, H., Abdelrahman, M., Dhanasekara, C. S., Salmon, A. B., Liang, H., Fernández, E., Musi, N., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02582-4
Metadata
- Authors
- Xu, Y., Wang, N., Tan, H.-Y., Li, S., Zhang, C., & Feng, Y.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Feng, Yibin
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2020-02-21
- Volume
- 11
- Pages
- 219-219
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC7046546
- OpenAlex
- W3008005014
- Cited by
- 420
- References
- 112
- Citations by year
- 2026: 32 · 2025: 56 · 2024: 61 · 2023: 74 · 2022: 106 · 2021: 66 · 2020: 25
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Hong Kong (104003919, 104004092, 200007008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Akkermansia muciniphila, obesity, gut microbiota, lipid metabolism, immune response, metabolic syndrome, type 2 diabetes, liver disease, mucosa, energy metabolism, probiotic therapy, host-microbe interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
