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Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems
Open accessAbstract
Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and intimately linked to diet. The gut microbiota interaction has been pointed out as a hot topic research at treating obesity and related metabolic diseases by influencing energy metabolism and immune system. In terms of the novel identified beneficial microbes, Akkermansia muciniphila (A.muciniphila ) is colonized in the mucosa layer of the gut and modulates basal metabolism. A.muciniphila is consistently correlated with obesity. The causal beneficial impact on A.muciniphila-treated obesity is coming to light, which is proved by a variety of animal models and human studies. A.muciniphila has been characterized as a beneficial player in body metabolism and create a great expectation for treatments of the metabolic disorders associated with obesity, as well as considered as new generation therapeutic agents. This paper aimed to was to investigate the underlying basic mechanism of A.muciniphila-related obesity and host interactions in recent discoveries, facilitating to establish the causal relationship in human and the A.muciniphila-associated therapeutic supplement.
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“Akkermansia muciniphila is well documented to confer protective effects against metabolic disorders including obesity [54, 55].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [54]
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Gut Microbiota: Modulation of Host Physiology in Obesity
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Different subtype strains of Akkermansia muciniphila abundantly colonize in southern China
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Gut Microbiota and Host Reaction in Liver Diseases
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The Gut Microbiome, Aging, and Longevity: A Systematic Review
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From correlation to causality: the case of Subdoligranulum
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Metadata
- Authors
- Xu, Y., Wang, N., Tan, H.-Y., Li, S., Zhang, C., & Feng, Y.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Feng, Yibin
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2020-02-21
- Volume
- 11
- Pages
- 219-219
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC7046546
- OpenAlex
- W3008005014
- Cited by
- 420
- References
- 112
- Citations by year
- 2026: 32 · 2025: 56 · 2024: 61 · 2023: 74 · 2022: 106 · 2021: 66 · 2020: 25
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Hong Kong (104003919, 104004092, 200007008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Akkermansia muciniphila, obesity, gut microbiota, lipid metabolism, immune response, metabolic syndrome, type 2 diabetes, liver disease, mucosa, energy metabolism, probiotic therapy, host-microbe interactions
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