Cited by 420Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesProbiotics and Fermented Foods

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Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

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Xu, Yu, Wang, Ning, Tan, Hor-Yue, Li, Sha, Zhang, Cheng, Feng, Yibin·2020·Frontiers in Microbiology

DOI 10.3389/fmicb.2020.00219PMC PMC7046546

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Abstract

Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and intimately linked to diet. The gut microbiota interaction has been pointed out as a hot topic research at treating obesity and related metabolic diseases by influencing energy metabolism and immune system. In terms of the novel identified beneficial microbes, Akkermansia muciniphila (A.muciniphila ) is colonized in the mucosa layer of the gut and modulates basal metabolism. A.muciniphila is consistently correlated with obesity. The causal beneficial impact on A.muciniphila-treated obesity is coming to light, which is proved by a variety of animal models and human studies. A.muciniphila has been characterized as a beneficial player in body metabolism and create a great expectation for treatments of the metabolic disorders associated with obesity, as well as considered as new generation therapeutic agents. This paper aimed to was to investigate the underlying basic mechanism of A.muciniphila-related obesity and host interactions in recent discoveries, facilitating to establish the causal relationship in human and the A.muciniphila-associated therapeutic supplement.

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Authors: Xu, Y., Wang, N., Tan, H.-Y., Li, S., Zhang, C., & Feng, Y.
Affiliations: University of Hong Kong (HK)
Corresponding author: Feng, Yibin
ORCID: Xu, Yu
Wang, Ning
Tan, Hor-Yue
Li, Sha
Zhang, Cheng
Feng, Yibin
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2020-02-21
Volume: 11
Pages: 219-219
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2020.00219
PMC: PMC7046546
OpenAlex: W3008005014
Cited by: 420
References: 112
Citations by year: 2026: 32 · 2025: 56 · 2024: 61 · 2023: 74 · 2022: 106 · 2021: 66 · 2020: 25
FWCI: 6.49
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: University of Hong Kong (104003919, 104004092, 200007008)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: Akkermansia muciniphila, obesity, gut microbiota, lipid metabolism, immune response, metabolic syndrome, type 2 diabetes, liver disease, mucosa, energy metabolism, probiotic therapy, host-microbe interactions

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Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

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