The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle
Open accessAbstract
Aging is associated with a progressive loss of muscle mass and strength and a decline in neurophysiological functions. Age-related neuromuscular junction (NMJ) plays a key role in musculoskeletal impairment that occurs with aging. However, whether changes in the NMJ precede or follow the decline of muscle mass and strength remains unresolved. Many factors such as mitochondrial dysfunction, oxidative stress, inflammation, changes in the innervation of muscle fibers, and mechanical properties of the motor units probably perform an important role in NMJ degeneration and muscle mass and strength decline in late life. This review addresses the primary events that might lead to NMJ dysfunction with aging, including studies on biomarkers, signaling pathways, and animal models. Interventions such as caloric restriction and exercise may positively affect the NMJ through this mechanism and attenuate the age-related progressive impairment in motor function.
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Cites
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Background
Cited by
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“Recent studies have increasingly demonstrated that NMJ instability is closely related to the occurrence and development of sarcopenia (Ang et al., 2022; Gonzalez-Freire et al., 2014; Monti et al., 2021).”
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Metadata
- Authors
- Gonzalez-Freire, M., de Cabo, R., Studenski, S. A., & Ferrucci, L.
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-08-11
- Volume
- 6
- Pages
- 208-208
- ISSN
- 1663-4365 (ISSN-L)
- OpenAlex
- W2141701416
- Cited by
- 356
- References
- 17
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- gold
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