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Periodontitis and Alzheimer’s Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation

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Teixeira, Francisco B., Saito, Miki T., Matheus, Filipe C., Prediger, Rui D., Yamada, Elizabeth S., Maia, Cristiane S. F., Lima, Rafael R.·2017·Frontiers in Aging Neuroscience
DOI 10.3389/fnagi.2017.00327
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Abstract

Periodontitis is an oral chronic infection/inflammatory condition, identified as a source of mediators of inflammation into the blood circulation, which may contribute to exacerbate several diseases. There is increasing evidence that inflammation plays a key role in the pathophysiology of Alzheimer's disease (AD). Although inflammation is present in both diseases, the exact mechanisms and crosslinks between periodontitis and AD are poorly understood. Therefore, this article aims to review possible comorbidity between periodontitis and AD. Here, the authors discuss the inflammatory aspects of periodontitis, how this oral condition produces a systemic inflammation and, finally, the contribution of this systemic inflammation for worsening neuroinflammation in the progression of AD.

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Metadata

Authors
Teixeira, F. B., Saito, M. T., Matheus, F. C., Prediger, R. D., Yamada, E. S., Maia, C. S. F., & Lima, R. R.
Venue
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Published
2017-10-10
Volume
9
Pages
327-327
ISSN
1663-4365 (ISSN-L)
DOI
10.3389/fnagi.2017.00327
OpenAlex
W2763573995
Cited by
174
References
23
FWCI
16.39
Type
journal article
Language
en
Open access
gold

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Teixeira, F. B., Saito, M. T., Matheus, F. C., Prediger, R. D., Yamada, E. S., Maia, C. S. F., & Lima, R. R. (2017). Periodontitis and Alzheimer’s Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2017.00327

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