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Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
Open accessAbstract
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, the immune system and microglial cells (as part of the cerebral immunity) play a central role. In other degenerative processes, such as Alzheimer's disease (AD), the role of microglia is far to be elucidated. In this "mini-review" article, we briefly highlight our recent data comparing the microglial response between amyloidogenic transgenic models, such as APP/PS1 and AD patients. Since the AD pathology could display regional heterogeneity, we focus our work at the hippocampal formation. In APP based models a prominent microglial response is triggered around amyloid-beta (Aβ) plaques. These strongly activated microglial cells could drive the AD pathology and, in consequence, could be implicated in the neurodegenerative process observed in models. On the contrary, the microglial response in human samples is, at least, partial or attenuated. This patent difference could simply reflect the lower and probably slower Aβ production observed in human hippocampal samples, in comparison with models, or could reflect the consequence of a chronic long-standing microglial activation. Beside this differential response, we also observed microglial degeneration in Braak V-VI individuals that, indeed, could compromise their normal role of surveying the brain environment and respond to the damage. This microglial degeneration, particularly relevant at the dentate gyrus, might be mediated by the accumulation of toxic soluble phospho-tau species. The consequences of this probably deficient immunological protection, observed in AD patients, are unknown.
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“AD-associated dysmorphic microglia in the hippocampus are characterized by the loss of fragmentation, beading, and spheroid formation (Navarro et al., 2018).”
From The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease (2022) · cites this paper as Navarro et al., 2018
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“In fact, dystrophic microglia are diametrically distinct from hypertrophic microglia, characterized by an exuberant overgrowth of microglial processes, typically found in the cortex surrounding amyloid plaques and likely reflective of hyperactive phagocytic clearance of extracellular aggregates (Navarro et al., 2018).”
From The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease (2022) · cites this paper as Navarro et al., 2018
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“several studies have suggested that microglial activation plays a beneficial role in early stages of AD pathology, but contributes to disease worsening in late stages of AD [66–68].”
From IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia (2019) · cites this paper as [67]
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“The observed alterations in microglia are similar to the dysmorphic microglia observed in the hippocampus of AD brains (Navarro et al., 2018; Streit et al., 2009, 2020; Davies et al., 2017; Shahidehpour et al., 2021), diametrically distinct from the hypertrophic microglia morphology observed in the cortex and typically associated with amyloid plaques (Navarro et al., 2018).”
From The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease (2022) · cites this paper as Navarro et al., 2018
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“Moreover, the AD-associated microglia response in the hippocampus has been proposed to be linked to tau pathology (Shahidehpour et al., 2021; Streit et al., 2020; Navarro et al., 2018).”
From The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease (2022) · cites this paper as Navarro et al., 2018
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Citations
Cites
Neuroinflammation in Alzheimer's disease
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BackgroundMicroglia in Alzheimer’s disease
Hansen, D. V., Hanson, J. E., & Sheng, M. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709069 · Cited by 1,935 · cited 2×
“These GWAS analysis have identified multiple polymorphisms associated with the microglial immune response (Guerreiro et al., 2013; Cuyvers and Sleegers, 2016; Hansen et al., 2018).”
BackgroundTREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736
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Metadata
- Authors
- Navarro, V., Sanchez-Mejias, E., Jimenez, S., Muñoz-Castro, C., Sanchez-Varo, R., Davila, J. C., Vizuete, M., Gutierrez, A., & Vitorica, J.
- Affiliations
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-05-11
- Volume
- 10
- Pages
- 140-140
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC5958192
- OpenAlex
- W2799331265
- Cited by
- 229
- References
- 53
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 33 · 2023: 35 · 2022: 32 · 2021: 31 · 2020: 43 · 2019: 27 · 2018: 3
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by-nc-nd)
- Repositorio Institucional de la Universidad de Málaga (University of Málaga) (submittedVersion, cc-by)
- Funders
- Instituto de Salud Carlos III (PI15/00957 and PI15/00796)
- Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (CTS-2035)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, Alzheimer's disease, microglial activation, amyloid plaques, hippocampus, Braak stages, phosphorylated tau, dentate gyrus, neuroinflammation, regional heterogeneity
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