The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives
Open accessAbstract
Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer’s disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study’s objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy. Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy. Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.
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“Cognitive decline encompasses mental health conditions like anxiety [45,46].”
From The Effect of Anxiety and Nutritional Habits on the Body Distortion of Athletes. (2025) · cites this paper as [46]
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“Experiential avoidance seeks to control the way or frequency of aversive private experiences [37] and has been associated with anxiety [38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54].”
From The Effect of Anxiety and Nutritional Habits on the Body Distortion of Athletes. (2025) · cites this paper as [46]
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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
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Cognitive impairment in depression: a systematic review and meta-analysis
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Mild Cognitive Impairment: Ten Years Later
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Depression and risk of developing dementia
Byers, A. L., & Yaffe, K. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.60 · Cited by 1,265
Katzman, M. A., Bleau, P., Blier, P., Chokka, P., Kjernisted, K., Van Ameringen, M., & the Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-s1-s1 · Cited by 1,090
A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder
Lee, R. S. C., Hermens, D. F., Porter, M. A., & Redoblado-Hodge, M. A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.10.023 · Cited by 737
Mild cognitive impairment, amnestic type
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Incidence and outcome of mild cognitive impairment in a population-based prospective cohort
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Steffens, D. C., Fahed, M., Manning, K. J., & Wang, L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02292-3 · Cited by 128
Laganà, V., Bruno, F., Altomari, N., Bruni, G., Smirne, N., Curcio, S., Mirabelli, M., Colao, R., Puccio, G., Frangipane, F., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.832199 · Cited by 105
Salari, N., Lotfi, F., Abdolmaleki, A., Heidarian, P., Rasoulpoor, S., Fazeli, J., Najafi, H., & Mohammadi, M. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-05967-w · Cited by 120
Lanctôt, K. L., Ismail, Z., Bawa, K. K., Cummings, J. L., Husain, M., Mortby, M. E., & Robert, P. H. (2023) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5882 · Cited by 107
Krell‐Roesch, J., Vassilaki, M. E., Mielke, M. M., Kremers, W. K., Lowe, V. J., Vemuri, P., Machulda, M. M., Christianson, T. J. H., Syrjanen, J. A., Stokin, G. B., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0456-z · Cited by 85
Metadata
- Authors
- Ma, L.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Ma, Lina
- ORCID
- Ma, Lina
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-01-30
- Volume
- 12
- Pages
- 9-9
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC7002324
- OpenAlex
- W3004098102
- Cited by
- 323
- References
- 115
- Citations by year
- 2026: 41 · 2025: 70 · 2024: 60 · 2023: 59 · 2022: 48 · 2021: 37 · 2020: 7
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Milstein Medical Asian American Partnership Foundation
- National Natural Science Foundation of China (2018YFC2002100, 81600927)
- Beijing Municipal Administration of Hospitals
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, depression, anxiety, apathy, neuropsychiatric symptoms, conversion to dementia, Alzheimer's disease, cognitive decline, risk factors, prevalence
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