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Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives
Open accessAbstract
Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer’s disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study’s objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy. Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy. Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.
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“Cognitive decline encompasses mental health conditions like anxiety [45,46].”
From The Effect of Anxiety and Nutritional Habits on the Body Distortion of Athletes. (2025) · cites this paper as [46]
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“Experiential avoidance seeks to control the way or frequency of aversive private experiences [37] and has been associated with anxiety [38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54].”
From The Effect of Anxiety and Nutritional Habits on the Body Distortion of Athletes. (2025) · cites this paper as [46]
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Metadata
- Authors
- Ma, L.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Ma, Lina
- ORCID
- Ma, Lina
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-01-30
- Volume
- 12
- Pages
- 9-9
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC7002324
- OpenAlex
- W3004098102
- Cited by
- 323
- References
- 115
- Citations by year
- 2026: 41 · 2025: 70 · 2024: 60 · 2023: 59 · 2022: 48 · 2021: 37 · 2020: 7
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Milstein Medical Asian American Partnership Foundation
- National Natural Science Foundation of China (2018YFC2002100, 81600927)
- Beijing Municipal Administration of Hospitals
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, depression, anxiety, apathy, neuropsychiatric symptoms, conversion to dementia, Alzheimer's disease, cognitive decline, risk factors, prevalence
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