Cited by 323Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesNeurological Disease Mechanisms and Treatments

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Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

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Ma, Lina·2020·Frontiers in Aging Neuroscience

DOI 10.3389/fnagi.2020.00009PMC PMC7002324

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Abstract

Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer’s disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study’s objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy. Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy. Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.

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Authors: Ma, L.
Affiliations: Capital Medical University (CN)
Corresponding author: Ma, Lina
ORCID: Ma, Lina
Venue: Frontiers in Aging Neuroscience
Publisher: Frontiers Media SA
Published: 2020-01-30
Volume: 12
Pages: 9-9
ISSN: 1663-4365 (ISSN-L)
DOI: 10.3389/fnagi.2020.00009
PMC: PMC7002324
OpenAlex: W3004098102
Cited by: 323
References: 115
Citations by year: 2026: 41 · 2025: 70 · 2024: 60 · 2023: 59 · 2022: 48 · 2021: 37 · 2020: 7
FWCI: 6.25
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Aging Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Milstein Medical Asian American Partnership Foundation
National Natural Science Foundation of China (2018YFC2002100, 81600927)
Beijing Municipal Administration of Hospitals
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: mild cognitive impairment, depression, anxiety, apathy, neuropsychiatric symptoms, conversion to dementia, Alzheimer's disease, cognitive decline, risk factors, prevalence

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Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

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