In vivo exploration of the connectivity between the subthalamic nucleus and the globus pallidus in the human brain using multi-fiber tractography
Open accessAbstract
The basal ganglia is part of a complex system of neuronal circuits that play a key role in the integration and execution of motor, cognitive and emotional function in the human brain. Deep Brain Stimulation (DBS) of the subthalamic nucleus and the globus pallidus pars interna provides an efficient treatment to reduce symptoms and levodopa-induced side effects in Parkinson’s Disease patients. While the underlying mechanism of action of DBS is still unknown, the potential modulation of white matter tracts connecting the surgical targets has become an active area of research. With the introduction of advanced diffusion MRI acquisition sequences and sophisticated post-processing techniques, the architecture of the human brain white matter can be explored in-vivo. The goal of this study is to investigate the white matter connectivity between the subthalamic nucleus and the globus pallidus. Two multi-fiber tractography methods were used to reconstruct pallido-subthalamic, subthalamo-pallidal and pyramidal fibers in five healthy subjects datasets of the Human Connectome Project. The anatomical accuracy of the identified tracts was evaluated by two expert neuroanatomists. Both multi-fiber approaches enabled the detection of complex fiber architecture in the basal ganglia. The evaluation by the neuroanatomists showed that the identified tracts were in agreement with the expected anatomy. False-negative tracts demonstrated the current limitations of the methods for clinical decision-making. Multi-fiber tractography methods combined with state-of-the art diffusion MRI data have the potential to help identify white matter tracts connecting DBS targets in functional neurosurgery intervention.
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Preoperative tractography can guide deep brain stimulation (DBS) or MR-guided focused ultrasound (MRgFUS) planning, identify the structural connectivity of the volume of tissue activated, and help avoid pathways associated with motor, cognitive, or mood-related adverse effects.
“Preoperative tractography can guide deep brain stimulation (DBS) or MR-guided focused ultrasound (MRgFUS) planning, identify the structural connectivity of the volume of tissue activated, and help avoid pathways associated with motor, cognitive, or mood-related adverse effects (Pujol et al., 2017; Rajamani et al., 2024; Vanegas-Arroyave et al., 2016).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Pujol et al., 2017
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“…(DBS) or MR-guided focused ultrasound (MRgFUS) planning, identify the structural connectivity of the volume of tissue activated, and help avoid pathways associated with motor, cognitive, or mood-related adverse effects ( Pujol et al., 2017; Rajamani et al., 2024; Vanegas-Arroyave et al., 2016).”
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- Authors
- Pujol, S., Cabeen, R., Sébille, S. B., Yelnik, J., François, C., Fernandez Vidal, S., Karachi, C., Zhao, Y., Cosgrove, G. R., Jannin, P., Kikinis, R., & Bardinet, E.
- Affiliations
- Brigham and Women's Hospital (US)
- Brown University (US)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Corresponding author
- Pujol, Sonia
- ORCID
- Venue
- Frontiers in Neuroanatomy
- Publisher
- Frontiers Media SA
- Published
- 2017-01-19
- Volume
- 10
- Pages
- 119-119
- ISSN
- 1662-5129 (ISSN-L)
- PMC
- PMC5243825
- OpenAlex
- W2578397323
- Cited by
- 21
- References
- 67
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 3
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroanatomy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (ANR-10-EQPX-0015, ANR-10-IAIHU06, ANR-10-EQPX-15, 10-IAIHU-06, ANR-11-INBS, ANR-11-INBS-0006, ANR-10, ANR-10-EQPX)
- Fondation Bettencourt Schueller
- National Institutes of Health (U54MH091657, ANR-10-IAIHU-06)
- McDonnell Center for Systems Neuroscience (U54MH091657)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015902, P41EB015898)
- NIH Blueprint for Neuroscience Research (U54MH091657)
- CHIST-ERA
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- subthalamic nucleus, globus pallidus internus, basal ganglia, white matter connectivity, deep brain stimulation, Parkinson's disease, diffusion MRI, Human Connectome Project
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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