MRtrix: Diffusion tractography in crossing fiber regions
Abstract
In recent years, diffusion‐weighted magnetic resonance imaging has attracted considerable attention due to its unique potential to delineate the white matter pathways of the brain. However, methodologies currently available and in common use among neuroscientists and clinicians are typically based on the diffusion tensor model, which has comprehensively been shown to be inadequate to characterize diffusion in brain white matter. This is due to the fact that it is only capable of resolving a single fiber orientation per voxel, causing incorrect fiber orientations, and hence pathways, to be estimated through these voxels. Given that the proportion of affected voxels has been recently estimated at 90%, this is a serious limitation. Furthermore, most implementations use simple “deterministic” streamlines tracking algorithms, which have now been superseded by “probabilistic” approaches. In this study, we present a robust set of tools to perform tractography, using fiber orientations estimated using the validated constrained spherical deconvolution method, coupled with a probabilistic streamlines tracking algorithm. This methodology is shown to provide superior delineations of a number of known white matter tracts, in a manner robust to crossing fiber effects. These tools have been compiled into a software package, called MRtrix, which has been made freely available for use by the scientific community. © 2012 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 22, 53–66, 2012
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CSD estimates multiple fiber directions within a voxel, resulting in a fiber orientation distribution (FOD) that may have multiple peaks.
“Instead of estimating one principal fiber direction, CSD estimates multiple fiber directions within a voxel, resulting in a fiber orientation distribution (FOD) that may have multiple peaks (e.g., four in case of two crossing fibers in one voxel) (Tournier et al. 2010, 2012).”
From Diffusion MRI-based cortical connectome reconstruction: dependency on tractography procedures and neuroanatomical characteristics (2018) · cites this paper as Tournier et al. 2012
MRtrix3 derives from the now deprecated MRtrix 0.2.x software package.
“It derives from the now deprecated MRtrix 0.2.x software package (Tournier et al., 2012) , which was itself started circa 2003, when few packages existed for the analysis of diffusion MRI data.”
From MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation (2019) · cites this paper as Tournier et al., 2012
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- Authors
- Tournier, J., Calamante, F., & Connelly, A.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Tournier, J‐Donald
- Venue
- International Journal of Imaging Systems and Technology
- Publisher
- Wiley
- Published
- 2012-02-14
- Volume
- 22
- Issue
- 1
- Pages
- 53-66
- ISSN
- 0899-9457 (ISSN-L)
- 1098-1098
- OpenAlex
- W2149092213
- Cited by
- 1,370
- References
- 73
- Citations by year
- 2026: 50 · 2025: 111 · 2024: 81 · 2023: 84 · 2022: 130 · 2021: 142 · 2020: 136 · 2019: 138 · 2018: 116 · 2017: 110 · 2016: 84 · 2015: 85 · 2014: 48 · 2013: 43 · 2012: 11
- FWCI
- 45.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Imaging Systems and Technology (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- State Government of Victoria
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- diffusion tractography, crossing fibers, constrained spherical deconvolution, diffusion-weighted imaging, white matter tracts, fiber orientation estimation
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