Elucidating the biological basis for the reinforcing actions of alcohol in the mesolimbic dopamine system: the role of active metabolites of alcohol

Suspending OpenMP Tasks on Asynchronous Events: Extending the Taskwait Construct

Pereira, R., Martin, M., Roussel, A., Carribault, P., & Gautier, T. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-40744-4_5 · Cited by 13,140 · see citing works

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works

Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders

Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870 · see citing works

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,447 · see citing works

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219 · see citing works

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

Spanagel, R., Herz, A., & Shippenberg, T. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2046 · Cited by 1,005 · see citing works

Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity

Oades, R. D., & Halliday, G. M. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90011-7 · Cited by 1,001 · see citing works

Overview: how is alcohol metabolized by the body?

(2006) · PubMed Central · Cited by 813 · see citing works

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

Gessa, G. L., Francesco Muntoni, A., Collu, M., Vargiu, L., & Mereu, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90381-6 · Cited by 770 · see citing works

Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior

Spanagel, R. (2009) · Physiological Reviews · doi:10.1152/physrev.00013.2008 · Cited by 636 · see citing works

Animal Models of Alcoholism: Neurobiology of High Alcohol-Drinking Behavior in Rodents

McBride, W. J. H., & Li, T. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i4.40 · Cited by 618 · see citing works

Neuropharmacology of alcohol addiction

Vengeliene, V., Bilbao, A., Molander, A., & Spanagel, R. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.30 · Cited by 574 · see citing works

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

Davis, V. E., & Walsh, M. J. (1970) · Science · doi:10.1126/science.167.3920.1005 · Cited by 562 · see citing works

Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro

Brodie, M. S., Shefner, S. A., & Dunwiddie, T. V. (1990) · Brain Research · doi:10.1016/0006-8993(90)91118-z · Cited by 485 · see citing works

Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

Cohen, G., & Collins, M. A. (1970) · Science · doi:10.1126/science.167.3926.1749 · Cited by 441 · see citing works

Ethanol Directly Excites Dopaminergic Ventral Tegmental Area Reward Neurons

Brodie, M. S., Pesold, C., & Appel, S. B. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04082.x · Cited by 388 · see citing works

Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats

Chiara, G. D., & Impérato, A. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90598-9 · Cited by 287 · see citing works

Endogenous Opioids and Addiction to Alcohol and other Drugs of Abuse

Gianoulakis, C. (2004) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026043451573 · Cited by 281 · see citing works

A DRUG SENSITISING THE ORGANISM TO ETHYL ALCOHOL

Hald, J., & Jacobsen, E. (1948) · The Lancet · doi:10.1016/s0140-6736(48)91514-1 · Cited by 277 · see citing works

Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking.

Li, T. (2000) · Journal of Studies on Alcohol · doi:10.15288/jsa.2000.61.5 · Cited by 273 · see citing works

Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats

Gatto, G. J., McBride, W. J., Murphy, J. M., Lumeng, L., & Li, T. (1994) · Alcohol · doi:10.1016/0741-8329(94)90083-3 · Cited by 261 · see citing works

THE ROLE OF ACETALDEHYDE IN THE ACTIONS OF ETHANOL

Eckfeldt, J. H., Takio, K., Mope, L., & Yonetani, T. (1975) · Cited by 251 · see citing works

Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons.

Lovinger, D. M., & White, G. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12934-9 · Cited by 214 · see citing works

Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats

Mereu, G., Fadda, F., & Gessa, G. L. (1984) · Brain Research · doi:10.1016/0006-8993(84)90890-4 · Cited by 209 · see citing works

Alcohol Drinking: Abnormal Intake Caused by Tetrahydropapaveroline in Brain

Myers, R. D., & Melchior, C. L. (1977) · Science · doi:10.1126/science.557839 · Cited by 183 · see citing works

Genome‐wide significant association between alcohol dependence and a variant in the <i>ADH</i> gene cluster

Frank, J., Cichon, S., Treutlein, J., Ridinger, M., Mattheisen, M., Hoffmann, P., Herms, S., Wodarz, N., Soyka, M., Zill, P., et al. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00395.x · Cited by 176 · see citing works

Neuropharmacological treatments for alcoholism: scientific basis and clinical findings

Johnson, B. A., & Ait‐Daoud, N. (2000) · Psychopharmacology · doi:10.1007/s002130000371 · Cited by 172 · see citing works

Brain acetaldehyde after ethanol administration

Tabakoff, B., Anderson, R. A., & Ritzmann, R. F. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90094-0 · Cited by 171 · see citing works

Acute effects of ethanol on GABAA and glycine receptor function

Mihic, S. J. (1999) · Neurochemistry International · doi:10.1016/s0197-0186(99)00053-4 · Cited by 170 · see citing works

Acetaldehyde Increases Dopaminergic Neuronal Activity in the VTA

Foddai, M., Dosia, G., Spiga, S., & Diana, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300326 · Cited by 164 · see citing works

Role of acetaldehyde in the actions of ethanol on the brain — A review

Hunt, W. A. (1996) · Alcohol · doi:10.1016/0741-8329(95)02026-8 · Cited by 162 · see citing works

Genes encoding enzymes involved in ethanol metabolism

Hurley, T. (2012) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v34.3.09 · Cited by 145 · see citing works

The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats

Rodd, Z. A., Meléndez, R. I., Zaffaroni, A., D, A. G. M., McBride, W. J., & Li, T. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00733-x · Cited by 145 · see citing works

A COLORIMETRIC DETERMINATION OF ACETALDEHYDE IN BLOOD

Stotz, E. H. (1943) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)72258-8 · Cited by 142 · see citing works

Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin

Rodd, Z. A., Bell, R. L., Zhang, Y., Murphy, J. M., D, A. G. M., Zaffaroni, A., Li, T., & McBride, W. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300561 · Cited by 141 · see citing works

The Effects of Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area Studied with Intracellular Recording in Brain Slices

Brodie, M. S., & Appel, S. B. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03644.x · Cited by 140 · see citing works

Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations

Peng, G., & Yin, S. (2009) · Human Genomics · doi:10.1186/1479-7364-3-2-121 · Cited by 136 · see citing works

The acetaldehyde content in rat brain during ethanol metabolism

Sippel, H. W. (1974) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1974.tb04380.x · Cited by 134 · see citing works

Ethanol Oxidation by Rat Brain in Vivo

Cohen, G., Sinet, P. M., & Heikkila, R. E. (1980) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1980.tb04833.x · Cited by 130 · see citing works

Effect of Acute Ethanol Administration on the Release of Opioid Peptides From the Midbrain Including the Ventral Tegmental Area

Jarjour, S., Bai, L., & Gianoulakis, C. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00924.x · Cited by 130 · see citing works

Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats

Brown, Z. W., Amit, Z., & Rockman, G. E. (1979) · Psychopharmacology · doi:10.1007/bf00427509 · Cited by 128 · see citing works

TETRAHYDROISOQUINOLINE ALKALOIDS: UPTAKE BY RAT BRAIN HOMOGENATES AND INHIBITION OF CATECHOLAMINE UPTAKE

Heikkila, R. E., Cohen, G., & Dembiec, D. (1971) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29028-0 · Cited by 128 · see citing works

Neuronal nicotinic acetylcholine receptors: a new target site of ethanol

Narahashi, T., Aistrup, G. L., Marszalec, W., & Nagata, K. (1999) · Neurochemistry International · doi:10.1016/s0197-0186(99)00055-8 · Cited by 119 · see citing works

Endogenous Opioids and Addiction to Alcohol and other Drugs of Abuse

Gianoulakis, C. (2009) · Current Topics in Medicinal Chemistry · doi:10.2174/156802609789630956 · Cited by 116 · see citing works

Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects

Karahanian, E., Quintanilla, M. E., Tampier, L., Rivera‐Meza, M., Bustamante, D., González-Lira, V., Morales, P., Herrera‐Marschitz, M., & Israel, Y. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01439.x · Cited by 113 · see citing works

Alkaloid products in the metabolism of alcohol and biogenic amines

Cohen, G. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90357-9 · Cited by 112 · see citing works

Neurobiology of tetrahydro-β-carbolines

Buckholtz, N. S. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90098-3 · Cited by 112 · see citing works

Distribution and Kinetics of Ethanol Metabolism in Rat Brain

Zimatkin, S. M., Liopo, A. V., & Deitrich, R. A. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03958.x · Cited by 111 · see citing works

Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system

Melis, M., Enrico, P., Peana, A. T., & Diana, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05887.x · Cited by 107 · see citing works

Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate

Correa, M., Arizzi, M. N., Betz, A. J., Mingote, S., & Salamone, J. D. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.013 · Cited by 105 · see citing works

The effect of 3-amino-1,2,4-triazole on voluntary ethanol consumption: Evidence for brain catalase involvement in the mechanism of action

C.M.G., A. (1992) · Neuropharmacology · doi:10.1016/0028-3908(92)90150-n · Cited by 103 · see citing works

Dopamine-derived tetrahydroisoquinoline alkaloids—Inhibitors of neuroamine metabolism

Collins, A. C., Cashaw, J. L., & Davis, V. E. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90015-4 · Cited by 103 · see citing works

Conditioned place preference induced by intraventricular infusions of acetaldehyde

Smith, B. R., Amit, Z., & Splawinsky, J. (1984) · Alcohol · doi:10.1016/0741-8329(84)90097-1 · Cited by 101 · see citing works

Preference for alcohol evoked by tetrahydropapaveroline (THP) chronically infused in the cerebral ventricle of the rat

Melchior, C. L., & MYERS, R. D. (1977) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(77)90006-5 · Cited by 98 · see citing works

Alcohol drinking in the rat induced by acute intracerebral infusion of two tetrahydroisoquinolines and a β-carboline

Myers, R. D., & Oblinger, M. M. (1977) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(77)90047-3 · Cited by 95 · see citing works

The Role of Acetaldehyde in the Actions of Ethanol

Truitt, E. B., & Walsh, M. J. (1971) · Springer eBooks · doi:10.1007/978-1-4615-6525-3_5 · Cited by 90 · see citing works

A critical evaluation of tetrahydroisoquinoline induced ethanol preference in rats

Duncan, C., & Deitrich, R. A. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90083-0 · Cited by 90 · see citing works

Histochemical Study of Aldehyde Dehydrogenase in the Rat CNS

Zimatkin, S. M. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02555.x · Cited by 84 · see citing works

Conditioned stimulus preference after acetaldehyde but not ethanol injections

Quertemont, É., & Witte, P. D. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00486-x · Cited by 82 · see citing works

Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with d-penicillamine, an inactivation agent for acetaldehyde

Font, L., Aragón, C. M. G., & Miquel, M. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0224-z · Cited by 80 · see citing works

Sensitization of Ventral Tegmental Area Dopamine Neurons to the Stimulating Effects of Ethanol

Ding, Z., Rodd, Z. A., Engleman, E. A., & McBride, W. J. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00985.x · Cited by 78 · see citing works

A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence

Ortiz, A., Griffiths, P., & Littleton, J. M. (1974) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1974.tb09266.x · Cited by 78 · see citing works

Key Role of Ethanol‐Derived Acetaldehyde in the Motivational Properties Induced by Intragastric Ethanol: A Conditioned Place Preference Study in the Rat

Peana, A. T., Enrico, P., Assaretti, A., Pulighe, E., Muggironi, G., Nieddu, M., Piga, A. G., Lintas, A., & Diana, M. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00574.x · Cited by 76 · see citing works

Blockade of ethanol induced conditioned taste aversion by 3-amino-1,2,4-triazole: Evidence for catalase mediated synthesis of acetaldehyde in rat brain

Aragón, C. M. G., Spivak, K. J., & Amit, Z. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90579-x · Cited by 75 · see citing works

Intraventricular self-administration of acetaldehyde and voluntary consumption of ethanol in rats

Brown, Z. W., Amit, Z., & Smith, B. R. (1980) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(80)91487-9 · Cited by 75 · see citing works

Catalase and the production of brain acetaldehyde: a possible mediator of the psychopharmacological effects of ethanol

SMITH, B. R., Aragón, C. M. G., & Amit, Z. (1997) · Addiction Biology · doi:10.1080/13556219772570 · Cited by 75 · see citing works

Ethanol Potentiation of Glycine-Induced Responses in Dissociated Neurons of Rat Ventral Tegmental Area

Ye, J. H., Tao, L., Ren, J. T., Schaefer, R., Krnjević, K., Liu, P. L., Schiller, D. A., & McArdle, J. J. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29665-8 · Cited by 74 · see citing works

TETRAHYDROPAPAVEROLINE: AN ALKALOID METABOLITE OF DOPAMINE IN VITRO

Walsh, M. J., Davis, V. E., & Yamanaka, Y. (1970) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28635-9 · Cited by 74 · see citing works

Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice

Koechling, U. M., & Amit, Z. (1994) · Alcohol · doi:10.1016/0741-8329(94)90036-1 · Cited by 73 · see citing works

Buspirone alters alcohol drinking induced in rats by tetrahydropapaveroline injected into brain monoaminergic pathways

Privette, T. H., Hornsby, R. L., & Myers, R. D. (1988) · Alcohol · doi:10.1016/0741-8329(88)90012-2 · Cited by 72 · see citing works

Nicotinic acetylcholine receptor subunits and receptor activity in the epithelial cell line HT29

Summers, A. E., Whelan, C. J., & Parsons, M. (2003) · University of Hertfordshire Research Archive (University of Hertfordshire) · doi:10.1016/s0024-3205 · Cited by 71 · see citing works

The Reinforcing Properties of Salsolinol in the Ventral Tegmental Area: Evidence for Regional Heterogeneity and the Involvement of Serotonin and Dopamine

Rodd, Z. A., Oster, S. M., Ding, Z., Toalston, J. E., Deehan, G. A., Bell, R. L., Li, T., & McBride, W. J. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00572.x · Cited by 68 · see citing works

Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects

Quertemont, É., Tambour, S., Bernaerts, P., Zimatkin, S. M., & Tirelli, E. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1911-x · Cited by 66 · see citing works

The Role of Acetaldehyde in the Central Effects of Ethanol

Quertemont, É., Grant, K. A., Correa, M., Arizzi, M. N., Salamone, J. D., Tambour, S., Aragón, C. M. G., McBride, W. J., Rodd, Z. A., D, A. G. M., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000156185.39073.d2 · Cited by 66 · see citing works

ADH and ALDH Polymorphisms and Alcohol Dependence in Mexican and Native Americans

Ehlers, C. L., Liang, T., & Gizer, I. R. (2012) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2012.694526 · Cited by 64 · see citing works

A Method for the Determination of “Free” Acetaldehyde in Plasma

Pikkarainen, P. H., Salaspuro, M. P., & Lieber, C. S. (1979) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1979.tb05311.x · Cited by 63 · see citing works

Acetaldehyde-induced Changes in the Monoamine and Amino Acid Extracellular Microdialysate Content of the Nucleus Accumbens

Ward, R. J., Colantuoni, C., Dahchour, A., Quertemont, É., & de Witte, P. A. M. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00007-5 · Cited by 63 · see citing works

Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine

Font, L., Aragón, C. M. G., & Miquel, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.020 · Cited by 62 · see citing works

A neuroanatomical substrate for alcohol drinking: Identification of tetrahydropapaveroline (THP)-reactive sites in the rat brain

Myers, R. D., & Privette, T. H. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90035-x · Cited by 62 · see citing works

Acetaldehyde sequestering prevents ethanol-induced stimulation of mesolimbic dopamine transmission

Enrico, P., Sirca, D., Mereu, M., Peana, A. T., Lintas, A., Golosio, A., & Diana, M. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.10.010 · Cited by 59 · see citing works

Microinjections of Acetaldehyde or Salsolinol into the Posterior Ventral Tegmental Area Increase Dopamine Release in the Nucleus Accumbens Shell

Deehan, G. A., Engleman, E. A., Ding, Z., McBride, W. J., & Rodd, Z. A. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12034 · Cited by 59 · see citing works

CYP2E1 and catalase influence ethanol sensitivity in the central nervous system

Vasiliou, V., Ziegler, T. L., Bludeau, P., Petersen, D. R., Gonzalez, F. J., & Deitrich, R. A. (2006) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000182777.95555.56 · Cited by 58 · see citing works

Addiction science and its genetics

Ball, D. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02061.x · Cited by 57 · see citing works

Possible involvement of acetaldehyde, norepinephrine and their tetrahydroisoquinoline derivatives in the regulation of ethanol self-administration

Amit, Z., Brown, Z. W., & Rockman, G. E. (1977) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(77)90049-7 · Cited by 56 · see citing works

A psychopharmacological study of the relationship between brain catalase activity and ethanol-induced locomotor activity in mice.

Arrieta, M. D. E., Miquel, M., & Aragón, C. M. G. (2000) · Journal of Studies on Alcohol · doi:10.15288/jsa.2000.61.493 · Cited by 55 · see citing works

Alteration of alcohol drinking in the rat by peripherally self-administered acetaldehyde

Myers, W. D., Ng, K., Marzuki, S., Myers, R. D., & Singer, G. H. S. (1984) · Alcohol · doi:10.1016/0741-8329(84)90103-4 · Cited by 55 · see citing works

2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde

Nagasawa, H. T., Goon, D. J. W., & DeMaster, E. G. (1978) · Journal of Medicinal Chemistry · doi:10.1021/jm00210a019 · Cited by 55 · see citing works

Alcohol drinking in the rat: Increases following intracerebroventricular treatment with tetrahydro-β-carbolines

Tuomisto, L. M., Airaksinen, M. M., Peura, P. K., & Eriksson, C. J. P. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90367-7 · Cited by 54 · see citing works

Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: Old and new vistas

Hipólito, L., Sánchez-Catalán, M. J., Martí‐Prats, L., Granero, L. M., & Polache, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.007 · Cited by 54 · see citing works

Prevention of Ethanol‐Induced Behavioral Stimulation by d‐Penicillamine: A Sequestration Agent for Acetaldehyde

Font, L., Miquel, M., & Aragón, C. M. G. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000171945.30494.af · Cited by 53 · see citing works

A multi-demensional examination of the positive reinforcing properties of acetaldehyde

Amit, Z., & Smith, B. R. (1985) · Alcohol · doi:10.1016/0741-8329(85)90077-1 · Cited by 53 · see citing works

Salsolinol Produces Reinforcing Effects in the Nucleus Accumbens Shell of Alcohol‐Preferring (P) Rats

Rodd, Z. A., Bell, R. L., Zhang, Y., D, A. G. M., Zaffaroni, A., McBride, W. J., & Li, T. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000056612.89957.b4 · Cited by 53 · see citing works

Shell/core differences in mu- and delta-opioid receptor modulation of dopamine efflux in nucleus accumbens

Hipólito, L., Sánchez-Catalán, M. J., Zanolini, I., Polache, A., & Granero, L. M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.012 · Cited by 52 · see citing works

Involvement of μ‐Opioid Receptor in the Salsolinol‐Associated Place Preference in Rats Exposed to Conditioned Fear Stress

Matsuzawa, S., Suzuki, T., & Misawa, M. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04624.x · Cited by 51 · see citing works

Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model

Rivera‐Meza, M., Quintanilla, M. E., Tampier, L., Mura, C. V., Sapag, A., & Israel, Y. (2009) · The FASEB Journal · doi:10.1096/fj.09-132563 · Cited by 49 · see citing works

Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of μ-opioid receptors

Hipólito, L., Sánchez-Catalán, M. J., Zornoza, T., Polache, A., & Granero, L. M. (2010) · Psychopharmacology · doi:10.1007/s00213-009-1751-9 · Cited by 49 · see citing works

Inhibition of monoamine uptake in synaptosomes by tetrahydroharmane and tetrahydroisoquinoline compounds

Tuomisto, L. M., & Tuomisto, J. (1973) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00500802 · Cited by 48 · see citing works

Motor stimulant effects of ethanol and acetaldehyde injected into the posterior ventral tegmental area of rats: role of opioid receptors

Sánchez-Catalán, M. J., Hipólito, L., Zornoza, T., Polache, A., & Granero, L. M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1495-6 · Cited by 48 · see citing works

Alterations in volitional alcohol intake produced in rats by chronic intraventricular infusions of acetaldehyde, paraldehyde or methanol.

Myers, R. D., & Wl, V. (1969) · PubMed · Cited by 48 · see citing works

A Critical Evaluation of Influence of Ethanol and Diet on Salsolinol Enantiomers in Humans and Rats

Lee, J., Ramchandani, V. A., Hamazaki, K., Engleman, E. A., McBride, W. J., Li, T., & Kim, H. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01087.x · Cited by 47 · see citing works

Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice

Tambour, S., Didone, V., Tirelli, E., & Quertemont, É. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.010 · Cited by 47 · see citing works

Catalase mediates acetaldehyde formation in the striatum of free-moving rats

Jamal, M., Ameno, K., Uekita, I., Kumihashi, M., Wang, W., & Ijiri, I. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.05.002 · Cited by 47 · see citing works

Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: Involvement of μ-opioid receptors

Hipólito, L., Martí‐Prats, L., Sánchez-Catalán, M. J., Polache, A., & Granero, L. M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.04.014 · Cited by 47 · see citing works

Acetaldehyde may mediate reinforcement and aversion produced by ethanol

Aragón, C. M. G., Abitbol, M., & Amit, Z. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90062-6 · Cited by 45 · see citing works

Differential effects on conditioned taste aversion learning with peripherally and centrally administered acetaldehyde

Brown, Z. W., Amit, Z., Smith, B. R., & Rockman, G. E. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90134-x · Cited by 45 · see citing works

Alcoholism or Acetaldehydism?

Raskin, N. H. (1975) · New England Journal of Medicine · doi:10.1056/nejm197502202920811 · Cited by 45 · see citing works

Acetaldehyde-reinforcing effects: a study on oral self-administration behavior

Peana, A. T. (2010) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2010.00023 · Cited by 45 · see citing works

Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating μ-Opioid Receptors

Xie, G., Hipólito, L., Zuo, W., Polache, A., Granero, L. M., Krnjević, K., & Ye, J.-H. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.186833 · Cited by 45 · see citing works

Gene Therapy Reduces Ethanol Intake in an Animal Model of Alcohol Dependence

Ocaranza, P., Quintanilla, M. E., Tampier, L., Karahanian, E., Sapag, A., & Israel, Y. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00553.x · Cited by 44 · see citing works

Increased alcohol intake in low alcohol drinking rats after chronic infusion of the β-carboline harman into the hippocampus

Adell, A., & MYERS, R. D. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90248-8 · Cited by 44 · see citing works

The stimulating effects of ethanol on ventral tegmental area dopamine neurons projecting to the ventral pallidum and medial prefrontal cortex in female Wistar rats: regional difference and involvement of serotonin-3 receptors

Ding, Z., Oster, S. M., Hall, S. R., Engleman, E. A., Hauser, S. R., McBride, W. J., & Rodd, Z. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2208-5 · Cited by 44 · see citing works

Acetaldehyde Metabolism In Vivo During Ethanol Oxidation

Eriksson, C. J. P. (1977) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-5181-6_21 · Cited by 44 · see citing works

Crucial Role of Acetaldehyde in Alcohol Activation of the Mesolimbic Dopamine System

Diana, M., Peana, A. T., Sirca, D., Lintas, A., Melis, M., & Enrico, P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1432.009 · Cited by 43 · see citing works

Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats

Tampier, L., Quintanilla, M. E., & Mardones, J. R. (1995) · Alcohol · doi:10.1016/0741-8329(95)00014-i · Cited by 43 · see citing works

Reward and Relapse: Complete Gene‐Induced Dissociation in an Animal Model of Alcohol Dependence

Quintanilla, M. E., Tampier, L., Karahanian, E., Rivera‐Meza, M., Herrera‐Marschitz, M., & Israel, Y. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01606.x · Cited by 40 · see citing works

The Effect on Experimental Animals of Antabuse (Tetraethylthiuramdisulphide) in Combination with Alcohol.

Larsen, V. (1948) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1948.tb03354.x · Cited by 40 · see citing works

Comparison of acetaldehyde and ethanol: Depression of motor activity in mice

Holtzman, S. G., & Schneider, F. H. (1974) · Life Sciences · doi:10.1016/0024-3205(74)90432-9 · Cited by 40 · see citing works

Formation of Acetaldehyde in the Organism in Relation to Dosage of Antabuse (Tetraethylthiuram‐disulphide) and to Alcohol‐concentration in Blood.

Hald, J., Jacobsen, E., & Larsen, V. (1949) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1949.tb03384.x · Cited by 40 · see citing works

What is in that Drink: The Biological Actions of Ethanol, Acetaldehyde, and Salsolinol

Deehan, G. A., Brodie, M. S., & Rodd, Z. A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_198 · Cited by 39 · see citing works

μ-Opioid receptors in the stimulation of mesolimbic dopamine activity by ethanol and morphine in Long-Evans rats: a delayed effect of ethanol

Valenta, J. P., Job, M. O., Mangieri, R. A., Schier, C. J., Howard, E. C., & Gonzales, R. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3041-9 · Cited by 38 · see citing works

Role of Dopamine D1 Receptors and Extracellular Signal Regulated Kinase in the Motivational Properties of Acetaldehyde as Assessed by Place Preference Conditioning

Spina, L., Longoni, R., Vinci, S., Ibba, F., Peana, A. T., Muggironi, G., Spiga, S., & Acquas, E. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01129.x · Cited by 37 · see citing works

Inhibition of catecholamine uptake and retention in synaptosomal preparations by tetrahydroisoquinoline and tetrahydroprotoberberine alkaloids

Alpers, H. S., McLaughlin, B. R., Nix, W. M., & Davis, V. E. (1975) · Biochemical Pharmacology · doi:10.1016/0006-2952(75)90361-5 · Cited by 37 · see citing works

Quantitative chiral analysis of salsolinol in different brain regions of rats genetically predisposed to alcoholism

Rojkovicova, T., Mechref, Y. S., Starkey, J. A., Wu, G., Bell, R. L., McBride, W. J., & Novotný, M. V. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.01.016 · Cited by 37 · see citing works

Alcohol induces formation of morphine precursors in the striatum of rats

Haber, H., Roske, I., Rottmann, M., Georgi, M., & Melzig, M. F. (1996) · Life Sciences · doi:10.1016/s0024-3205(96)00597-8 · Cited by 36 · see citing works

The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats

Tampier, L., Quintanilla, M. E., Karahanian, E., Rivera‐Meza, M., Herrera‐Marschitz, M., & Israel, Y. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12101 · Cited by 35 · see citing works

Effects of naloxone and buprenorphine on intravenous acetaldehyde self-injection in rats

Myers, W. D., Ng, K. T., & Singer, G. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90168-9 · Cited by 34 · see citing works

Binding of β‐Carbolines and Tetrahydroisoquinolines by Opiate Receptors of the δ‐Type

Airaksinen, M. M., Saano, V., Steidel, E., Juvonen, H., Huhtikangas, A., & Gynther, J. (1984) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1984.tb01998.x · Cited by 34 · see citing works

Acetaldehyde-reinforcing effects: differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats

Quintanilla, M. E., & Tampier, L. (2003) · Alcohol · doi:10.1016/j.alcohol.2003.07.001 · Cited by 34 · see citing works

Efficacy of d-penicillamine, a sequestering acetaldehyde agent, in the prevention of alcohol relapse-like drinking in rats

Orrico‐Sánchez, A., Hipólito, L., Sánchez-Catalán, M. J., Martí‐Prats, L., Zornoza, T., Granero, L. M., & Polache, A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3065-1 · Cited by 33 · see citing works

Reduction of Ethanol‐Derived Acetaldehyde Induced Motivational Properties by l ‐Cysteine

Peana, A. T., Assaretti, A., Muggironi, G., Enrico, P., & Diana, M. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00809.x · Cited by 32 · see citing works

Systemic administration of d-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats

Martí‐Prats, L., Sánchez-Catalán, M. J., Hipólito, L., Orrico‐Sánchez, A., Zornoza, T., Polache, A., & Granero, L. M. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.07.081 · Cited by 32 · see citing works

Catalase inhibition attenuates the acquisition of ethanol and saccharin-quinine consumption in laboratory rats

Rotzinger, S., Smith, B. R., & Amit, Z. (1994) · Behavioural Pharmacology · doi:10.1097/00008877-199404000-00012 · Cited by 32 · see citing works

Central reinforcing effects of ethanol are blocked by catalase inhibition

Nizhnikov, M. E., Molina, J. C., & Spear, N. E. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.08.006 · Cited by 31 · see citing works

Ethanol injected into the hypothalamic arcuate nucleus induces behavioral stimulation in rats: an effect prevented by catalase inhibition and naltrexone

Pastor, R., & Aragón, C. M. G. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328315ecd7 · Cited by 31 · see citing works

Catalase inhibition in the Arcuate nucleus blocks ethanol effects on the locomotor activity of rats

Sanchis‐Segura, C., Correa, M., Miquel, M., & Aragón, C. M. G. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.025 · Cited by 30 · see citing works

Effect of opioid receptor blockade on acetaldehyde self-administration and ERK phosphorylation in the rat nucleus accumbens

Peana, A. T., Muggironi, G., Fois, G. R., Zinellu, M., Vinci, S., & Acquas, E. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.06.003 · Cited by 30 · see citing works

Aversion to acetaldehyde

Quintanilla, M. E., Callejas, O., & Tampier, L. (2002) · Alcohol · doi:10.1016/s0741-8329(01)00197-5 · Cited by 30 · see citing works

Tetrahydro-β-carbolines: Effect on alcohol intake in rats

Airaksinen, M. M., Mähönen, M., Tuomisto, L. M., Peura, P. K., & Eriksson, C. J. P. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90230-7 · Cited by 30 · see citing works

Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens: Shell/core differences

Hipólito, L., Sánchez-Catalán, M. J., Granero, L. M., & Polache, A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.02.014 · Cited by 29 · see citing works

Mechanism of the protective action of cysteine and penicillamine against acetaldehyde-induced mitochondrial injury

Cederbaum, A. I., & Rubin, E. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90130-1 · Cited by 28 · see citing works

Anatomical localization in hippocampus of tetrahydro-β-carboline-induced alcohol drinking in the rat

Huttunen, P., & Myers, R. D. (1987) · Alcohol · doi:10.1016/0741-8329(87)90041-3 · Cited by 28 · see citing works

Intravenous self-administration of ethanol and acetaldehyde by rats.

Takayama, S., & Uyeno, E. T. (1985) · PubMed · Cited by 28 · see citing works

Effects of tetrahydropapaveroline in the nucleus accumbens and the ventral tegmental area on ethanol preference in the rat

Duncan, C. C., & Fernando, P. W. (1991) · Alcohol · doi:10.1016/0741-8329(91)91314-r · Cited by 27 · see citing works

Alcohol effects on the 5-HT3 ligand-gated ion channel

Lovinger, D. M., & Zhou, Q. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00191-x · Cited by 27 · see citing works

Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats

Arrieta, M. D. E., Witte, P. D., & Quertemont, É. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1427-9 · Cited by 26 · see citing works

Characterization of brain acetaldehyde oxidizing systems in the mouse

Petersen, D. R., & Tabakoff, B. (1979) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(79)90054-1 · Cited by 26 · see citing works

Ethanol and acetaldehyde levels in cerebrospinal fluid during ethanol oxidation in the rat

Kilanmaa, K., & Virtanen, P. (1978) · Neuroscience Letters · doi:10.1016/0304-3940(78)90032-0 · Cited by 26 · see citing works

Acetaldehyde Oral Self‐Administration: Evidence from the Operant‐Conflict Paradigm

Cacace, S., Plescia, F., Barberi, I., & Cannizzaro, C. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01725.x · Cited by 26 · see citing works

Ethanol intake and ethanol-induced locomotion and locomotor sensitization in Cyp2e1 knockout mice

Correa, M., Viaggi, C., Escrig, M. A., Pascual, M., Guerri, C., Vaglini, F., Aragón, C. M. G., & Corsini, G. U. (2009) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328324e726 · Cited by 26 · see citing works

Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H2O2 scavenger alpha lipoic acid

Ledesma, J. C., & Aragón, C. M. G. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2831-9 · Cited by 25 · see citing works

Tetrahydropapaveroline Injected in the Ventral Tegmental Area Shifts Dopamine Efflux Differentially in the Shell and Core of Nucleus Accumbens in High-Ethanol-Preferring (HEP) Rats

Myers, R. D., & Robinson, D. E. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00008-7 · Cited by 24 · see citing works

Mushrooms and a Toxic Reaction to Alcohol

Reynolds, W. A., & Lowe, F. H. (1965) · New England Journal of Medicine · doi:10.1056/nejm196503252721209 · Cited by 24 · see citing works

Selective release of serotonin by endogenous alkaloids, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, in the rat striatum; in vivo microdialysis study

Maruyama, W., Nakahara, D., Dostert, P., Hashiguchi, H., Ohta, S., Hirobe, M., Takahashi, A., Nagatsu, T., & Naoi, M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90749-b · Cited by 24 · see citing works

Effect of Ethanol on (R)- and (S)-Salsolinol, Salsoline, and THP in the Nucleus Accumbens of AA and ANA Rats

Baum, S. S., Hill, R., Kiianmaa, K., & Rommelspacher, H. (1999) · Alcohol · doi:10.1016/s0741-8329(98)00080-9 · Cited by 24 · see citing works

Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats.

Tampier, L., & Quintanilla, M. E. (2002) · Journal of Studies on Alcohol · doi:10.15288/jsa.2002.63.257 · Cited by 23 · see citing works

What is in that Drink: The Biological Actions of Ethanol, Acetaldehyde, and Salsolinol

Deehan, G. A., Brodie, M. S., & Rodd, Z. A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_198 · Cited by 23 · see citing works

Sex differences in acetaldehyde on body temperature and open-field performance in the rat

Myers, W. D., Gibson, S. J., Ng, K. T., & Singer, G. H. S. (1987) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(87)90081-0 · Cited by 22 · see citing works

An acetaldehyde-sequestering agent inhibits appetitive reinforcement and behavioral stimulation induced by ethanol in preweanling rats

Pautassi, R. M., Nizhnikov, M. E., Fabio, M. C., & Spear, N. E. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.10.005 · Cited by 22 · see citing works

Reduction of Ethanol Consumption in Alcohol-Preferring Rats by Dual Expression Gene Transfer

Rivera‐Meza, M., Quintanilla, M. E., & Tampier, L. (2012) · Alcohol and Alcoholism · doi:10.1093/alcalc/agr161 · Cited by 21 · see citing works

5-HT, dopamine, norepinephrine, and related metabolites in brain of low alcohol drinking (LAD) rats shift after chronic intra-hippocampal infusion of harman

Adell, A., & MYERS, R. D. (1995) · Neurochemical Research · doi:10.1007/bf00970546 · Cited by 20 · see citing works

Characterization of the in vivo actionof(R)-salsolino, an endogenous metabolite of alcohol, on serotonin and dopamine metabolism: A microdialysis study

Nakahara, D., Maruyama, W., Hashiguti, H., & Naoi, M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91684-5 · Cited by 20 · see citing works

Anatomical mapping of tetrahydropapaveroline-reactive sites in brain mediating suppression of alcohol drinking in the rat

Privette, T. H., & Myers, R. D. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90017-8 · Cited by 19 · see citing works

Common and Rare Variants in Alcohol Dependence

Edenberg, H. J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.007 · Cited by 18 · see citing works

The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice

Ledesma, J. C., Font, L., & Aragón, C. M. G. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.12.003 · Cited by 18 · see citing works

The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats

March, S. M., Abate, P., Spear, N. E., & Molina, J. C. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2920-9 · Cited by 18 · see citing works

Tetrahydroisoquinoline and opioid substrates of alcohol actions.

Hl, A., & Shippenberg, T. S. (1982) · PubMed · Cited by 17 · see citing works

Effect of l-cysteine on acetaldehyde self-administration

Peana, A. T., Muggironi, G., Fois, G. R., Zinellu, M., Sirca, D., & Diana, M. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.10.004 · Cited by 17 · see citing works

Preexposure Effects of Nicotine and Acetaldehyde on Conditioned Taste Aversion Induced by Both Drugs

Kunin, D., Latendresse, M. W., Gaskin, S., Smith, B. R., & Amit, Z. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00284-7 · Cited by 17 · see citing works

A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats

McCoy, J. G., Strawbridge, C., McMurtrey, K. D., Kane, V. B., & Ward, C. P. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00018-2 · Cited by 16 · see citing works

Similar antagonistic effects of Ca N-acetylhomotaurinate on depression of motor activity and lethality induced by acetaldehyde or ethanol.

Durlach, J., Rinjard, P., Sprince, H., & Gg, S. (1988) · PubMed · Cited by 15 · see citing works

Difficulties in Measuring Human Blood Acetaldehyde Concentrations During Ethanol Intoxication

Eriksson, C. J. P., Hillbom, M., & Sovijärvi, A. R. (1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3632-7_32 · Cited by 13 · see citing works

The Rate of Acetaldehyde Metabolism in Isolated Livers and Hind Limbs of Rabbits Treated with Antabuse (Tetraethylthiuramdisulphide).

Hald, J., Jacobsen, E., & Larsen, V. (1949) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1949.tb03395.x · Cited by 13 · see citing works

Salsolinol Facilitates Glutamatergic Transmission to Dopamine Neurons in the Posterior Ventral Tegmental Area of Rats

Xie, G., & Ye, J.-H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036716 · Cited by 12 · see citing works

Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol Challenges

Rhoads, D. E., Contreras, C., & Fathalla, S. (2012) · Enzyme Research · doi:10.1155/2012/572939 · Cited by 11 · see citing works

Alteration of Ethanol Preference in Rats; Effects of β-Carbolines

Geller, I., & Purdy, R. H. (1975) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0632-1_20 · Cited by 10 · see citing works

The Effects of Ethyl Alcohol and Acetaldehyde on Maze Behaviour and Motor Co-Ordination in Rats

Carpenter, R., & MacLeod, L. D. (1952) · Journal of Mental Science · doi:10.1192/bjp.98.410.167 · Cited by 10 · see citing works

Voluntary ethanol consumption in the rat following peripheral administrations of 3-carboxy-salsolinol.

Purvis, P. L., Hirst, M., & Jc, B. (1980) · PubMed · Cited by 6 · see citing works

Proceedings: Chronic administration of acetaldehyde to mice: behavioural and biochemical similarities with chronic ethanol administration.

Griffiths, P. J., Littleton, J. M., & Ortiz, A. (1974) · PubMed · Cited by 2 · see citing works

Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental &amp; Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works

Lipids and Oxidative Stress Associated with Ethanol‐Induced Neurological Damage

Hernández-Hernández, J. A., López-Sánchez, R. C., & Rendón-Ramírez, A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1543809 · Cited by 161 · see citing works

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works

At the intersection of alcohol use disorder and chronic pain.

Maleki, N., Tahaney, K. D., Thompson, B., & Oscar‐Berman, M. (2019) · Neuropsychology · doi:10.1037/neu0000558 · Cited by 84 · see citing works

Alcohol-induced alterations in dopamine modulation of prefrontal activity

Trantham‐Davidson, H., & Chandler, L. J. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.09.001 · Cited by 79 · see citing works

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

Peana, A. T., Sánchez-Catalán, M. J., Hipólito, L., Rosas, M., Porru, S., Bennardini, F., Romualdi, P., Caputi, F. F., Candeletti, S., Polache, A., et al. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00081 · Cited by 57 · see citing works

The “First Hit” Toward Alcohol Reinforcement: Role of Ethanol Metabolites

Israel, Y., Quintanilla, M. E., Karahanian, E., Rivera‐Meza, M., & Herrera‐Marschitz, M. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12709 · Cited by 44 · see citing works

Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake

Quintanilla, M. E., Rivera‐Meza, M., Berríos‐Cárcamo, P., Bustamante, D., Buscaglia, M., Morales, P., Karahanian, E., Herrera‐Marschitz, M., & Israel, Y. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.07.003 · Cited by 43 · see citing works

Acetaldehyde self-administration by a two-bottle choice paradigm: Consequences on emotional reactivity, spatial learning, and memory

Plescia, F., Brancato, A., Vènniro, M., Maniaci, G., Cannizzaro, E., Sutera, F. M., De, V., Giannola, L. I., & Cannizzaro, C. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.01.002 · Cited by 32 · see citing works

Gene–ethanol interactions underlying fetal alcohol spectrum disorders

McCarthy, N., & Eberhart, J. K. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1578-3 · Cited by 31 · see citing works

Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line

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Clinical Therapeutic Effect of Naloxone Combined with Hemodialysis on Acute Severe Alcoholism

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Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA

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Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence

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BDNF restores impaired long-term potentiation of GABAergic synapses induced by chronic ethanol exposure in the VTA and attenuates reward-seeking behavior

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Role of Lactobacillus plantarum-Derived Extracellular Vesicles in Regulating Alcohol Consumption

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Chronic inflammatory pain suppresses alcohol intake and accumbal dopamine response

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Nitric Oxide Signaling Pathway in Ventral Tegmental Area is Involved in Regulation of 7,8-Dihydroxyflavone on Alcohol Consumption in Rats

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Effect of Pain in the Development of Alcohol Use Disorders: Ethanol-evoked Dopamine Release Alterations in the Rat Nucleus AccumbensPreprint

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A multi-reward framework to improve translation in alcohol use disorder

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Alcohol and the Metabolic Implications of ALDH2 Polymorphism

Matsumoto, A. (2026) · Springer eBooks · doi:10.1007/978-3-031-35658-2_47-1

Reviewed by:

Deehan, G. A., Hauser, S. R., Wilden, J. A., Truitt, W. A., Rodd, Z. A., Melis, M., & Department Of (2013)

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Alcohol as Prodrug of Salsolinol

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