Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat
Open accessAbstract
Recent evidence implicates adult hippocampal neurogenesis in regulating behavioral and physiologic responses to stress. Hippocampal neurogenesis occurs across the lifespan, however the rate of cell birth is up to 300% higher in adolescent mice compared to adults. Adolescence is a sensitive period in development where emotional circuitry and stress reactivity undergo plasticity establishing life-long set points. Therefore neurogenesis occurring during adolescence may be particularly important for emotional behavior. However, little is known about the function of hippocampal neurons born during adolescence. In order to assess the contribution of neurons born in adolescence to the adult stress response and depression-related behavior, we transiently reduced cell proliferation either during adolescence, or during adulthood in GFAP-Tk mice. We found that the intervention in adolescence did not change adult baseline behavioral response in the forced swim test, sucrose preference test or social affiliation test, and did not change adult corticosterone responses to an acute stressor. However following chronic social defeat, adult mice with reduced adolescent neurogenesis showed a resilient phenotype. A similar transient reduction in adult neurogenesis did not affect depression-like behaviors or stress induced corticosterone. Our study demonstrates that hippocampal neurons born during adolescence, but not in adulthood are important to confer susceptibility to chronic social defeat.
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Abrogation of hippocampal neurogenesis in adolescence blocks susceptibility to chronic social defeat in adulthood.
“abrogation of hippocampal neurogenesis in adolescence blocked susceptibility to chronic social defeat in adulthood.8”
From Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression (2017) · cites this paper as [8]
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van der Kooij, M. A., Jene, T., Treccani, G., Miederer, I., Hasch, A., Voelxen, N., Walenta, S., & Müller, M. B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804412115 · Cited by 92 · see citing works
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- Authors
- Kirshenbaum, G. S., Lieberman, S. R., Briner, T. J., Leonardo, E. D., & Dranovsky, A.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Leonardo, E. David
- Dranovsky, Alex
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-08-28
- Volume
- 8
- Pages
- 289-289
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC4147831
- OpenAlex
- W1980042496
- Cited by
- 23
- References
- 42
- Citations by year
- 2024: 1 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 5
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Columbia Academic Commons (Columbia University)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Canadian Institutes of Health Research
- National Institute of Mental Health (R01MH091844, R01MH091427, K08MH079088)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult hippocampal neurogenesis, chronic social defeat, depression-like behavior, stress resilience, corticosterone, social affiliation, forced swim test, sucrose preference
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