Neurons born in the adult dentate gyrus form functional synapses with target cells
Open accessAbstract
Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. By combining retroviral expression of green fluorescent protein in adult-born neurons of the mouse dentate gyrus with immuno-electron microscopy, we found output synapses that were formed by labeled terminals on appropriate target cells in the CA3 area and the hilus. Furthermore, retroviral expression of channelrhodopsin-2 allowed us to light-stimulate newborn granule cells and identify postsynaptic target neurons by whole-cell recordings in acute slices. Our structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The process by which newly generated neurons in normal development are incorporated into the granular cell layer is well established and involves expression of specific markers and development of defined neuronal morphology.
“The process by which newly generated neurons in normal development are incorporated into the granular cell layer is well established and involves expression of specific markers and development of defined neuronal morphology24,26,34,35.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [34]
The Results describe morphological maturation of adult-born granule-cell axons and compare their mature boutons with those of neurons born during early postnatal development. But the paper does not establish a process of incorporation into the granule cell layer during normal development or describe the expression of specific developmental markers; GFP was introduced to label the cells. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMossy fibers from new granule cells begin to form synapses with excitatory pyramidal cells in CA3 and CA2 and with hilar mossy cells by approximately 2-3 weeks post-mitosis.
“Mossy fibers from new granule cells begin to form synapses with excitatory pyramidal cells in the CA3 and CA2 subregions (Gu et al., 2012; Llorens-Martín et al., 2015; Toni et al., 2008) as well as with hilar mossy cells (Toni et al., 2008) by approximately 2–3 weeks post-mitosis (Figure 1B).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Toni et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,886 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Self-citationFunctional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works
Self-citationA monomeric red fluorescent protein
Campbell, R. E., Tour, O., Palmer, A. E., Steinbach, P. A., Baird, G. S., Zacharias, D. A., & Tsien, R. Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082243699 · Cited by 2,346 · see citing works
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,829 · see citing works
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P., Alonso, M., & Grubb, M. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1867 · Cited by 1,364 · see citing works
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works
GABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works
Self-citationA Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927 · see citing works
GABAergic Cells Are the Major Postsynaptic Targets of Mossy Fibers in the Rat Hippocampus
Acsády, L., Kamondi, A., Sı́k, A., Freund, T., & Buzsáki, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03386.1998 · Cited by 741 · see citing works
Jonas, P., Major, G., & Sakmann, B. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019965 · Cited by 720 · see citing works
Neuronal differentiation in the adult hippocampus recapitulates embryonic development
Espósito, M. S., Piatti, V. C., Laplagne, D. A., Morgenstern, N. A., Ferrari, C. C., Pitossi, F. J., & Schinder, A. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3114-05.2005 · Cited by 679 · see citing works
Self-citationPotential role for adult neurogenesis in the encoding of time in new memories
Aimone, J. B., Wiles, J., & Gage, F. H. (2006) · Nature Neuroscience · doi:10.1038/nn1707 · Cited by 644 · see citing works
Self-citationEffects of Adult Neurogenesis on Synaptic Plasticity in the Rat Dentate Gyrus
Snyder, J. S., Kee, N., & Wojtowicz, J. M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2423 · Cited by 619 · see citing works
Amaral, D. G., & Dent, J. A. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901950106 · Cited by 606 · see citing works
Synapse formation on neurons born in the adult hippocampus
Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience · doi:10.1038/nn1908 · Cited by 579 · see citing works
Self-citationLi, X., Gutierrez, D. V., Hanson, M. G., Han, J., Mark, M. D., Chiel, H. J., Hegemann, P., Landmesser, L. T., & Herlitze, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509030102 · Cited by 543 · see citing works
Chapter 1 Chapter Neurons, numbers and the hippocampal network
Amaral, D. G., Ishizuka, N., & Claiborne, B. J. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)61237-6 · Cited by 523 · see citing works
Chicurel, M. E., & Harris, K. M. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903250204 · Cited by 417 · see citing works
The multifarious hippocampal mossy fiber pathway: a review
Henze, D. A., Urban, N. N., & Barrionuevo, G. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00146-9 · Cited by 389 · see citing works
Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
Laplagne, D. A., Esposito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040409 · Cited by 359 · see citing works
Self-citationKamiya, H., Shinozaki, H., & Yamamoto, C. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021395 · Cited by 327 · see citing works
Standen, N. B., & Stanfield, P. R. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012379 · Cited by 317 · see citing works
Scharfman, H. E., Kunkel, D. D., & Schwartzkroin, P. A. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90100-i · Cited by 239 · see citing works
Scharfman, H. E. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.1.179 · Cited by 215 · see citing works
Walker, M. C., Ruiz, A. J., & Kullmann, D. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00245-8 · Cited by 187 · see citing works
Scharfman, H. E. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.5.2167 · Cited by 128 · see citing works
Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis
Laplagne, D. A., Kamienkowski, J. E., Esposito, M. S., Piatti, V. C., Zhao, C., Gage, F. H., & Schinder, A. F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05549.x · Cited by 125 · see citing works
Self-citationThe dual glutamatergic–GABAergic phenotype of hippocampal granule cells
Gutiérrez, R. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.04.005 · Cited by 120 · see citing works
A Hypothesis About the Role of Adult Neurogenesis in Hippocampal Function
Schinder, A. F., & Gage, F. H. (2004) · Physiology · doi:10.1152/physiol.00012.2004 · Cited by 108 · see citing works
Self-citationSynaptic extensions from the mossy fibers of the fascia dentata
Amaral, D. G. (1979) · Anatomy and Embryology · doi:10.1007/bf00317638 · Cited by 100 · see citing works
Frotscher, M. (1989) · Experimental Brain Research · doi:10.1007/bf00247950 · Cited by 79 · see citing works
Seress, L., & Ribak, C. E. (1995) · Hippocampus · doi:10.1002/hipo.450050308 · Cited by 64 · see citing works
Self-citationSoriano, E., & Frotscher, M. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330309 · Cited by 62 · see citing works
Kneisler, T. B., & Dingledine, R. J. (1995) · Hippocampus · doi:10.1002/hipo.450050302 · Cited by 50 · see citing works
Shapiro, L. A., Upadhyaya, P., & Ribak, C. E. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.032 · Cited by 34 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · see citing works
Self-citationOptogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881 · see citing works
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works
Self-citationNeurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072 · see citing works
Self-citationHippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H.-L. (., Wheeler, A. L., Guskjolen, A., Niibori, Y., Shoji, H., et al. (2014) · Science · doi:10.1126/science.1248903 · Cited by 761 · see citing works
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Self-citationAimone, J. B., Deng, W., & Gage, F. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.010 · Cited by 663 · see citing works
Self-citationMicroglia mediate forgetting via complement-dependent synaptic elimination
Wang, C., Yue, H., Hu, Z., Shen, Y., Ma, J., Li, J., Wang, X.-D., Wang, L., Sun, B., Shi, P., et al. (2020) · Science · doi:10.1126/science.aaz2288 · Cited by 629 · see citing works
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635 · see citing works
Self-citationCell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits
Kohara, K., Pignatelli, M., Rivest, A. J., Jung, H.-Y., Kitamura, T., Suh, J., Frank, D., Kajikawa, K., Mise, N., Obata, Y., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3614 · Cited by 528 · see citing works
Cardiovascular fitness is associated with cognition in young adulthood
Åberg, M. A. I., Pedersen, N. L., Torén, K., Svartengren, M., Bäckstrand, B., Johnsson, T., Cooper-Kuhn, C. M., Åberg, N. D., Nilsson, M., & Kuhn, H. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905307106 · Cited by 382 · see citing works
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
Stone, S. S. D., Teixeira, C. M., DeVito, L. M., Zaslavsky, K., Josselyn, S. A., Lozano, A. M., & Frankland, P. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3100-11.2011 · Cited by 384 · see citing works
The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?
Lazic, S. E. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-5 · Cited by 381 · see citing works
Distinct contribution of adult-born hippocampal granule cells to context encoding
Danielson, N. B., Kaifosh, P., Zaremba, J. D., Lovett-Barron, M., Tsai, J., Denny, C. A., Balough, E. M., Goldberg, A. R., Drew, L. J., Hen, R., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.019 · Cited by 352 · see citing works
Adult‐born hippocampal neurons promote cognitive flexibility in mice
Burghardt, N. S., Park, E. H., Hen, R., & Fenton, A. A. (2012) · Hippocampus · doi:10.1002/hipo.22013 · Cited by 311 · see citing works
DNA repair deficiency and neurological disease
McKinnon, P. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2559 · Cited by 323 · see citing works
Adult neurogenesis: integrating theories and separating functions
Aimone, J. B., Deng, W., & Gage, F. H. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.003 · Cited by 303 · see citing works
Self-citationAdult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236 · see citing works
Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus
Song, J., Sun, J., Moss, J., Wen, Z., Sun, G. J., Hsu, D., Zhong, C., Davoudi, H., Christian, K. M., Toni, N., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3572 · Cited by 223 · see citing works
Self-citationAdult neurogenesis modifies excitability of the dentate gyrus
Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H.-K., Hen, R., Xu, X., & Sahay, A. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00204 · Cited by 192 · see citing works
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus
Lacefield, C. O., Itskov, V., Reardon, T., Hen, R., & Gordon, J. A. (2012) · Hippocampus · doi:10.1002/hipo.20860 · Cited by 188 · see citing works
Use it or lose it: how neurogenesis keeps the brain fit for learning
Shors, T. J., Anderson, M. L., Curlik, D. M., & Nokia, M. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.023 · Cited by 190 · see citing works
Forgetting as a form of adaptive engram cell plasticity
Ryan, T. J., & Frankland, P. W. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00548-3 · Cited by 182 · see citing works
Wilke, S. A., Antonios, J. K., Bushong, E. A., Badkoobehi, A., Malek, E., Hwang, M., Terada, M., Ellisman, M. H., & Ghosh, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1600-12.2013 · Cited by 179 · see citing works
Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons
Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., & Hen, R. (2016) · Hippocampus · doi:10.1002/hipo.22557 · Cited by 169 · see citing works
Clark, P. J., Brzezinska, W. J., Puchalski, E. K., Krone, D. A., & Rhodes, J. S. (2009) · Hippocampus · doi:10.1002/hipo.20543 · Cited by 138 · see citing works
Merino-Serrais, P., Benavides-Piccione, R., Blazquez-Llorca, L., Kastanauskaite, A., Rábano, A., Avila, J., & DeFelipe, J. (2013) · Brain · doi:10.1093/brain/awt088 · Cited by 134 · see citing works
Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice
Cuartero, M. I., de la Parra, J., Pérez-Ruiz, A., Bravo-Ferrer, I., Durán-Laforet, V., García-Culebras, A., García-Segura, J. M., Dhaliwal, J., Frankland, P. W., Lizasoain, I., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120412 · Cited by 128 · see citing works
Saaltink, D.-J., & Vreugdenhil, E. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1568-5 · Cited by 127 · see citing works
Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis
Song, J., Olsen, R. H. J., Sun, J., Ming, G.-L., & Song, H. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018937 · Cited by 125 · see citing works
Fuss, J., Ben Abdallah, N. M. B., Hensley, F. W., Weber, K.-J., Hellweg, R., & Gass, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012769 · Cited by 110 · see citing works
“Approximately 70% of the target cells of mossy fibers of adult born neurons are inhibitory interneurons [44].”
BackgroundDauncey, M. J. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990188 · Cited by 107 · see citing works
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice
Ou-Yang, M.-H., Kurz, J. E., Nomura, T., Popovic, J., Rajapaksha, T. W., Dong, H., Contractor, A., Chetkovich, D. M., Tourtellotte, W. G., & Vassar, R. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao5620 · Cited by 94 · see citing works
Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus
Teixeira, C. M., Kron, M. M., Masachs, N., Zhang, H., Lagace, D. C., Martinez, A., Reillo, I., Duan, X., Bosch, C., Pujadas, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1857-12.2012 · Cited by 97 · see citing works
AAV ablates neurogenesis in the adult murine hippocampus
Johnston, S., Parylak, S. L., Kim, S., Mac, N., Lim, C., Gallina, I., Bloyd, C., Newberry, A., Saavedra, C. D., Novak, O., et al. (2021) · eLife · doi:10.7554/elife.59291 · Cited by 87 · see citing works
Self-citationOntogeny of memory: an update on 40 years of work on infantile amnesia
Madsen, H. B., & Kim, J. H. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.030 · Cited by 92 · see citing works
Adult hippocampal neurogenesis and its role in cognition.
Oomen, C. A., Bekinschtein, P., Kent, B. A., Saksida, L. M., & Bussey, T. J. (2014) · WIREs Cognitive Science · doi:10.1002/wcs.1304 · Cited by 93 · see citing works
Novel connection between newborn granule neurons and the hippocampal CA2 field
Llorens-Martín, M., Jurado-Arjona, J., Avila, J., & Hernández, F. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.021 · Cited by 83 · see citing works
Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration
Gomez-Nicola, D., Suzzi, S., Vargas-Caballero, M., Fransen, N. L., Al-Malki, H., Cebrian-Silla, A., Garcia-Verdugo, J. M., Riecken, K., Fehse, B., & Perry, V. H. (2014) · Brain · doi:10.1093/brain/awu155 · Cited by 84 · see citing works
The hippocampus and exercise: histological correlates of MR-detected volume changes
Biedermann, S. V., Fuss, J., Steinle, J., Auer, M. K., Dormann, C., Falfán-Melgoza, C., Ende, G., Gass, P., & Weber-Fahr, W. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0976-5 · Cited by 72 · see citing works
Ma, X., Xiao, W., Li, H., Pang, P., Xue, F., Wan, L., Pei, L., & Yan, H. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.011 · Cited by 67 · see citing works
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB
Maimon, R., Chillon-Marinas, C., Snethlage, C. E., Singhal, S. M., McAlonis-Downes, M., Ling, K., Rigo, F., Bennett, C. F., Da Cruz, S., Hnasko, T. S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00864-y · Cited by 62 · see citing works
Krzisch, M., Temprana, S. G., Mongiat, L. A., Armida, J., Schmutz, V., Virtanen, M. A., Kocher-Braissant, J., Kraftsik, R., Vutskits, L., Conzelmann, K.-K., et al. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0768-y · Cited by 57 · see citing works
Self-citationMcAuliffe, J. J., Bronson, S. L., Hester, M. S., Murphy, B. L., Dahlquist‐Topalá, R., Richards, D. A., & Danzer, S. C. (2011) · Hippocampus · doi:10.1002/hipo.20726 · Cited by 47 · see citing works
Watanabe, Y., Murakami, T., Kawashima, M., Hasegawa-Baba, Y., Mizukami, S., Imatanaka, N., Akahori, Y., Yoshida, T., & Shibutani, M. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9660-2 · Cited by 34 · see citing works
Tirone, F., Farioli-Vecchioli, S., Micheli, L., Ceccarelli, M., & Leonardi, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00059 · Cited by 32 · see citing works
Zhong, H., Rong, J., Zhu, C., Liang, M., Li, Y., & Zhou, R. (2020) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa020 · Cited by 28 · see citing works
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat
Kirshenbaum, G. S., Lieberman, S. R., Briner, T. J., Leonardo, E. D., & Dranovsky, A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00289 · Cited by 23 · see citing works
- Authors
- Toni, N., Laplagne, D. A., Zhao, C., Lombardi, G., Ribak, C. E., Gage, F. H., & Schinder, A. F.
- Affiliations
- Salk Institute for Biological Studies (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- University of California, Irvine (US)
- Corresponding author
- Gage, Fred H
- Schinder, Alejandro F
- Venue
- Nature Neuroscience
- Published
- 2008-07-11
- Volume
- 11
- Issue
- 8
- Pages
- 901-907
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2572641
- OpenAlex
- W2125095601
- Cited by
- 741
- References
- 37
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 24 · 2023: 26 · 2022: 16 · 2021: 31 · 2020: 29 · 2019: 40 · 2018: 43 · 2017: 42 · 2016: 47 · 2015: 53 · 2014: 54 · 2013: 56 · 2012: 59
- FWCI
- 18.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- Howard Hughes Medical Institute
- James S. McDonnell Foundation
- Consejo Nacional de Investigaciones Científicas y Técnicas
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS050217, R01NS038331, NS038331, NS050217)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult neurogenesis, dentate gyrus, granule cells, synaptogenesis, axon terminals, CA3 pyramidal cells, hilar interneurons, mossy cells, glutamate release, channelrhodopsin-2, retroviral labeling, hippocampus, synapse maturation
- MeSH terms
- Action Potentials, Animals, Carrier Proteins, Female, Humans, Interneurons, Light, Luminescent Proteins, Mice, Inbred C57BL, Moloney murine leukemia virus, Synaptic Transmission, Neurons, Organ Culture Techniques, Photic Stimulation, Synapses, Presynaptic Terminals, Genes, Reporter, Gene Transfer Techniques, Patch-Clamp Techniques, Glutamic Acid, GABA Antagonists, Dentate Gyrus, Mossy Fibers, Hippocampal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
