The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Quantitating the subtleties of microglial morphology with fractal analysis
Open accessAbstract
It is well established that microglial form and function are inextricably linked. In recent years, the traditional view that microglial form ranges between "ramified resting" and "activated amoeboid" has been emphasized through advancing imaging techniques that point to microglial form being highly dynamic even within the currently accepted morphological categories. Moreover, microglia adopt meaningful intermediate forms between categories, with considerable crossover in function and varying morphologies as they cycle, migrate, wave, phagocytose, and extend and retract fine and gross processes. From a quantitative perspective, it is problematic to measure such variability using traditional methods, but one way of quantitating such detail is through fractal analysis. The techniques of fractal analysis have been used for quantitating microglial morphology, to categorize gross differences but also to differentiate subtle differences (e.g., amongst ramified cells). Multifractal analysis in particular is one technique of fractal analysis that may be useful for identifying intermediate forms. Here we review current trends and methods of fractal analysis, focusing on box counting analysis, including lacunarity and multifractal analysis, as applied to microglial morphology.
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Cited by
Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225
Young, K., & Morrison, H. (2018) · Journal of Visualized Experiments · doi:10.3791/57648 · Cited by 574
Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.007 · Cited by 545
Fernández-Arjona, M. D. M., Grondona, J. M., Granados-Durán, P., Fernández-Llebrez, P., & López-Ávalos, M. D. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00235 · Cited by 417
Microglia and the brain: Complementary partners in development and disease
Hammond, T. R., Robinton, D., & Stevens, B. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060509 · Cited by 288
Metadata
- Authors
- Karperien, A., Ahammer, H., & Jelinek, H. F.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 3-3
- ISSN
- 1662-5102 (ISSN-L)
- OpenAlex
- W1988785687
- Cited by
- 538
- References
- 13
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- gold
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- Karperien, A., Ahammer, H., & Jelinek, H. F. (2013). Quantitating the subtleties of microglial morphology with fractal analysis. Frontiers in Cellular Neuroscience. https://doi.org/10.3389/fncel.2013.00003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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