Evidence for activation of microglia in patients with psychiatric illnesses
Abstract
Activation of microglia/macrophages is a key event in response to pathological changes in the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with activated microglia cells. In order to elucidate a potential role of microgliosis in severe psychiatric illnesses, post-mortem frontal cortex and hippocampus of patients with schizophrenia (n = 14) and affective disorder (n = 6) and control specimens (n = 13) were studied. Additionally Alzheimer's disease cases (n = 8) were included as a human model system with typical neurodegenerative alterations and microglia activation. All patient groups revealed subjects with abundant microglia immunostaining (schizophrenia, three patients; affective disorder, one patient; Alzheimer's disease, four patients) in both gray and white matter. This finding provides evidence for distinct neuropathological changes in brains of patients with schizophrenia and affective disorder. The activation of microglia cells, which represent a major part of the brain immune response, may help to unravel the pathophysiological processes in severe psychiatric illnesses.
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Schizophrenia neuropathology has been reported to be closely associated with cytokines and microglial activation.
“In this context, the neuropathology of schizophrenia has been reported to be closely associated with cytokines and microglial activation (Bayer et al., 1999; Brown, 2011; Juckel et al., 2011; Meyer et al., 2009; Monji et al., 2009; Najjar et al., 2013; Radewicz et al., 2000; Vuillermot et al., 2010).”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Bayer et al., 1999
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works
Dementia Praecox and Paraphrenia.
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-6-1058_8 · Cited by 2,906 · see citing works
Reactive astrocytes: cellular and molecular cues to biological function
Ridet, J., Privat, A., Malhotra, S. K., & Gage, F. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01139-9 · Cited by 1,766 · see citing works
Is Schizophrenia a Progressive Neurodevelopmental Disorder? Toward a Unitary Pathogenetic Mechanism
Woods, B. T. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.12.1661 · Cited by 413 · see citing works
Viruses, schizophrenia, and bipolar disorder
Yolken, R. H., & Torrey, Ε. F. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.1.131 · Cited by 356 · see citing works
Recent advances in defining the neuropathology of schizophrenia
Arnold, S. E., & Trojanowski, J. Q. (1996) · Acta Neuropathologica · doi:10.1007/s004010050512 · Cited by 205 · see citing works
Arnold, S., Trojanowski, J., Gur, R., Blackwell, P. M., Han, L.-Y., & Choi, C. H. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.3.225 · Cited by 201 · see citing works
Course of Schizophrenia: Neuropsychological Evidence for a Static Encephalopathy
Goldberg, T. E., Hyde, T. M., Kleinman, J. E., & Weinberger, D. R. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.4.797 · Cited by 186 · see citing works
Is there gliosis in schizophrenia? Investigation of the temporal lobe
Roberts, G. W., Colter, N., Lofthouse, R., Johnstone, E. C., & Crow, T. J. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90104-1 · Cited by 154 · see citing works
Gliosis in schizophrenia: A survey
Roberts, G. W., Colter, N., Lofthouse, R., Bogerts, B., Zech, M.-P., & Crow, T. J. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90285-4 · Cited by 150 · see citing works
Is There Cognitive Decline in Schizophrenia?
Hyde, T. M., Nawroz, S., Goldberg, T. E., Bigelow, L. B., Strong, D., Ostrem, J. L., Weinberger, D. R., & Kleinman, J. E. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.4.494 · Cited by 138 · see citing works
No evidence for astrogliosis in brains of schizophrenic patients. A post‐mortem study
Falkai, P., Honer, David, Bogerts, Majtenyi, & Bayer (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00162.x · Cited by 132 · see citing works
Self-citationArnold, S. E., Franz, B. R., Trojanowski, J. Q., Moberg, P. J., & Gur, R. E. (1996) · Acta Neuropathologica · doi:10.1007/s004010050425 · Cited by 112 · see citing works
Heterogeneity of the Psychoses: Is There a Neurodegenerative Psychosis?
Knoll, J. L., Garver, D., Ramberg, J. E., Kingsbury, S. J., Croissant, D., & McDermott, B. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033332 · Cited by 87 · see citing works
Schmitt, Brook, G. A., Buss, Nacimiento, Noth, & Kreutzberg (1998) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1998.00103.x · Cited by 51 · see citing works
Popović, M., Caballero‐Bleda, M., Puelles, L., & Popović, N. (1998) · International Journal of Neuroscience · doi:10.3109/00207459809003341 · Cited by 49 · see citing works
Chen, E. Y. H., LAM, L. C. W., Chen, R. Y. L., Nguyen, D. G. H., & Chan, C. K. Y. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09816.x · Cited by 37 · see citing works
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Depression as a Microglial Disease
Yirmiya, R., Rimmerman, N., & Reshef, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.001 · Cited by 944 · see citing works
Maternal immune activation and abnormal brain development across CNS disorders
Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880 · see citing works
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791 · see citing works
Neuroinflammation and psychiatric illness
Najjar, S., Pearlman, D. M., Alper, K., Najjar, A., & Devinsky, O. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-43 · Cited by 733 · see citing works
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works
Fillman, S. G., Cloonan, N., Catts, V. S., Miller, L. C., Wong, J., McCrossin, T., Cairns, M., & Weickert, C. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.110 · Cited by 609 · see citing works
Graeber, M. B. (2010) · Science · doi:10.1126/science.1190929 · Cited by 608 · see citing works
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Réus, G. Z., Fries, G. R., Stertz, L., Badawy, M., Passos, I. C., Barichello, T., Kapczinski, F., & Quevedo, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.018 · Cited by 594 · see citing works
Hopperton, K. E., Mohammad, D., Trépanier, M. O., Giuliano, V, & Bazinet, R. P. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.246 · Cited by 567 · see citing works
Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study
Doorduin, J., de Vries, E. F. J., Willemsen, A. T. M., de Groot, J. C., Dierckx, R., & Klein, H. C. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.066647 · Cited by 561 · see citing works
Quantitating the subtleties of microglial morphology with fractal analysis
Karperien, A., Ahammer, H., & Jelinek, H. F. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00003 · Cited by 517 · see citing works
The immune response in autism: a new frontier for autism research
Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528 · see citing works
NOX Enzymes in the Central Nervous System: From Signaling to Disease
Sorce, S., & Krause, K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2578 · Cited by 472 · see citing works
Bloomfield, P. S., Selvaraj, S., Veronese, M., Rizzo, G., Bertoldo, A., Owen, D. R., Bloomfield, M., Bonoldi, I., Kalk, N. J., Turkheimer, F., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101358 · Cited by 446 · see citing works
Cytokines and schizophrenia: microglia hypothesis of schizophrenia
Monji, A., Kato, T., & Kanba, S. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.01945.x · Cited by 508 · see citing works
Microglia morphophysiological diversity and its implications for the CNS
Vidal-Itriago, A., Radford, R. A. W., Aramideh, J. A., Maurel, C., Scherer, N. M., Don, E. K., Lee, A., Chung, R. S., Graeber, M. B., & Morsch, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.997786 · Cited by 412 · see citing works
Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness
Berk, M., Dean, O. M., Drexhage, H. A., McNeil, J. J., Moylan, S., O'Neil, A. E., Davey, C. G., Sanna, L., & Maes, M. H. J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-74 · Cited by 392 · see citing works
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369 · see citing works
Glial cell abnormalities in major psychiatric disorders: the evidence and implications
Cotter, D. R., Pariante, C. M., & Everall, I. P. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00527-5 · Cited by 465 · see citing works
Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review
Trépanier, M. O., Hopperton, K. E., Mizrahi, R., Mechawar, N., & Bazinet, R. P. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.90 · Cited by 360 · see citing works
Beumer, W., Gibney, S. M., Drexhage, R. C., Pont-Lezica, L., Doorduin, J., Klein, H. C., Steiner, J., Connor, T. J., Harkin, A., Versnel, M. A., et al. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212100 · Cited by 347 · see citing works
Bayer, T. A., Falkai, P., & Maier, W. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00039-4 · Cited by 346 · see citing works
The neuropathology of primary mood disorder
Harrison, P. J. (2002) · Brain · doi:10.1093/brain/awf149 · Cited by 321 · see citing works
Neuroinflammation and white matter pathology in schizophrenia: systematic review
Najjar, S., & Pearlman, D. M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.04.041 · Cited by 317 · see citing works
Neuroinflammation in schizophrenia especially focused on the role of microglia
Monji, A., Kato, T. A., Mizoguchi, Y., Horikawa, H., Seki, Y., Kasai, M., Yamauchi, Y., Yamada, S., & Kanba, S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.002 · Cited by 314 · see citing works
Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
Neniškytė, U., & Gross, C. T. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.110 · Cited by 309 · see citing works
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299 · see citing works
Borrell, J. I. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00360-8 · Cited by 307 · see citing works
Microglial Dysregulation in Psychiatric Disease
Frick, L. R., Williams, K., & Pittenger, C. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/608654 · Cited by 299 · see citing works
Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization
Howes, O. D., & McCutcheon, R. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.278 · Cited by 288 · see citing works
The Role of Immune System in Schizophrenia
Müller, N., & Schwarz, M. (2010) · Current Immunology Reviews · doi:10.2174/157339510791823673 · Cited by 297 · see citing works
Autoimmunity, Inflammation, and Psychosis: A Search for Peripheral Markers
Bergink, V., Gibney, S. M., & Drexhage, H. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.037 · Cited by 269 · see citing works
Meyer, U., Schwarz, M., & Müller, N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.003 · Cited by 255 · see citing works
Hellwig, S., Brioschi, S., Dieni, S., Frings, L., Masuch, A., Blank, T., & Biber, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.008 · Cited by 252 · see citing works
Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders
Zengeler, K. E., & Lukens, J. R. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00487-7 · Cited by 254 · see citing works
Kreisl, W. C., Jenko, K. J., Hines, C. S., Lyoo, C. H., Corona, W., Morse, C. L., Zoghbi, S. S., Hyde, T. M., Kleinman, J. E., Pike, V. W., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.131 · Cited by 251 · see citing works
Najjar, S., Pearlman, D. M., Devinsky, O., Najjar, A., & Zagzag, D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-142 · Cited by 248 · see citing works
Regulating Factors for Microglial Activation.
Nakamura, Y. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.945 · Cited by 241 · see citing works
Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
Steiner, J. H., Mawrin, C., Ziegeler, A., Bielau, H., Ullrich, O., Bernstein, H., & Bogerts, B. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0090-8 · Cited by 230 · see citing works
Mattei, D., Ivanov, A., Ferrai, C., Jordan, P., Guneykaya, D., Buonfiglioli, A., Schaafsma, W., Przanowski, P., Deuther-Conrad, W., Brust, P., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.80 · Cited by 222 · see citing works
Microglial activation and progressive brain changes in schizophrenia
Laskaris, L., Biase, M. A. D., Everall, I., Chana, G., Christopoulos, A., Skafidas, E. S., Cropley, V., & Pantelis, C. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13364 · Cited by 227 · see citing works
Strous, R. D., & Shoenfeld, Y. (2006) · Journal of Autoimmunity · doi:10.1016/j.jaut.2006.07.006 · Cited by 225 · see citing works
The neurobiology and treatment of first-episode schizophrenia
Kahn, R. S., & Sommer, I. E. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.66 · Cited by 219 · see citing works
Neuroinflammation in schizophrenia: meta-analysis of <i>in vivo</i> microglial imaging studies
Marques, T. R., Ashok, A. H., Pillinger, T., Veronese, M., Turkheimer, F. E., Dazzan, P., Sommer, I. E. C., & Howes, O. D. (2019) · Psychological Medicine · doi:10.1017/s0033291718003057 · Cited by 213 · see citing works
Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission
Müller, N., & Schwarz, M. (2006) · Neurotoxicity Research · doi:10.1007/bf03033242 · Cited by 214 · see citing works
Bauman, M. L. (2006) · Johns Hopkins University Press eBooks · doi:10.1353/book.3225 · Cited by 215 · see citing works
Antidepressant therapies inhibit inflammation and microglial M1-polarization
Kalkman, H. O., & Feuerbach, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.001 · Cited by 212 · see citing works
Webster, M. J., O’Grady, J., Kleinman, J. E., & Weickert, C. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.037 · Cited by 206 · see citing works
Comer, A. L., Carrier, M., Tremblay, M., & Cruz‐Martín, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00274 · Cited by 204 · see citing works
Microglia of Prefrontal White Matter in Suicide
Schnieder, T. P., Trencevska, I., Rosoklija, G., Stankov, A., Mann, J. J., Smiley, J., & Dwork, A. J. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000107 · Cited by 202 · see citing works
Nitta, M., Kishimoto, T., Müller, N., Weiser, M., Davidson, M., Kane, J. M., & Correll, C. U. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt070 · Cited by 204 · see citing works
Pillinger, T., Osimo, E. F., Brugger, S., Mondelli, V., McCutcheon, R. A., & Howes, O. D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sby160 · Cited by 190 · see citing works
Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy
Bernstein, H., Steiner, J. H., Guest, P. C., Dobrowolny, H., & Bogerts, B. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.035 · Cited by 203 · see citing works
Fineberg, A. M., & Ellman, L. M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.001 · Cited by 200 · see citing works
Rajkowska, G., Miguel-Hidalgo, J. J., Makkos, Z., Meltzer, H. Y., Overholser, J. C., & Stockmeier, C. A. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00339-0 · Cited by 196 · see citing works
The Epidemiologic Evidence Linking Autoimmune Diseases and Psychosis
Benros, M. E., Eaton, W. W., & Mortensen, P. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.023 · Cited by 196 · see citing works
Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy
Bernstein, H., Steiner, J. H., & Bogerts, B. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.59 · Cited by 189 · see citing works
Autoimmune diseases and infections as risk factors for schizophrenia
Benros, M. E., Mortensen, P. B., & Eaton, W. W. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06638.x · Cited by 190 · see citing works
Review of Immunological and Immunopathological Findings in Schizophrenia
Rothermundt, M., Arolt, V., & Bayer, T. A. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2001.0648 · Cited by 187 · see citing works
Dupont, A.-C., Largeau, B., Santiago Ribeiro, M., Guilloteau, D., Tronel, C., & Arlicot, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040785 · Cited by 182 · see citing works
Immune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives
Ermakov, E. A., Melamud, M. M., Buneva, V. N., & Ivanova, S. А. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.880568 · Cited by 184 · see citing works
Webster, M. J., Knable, M. B., Johnston-Wilson, N., Nagata, K., Inagaki, M., & Yolken, R. H. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2001.0646 · Cited by 179 · see citing works
Nawa, H., & Takei, N. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.002 · Cited by 174 · see citing works
Takao, K., Kobayashi, K., Hagihara, H., Ohira, K., Shoji, H., Hattori, S., Koshimizu, H., Umemori, J., Toyama, K., Nakamura, H. K., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.38 · Cited by 173 · see citing works
Maternal immune activation in neurodevelopmental disorders
Solek, C. M., Farooqi, N., Verly, M., Lim, T. K., & Ruthazer, E. S. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24612 · Cited by 168 · see citing works
Boerrigter, D., Weickert, T. W., Lenroot, R., O׳Donnell, M., Galletly, C. A., Liu, D., Burgess, M., Cadiz, R., Jacomb, I., Catts, V. S., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0962-y · Cited by 171 · see citing works
Kenk, M., Selvanathan, T., Rao, N. P., Suridjan, I., Rusjan, P., Remington, G. J., Meyer, J. H., Wilson, A. A., Houle, S., & Mizrahi, R. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu157 · Cited by 169 · see citing works
Microglial activation in a neuroinflammational animal model of schizophrenia – a pilot study
Juckel, G., Manitz, M. P., Brüne, M., Friebe, A., Heneka, M. T., & Wolf, R. J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.018 · Cited by 165 · see citing works
Steiner, J. H., Bogerts, B., Sarnyai, Z., Walter, M., Gos, T., Bernstein, H., & Myint, A.-M. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.583941 · Cited by 159 · see citing works
Neuroimmune biomarkers in schizophrenia
Tomasik, J., Rahmoune, H., Guest, P. C., & Bahn, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.025 · Cited by 158 · see citing works
Physical Exercise and Neuroinflammation in Major Depressive Disorder
Ignácio, Z. M., da Silva, R. S., Plissari, M. E., Quevedo, J., & Réus, G. Z. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01670-1 · Cited by 153 · see citing works
CXCL10 Triggers Early Microglial Activation in the Cuprizone Model
Clarner, T., Janssen, K., Nellessen, L., Stangel, M., Skripuletz, T., Krauspe, B., Hess, F.-M., Denecke, B., Beutner, C., Linnartz-Gerlach, B., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401459 · Cited by 150 · see citing works
Increased expression of astrocyte markers in schizophrenia: Association with neuroinflammation
Catts, V. S., Wong, J., Fillman, S. G., Fung, S. J., & Weickert, C. S. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414531078 · Cited by 148 · see citing works
Cytokines and the neurodevelopmental basis of mental illness
Ratnayake, U., Quinn, T., Walker, D. W., & Dickinson, H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00180 · Cited by 136 · see citing works
Microglia and Brain Plasticity in Acute Psychosis and Schizophrenia Illness Course: A Meta-Review
Picker, L. D., Morrens, M., Chance, S. A., & Boche, D. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00238 · Cited by 136 · see citing works
Estrogen Action in Neuroprotection and Brain Inflammation
Pozzi, S., Benedusi, V., Maggi, A. C., & Vegeto, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.035 · Cited by 136 · see citing works
The Cytokine Model of Schizophrenia: Emerging Therapeutic Strategies
Girgis, R. R., Kumar, S. S., & Brown, A. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.002 · Cited by 135 · see citing works
Alzheimer's disease; taking the edge off with cannabinoids?
Campbell, V. A., & Gowran, A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707446 · Cited by 132 · see citing works
HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis
Swaroop, S., Sengupta, N., Suryawanshi, A. R., Adlakha, Y. K., & Basu, A. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0486-x · Cited by 132 · see citing works
Jiang, Z., Rompala, G. R., Zhang, S., Cowell, R. M., & Nakazawa, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.004 · Cited by 128 · see citing works
Missault, S., Van den Eynde, K., Vanden Berghe, W., Fransen, E., Weeren, A., Timmermans, J. P., Kumar-Singh, S., & Dedeurwaerdere, S. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.06.013 · Cited by 128 · see citing works
Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
Bennett, M. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.003 · Cited by 126 · see citing works
Purves-Tyson, T. D., Weber‐Stadlbauer, U., Richetto, J., Rothmond, D. A., Labouesse, M. A., Polesel, M., Robinson, K., Weickert, C. S., & Meyer, U. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0434-0 · Cited by 125 · see citing works
Neuroinflammation in schizophrenia: the role of nuclear factor kappa B
Murphy, C. E., Walker, A. K., & Weickert, C. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01607-0 · Cited by 128 · see citing works
Ribeiro, B. M. M., do Carmo, M. R. S., Freire, R. S., Rocha, N. F. M., Borella, V., Menezes, A. T., Monte, A. S., Gomes, P. X. L., de Sousa, F. C. F., Vale, M. L., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.10.040 · Cited by 123 · see citing works
He, Y., Kosciolek, T., Tang, J., Zhou, Y., Li, Z., Ma, X., Zhu, Q., Yuan, N., Yuan, L., Li, C., et al. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.05.011 · Cited by 123 · see citing works
Kato, T. A., Mizoguchi, Y., Monji, A., Horikawa, H., Suzuki, S. O., Seki, Y., Iwaki, T., Hashioka, S., & Kanba, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05435.x · Cited by 122 · see citing works
Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder
Wu, S., Yin, Y., & Du, L. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01153-9 · Cited by 126 · see citing works
Cattane, N., Richetto, J., & Cattaneo, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.001 · Cited by 118 · see citing works
Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works
Searching for Neuropathology: Gliosis in Schizophrenia
Schnieder, T. P., & Dwork, A. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.027 · Cited by 107 · see citing works
The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view
Müller, N., & Schwarz, M. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_33 · Cited by 107 · see citing works
The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration
Gowran, A., Noonan, J., & Campbell, V. A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00195.x · Cited by 103 · see citing works
Tang, J., Yu, W., Chen, S., Gao, Z., & Xiao, B. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2504-0 · Cited by 101 · see citing works
Ahn, H. J., Glickman, J. F., Poon, K., Zamolodchikov, D., Jno-Charles, O. C., Norris, E. H., & Strickland, S. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131751 · Cited by 101 · see citing works
den Eynde, K. V., Missault, S., Fransén, E., Raeymaekers, L., Willems, R., Drinkenburg, W. H. I. M., Timmermans, J., Kumar‐Singh, S., & Dedeurwaerdere, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.005 · Cited by 99 · see citing works
Holmes, S. E., Hinz, R., Drake, R., Gregory, C. J., Conen, S., Matthews, J. C., Anton‐Rodriguez, J., Gerhard, A., & Talbot, P. S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.180 · Cited by 97 · see citing works
Impaired monocyte activation in schizophrenia
Müller, N., Wagner, J. K., Krause, D., Weidinger, E., Wildenauer, A., Obermeier, M., Dehning, S., Gruber, R., & Schwarz, M. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.049 · Cited by 97 · see citing works
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95 · see citing works
- Authors
- Bayer, T. A., Buslei, R., Havas, L., & Falkai, P.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Bayer, Thomas A
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 271
- Issue
- 2
- Pages
- 126-128
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2069782517
- Cited by
- 323
- References
- 19
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 11 · 2021: 20 · 2020: 13 · 2019: 13 · 2018: 26 · 2017: 22 · 2016: 18 · 2015: 22 · 2014: 26 · 2013: 27 · 2012: 18
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- microglial activation, HLA-DR, schizophrenia, mood disorders, bipolar disorder, Alzheimer's disease, postmortem brain, frontal cortex, hippocampus, neuroinflammation, brain immune response, neuropathology
- MeSH terms
- Aged, Mental Disorders, Female, HLA-DR Antigens, Humans, Immunohistochemistry, Macrophage Activation, Male, Middle Aged, Schizophrenia, Microglia, Mood Disorders
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