Allopregnanolone and neuroinflammation: a focus on multiple sclerosis

Immunology of multiple sclerosis

Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149 · see citing works

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724 · see citing works

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J.-J., Lindemann, P., Norenberg, M. D., Nutt, D., Weizman, A., Zhang, M.-R., et al. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.06.005 · Cited by 1,389 · see citing works

Neuroactive steroids

Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,328 · see citing works

Neurosteroids: endogenous regulators of the GABAA receptor

Belelli, D., & Lambert, J. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1703 · Cited by 1,159 · see citing works

New concepts in the immunopathogenesis of multiple sclerosis

Hemmer, B., Archelos, J., & Hartung, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn784 · Cited by 605 · see citing works

Neurosteroids: biochemistry and clinical significance

Mellon, S. H., & Griffin, L. D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00503-3 · Cited by 538 · see citing works

Inhibitory role for GABA in autoimmune inflammation

Bhat, R., Axtell, R., Mitra, A., Miranda, M., Lock, C., Tsien, R. W., & Steinman, L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915139107 · Cited by 509 · see citing works

Will the real multiple sclerosis please stand up?

Stys, P. K., Zamponi, G. W., van Minnen, J., & Geurts, J. J. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3275 · Cited by 475 · see citing works

Cholesterol transport in steroid biosynthesis: Role of protein–protein interactions and implications in disease states

Rone, M. B., Fan, J., & Papadopoulos, V. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.03.001 · Cited by 399 · see citing works

Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

Griffin, L. D., Gong, W., Verot, L., & Mellon, S. H. (2004) · Nature Medicine · doi:10.1038/nm1073 · Cited by 395 · see citing works

The Neurosteroids Progesterone and Allopregnanolone Reduce Cell Death, Gliosis, and Functional Deficits after Traumatic Brain Injury in Rats

Djebaı̈li, M., Guo, Q., Pettus, E. H., Hoffman, S. W., & Stein, D. G. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.106 · Cited by 387 · see citing works

Neuroactive steroids.

Paul, S. M., & Purdy, R. H. (1992) · PubMed · Cited by 384 · see citing works

The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: From pathology to imaging

Venneti, S., Lopresti, B. J., & Wiley, C. A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.10.002 · Cited by 373 · see citing works

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

Lavisse, S., Guillermier, M., Hérard, A., Petit, F., Delahaye, M., Camp, N. V., Haim, L. B., Lebon, V., Rémy, P., Dollé, F., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1487-12.2012 · Cited by 362 · see citing works

Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury

HE, J., EVANS, C., Hoffman, S. D., Oyesiku, N. M., & Stein, D. G. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.008 · Cited by 332 · see citing works

Astrocytes are GABAergic cells that modulate microglial activity

Lee, M., Schwab, C., & McGeer, P. L. (2010) · Glia · doi:10.1002/glia.21087 · Cited by 321 · see citing works

Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum

Ghoumari, A. M., Ibanez, C., El‐Etr, M., Leclerc, P., Eychenne, B., O’Malley, B. W., Baulieu, E. E., & Schumacher, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01881.x · Cited by 291 · see citing works

The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple Sclerosis

Moscarello, M. A., Mastronardi, F. G., & Wood, D. D. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9144-5 · Cited by 264 · see citing works

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

Wang, J. M., Singh, C., Liu, L., Irwin, R. W., Chen, S., Chung, E. J., Thompson, R. F., & Brinton, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001422107 · Cited by 263 · see citing works

The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein Expression

Wang, J. M., Johnston, P. B., Ball, B. G., & Brinton, R. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4520-04.2005 · Cited by 261 · see citing works

Impaired neurosteroid synthesis in multiple sclerosis

Noorbakhsh, F., Ellestad, K. K., Maingat, F. G., Warren, K. G., Han, M. H., Steinman, L., Baker, G. B., & Power, C. (2011) · Brain · doi:10.1093/brain/awr200 · Cited by 230 · see citing works

Steroid Hormone Regulation of Cytokine Secretion by Proteolipid Protein-Specific CD4+ T Cell Clones Isolated from Multiple Sclerosis Patients and Normal Control Subjects

Correale, J. D., Arias, M., & Gilmore, W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3365 · Cited by 229 · see citing works

Microglia and multiple sclerosis

Jack, C., Ruffini, F., Bar-Or, A., & Antel, J. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20482 · Cited by 205 · see citing works

Neurosteroids as modulators of neurogenesis and neuronal survival

Charalampopoulos, I., Remboutsika, E., Margioris, A. N., & Gravanis, A. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.07.004 · Cited by 201 · see citing works

The innate immune system in demyelinating disease

Mayo, L., Quintana, F. J., & Weiner, H. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01135.x · Cited by 184 · see citing works

Allopregnanolone, a Progesterone Metabolite, Is More Effective Than Progesterone in Reducing Cortical Infarct Volume After Transient Middle Cerebral Artery Occlusion

Sayeed, I., Guo, Q., Hoffman, S. W., & Stein, D. G. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2005.12.011 · Cited by 175 · see citing works

GABAA receptors mediate inhibition of T cell responses

Tian, J., Chau, C. H., Hales, T. G., & Kaufman, D. L. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00264-1 · Cited by 165 · see citing works

Neurosteroids as regenerative agents in the brain: therapeutic implications

Brinton, R. D. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.31 · Cited by 164 · see citing works

Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures

Ghoumari, A. M., Baulieu, E. E., & Schumacher, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.023 · Cited by 161 · see citing works

Progesterone and allopregnanolone attenuate blood–brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases

Ishrat, T., Sayeed, I., Atif, F., Hua, F., & Stein, D. G. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.08.023 · Cited by 159 · see citing works

A TSPO ligand is protective in a mouse model of multiple sclerosis

Daugherty, D. J., Selvaraj, V., Chechneva, O. V., Liu, X., Pleasure, D., & Deng, W. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202124 · Cited by 158 · see citing works

Oligodendrocytes and the early multiple sclerosis lesion

Prineas, J. W., & Parratt, J. D. E. (2012) · Annals of Neurology · doi:10.1002/ana.23634 · Cited by 149 · see citing works

Ganaxolone

Nohria, V., & Giller, E. L. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2006.11.003 · Cited by 145 · see citing works

Effects of progesterone in the spinal cord of a mouse model of multiple sclerosis

Garay, L. I., Deniselle, M. C. G., Lima, A. E., Roig, P., & Nicola, A. F. D. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.040 · Cited by 140 · see citing works

Pharmacokinetic and behavioral effects of allopregnanolone in healthy women

Timby, E., Balgård, M., Nyberg, S., Spigset, O., Andersson, A., Porankiewicz, J., Purdy, R. H., Zhu, D., Bäckström, T. C., & Poromaa, I. S. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0148-7 · Cited by 134 · see citing works

Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice

Singh, C., Liu, L., Wang, J. M., Irwin, R. W., Yao, J., Chen, S., Henry, S., Thompson, R. F., & Brinton, R. D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.008 · Cited by 129 · see citing works

GABA (A) receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6/IL-12 production

Reyes-García, M. G., Hernández, F. H., Hernández‐Téllez, B., & García-Tamayo, F. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.05.013 · Cited by 121 · see citing works

Neurosteroids as Endogenous Inhibitors of Neuronal Cell Apoptosis in Aging

Charalampopoulos, I., Alexaki, V. I., Tsatsanis, C., MINAS, V., Dermitzaki, E., Lazaridis, I., Vardouli, L., Stournaras, C., Margioris, A. N., Castanas, E., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.003 · Cited by 113 · see citing works

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18 kDa Translocator Protein Radioligand [18F]DPA-714

Abourbeh, G., Thezé, B., Maroy, R., Dubois, A., Brulon, V., Fontyn, Y., Dollé, F., Tavitian, B., & Boisgard, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2900-11.2012 · Cited by 112 · see citing works

Impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis

Kipp, M., & Beyer, C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.004 · Cited by 108 · see citing works

Clinical Evaluation of Ganaxolone in Pediatric and Adolescent Patients with Refractory Epilepsy

Pieribone, V. A., Tsai, J., Soufflet, C., Rey, E., Shaw, K., Giller, E. L., & Dulac, O. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01182.x · Cited by 107 · see citing works

Allopregnanolone as regenerative therapeutic for Alzheimer's disease: Translational development and clinical promise

Irwin, R. W., & Brinton, R. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.004 · Cited by 106 · see citing works

Neurosteroids reduce inflammation after TBI through CD55 induction

VanLandingham, J. W., Cekic, M. M., Cutler, S. M., Hoffman, S. W., & Stein, D. G. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.08.045 · Cited by 106 · see citing works

Different Subtypes of GABA-A Receptors Are Expressed in Human, Mouse and Rat T Lymphocytes

Mendu, S. K., Bhandage, A. K., Jin, Z., & Birnir, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042959 · Cited by 105 · see citing works

Alzheimer?s disease: the impact of age-related changes in reproductive hormones

Simpkins, J. W., Yang, S., Wen, Y., & Singh, M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4382-2 · Cited by 96 · see citing works

Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial–neuronal interactions

Mead, E., Mosley, A. J., Eaton, S. D., Dobson, L., Heales, S., & Pocock, J. M. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07659.x · Cited by 86 · see citing works

Steroid hormones in multiple sclerosis

El‐Etr, M., Vukusic, S., Gignoux, L., Durand‐Dubief, F., Achiti, I., Baulieu, E. E., & Confavreux, C. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.004 · Cited by 79 · see citing works

Axonal Regeneration and Neuroinflammation: Roles for the Translocator Protein 18 kDa

Girard, C., Liu, S., Adams, D., Lacroix, C., Sinéus, M., Boucher, C., Papadopoulos, V., Rupprecht, R., Schumacher, M., & Groyer, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02215.x · Cited by 75 · see citing works

The 18 kDa Translocator Protein (TSPO): A New Perspective in Mitochondrial Biology

Gatliff, J., & Campanella, M. (2012) · Current Molecular Medicine · doi:10.2174/1566524011207040356 · Cited by 74 · see citing works

Translocator Protein (18 kDa) as a Target for Novel Anxiolytics with a Favourable Side‐Effect Profile

Nothdurfter, C., Rammes, G., Baghai, T. C., Schüle, C., Schumacher, M., Papadopoulos, V., & Rupprecht, R. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02166.x · Cited by 71 · see citing works

TSPO-specific ligand Vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation

Zhao, Y., Yu, J., Li, Q., Ma, C., Lü, C., & Xiao, B. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x12000129 · Cited by 65 · see citing works

Effect of Oral Contraceptives on Experimental Demyelinating Disease

Arnason, B. G. W., & Richman, D. P. (1969) · Archives of Neurology · doi:10.1001/archneur.1969.00480130117012 · Cited by 65 · see citing works

GABA transport and neuroinflammation are coupled in multiple sclerosis: Regulation of the GABA transporter-2 by ganaxolone

Paul, A. M., Branton, W. G., Walsh, J. G., Polyak, M. J., Lu, J., Baker, G. B., & Power, C. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.037 · Cited by 54 · see citing works

Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease

Adeosun, S. O., Hou, X., Jiao, Y., Zheng, B., Henry, S., Hill, R., He, Z., Pani, A. K., Kyle, P. B., Ou, X., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050040 · Cited by 54 · see citing works

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

Leaver, K. R., Reynolds, A. J., Bodard, S., Guilloteau, D., Chalon, S., & Kassiou, M. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn200099e · Cited by 48 · see citing works

Neurosteroids, with special reference to the effect of progesterone on myelination in peripheral nerves

Baulieu, E.-E., & Schumacher, M. (1997) · Multiple Sclerosis Journal · doi:10.1177/135245859700300209 · Cited by 43 · see citing works

RON‐regulated innate immunity is protective in an animal model of multiple sclerosis

Tsutsui, S., Noorbakhsh, F., Sullivan, A., Henderson, A. J., Warren, K. G., Toney‐Earley, K., Waltz, S. E., & Power, C. (2005) · Annals of Neurology · doi:10.1002/ana.20502 · Cited by 39 · see citing works

Effects of allopregnanolone on sedation in men, and in women on oral contraceptives

van Broekhoven, F., Bäckström, T. C., van Luijtelaar, G., Buitelaar, J. K., Smits, P., & Verkes, R. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.009 · Cited by 37 · see citing works

GABAA Receptors: Autoradiographic Localization of Different Ligand Sites and Identification of Subtypes of the Benzodiazepine Binding Site

Sur, C., & Atack, J. R. (2003) · Humana Press eBooks · doi:10.1385/1-59259-118-3:39 · Cited by 36 · see citing works

Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia

Moralı́, G., Montes, P., Hernández-Morales, L., Monfil, T., Espinosa‐García, C., & Cervantes, M. (2011) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2011-0571 · Cited by 35 · see citing works

Progesterone and its metabolites 5-dihydroprogesterone and 5-3-tetrahydroprogesterone decrease LPS-induced NO release in the murine microglial cell line, BV-2.

Müller, E., & Kerschbaum, H. (2006) · PubMed · Cited by 35 · see citing works

Hormonal Influences in Multiple Sclerosis

Shuster, E. A. (2007) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-73677-6_11 · Cited by 29 · see citing works

Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice

Singh, S., Hota, D., Prakash, A., KHANDUJA, K. L., Arora, S. K., & Chakrabarti, A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.10.003 · Cited by 28 · see citing works

Neurosteroid levels are increased in vivo after LPS treatment and negatively regulate LPS-induced TNF production.

Ghezzi, P., Santo, E. D., Sacco, S., Foddi, C., Barbaccia, M. L., & Mennini, T. (2000) · PubMed · Cited by 27 · see citing works

Anticonvulsant action of allopregnanolone in immature rats

Mareš, P., Mikulecká, A., Haugvicová, R., & Kasal, A. (2006) · Epilepsy Research · doi:10.1016/j.eplepsyres.2006.03.009 · Cited by 23 · see citing works

Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies

Diehlmann, A., Ida, N., Weggen, S., Grünberg, J., Haass, C., Masters, C. L., Bayer, T. A., & Beyreuther, K. T. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990515)56:4 · Cited by 21 · see citing works

Niemann-Pick; Type C

Patterson, M. C., & Pentchev, P. G. (1996) · Neurology · doi:10.1212/wnl.46.6.1785-b · Cited by 20 · see citing works

Anticonvulsant Action of a New Analogue of Allopregnanolone in Immature Rats

Mareš, P., Kubová, H., & Kasal, A. (2010) · Physiological Research · doi:10.33549/physiolres.931754 · Cited by 19 · see citing works

Effects of neurosteroids on neuronal survival: Molecular basis and clinical perspectives

Leśkiewicz, M., Budziszewska, B., Basta‐Kaim, A., Zając, A., Kaciński, M., & Lason, A. (2006) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2006-1624 · Cited by 17 · see citing works

Effects of estrogen, progestin and combined estrogen-progestin oral contraceptive preparations on experimental allergic encephalomyelitis.

Arnason, B. G. W., & Richman, D. P. (1969) · PubMed · Cited by 16 · see citing works

GABAA Receptor

Olsen, R. W., & Li, G.-D. (2013) · Encyclopedia of Biological Chemistry · doi:10.1016/b978-0-12-378630-2.00339-x · Cited by 11 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Zorumski, C. F., Paul, S. M., Covey, D. F., & Mennerick, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100196 · Cited by 305 · see citing works

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

Zárate, S., Stevnsner, T., & Gredilla, R. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00430 · Cited by 286 · see citing works

Impact of sex hormones on immune function and multiple sclerosis development

Ysrraelit, M. C., & Correale, J. D. (2018) · Immunology · doi:10.1111/imm.13004 · Cited by 253 · see citing works

Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials

Stein, D. G. (2015) · Brain Injury · doi:10.3109/02699052.2015.1065344 · Cited by 249 · see citing works

Neurosteroids as regulators of neuroinflammation

Yılmaz, C., Karali, K., Fodelianaki, G., Gravanis, A., Chavakis, T., Charalampopoulos, I., & Alexaki, V. I. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100788 · Cited by 245 · see citing works

Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant

Guennoun, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155271 · Cited by 167 · see citing works

Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions

Crowley, T., Cryan, J. F., Downer, E. J., & O’Leary, O. F. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.001 · Cited by 150 · see citing works

Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain

Balan, I. S., Beattie, M. C., O’Buckley, T. K., Aurelian, L., & Morrow, A. L. (2019) · Scientific Reports · doi:10.1038/s41598-018-37409-6 · Cited by 118 · see citing works

Allopregnanolone: An overview on its synthesis and effects

Diviccaro, S., Cioffi, L., Falvo, E., Giatti, S., & Melcangi, R. C. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12996 · Cited by 110 · see citing works

Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways

Cano, A. C., Fonseca, E., Ettcheto, M., Sánchez‐López, E., de Rojas, I., Alonso-Lana, S., Morató, X., Souto, E. B., Toledo, M., Boada, M., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14101057 · Cited by 83 · see citing works

Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders

Irwin, R. W., Solinsky, C. M., & Brinton, R. D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00203 · Cited by 72 · see citing works

Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease

Boero, G., Porcu, P., & Morrow, A. L. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100203 · Cited by 62 · see citing works

Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease

Deems, N. P., & Leuner, B. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100820 · Cited by 63 · see citing works

Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis

Ramien, C., Taenzer, A., Lupu, A., Heckmann, N., Engler, J. B., Patas, K., Friese, M. A., & Gold, S. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.12.015 · Cited by 59 · see citing works

Hormonal Regulation of Oligodendrogenesis II: Implications for Myelin Repair

Breton, J., Long, K. L. P., Barraza, M., Perloff, O. S., & Kaufer, D. (2021) · Biomolecules · doi:10.3390/biom11020290 · Cited by 56 · see citing works

A Rationale for Allopregnanolone Treatment of Alcohol Use Disorders: Basic and Clinical Studies

Morrow, A. L., Boero, G., & Porcu, P. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14253 · Cited by 51 · see citing works

Nongenomic actions of neurosteroid pregnenolone and its metabolites

Weng, J., & Chung, B. (2016) · Steroids · doi:10.1016/j.steroids.2016.01.017 · Cited by 48 · see citing works

Analytical challenges for measuring steroid responses to stress, neurodegeneration and injury in the central nervous system

Schumacher, M., Guennoun, R., Mattern, C., Oudinet, J., Labombarda, F., Nicola, A. F. D., & Lière, P. (2015) · Steroids · doi:10.1016/j.steroids.2015.08.013 · Cited by 45 · see citing works

Role of Peripheral Immune Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Dhaiban, S., Al‐Ani, M., Elemam, N. M., Al-Aawad, M. H., Al-Rawi, Z., & Maghazachi, A. A. (2021) · Sci · doi:10.3390/sci3010012 · Cited by 40 · see citing works

Steroid Sulfation in Neurodegenerative Diseases

Vítků, J., Hill, M., Kolátorová, L., Havrdová, E., & Kancheva, R. L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.839887 · Cited by 40 · see citing works

Current status and future perspectives: TSPO in steroid neuroendocrinology

Selvaraj, V., & Tu, L. N. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0241 · Cited by 38 · see citing works

Enhanced remyelination during late pregnancy: involvement of the GABAergic system

Kalakh, S., & Mouihate, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-44050-4 · Cited by 38 · see citing works

Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study

Rustichelli, C., Bellei, E., Bergamini, S., Monari, E., Baraldi, C., Castro, F. L., Tomasi, A., & Ferrari, A. (2020) · Cephalalgia · doi:10.1177/0333102420937742 · Cited by 38 · see citing works

Sex steroid hormones as neuroprotective elements in ischemia models

Rubio, A. E. C., Pérez-Álvarez, M. J., Chala, C. L., & Wandosell, F. G. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0129 · Cited by 37 · see citing works

BV-2 Microglial Cells Respond to Rotenone Toxic Insult by Modifying Pregnenolone, 5α-Dihydroprogesterone and Pregnanolone Levels

Avallone, R., Lucchi, C., Puja, G., Codeluppi, A., Filaferro, M., Vitale, G., Rustichelli, C., & Biagini, G. (2020) · Cells · doi:10.3390/cells9092091 · Cited by 36 · see citing works

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

Balan, I. S., Boero, G., Chéry, S. L., McFarland, M. H., Lopez, A. G., & Morrow, A. L. (2024) · Life · doi:10.3390/life14050582 · Cited by 33 · see citing works

PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression

Matrisciano, F., & Pinna, G. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100222 · Cited by 35 · see citing works

Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones

Wu, Y., Hang, Z., Tong, L., & Du, H. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03784-w · Cited by 34 · see citing works

The Hypothalamic-Pituitary-Ovarian Axis, Ovarian Disorders, and Brain Aging

Valera, H., Chen, A., & Grive, K. J. (2025) · Endocrinology · doi:10.1210/endocr/bqaf137 · Cited by 32 · see citing works

Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements

Balan, I. S., Aurelian, L., Williams, K. S., Campbell, B., Meeker, R. B., & Morrow, A. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940095 · Cited by 32 · see citing works

Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites

Giatti, S., Diviccaro, S., Falvo, E., García‐Segura, L. M., & Melcangi, R. C. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100836 · Cited by 32 · see citing works

Emerging Evidence for Endogenous Neurosteroid Modulation of Pro-Inflammatory and Anti-Inflammatory Pathways that Impact Neuropsychiatric Disease.

Morrow, A., Boero, G., & Balan, I. (2024) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105558 · Cited by 25 · see citing works

New directions in neurosteroid therapeutics in neuropsychiatry

Zorumski, C. F., Covey, D. F., Izumi, Y., Evers, A. S., Maguire, J. L., & Mennerick, S. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106119 · Cited by 27 · see citing works

Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans

Naylor, J. C., Kilts, J. D., Shampine, L. J., Parke, G. J., Wagner, H. R., Szabo, S. T., Smith, K. D., Allen, T. B., Telford-Marx, E. G., Dunn, C. E., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.0287 · Cited by 26 · see citing works

Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice

Parks, E. E., Logan, S., Yeganeh, A., Farley, J. A., Owen, D. B., & Sonntag, W. E. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000479 · Cited by 26 · see citing works

Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3α,5α)3‐hydroxypregnan‐20‐one (3α,5α‐THP) in the amygdala of the cynomolgus monkey

Beattie, M. C., Maldonado‐Devincci, A. M., Porcu, P., O’Buckley, T. K., Daunais, J. B., Grant, K. A., & Morrow, A. L. (2015) · Addiction Biology · doi:10.1111/adb.12326 · Cited by 25 · see citing works

Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus

Romano, S., Mitro, N., Diviccaro, S., Spezzano, R., Audano, M., García‐Segura, L. M., Caruso, D., & Melcangi, R. C. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.11.019 · Cited by 25 · see citing works

There is increasing evidence to suggest that brain inflammation could play a key role in the aetiology of psychiatric illness. Could inflammation be a cause of the premenstrual syndromes PMS and PMDD?

Bannister, E. (2019) · Post Reproductive Health · doi:10.1177/2053369119875386 · Cited by 24 · see citing works

Association of serum allopregnanolone with restricted and repetitive behaviors in adult males with autism

Chew, L., Sun, K., Sun, W., Wang, Z., Rajadas, J., Flores, R. E., Arnold, E., Jo, B., & Fung, L. K. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105039 · Cited by 22 · see citing works

The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies

Rayatpour, A., Farhangi, S., Verdaguer, E., Olloquequi, J., Ureña, J. M., Auladell, C., & Javan, M. (2021) · Pharmaceuticals · doi:10.3390/ph14101031 · Cited by 19 · see citing works

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis

Collongues, N., Becker, G., Jolivel, V., Ayme-Dietrich, E., de Séze, J., Binamé, F., Patte-Mensah, C., Monassier, L., & Mensah-Nyagan, A. (2022) · Neurological Therapeutics · doi:10.1007/s40120-022-00363-7 · Cited by 16 · see citing works

Therapeutic effects of D-aspartate in a mouse model of multiple sclerosis

Afraei, S., D’Aniello, A., Sedaghat, R., Ekhtiari, P., Azizi, G., Tabrizian, N., Magliozzi, L., Aghazadeh, Z., & Mirshafiey, A. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.10.025 · Cited by 20 · see citing works

Assessment of neuroactive steroids in cerebrospinal fluid comparing acute relapse and stable disease in relapsing-remitting multiple sclerosis

Orefice, N. S., Carotenuto, A., Mangone, G., Bues, B., Rehm, R., Cerillo, I., Saccà, F., Calignano, A., & Orefice, G. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.02.012 · Cited by 18 · see citing works

Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress

Lucchi, C., Codeluppi, A., Filaferro, M., Vitale, G., Rustichelli, C., Avallone, R., Mandrioli, J., & Biagini, G. (2023) · Antioxidants · doi:10.3390/antiox12040963 · Cited by 17 · see citing works

Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics

Naylor, J. C., Kilts, J. D., Szabo, S. T., Dunn, C. E., Keefe, F. J., Tupler, L. A., Shampine, L. J., Morey, R. A., Strauss, J. L., Hamer, R. M., et al. (2015) · Pain Medicine · doi:10.1111/pme.12860 · Cited by 17 · see citing works

Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis

Tremolanti, C., Cavallini, C., Meyer, L., Klein, C., Pozzo, E. D., Costa, B., Germelli, L., Taliani, S., Patte‐Mensah, C., & Mensah‐Nyagan, A. G. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02737-2 · Cited by 16 · see citing works

The Impact of Gonadal Hormones on the Expression of Human Neurological Disorders

Schipper, H. M. (2015) · Neuroendocrinology · doi:10.1159/000440620 · Cited by 16 · see citing works

Therapeutic potential of enzymes, neurosteroids, and synthetic steroids in neurodegenerative disorders: A critical review

Servi, R., Akkoç, R. F., Aksu, F., & Servi, S. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106766 · Cited by 16 · see citing works

Targeting the Immune System With Pharmacotherapy in Schizophrenia

Melbourne, J. K., Feiner, B., Rosen, C., & Sharma, R. P. (2017) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-017-0114-0 · Cited by 14 · see citing works

Allopregnanolone suppresses glioblastoma survival through decreasing DPYSL3 and S100A11 expression

Feng, Y., Lim, S.-W., Lin, H., Wang, S., Hsu, S., Kao, T., Ko, C., & Hsu, T. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106067 · Cited by 13 · see citing works

Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning

Izumi, Y., O’Dell, K. A., Cashikar, A. G., Paul, S. M., Covey, D. F., Mennerick, S. J., & Zorumski, C. F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304481 · Cited by 12 · see citing works

Increased Serum Levels of C21 Steroids in Female Patients With Multiple Sclerosis

Kančeva, R., Stárka, L., Kancheva, L., Hill, M., Velíková, M., & Havrdová, E. (2015) · Physiological Research · doi:10.33549/physiolres.933145 · Cited by 11 · see citing works

Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex

Cadeddu, R., Mosher, L. J., Nordkild, P., Gaikwad, N. W., Ratto, G. M., Scheggi, S., & Bortolato, M. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100489 · Cited by 10 · see citing works

Allopregnanolone pleiotropic action in neurons and astrocytes: calcium signaling as a unifying mechanism

Wang, T., Chen, S., Mao, Z., Shang, Y., & Brinton, R. D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1286931 · Cited by 8 · see citing works

Altered Steroidome in Women with Multiple Sclerosis

Kancheva, R. L., Hill, M., Velíková, M., Kancheva, L. S., Včelák, J., Ampapa, R., Židó, M., Štětkářová, I., Libertínová, J., Vosátková, M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212033 · Cited by 8 · see citing works

Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage

Colciago, A., & Magnaghi, V. (2016) · Neural Plasticity · doi:10.1155/2016/5985021 · Cited by 8 · see citing works

Effect of voluntary wheel running on neuroactive steroid levels in murine experimental autoimmune encephalomyelitis

Mifflin, K. A., Baker, G. B., & Kerr, B. J. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.08.040 · Cited by 8 · see citing works

The protective role of interaction between vitamin D, sex hormones and calcium in multiple sclerosis

Haghmorad, D., Soltanmohammadi, A., Tavaf, M. J., Zargarani, S., Yazdanpanah, E., Shadab, A., & Yousefi, B. (2022) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2147431 · Cited by 9 · see citing works

Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination

Mancino, D. N., Leicaj, M. L., Lima, A. E., Roig, P., Guennoun, R., Schumacher, M., Nicola, A. F. D., & Garay, L. I. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105820 · Cited by 7 · see citing works

Peripartum allopregnanolone blood concentrations and depressive symptoms: a systematic review and individual participant data meta-analysis

Schoretsanitis, G., Osborne, L. M., Poromaa, I. S., Wenzel, E., Payne, J. L., Barbui, C., Gastaldon, C., & Deligiannidis, K. M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02747-7 · Cited by 8 · see citing works

Disability progression in multiple sclerosis is associated with plasma neuroactive steroid profile

Cheng, C. C., Gómez, D., McCombe, J. A., Smyth, P. S., Giuliani, F., Blevins, G., Baker, G. B., & Power, C. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05203-4 · Cited by 7 · see citing works

Behavioral, Electrophysiological, and Histological Characterization of a New Rat Model for Neoadjuvant Chemotherapy–Induced Neuropathic Pain: Therapeutic Potential of Duloxetine and Allopregnanolone Concomitant Treatment

Matta, C., Meyer, L., Mensah‐Nyagan, A. G., & Taleb, O. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00176-2 · Cited by 7 · see citing works

Neurosteroids and neurological disorders

Park, G., Kim, H., Won, S., Kim, N. H., & Choi, S. (2025) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.24.353 · Cited by 6 · see citing works

Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis

Milosevic, A., Lavrnja, I. C., Savić, D. Z., Milosevic, K., Škuljec, J., Bjelobaba, I. M., & Janjic, M. M. (2023) · Cells · doi:10.3390/cells12071045 · Cited by 6 · see citing works

The Dipeptidyl Peptidase-4 Inhibitor Saxagliptin as a Candidate Treatment for Disorders of Consciousness: A Deep Learning and Retrospective Clinical Analysis

Toker, D., Chiang, J. N., Vespa, P. M., Caroline Schnakers, A., & Monti, M. M. (2025) · Neurocritical Care · doi:10.1007/s12028-025-02217-0 · Cited by 5 · see citing works

Effects of GABAergic Agents on Multiple Sclerosis. A Narrative Review of In-vivo Models

Stamoula, Ε., Ainatzoglou, A., Dardalas, I., Vavilis, T., Stamatellos, V., Siafis, S., Psathas, T., Boskou, I., & Papazisis, G. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666221003091444 · Cited by 5 · see citing works

Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids

Akkerman, V., Reinholdt, P., Schnoor-Madsen, R., Lauritsen, L., Bader, J., Qian, M., Xu, Y., Akk, G., Scheidt, H. A., Müller, P., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00571 · Cited by 4 · see citing works

The Effects of D-aspartate on Neurosteroids, Neurosteroid Receptors, and Inflammatory Mediators in Experimental Autoimmune Encephalomyelitis

Goudarzvand, M., Panahi, Y., Yazdani, R., Miladi, H., Tahmasebi, S., Sherafat, A., Afraei, S., Abouhamzeh, K., Jamee, M., Al‐Hussieni, K. J. M. R., et al. (2018) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530318666181005093459 · Cited by 4 · see citing works

Sex Differences in Immunity and Inflammation: Implications for Brain and Behavior

Neigh, G. N., Nemeth, C. L., & Rowson, S. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00001-9 · Cited by 4 · see citing works

Investigation of THDOC effects on pathophysiological signs of Alzheimer’s disease as an endogenous neurosteroid: inhibition of acetylcholinesterase and plaque deposition

Saleh, H., & Sadeghi, L. (2019) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2019_024 · Cited by 4 · see citing works

Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome

Amin, S. N., Abdalgeleel, S. A., Al‐Gahtany, M., Shaltout, S. A., Gazzar, W. B. E., & Elberry, D. A. (2021) · Brain Sciences · doi:10.3390/brainsci11050644 · Cited by 3 · see citing works

Multiple sclerosis lesions exhibit sex-specific steroid changes

Luchetti, S., Mason, M. R. J., Lière, P., Pianos, A., Cossu, S., Hofstee, M. I., Sluiter, A. A., Adelia, van Scheppingen, J., Aronica, E., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107040 · Cited by 2 · see citing works

Synthesis of a New Bioconjugate Steroid Pyridinium Salt Derived from Allopregnanolone Acetate

Rodríguez‐Matsui, H., Sánchez-Juárez, J. L., Tellez, V. C., Terán, J. L., Sandoval-Ramı́rez, J., & Carrasco‐Carballo, A. (2025) · Molbank · doi:10.3390/m2050 · Cited by 2 · see citing works

Anti-Inflammatory and Antioxidant Strategies in Epilepsy: From Molecular Mechanisms to Threshold Management

Трофимов, А. Н., Shcherbakova, K., Schwarz, A. P., Akbay, B., Karapina, O., Myrkhiyeva, Z., Shirokov, E., Kizatov, B., Zhukanov, K., Baktursyn, A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156606 · Cited by 3 · see citing works

Sex steroids, neurosteroidogenesis, and inflammation in multiple sclerosis and related animal models

Garay, L. I., Meyer, M., Guennoun, R., Schumacher, M., Deniselle, M. C. G., & Nicola, A. F. D. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.100286 · Cited by 2 · see citing works

Biological Mechanisms in Pregnant Women With Anxiety (Happy Mother-Healthy Baby Supplement Study): Protocol for a Longitudinal Mixed Methods Observational Study

Sherer, M. L., Malik, A., Osborne, L. M., Rowther, A. A., Zaidi, A., Atif, N., Rahman, A., Kahloon, L. E., Salman, M., Yenokyan, G., et al. (2022) · JMIR Research Protocols · doi:10.2196/43193 · Cited by 2 · see citing works

Combined Use of Intranasal Methylprednisolone and Allopregnanolone: Revisiting Anti-inflammatory and Remyelinating Treatment in a Murine Model of Multiple Sclerosis

Pérez‐Osorio, I. N., Espinosa, A., Álvarez-Gutiérrez, C., González-Flores, R., Besedovsky, H. O., Fragoso, G., Torres-Ramos, M., & Sciutto, E. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2912420 · Cited by 1 · see citing works

Effect of Treatment on Steroidome in Women with Multiple Sclerosis

Hill, M., Kancheva, R. L., Velíková, M., Kancheva, L., Včelák, J., Ampapa, R., Židó, M., Štětkářová, I., Libertínová, J., Vosátková, M., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051835 · Cited by 1 · see citing works

Neuroactive Steroids and Related Steroids in Autism Spectrum Disorders

Zheng, H. F., Wang, W. Q., Li, X. M., Rauw, G. A., MellAAdo, J. M. L., & Baker, G. B. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000368 · Cited by 1 · see citing works

The Impact of the 5α-Reductase Inhibitors (5α-RIs) on Male Sexual Function and Psychological Well-Being

Traish, A. M. (2015) · Current Sexual Health Reports · doi:10.1007/s11930-015-0061-y · Cited by 1 · see citing works

Editorial on “New perspectives in neurosteroids action: a special player allopregnanolone”

Magnaghi, V., & Puia, G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00133 · Cited by 1 · see citing works

Neurosteroids and the Nervous System: From Physiology to Pathology

Talebi, F., & Noorbakhsh, F. (2015) · The Neuroscience Journal of Shefaye Khatam · doi:10.18869/acadpub.shefa.3.3.87

Neuroactive Steroids and Neuroinflammation

Giatti, S., & Melcangi, R. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801914-6.00014-3

Sex-Related Factors in Multiple Sclerosis

Gold, S. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801914-6.00007-6

Nicotinic Signalling and Neurosteroid Modulation in Principal Neurons of the Hippocampal Formation and Prefrontal Cortex

Chung, B. Y. T. (2018) · The Atrium (University of Guelph)

Sex Hormones as Risk Factors for Dementia

Mante, P. K., & Adomako, N. O. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_4

5 -Alpha-dihydroxyprogesterone may contribute to perceptual processing and attention of the cases with relapsing remitting multiple sclerosis

Ozcan, E., Akduman, R. C., Eyüpoglu, S., Bingöl, A., Ekmekçi, Ö. B., & Hatipoğlu, E. (2023) · Neurological Research · doi:10.1080/01616412.2023.2258040

Sex hormones and diseases of the nervous system

Schipper, H. M. (2025) · Brain medicine : · doi:10.61373/bm025w.0008

Steroidomic Changes in the Cerebrospinal Fluid of Women with Multiple Sclerosis

Kancheva, R. L., Havrdová, E., Velíková, M., Kancheva, L. S., Včelák, J., Ampapa, R., Židó, M., Štětkářová, I., Škodová, T., & Hill, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125904

Epilepsy associated with multiple sclerosis (сurrent state of the problem)

Vasilenko, A. F., Евгеньевна, Д. В., & Голдобин, В. В. (2025) · Medical alphabet · doi:10.33667/2078-5631-2025-32-30-34

“The Interaction Between Oxidative Stress and Neurosteroid Imbalance in Multiple Sclerosis: Exploring a New Pathway in Disease Mechanisms and Potential Treatment Approaches”

Raafat, M. A., Al-Hasnaawei, S., Mousa, H. M., Malathi, H., Sahu, S., Prathiba, S., Singh, G., & Sinha, A. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70673

Differences between human and rat 5α-Reductase 1 inhibition by phenolic disinfectants: Comparative kinetics and binding modes for neurosteroid synthesis

Han, X., Li, W., Huang, Y., Wang, L., Zhao, T., Chen, X., Lin, H., Wang, Y., Ge, R., & Ma, J. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112186

Neuroactive steroids as targets of micro- and nano-plastics: Putative impact on brain function and disease

Porcu, P., Serra, M., Pisanu, A., Pisu, M. G., & Fattore, L. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101266

Positive association between sex hormones and inflammatory cytokines in trauma-exposed premenopausal women

Tahmin, C. I., Kim, J., Corbin, C., Bracewell, D., Cook, M. D., Chekouo, T., & Fonkoue, I. T. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101324

Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection

Jolivel, V., Brun, S., Binamé, F., Benyounes, J., Taleb, O., Bagnard, D., Seze, J. D., Patte‐Mensah, C., & Mensah‐Nyagan, A. G. (2021) · Cells · doi:10.3390/cells10030698 · Cited by 42 · see citing works

Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment

Bäckström, T. C., Doverskog, M., Blackburn, T. P., Scharschmidt, B. F., & Felipo, V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105668 · Cited by 14 · see citing works

Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders

Irwin, R. W., Solinsky, C. M., & Brinton, R. D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00203 · Cited by 72 · see citing works

Allopregnanolone pleiotropic action in neurons and astrocytes: calcium signaling as a unifying mechanism

Wang, T., Chen, S., Mao, Z., Shang, Y., & Brinton, R. D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1286931 · Cited by 8 · see citing works

Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease

Chen, S., Wang, T., Yao, J., & Brinton, R. D. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00874-x · Cited by 34 · see citing works