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GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice
Open accessAbstract
The differential regulation of the two major N-methyl-D-aspartate receptor (NMDAR) subunits GluN2A and GluN2B during development in forebrain pyramidal cells has been thoroughly investigated. In contrast, much less is known about the role of GluN2D, which is expressed at low levels and is downregulated following the second postnatal week. However, it appears that few cells, presumably interneurons, continue to express GluN2D also in juvenile mice. To investigate which hippocampal cell types express this subunit, we generated transgenic mice with EGFP-tagged GluN2D receptors. The expression of the transgene was confined to hippocampal interneurons, most of which were parvalbumin- and/or somatostatin-positive. Electrophysiological and morphological analyses showed that GluN2D was present mainly in fast spiking basket and axo-axonic cells. Based on pharmacological evidence and electrophysiological analysis of GluN2D knockout mice, we conclude that GluN2D-containing NMDARs mediate synaptic currents in hippocampal interneurons of young and juvenile mice and in CA1 pyramidal neurons of newborn mice.
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“By using Grin2d-deficient mice, its contribution in synaptic transmission of hippocampal interneurons of young mice as well as of the pyramidal CA1 neurons of newborn pups has been proven65.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [65]
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Metadata
- Authors
- Engelhardt, J. V., Bocklisch, C., Tönges, L., Herb, A., Mishina, M., & Monyer, H.
- Affiliations
- German Cancer Research Center (DE)
- Ritsumeikan University (JP)
- Corresponding author
- Monyer, Hannah
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-03-25
- Volume
- 9
- Pages
- 95-95
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4373385
- OpenAlex
- W1983068587
- Cited by
- 103
- References
- 56
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 5
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DZNE Pub (submittedVersion, cc-by)
- Funders
- Japan Society for the Promotion of Science (24249014, 22123008)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- GluN2D, NMDA receptor subunits, hippocampal interneurons, pyramidal neurons, basket cells, axo-axonic cells, parvalbumin, somatostatin, synaptic currents, juvenile development, CA1, fast spiking
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