Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Interleukin-10 and the Interleukin-10 Receptor

Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913

Macrophage activation and polarization

Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160

Alternative Activation of Macrophages: An Immunologic Functional Perspective

Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531

Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine

Lynch, M. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868448 · Cited by 146

IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake

Patel, R. R., Wolfe, S. A., Bajo, M., Abeynaike, S. A., Pahng, A. R., Borgonetti, V., D’Ambrosio, S. R., Nikzad, R., Edwards, S., Paust, S., et al. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101952 · Cited by 71

Interleukin-10 deficiency exacerbates inflammation-induced tau pathology

Weston, L. L., Jiang, S., Chisholm, D., Jantzie, L. L., & Bhaskar, K. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02211-1 · Cited by 69

Low-dose LPS alleviates early brain injury after SAH by modulating microglial M1/M2 polarization via USP19/FOXO1/IL-10/IL-10R1 signaling

Tao, W., Zhang, G., Liu, C., Jin, L., Li, X., & Yang, S. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102863 · Cited by 64

Microglia dynamics in adolescent traumatic brain injury

Eyolfson, E., Khan, A. C., Mychasiuk, R., & Lohman, A. W. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01994-z · Cited by 68

Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk

Izzy, S., Yahya, T., Albastaki, O., Abou‐El‐Hassan, H., Aronchik, M., Cao, T., de Oliveira, M. G., Lu, K.-J., Moreira, T. G., da Silva, P., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01877-7 · Cited by 65

Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?

Kunz, N., & Kemper, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629986 · Cited by 63

Lutein Exerts Antioxidant and Anti-Inflammatory Effects and Influences Iron Utilization of BV-2 Microglia

Pap, R., Pandur, E., Jánosa, G., Sipos, K., Agócs, A., & Deli, J. (2021) · Antioxidants · doi:10.3390/antiox10030363 · Cited by 64

CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury

Ho, M.-H., Yen, C., Hsieh, T.-H., Kao, T., Chiu, J.-Y., Chiang, Y. H., Hoffer, B. J., Chang, W., & Chou, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102067 · Cited by 57

An integrated cytokine and kynurenine network as the basis of neuroimmune communication

Stone, T. W., Clanchy, F. I. L., Huang, Y., Chiang, N., Darlington, L. G., & Williams, R. O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002004 · Cited by 57

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

Quintana, J. F., Chandrasegaran, P. R. G., Sinton, M. C., Briggs, E. M., Otto, T. D., Heslop, R., Bentley-Abbot, C., Loney, C., de Lecea, L., Mabbott, N. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33542-z · Cited by 49

Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms

Shaito, A. A., Kobeissy, F. H., Haidar, M. A., Ibeh, S., Shakkour, Z., Reslan, M. A., Nwaiwu, J. I., Moqidem, Y. A., Sader, G., Nickles, R. G., et al. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666211202123322 · Cited by 51

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

Harder, J. M., Williams, P. A., Braine, C., Yang, H. S., Thomas, J. M., Foxworth, N. E., John, S. W. M., & Howell, G. R. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02011-z · Cited by 49

Non-Coding RNA in Microglia Activation and Neuroinflammation in Alzheimer’s Disease

He, C., Li, Z., Yang, M., Yu, W., Luo, R., Zhou, J., He, J., Chen, Q., Song, Z., & Cheng, S. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s422114 · Cited by 49

Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-кB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice

Zhang, L., Lu, X., Gong, L., Cui, L., Zhang, H., Zhao, W., Jiang, P., Hou, G., & Hou, Y. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00878-3 · Cited by 48

Immune Response in Traumatic Brain Injury

Cáceres, E. L., Olivella-Gómez, J., Napoli, M. D., Raihane, A. S., & Divani, A. A. (2024) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-024-01382-7 · Cited by 53

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids

Chichagova, V., Georgiou, M., Carter, M., Dorgau, B., Hilgen, G., Collin, J., Queen, R., Chung, G., Ajeian, J., Moya‐Molina, M., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17670 · Cited by 37

Interleukin 4 Reduces Brain Hyperexcitability after Traumatic Injury by Downregulating TNF-α, Upregulating IL-10/TGF-β, and Potential Directing Macrophage/Microglia to the M2 Anti-inflammatory Phenotype

Radpour, M., Khoshkroodian, B., Asgari, T., Pourbadie, H. G., & Sayyah, M. (2023) · Inflammation · doi:10.1007/s10753-023-01843-0 · Cited by 37

Potential roles of branched-chain amino acids in neurodegeneration

Yoo, H.-S., Shanmugalingam, U., & Smith, P. D. (2022) · Nutrition · doi:10.1016/j.nut.2022.111762 · Cited by 37

DJ-1 Regulates Microglial Polarization Through P62-Mediated TRAF6/IRF5 Signaling in Cerebral Ischemia-Reperfusion

Wang, T., Zhao, N., Li, P., Li, Y., Huang, X., Zhu, J., Chen, Y., Yu, S., & Zhao, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.593890 · Cited by 32

iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer’s Disease

Ihnatovych, I., Birkaya, B. G., Notari, E., & Szigeti, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249668 · Cited by 31

Roles of the Notch signaling pathway and microglia in autism

Zhang, Y., Wang, T., Li, Y., Deng, Y.-N., & Shen, F. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114131 · Cited by 31

Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model

Boyce, M., Xin, Y., Chowdhury, O., Shang, P., Liu, H., Koontz, V., Strizhakova, A., Nemani, M., Hose, S., Zigler, J. S., et al. (2022) · Cells · doi:10.3390/cells11223535 · Cited by 31

Maternal and Placental DNA Methylation Changes Associated with the Pathogenesis of Gestational Diabetes Mellitus

Xu, P., Dong, S., Wu, L., Bai, Y., Bi, X., Li, Y., & Shu, C. (2022) · Nutrients · doi:10.3390/nu15010070 · Cited by 33

The “molecular soldiers” of the CNS: astrocytes, a comprehensive review on their roles and molecular signatures

Rupareliya, V. P., Singh, A. A., Butt, A. M., A, H., & Kumar, H. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176048 · Cited by 29

The Effects of Incensole Acetate on Neuro-inflammation, Brain-Derived Neurotrophic Factor and Memory Impairment Induced by Lipopolysaccharide in Rats

Marefati, N., Beheshti, F., Vafaee, F., Barabadi, M., & Hosseini, M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03381-3 · Cited by 30

Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia

Rafiei, M., Shojaei, A., & Chau, Y. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2465909 · Cited by 32

Traumatic brain injury in adolescence: A review of the neurobiological and behavioural underpinnings and outcomes

Christensen, J., Eyolfson, E., Salberg, S., & Mychasiuk, R. (2020) · Developmental Review · doi:10.1016/j.dr.2020.100943 · Cited by 28

Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression

Yang, F., Bi, Y., & Chen, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.635762 · Cited by 27

Does Modern Lifestyle Favor Neuroimmunometabolic Changes? A Path to Obesity

Marques, C. G., Quaresma, M. V. L. D. S., Nakamoto, F. P., Magalhães, A. C. O., Lucin, G. A., & dos Santos, R. V. T. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.705545 · Cited by 30

Elevation of inactive cleaved annexin A1 in the neocortex is associated with amyloid, inflammatory and apoptotic markers in neurodegenerative dementias

Chua, X. Y., Chong, J. R., Cheng, A. L., Lee, J. H., Ballard, C. G., Aarsland, D., Francis, P. T., & Lai, M. K. P. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105251 · Cited by 26

Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses

Solomon, S., Sampathkumar, N. K., Carre, I., Mondal, M., Chennell, G., Vernon, A. C., Ruepp, M.-D., & Mitchell, J. C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04473-1 · Cited by 23

Effects of lead exposure on the activation of microglia in mice fed with high‐fat diets

Wu, L., Li, S., Pang, S., Zhang, B., Wang, J., He, B., Lv, L., Wang, W., Zhao, N., & Zhang, Y. (2021) · Environmental Toxicology · doi:10.1002/tox.23312 · Cited by 22

Humoral immunity at the brain borders in homeostasis

Posner, D. A., Lee, C. Y. C., Portet, A., & Clatworthy, M. R. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102188 · Cited by 21

Association of Single Nucleotide Polymorphisms of the IL-6 , IL-10 , and TNF-α Genes with Susceptibility to Gestational Diabetes Mellitus

Wei, Q., Chen, X., & Chen, H. (2020) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2020.0069 · Cited by 22

Lutein and inflammation: a comprehensive review of its mechanisms of action

Prathyusha, P., Viswanathan, G., Tomcy, A. T., Binitha, P. P., Bava, S. V., & Sindhu, E. R. (2025) · Exploration of Drug Science · doi:10.37349/eds.2025.100885 · Cited by 21

Oligodendrocytes in central nervous system diseases: the effect of cytokine regulation

Zhang, C., Qiu, M. S., & Fu, H. Q. (2024) · Neural Regeneration Research · doi:10.4103/1673-5374.392854 · Cited by 21

Long‐term environmental enrichment reduces microglia morphological diversity of the molecular layer of dentate gyrus

de Oliveira, T. C. G., Paulo, D. C., de Lima, C. M., de Oliveira, R. B., Filho, C. S., Diniz, D. G., Bento‐Torres, J., & Diniz, C. W. P. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14920 · Cited by 21

Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases

Tsukahara, T., Haniu, H., Uemura, T., & Matsuda, Y. (2020) · Biomedicines · doi:10.3390/biomedicines8110446 · Cited by 20

Microglial activation and over pruning involved in developmental epilepsy

Wu, Q., Wang, H., Liu, X., Zhao, Y., & Peng, S. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac111 · Cited by 21

A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood–Brain Barrier Crossing Therapeutic Strategies

Chim, S. M., Howell, K., Kokkosis, A. G., Zambrowicz, B., Karalis, K. P., & Pavlopoulos, E. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16101314 · Cited by 22

Prolactin treatment reduces kainic acid-induced gliosis in the hippocampus of ovariectomized female rats

Reyes-Mendoza, J., & Morales, T. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147014 · Cited by 17

Minocycline prevents the inflammatory response after retinal detachment, where microglia phenotypes being regulated through A20

Gao, W., Du, J., Chi, Y., Zhu, R., Gao, X., & Yang, L. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108403 · Cited by 17

Intermittent supplementation with Akkermansia muciniphila and galactooligosaccharides modulates Alzheimer’s disease progression, gut microbiota, and colon short-chain fatty acid profiles in mice

Kunevičius, A., Vijaya, A. K., Atzeni, A., Mingaila, J., Šimoliūnė, I., Jamontas, R., Kezeviciute, E., Gueimonde, M., Meškys, R., Baltriukienė, D., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1617980 · Cited by 17

Identifying the mechanism underlying antidepressant-like effects of loganin by network pharmacology in combination with experimental validation

Xia, C., Xu, J., Li, L., Lian, W., Yan, Y., Ma, B.-Z., He, J., & Zhang, W. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114526 · Cited by 17

Limosilactobacillus reuteri DSM17938 Attenuates Neuroinflammatory Responses After Spinal Cord Injury by Modulating Tryptophan Metabolism

Cen, Q., Cui, Y., Feng, J., Li, Z., Wei, J., Wang, L., Chang, C., Pang, R., Wang, J., & Zhang, A. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10545-y · Cited by 17

Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Rojas, P., Ramirez, A. I., Cadena, M., Fernández‐Albarral, J. A., Salobrar‐García, E., López‐Cuenca, I., Santos‐García, I., de Lago, E., Urcelay-Segura, J. L., Ramirez, J. M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041663 · Cited by 17

A 3D in vitro co-culture model for evaluating biomaterial-mediated modulation of foreign-body responses

Cakmak, B., Saglam‐Metiner, P., Beceren, G., Zhang, Y. S., & Yeşil-Çeliktaş, Ö. (2022) · Bio-Design and Manufacturing · doi:10.1007/s42242-022-00198-z · Cited by 15

Increased Hydrostatic Pressure Promotes Primary M1 Reaction and Secondary M2 Polarization in Macrophages

Wang, B., Kasper, M., Laffer, B., zu Hörste, G. M., Wasmuth, S., Busch, M., Jalilvand, T. V., Thanos, S., Heiligenhaus, A., Bauer, D., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573955 · Cited by 14

Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1

Steinberg, N., Galleguillos, D., Zaidi, A. K., Horkey, M., & Sipione, S. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02963-y · Cited by 14

Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model

Lee, S., Kim, J., You, J.-S., Hyun, Y.-M., Kim, J. Y., & Lee, J. E. (2024) · Scientific Reports · doi:10.1038/s41598-024-60358-2 · Cited by 16

Role of Regulatory T Cells in Intracerebral Hemorrhage

Shang, Y., Zheng, L., Du, Y., Shang, T., Liu, X., & Zou, W. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04281-7 · Cited by 14

Normobaric intermittent hypoxic training regulates microglia phenotype and enhances phagocytic activity

Tantingco, G., & Ryou, M. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220919361 · Cited by 13

Characterization of an Immortalized Human Microglial Cell Line as a Tool for the Study of Diabetic Retinopathy

Mazzeo, A., Porta, M., & Beltramo, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105745 · Cited by 12

TH2 sensitization in the skin‐gut‐brain axis: How early‐life Th2‐mediated inflammation may negatively perpetuate developmental and psychologic abnormalities

Jackson, L., Cole, E. F., Arbiser, J. L., Silverberg, J. I., & Lawley, L. P. (2021) · Pediatric Dermatology · doi:10.1111/pde.14657 · Cited by 13

Bioactive Self‐Assembled Nanoregulator Enhances Hematoma Resolution and Inhibits Neuroinflammation in the Treatment of Intracerebral Hemorrhage

Yu, W., Che, C., Yang, Y., Zhao, Y., Liu, J., Chen, A., & Shi, J. (2024) · Advanced Science · doi:10.1002/advs.202408647 · Cited by 12

Neonatal microglia and proteinase inhibitors‐treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation

Zheng, P., Bai, Q., Feng, J., Zhao, B., Duan, J., Zhao, L., Liu, N., Ren, D., Zou, S., & Chen, W. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10249 · Cited by 10

Combination Gene Delivery Reduces Spinal Cord Pathology in Rats With Peripheral Neuropathic Pain

Ji, H., Kim, K.-R., Park, J.-J., Lee, J. Y., Sim, Y., Choi, H., & Kim, S. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.07.007 · Cited by 11

Regulatory T Cells Secrete IL10 to Suppress Neuroinflammation in Early Stage after Subarachnoid Hemorrhage

Zhou, J., Yang, F., Li, H., Xu, P., Wang, Z., Shao, F., Shao, A., & Zhang, J. (2023) · Medicina · doi:10.3390/medicina59071317 · Cited by 10

Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma model

Hetze, S., Barthel, L., Lückemann, L., Günther, H. S., Wülfing, C., Salem, Y., Jakobs, M., Hörbelt, T., Petschulat, J., Bendix, I., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.09.006 · Cited by 13

Activation of Hippocampal ACE2 Prevents the Dysbiosis-induced Depression-like Behavior in Mice by Enhanced Neurogenesis and Neuroprotection via Mas Receptor

Takahashi, K., Nakagawasai, O., Kurokawa, K., Miyagawa, K., Mochida-Saito, A., Takeda, H., & Tsuji, M. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10232-3 · Cited by 9

Stem cell-mediated recovery in stroke: partnering with the immune system

McMillan, N., McMillan, A., Kiliaan, P. C. J., Yahya, T., Thakkar, R., Weiner, H. L., Smirnakis, S. M., Yavagal, D. R., & Izzy, S. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00985-4 · Cited by 9

Novel Somatostatin Receptor-4 Agonist SM-I-26 Mitigates Lipopolysaccharide-Induced Inflammatory Gene Expression in Microglia

Silwal, A., House, A., Sandoval, K. E., Vijeth, S., Umbaugh, D. S., Crider, A. M., Mobayen, S., Neumann, W. L., & WITT, K. A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03482-z · Cited by 8

Brazilin-rich extract from Sappan wood attenuates neuroinflammation through the restoration of the gut microbiota: improving cognitive function in mice with age-related Alzheimer’s disease

Sun, Q., Cui, Z., Li, J., Zhang, Q., Zheng, J., Lu, F., & Liu, F. (2024) · Aging advances. · doi:10.4103/agingadv.agingadv-d-24-00017 · Cited by 8

Neuro-immune interactions in coronary microvascular disease: mechanisms and therapeutic prospect

Zhao, G., Wu, G., Ma, J., Ren, S., Liu, T., Wu, X., & Wang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1631083 · Cited by 8

Exploring the Connectivity of Neurodegenerative Diseases: Microglia as the Center

Wang, Y., Cui, L., Zhao, H., He, H., Chen, L., Song, X., Liu, D., Qiu, J., & Sun, Y. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s440377 · Cited by 7

From the different pathogenesis of epileptogenesis: vitamins as an adjunctive treatment for epilepsy

Sun, W., Wang, Y., Xiao, B., & Luo, Z. (2025) · Acta Epileptologica · doi:10.1186/s42494-025-00228-0 · Cited by 7

Comparative profiling of immune genes improves the prognoses of lower grade gliomas

Wang, Z., Cheng, W., Zhao, Z., Wang, Z., Zhang, C., Li, G., Wu, A., & Jiang, T. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2021.0173 · Cited by 7

Research Note: Heat stress affects immune and oxidative stress indices of the immune organs of broilers by changing the expressions of adenosine triphosphate-binding cassette subfamily G member 2, sodium-dependent vitamin C transporter-2, and mitochondrial calcium uniporter

Wang, Y., Yang, X., Li, S., Wu, Q., Guo, H., Wang, H., Su, P., & Wang, J. (2023) · Poultry Science · doi:10.1016/j.psj.2023.102814 · Cited by 7

Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury

Zhang, Y., Zhao, Y., Wang, Y., Li, J., Huang, Y., Lyu, F., Wang, Y., Wei, P., Yuan, Y., Fu, Y., et al. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231197173 · Cited by 7

Phenotypic Differences in Primary Murine Microglia Treated with NOD1, NOD2, and NOD1/2 Agonists

Wasmuth, S., Jalilvand, T. V., Laffer, B., Busch, M., Bauer, D., Langmann, T., Thanos, S., Kasper, M., & Heiligenhaus, A. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01466-x · Cited by 8

Possible involvement of microglial P2RY12 and peripheral IL-10 in postpartum depression

Kim, H.-J., You, M., Sung, S., Rim, C., & Kwon, M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1162966 · Cited by 7

Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity

Ikutame, D., Urata, K., Oto, T., Fujiwara, S., Iinuma, T., Shibuta, I., Hayashi, Y., Hitomi, S., Iwata, K., & Shinoda, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217871 · Cited by 7

Effects of Suberoylanilide Hydroxamic Acid (SAHA) on the Inflammatory Response in Lipopolysaccharide-Induced N9 Microglial Cells

Çelik, Z. B., & Günaydın, C. (2022) · Cureus · doi:10.7759/cureus.32428 · Cited by 6

α-Gal Nanoparticles in CNS Trauma: I. In Vitro Activation of Microglia Towards a Pro-Healing State

Gopalakrishnan, B., Galili, U., Dunbar, A., Solorio, L., Shi, R., & Li, J. (2023) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-023-00613-1 · Cited by 6

Regulatory T cells in stroke inflammation: Therapeutic perspectives

Sun, Z., Zhou, H., Wang, Y., & Li, Z. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01424 · Cited by 6

Behavior, synaptic mitochondria, and microglia are differentially impacted by chronic adolescent stress and repeated endotoxin exposure in male and female rats

Wegener, A. J., Hyer, M. M., Targett, I. L., Kloster, A., Shaw, G. A., Rodriguez, A. M. M., Dyer, S. K., & Neigh, G. N. (2024) · Stress · doi:10.1080/10253890.2023.2299971 · Cited by 6

CNS resident macrophages exhibit region-specific states and immunogenic responses during Rbpj-deficient brain arteriovenous malformation

Nakisli, S., Fanelli, K., LaComb, J., Arnold, L. J., & Nielsen, C. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-86150-4 · Cited by 4

Harnessing the innate immune system for glioblastoma therapeutics

McLean, H., Drill, M., Sequeira, R. P., Jayakrishnan, P. C., Jeffree, R. L., Hunn, M., O'Brien, T. J., Hamilton, J., & Monif, M. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578713 · Cited by 3

Differential downstream signaling in microglia lacking Alzheimer’s-related TREM2 or its adaptor TYROBP/DAP12

Quipildor, G. F., Belfiore, R., Althobaiti, K., Najarzadeh, Z., Glabe, C. C., Readhead, B. P., Gandy, S., Salton, S. R., & Ehrlich, M. E. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-025-00012-x · Cited by 6

IL-10-Mediated Regulation of Microglial Inflammation in Brain Meningitis: Novel Insights and Therapeutic Potential

Li, X., Gao, L., Li, C., Wang, B., & Che, Y. (2024) · Discovery Medicine · doi:10.24976/discov.med.202436184.87 · Cited by 3

Geraniin Alleviates Mouse Laser‐Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell ACE2 /Ang‐(1–7)/ MasR / IL ‐10 Pathway

Lu, H., Cai, Q., Li, L., Gu, J., Zhang, Y., Sun, H., Su, H., & Song, L. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70228 · Cited by 3

Amelioration of Inflammation and Metabolic Blockage in GALC Deficient Mice After Enzyme Replacement Therapy via Extracellular Vesicles

Zelada, D., Saldivia, N., Samano, S., George, D., Chaudhari, K., Nguyen, D. A., Simchuk, D., van Breemen, R. B., & Givogri, M. I. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s523938 · Cited by 3

A novel hybrid protein promotes Aβ clearance and reduces inflammatory response through MerTKPreprint

Samentar, L., Salazar, A., Pan, P., Etebar, K., Choy, K., Uddin, D., Eliseeff, P., Bugayong, A. M., Garrido, J. A. M. G., Emini, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.03.467048 · Cited by 2

IL-10–STAT3-Dependent Transcriptional Regulation in Microglia: Alzheimer’s Disease and Neuroinflammation

Kim, M. E., & Lee, J. S. (2026) · Biomedicines · doi:10.3390/biomedicines14040826 · Cited by 2

Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.

van Deijk, W. A., Blom, P. S., & van der Vijver, J. C. M. (1979) · PubMed · Cited by 2

Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemiaPreprint

Castillo-González, J., Vargas-Rodríguez, P., Serrano-Martínez, I., Cuenca-Martagón, A., Forte-Lago, I., Price, M., Buscemi, L., Hirt, L., Ruiz, J. L., & González-Rey, E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.11.611691 · Cited by 2

“Armed in-vitro retina”-generating microglial retinal organoids, where are we now?

Liu, Y., Gao, L., Chen, W., Yan, Y., Ye, Z., & Li, Z. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1574283 · Cited by 2

Adrenergic signaling during parasitic infections

Gardias, P., & Bąska, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1691005 · Cited by 1

Effects of acute THC challenge on behavior and neuroinflammation in HIV-1 Tg26 mice vary based on HIV status, chronic THC history, and sex

Ravula, H., Yadav-Samudrala, B. J., Sawaqed, L. E., Arciniega, C., Hu, W., Jiang, W., & Fitting, S. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106476 · Cited by 1

β-hydroxybutyrate alleviates motor impairment and neurological damage in hypoxic-ischemic encephalopathy mice

Huang, Z., Lin, B., Li, C., Huang, X., Zhu, L., Xu, Y., & Yang, C. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116144 · Cited by 2

Adverse interactions of plastic nanoparticles with cultured primary microglial cells

Adamiak, K., & Strużyńska, L. (2026) · Toxicology · doi:10.1016/j.tox.2026.154527 · Cited by 1

Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia

Castillo-González, J., Vargas-Rodríguez, P., Serrano-Martínez, I., Cuenca-Martagón, A., Forte‐Lago, I., Price, M., Buscemi, L., Hirt, L., Ruiz, J. L., & González‐Rey, E. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-026-01271-w · Cited by 3

Platelet-Rich Plasma Modulates Neuroinflammation in an iPSC Model of Sensory Neurons and Microglia

Mercader-Ruiz, J., Marijuán-Pinel, D., Delgado, D., Aguirre, D. L., Sansinanea, X., Guadilla, J., & Sánchez, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167127 · Cited by 1

Microglia regulate cognition and stress-related cognitive disorders

Zhou, M., Salinas, S., Cornell, J. L., & Bui, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-817558-3.00014-7 · Cited by 1

Microglia and Neuroinflammation

Mondal, H., & Mondal, S. (2023) · Advances in bioinformatics and biomedical engineering book series · doi:10.4018/978-1-6684-9675-6.ch006 · Cited by 1

Restoration of Spatial Learning Through Oral Administration of Lipopolysaccharides in Diabetes-related Cognitive Dysfunction

Inagawa, H., Oda, M., Tjhin, V. T., Kohchi, C., & Soma, G. (2024) · In Vivo · doi:10.21873/invivo.13682 · Cited by 1

Viral vector-mediated interleukin 10 for gene therapy on chronic pain

Kanao-Kanda, M., Kanda, H., Liu, S., Kawamata, T., Candiotti, K. A., & Hao, S. (2025) · Molecular Pain · doi:10.1177/17448069251390266 · Cited by 1

Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.Preprint

Solomon, S., Sampathkumar, N. K., Carre, I., Mondal, M., Chennell, G., Vernon, A. C., Ruepp, M., & Mitchell, J. C. (2022) · Research Square · doi:10.21203/rs.3.rs-1420006/v2 · Cited by 1

The Effect of IL-10 on M2-Activated Human Microglia (S12.006)

Healy, L. M., Moore, C. S., Touil, H., Ludwin, S. K., Bar‐Or, A., & Antel, J. P. (2015) · Neurology · doi:10.1212/wnl.84.14_supplement.s12.006 · Cited by 2

Der Einfluss von Interleukin-10 auf den Phänotyp primärer Mikroglia

Laffer, B. (2019) · DuEPublico (University of Duisburg-Essen) · doi:10.17185/duepublico/71092

Comparison of polarization properties of human adult microglia and blood‐derived macrophages

Durafourt, B. A., Moore, C. S., Zammit, D., Johnson, T., Zaguia, F., Guiot, M., Bar‐Or, A., & Antel, J. P. (2012) · Glia · doi:10.1002/glia.22298 · Cited by 470

Interferon regulatory factor 7 participates in the M 1‐like microglial polarization switch

Tanaka, T., Murakami, K., Bandô, Y., & Yoshida, S. (2014) · Glia · doi:10.1002/glia.22770 · Cited by 123

Regulation of microglial activation by TGF-β, IL-10, and CSF-1

Lodge, P. A., & Sriram, S. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.60.4.502 · Cited by 156