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Cited by 41Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Synaptic polarity of the interneuron circuit controlling C. elegans locomotion

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Rakowski, Franciszek, Srinivasan, Jagan, Sternberg, Paul W., Karbowski, Jan·2013·Frontiers in Computational Neuroscience
DOI 10.3389/fncom.2013.00128PMC PMC3788333
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Abstract

Caenorhabditis elegans is the only animal for which a detailed neural connectivity diagram has been constructed. However, synaptic polarities in this diagram, and thus, circuit functions are largely unknown. Here, we deciphered the likely polarities of seven pre-motor neurons implicated in the control of worm's locomotion, using a combination of experimental and computational tools. We performed single and multiple laser ablations in the locomotor interneuron circuit and recorded times the worms spent in forward and backward locomotion. We constructed a theoretical model of the locomotor circuit and searched its all possible synaptic polarity combinations and sensory input patterns in order to find the best match to the timing data. The optimal solution is when either all or most of the interneurons are inhibitory and forward interneurons receive the strongest input, which suggests that inhibition governs the dynamics of the locomotor interneuron circuit. From the five pre-motor interneurons, only AVB and AVD are equally likely to be excitatory, i.e., they have probably similar number of inhibitory and excitatory connections to distant targets. The method used here has a general character and thus can be also applied to other neural systems consisting of small functional networks.

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  • The main role of AVB is to influence B-class motorneurons to turn on and off forward locomotion, whereas the main role of AVA is to influence A-class motorneurons to turn on and off backward locomotion.

    “the main role of the AVB class is to influence the B-class motorneuron to turn on and off forward locomotion, whereas the main role of AVA is to influence the A-class motorneuron to turn on and off backward locomotion (Kawano et al., 2011; Qi, Garren, Shu, Tsien, & Jin, 2012; Rakowski, Srinivasan, Sternberg, & Karbowski, 2013; Zheng, Brockie, Mellem, Madsen, & Maricq, 1999).”

    From Potential role of a ventral nerve cord central pattern generator in forward and backward locomotion in Caenorhabditis elegans (2018) · cites this paper as Rakowski et al., 2013

    The Introduction (page not specified) describes AVB as mainly connected to B-class motor neurons involved in forward motion, and AVA as mainly connected to A-class motor neurons involved in backward motion. The Discussion also describes AVB signaling to B neurons and AVA exciting A neurons. But the paper cautions that movement direction depends on the collective circuit and the balance of motor-neuron activity; it does not establish that either interneuron independently turns its associated movement on and off. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Metadata

Authors
Rakowski, F., Srinivasan, J., Sternberg, P. W., & Karbowski, J.
Affiliations
  • Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw (PL)
  • California Institute of Technology (US)
  • University of Warsaw (PL)
Corresponding author
Karbowski, Jan
ORCID
Venue
Frontiers in Computational Neuroscience
Publisher
Frontiers Media SA
Published
2013
Volume
7
Pages
128-128
ISSN
1662-5188 (ISSN-L)
DOI
10.3389/fncom.2013.00128
PMC
PMC3788333
OpenAlex
W2146252121
Cited by
41
References
5
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 1
FWCI
1.31
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Computational Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • arXiv (Cornell University) (submittedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • arXiv (Cornell University)
Funders
Uniwersytet Warszawski
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
Caenorhabditis elegans locomotion, laser ablation, inhibition, neuronal connectivity

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