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Lipidomics Analysis of Behavioral Variant Frontotemporal Dementia: A Scope for Biomarker Development
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Cholesterol dysregulation and lipid dyshomeostasis have been identified in several neurodegenerative diseases.
“Importantly, cholesterol dysregulation6–9 and lipid dyshomeostasis8,10–15 have been identified in several neurodegenerative diseases.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [12]
Observed changes in cholesterol, CE, and lipid metabolism support previous observations of altered lipid metabolism in FTLD patient tissue samples, which may contribute to development of tau pathology at early stages.
“The observed changes in cholesterol, CE, and lipid metabolism in this study support previous observations of altered lipid metabolism in FTLD patient tissue samples12,13,72, which may contribute to the development of tau pathology at the early stages of the disease.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [12]
Previous studies have associated alterations of cholesterol and lipid metabolism in FTLD brain tissue and serum/plasma samples.
“Previous studies have associated alterations of cholesterol and lipid metabolism in FTLD brain tissue72 and serum/plasma samples12,13.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [12]
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Lipidomics reveals a remarkable diversity of lipids in human plasma
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Imaging and fluid biomarkers in frontotemporal dementia
Meeter, L. H., Kaat, L. D., Rohrer, J. D., & van Swieten, J. C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.75 · Cited by 210
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Cited by
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Fluid biomarkers in frontotemporal dementia: past, present and future
Swift, I. J., Sogorb-Esteve, A., Heller, C., Synofzik, M., Otto, M., Graff, C., Galimberti, D., Todd, E., Heslegrave, A. J., van der Ende, E. L., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-323520 · Cited by 122
Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders
Godoy-Corchuelo, J. M., Fernández-Beltrán, L. C., Ali, Z., Gil-Moreno, M. J., López-Carbonero, J. I., Guerrero-Sola, A., Larrad-Sainz, A., Matias-Guiu, J., Matias-Guiu, J. A., Cunningham, T. J., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10051105 · Cited by 35
Metabolomic changes associated with frontotemporal lobar degeneration syndromes
Murley, A. G., Jones, P. S., Coyle Gilchrist, I., Bowns, L., Wiggins, J., Tsvetanov, K. A., & Rowe, J. B. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09824-1 · Cited by 18
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Acosta Ingram, D., Turkes, E., Kim, T. Y., Vo, S., Sweeney, N., Bonte, M.-A., Rutherford, R., Julian, D. L., Pan, M., Marsh, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58585-w · Cited by 12
Metadata
- Authors
- Kim, W. S., Jary, E., Pickford, R., He, Y., Ahmed, R. M., Piguet, O., Hodges, J. R., & Halliday, G. M.
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2018-02-28
- Volume
- 9
- ISSN
- 1664-2295
- PMC
- PMC5835505
- Cited by
- 50
- References
- 4
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