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Lipidomics Analysis of Behavioral Variant Frontotemporal Dementia: A Scope for Biomarker Development

Kim, Woojin Scott, Jary, Eve, Pickford, Russell, He, Ying, Ahmed, Rebekah M., Piguet, Olivier, Hodges, John R., Halliday, Glenda M.·2018·Frontiers in Neurology

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Crossref · 10.3389/fneur.2018.00104

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  • Cholesterol dysregulation and lipid dyshomeostasis have been identified in several neurodegenerative diseases.

    “Importantly, cholesterol dysregulation6–9 and lipid dyshomeostasis8,10–15 have been identified in several neurodegenerative diseases.”
  • Observed changes in cholesterol, CE, and lipid metabolism support previous observations of altered lipid metabolism in FTLD patient tissue samples, which may contribute to development of tau pathology at early stages.

    “The observed changes in cholesterol, CE, and lipid metabolism in this study support previous observations of altered lipid metabolism in FTLD patient tissue samples12,13,72, which may contribute to the development of tau pathology at the early stages of the disease.”
  • Previous studies have associated alterations of cholesterol and lipid metabolism in FTLD brain tissue and serum/plasma samples.

    “Previous studies have associated alterations of cholesterol and lipid metabolism in FTLD brain tissue72 and serum/plasma samples12,13.”

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Research works printed but not linked: 44

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Metadata

Authors
Kim, W. S., Jary, E., Pickford, R., He, Y., Ahmed, R. M., Piguet, O., Hodges, J. R., & Halliday, G. M.
Venue
Frontiers in Neurology
Published
2018-02-28
Volume
9
ISSN
1664-2295
Cited by
50
References
4

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