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Cited by 225Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsFunctional Brain Connectivity Studies

Whole brain myelin mapping using T1- and T2-weighted MR imaging data.

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Ganzetti, Marco, Wenderoth, Nicole, Mantini, Dante·2014·Frontiers in Human Neuroscience
DOI 10.3389/fnhum.2014.00671PMC PMC4151508
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Abstract

Despite recent advancements in MR imaging, non-invasive mapping of myelin in the brain still remains an open issue. Here we attempted to provide a potential solution. Specifically, we developed a processing workflow based on T1-w and T2-w MR data to generate an optimized myelin enhanced contrast image. The workflow allows whole brain mapping using the T1-w/T2-w technique, which was originally introduced as a non-invasive method for assessing cortical myelin content. The hallmark of our approach is a retrospective calibration algorithm, applied to bias-corrected T1-w and T2-w images, that relies on image intensities outside the brain. This permits standardizing the intensity histogram of the ratio image, thereby allowing for across-subject statistical analyses. Quantitative comparisons of image histograms within and across different datasets confirmed the effectiveness of our normalization procedure. Not only did the calibrated T1-w/T2-w images exhibit a comparable intensity range, but also the shape of the intensity histograms was largely corresponding. We also assessed the reliability and specificity of the ratio image compared to other MR-based techniques, such as magnetization transfer ratio (MTR), fractional anisotropy (FA), and fluid-attenuated inversion recovery (FLAIR). With respect to these other techniques, T1-w/T2-w had consistently high values, as well as low inter-subject variability, in brain structures where myelin is most abundant. Overall, our results suggested that the T1-w/T2-w technique may be a valid tool supporting the non-invasive mapping of myelin in the brain. Therefore, it might find important applications in the study of brain development, aging and disease.

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  • Other quantitative MRI techniques such as calibrated T1w/T2w ratio mapping, inhomogeneous magnetization transfer (ihMT) imaging, and T2 relaxation-based myelin water imaging (MWI) are likely less affected by fiber orientation.

    “other quantitative MRI techniques such as calibrated T1w/T2w ratio mapping (Ganzetti et al., 2014; Uddin et al., 2018), inhomogeneous magnetization transfer (ihMT) imaging (Manning et al., 2017; Swanson et al., 2017), and T2 relaxation-based myelin water imaging MWI (Prasloski et al., 2012; Lee et al., 2018) are likely less affected by fiber orientation”

    From Potential Pitfalls of Using Fractional Anisotropy, Axial Diffusivity, and Radial Diffusivity as Biomarkers of Cerebral White Matter Microstructure (2022) · cites this paper as Ganzetti et al., 2014

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Cited by

Sorted by citations

Authors
Ganzetti, M., Wenderoth, N., & Mantini, D.
Affiliations
ETH Zurich (CH)
Corresponding author
Mantini, Dante
ORCID
Venue
Frontiers in Human Neuroscience
Publisher
Frontiers Media SA
Published
2014-09-02
Volume
8
Pages
671-671
ISSN
1662-5161 (ISSN-L)
DOI
10.3389/fnhum.2014.00671
PMC
PMC4151508
OpenAlex
W2008880867
Cited by
225
References
5
Citations by year
2026: 23 · 2025: 25 · 2024: 24 · 2023: 28 · 2022: 30 · 2021: 21 · 2020: 23 · 2019: 11 · 2018: 20 · 2017: 6 · 2016: 9 · 2015: 5
FWCI
5.22
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Human Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
  • ETH Zürich Research Collection (cc-by)
Funders
Wellcome Trust (101253/Z/13/Z., 101253)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
myelin mapping, bias correction, magnetization transfer ratio, fractional anisotropy, FLAIR, white matter, non-invasive brain imaging

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