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Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

Capurro, Alberto, Bodea, Liviu-Gabriel, Schaefer, Patrick, Luthi-Carter, Ruth, Perreau, Victoria M.·2015·Frontiers in Neuroscience
DOI 10.3389/fnins.2014.00441PMC PMC4288238
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  • Intersection of the microglia signature gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets.

    “We then intersected this gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders derived from microarray or RNA-seq analysis of intact tissue (39–53). Two-sided Fisher’s exact tests revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets (Table S3).”

    From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [41]

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Authors
Capurro, A., Bodea, L.-G., Schaefer, P., Luthi-Carter, R., & Perreau, V. M.
Venue
Frontiers in Neuroscience
Publisher
Frontiers Media SA
Published
2015-01-09
Volume
8
ISSN
1662-453X
DOI
10.3389/fnins.2014.00441
PMC
PMC4288238
Cited by
17
References
2

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