Cited by 292Stress Responses and CortisolRedox biology and oxidative stressAdrenal Hormones and Disorders

The DOI matches its Crossref record; 71 of the 73 references it cites were found in a registry or an index.

Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

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Abstract

Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.

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Crossref · 10.3389/fnins.2014.00456

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Research works printed but not linked: 3

  1. Barycki, 2007, Antioxidant Molecules and Redox Cofactors, Redox Biochemistry
  2. Fridovich, 2007, Antioxidant Enzymes, Redox Biochemistry
  3. Rovira, 2007, Redox Regulation of Physiological Processes, Redox Biochemistry

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Metadata

Authors
Spiers, J. G., Chen, H.-J. C., Sernia, C., & Lavidis, N. A.
Affiliations
The University of Queensland (AU)
Corresponding author
Spiers, Jereme G.
Venue
Frontiers in Neuroscience
Published
2015-01-19
Volume
8
Pages
456-456
ISSN
1662-453X (ISSN-L)
OpenAlex
W1984410984
Cited by
292
References
73
Citations by year
2026: 24 · 2025: 39 · 2024: 23 · 2023: 33 · 2022: 30 · 2021: 39 · 2020: 29 · 2019: 21 · 2018: 17 · 2017: 20 · 2016: 11 · 2015: 6
FWCI
1.45
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypothalamic-pituitary-adrenal axis, glucocorticoids, oxidative stress, redox systems, hippocampus, stress, adrenal cortex, neuroendocrinology

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