Anxiolytic- and antidepressant-like effects of fish oil-enriched diet in brain-derived neurotrophic factor deficient mice
Open accessAbstract
Despite significant advances in the understanding of the therapeutic activity of antidepressant drugs, treatment-resistant depression is a public health issue prompting research to identify new therapeutic strategies. Evidence strongly suggests that nutrition might exert a significant impact on the onset, the duration and the severity of major depression. Accordingly, preclinical and clinical investigations demonstrated the beneficial effects of omega-3 fatty acids in anxiety and mood disorders. Although the neurobiological substrates of its action remain poorly documented, basic research has shown that omega-3 increases brain-derived neurotrophic factor (BDNF) levels in brain regions associated with depression, as antidepressant drugs do. In contrast, low BDNF levels and hippocampal atrophy were observed in animal models of depression. In this context, the present study compared the effects of long-lasting fish oil-enriched diet, an important source of omega-3 fatty acids, between heterozygous BDNF+/- mice and their wild-type littermates. Our results demonstrated lower activation of Erk in BDNF+/- mice whereas this deficit was rescued by fish oil-enriched diet. In parallel, BDNF+/- mice displayed elevated hippocampal extracellular 5-HT levels in relation with a local decreased serotonin transporter protein level. Fish oil-enriched diet restored normal serotonergic tone by increasing the protein levels of serotonin transporter. At the cellular level, fish oil-enriched diet increased the pool of immature neurons in the dentate gyrus of BDNF+/- mice and the latter observations coincide with its ability to promote anxiolytic- and antidepressant-like response in these mutants. Collectively, our results demonstrate that the beneficial effects of long-term exposure to fish oil-enriched diet in behavioral paradigms known to recapitulate diverse abnormalities related to the depressive state specifically in mice with a partial loss of BDNF. These findings contrast with the mechanism of action of currently available antidepressant drugs for which the full manifestation of their therapeutic activity depends on the enhancement of serotoninergic and BDNF signalling. Further studies are warranted to determine whether fish oil supplementation could be used as an add-on strategy to conventional pharmacological interventions in treatment-resistant patients and relevant animal models.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
N-3 supplementation dampens neuroinflammation and attenuates behavioral indices of mood deficits in rodents.
“Several reports link higher n-3 consumption with lower prevalence and severity of mood disturbances in humans [45] and demonstrate that n-3 supplementation dampens neuroinflammation and attenuates behavioral indices of mood deficits in rodents [46,47].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Rao, J. S., Ertley, R. N., Lee, H.-J., DeMar, J. C., Arnold, J. T., Rapoport, S. I., & Bazinet, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001888 · Cited by 280 · see citing works
RetractedFrom inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Guidelines for reporting experiments involving animals: the ARRIVE guidelines
McGrath, J., Drummond, G., McLachlan, E., Kilkenny, C., & Wainwright, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00873.x · Cited by 1,592 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
Components of the AIN-93 Diets as Improvements in the AIN-76A Diet
Reeves, P. G. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.838s · Cited by 1,363 · see citing works
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067 · see citing works
Long story short: the serotonin transporter in emotion regulation and social cognition
Canli, T., & Lesch, K.-P. (2007) · Nature Neuroscience · doi:10.1038/nn1964 · Cited by 1,034 · see citing works
Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975 · see citing works
Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862 · see citing works
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Sairanen, M., Lucas, G., Ernfors, P., Castrén, M., & Castrén, E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3741-04.2005 · Cited by 763 · see citing works
Bengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D. E., Heils, A., Mößner, R., Westphal, H., & Lesch, K. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.4.649 · Cited by 719 · see citing works
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works
Genetics of emotional regulation: the role of the serotonin transporter in neural function
Hariri, A. R., & Holmes, A. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.02.011 · Cited by 666 · see citing works
Monoamine neurocircuitry in depression and strategies for new treatments
Hamon, M., & Blier, P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.009 · Cited by 643 · see citing works
Schmidt, H. D., & Duman, R. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 636 · see citing works
TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634 · see citing works
Rossi, C., Angelucci, A., Costantin, L., Braschi, C., Mazzantini, M., Babbini, F., Fabbri, M. E., Tessarollo, L., Maffei, L., Berardi, N., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05059.x · Cited by 619 · see citing works
Peet, M., & Horrobin, D. F. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.913 · Cited by 615 · see citing works
Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients
Peet, M., Murphy, B., Shay, J., & Horrobin, D. F. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00206-0 · Cited by 581 · see citing works
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
Wu, A., Ying, Z., & Gomez-Pinilla, F. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1457 · Cited by 518 · see citing works
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works
Lin, P.-Y., & Su, K.-P. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0712 · Cited by 481 · see citing works
Targeting the murine serotonin transporter: insights into human neurobiology
Murphy, D. L., & Lesch, K.-P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2284 · Cited by 478 · see citing works
Taliaz, D., Stall, N., Dar, D. E., & Zangen, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.67 · Cited by 454 · see citing works
Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models
Schmidt, H. D., & Duman, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.114 · Cited by 403 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works
Page, M. E., Detke, M. J., Dalvi, A., Kirby, L. G., & Lucki, I. (1999) · Psychopharmacology · doi:10.1007/s002130051156 · Cited by 385 · see citing works
Marangell, L. B., Martinez, J. M., Zboyan, H. A., Kertz, B. L., Kim, H. F. S., & Puryear, L. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.5.996 · Cited by 380 · see citing works
Mamounas, L. A., Altar, C. A., Blue, M. E., Kaplan, D. R., Tessarollo, L., & Lyons, W. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00771.2000 · Cited by 344 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
Dwivedi, Y., Rizavi, H. S., Roberts, R. C., Conley, R. C., Tamminga, C. A., & Pandey, G. N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00300.x · Cited by 333 · see citing works
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
Lafourcade, M., Larrieu, T., Mato, S., Duffaud, A. M., Sepers, M. D., Matias, I., Smedt, V. D., Labrousse, V. F., Brétillon, L., Matute, C., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2736 · Cited by 314 · see citing works
Holmes, A., Yang, R. J., Lesch, K., Crawley, J. N., & Murphy, D. L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300266 · Cited by 312 · see citing works
Su, K.-P., Huang, S.-Y., Chiu, T.-H., Huang, K.-C., Huang, C.-L., Chang, H.-C., & Pariante, C. M. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0418 · Cited by 308 · see citing works
Zhang, J.-C., Wu, J., Fujita, Y., Yao, W., Ren, Q., Yang, C., Li, S.-X., Shirayama, Y., & Hashimoto, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu077 · Cited by 289 · see citing works
Gourley, S. L., Wu, F. J., Kiraly, D. D., Ploski, J. E., Kedves, A. T., Duman, R. S., & Taylor, J. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.016 · Cited by 287 · see citing works
Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats
Chalon, S., Vancassel, S., Belzung, C., Guilloteau, D., Leguisquet, A.-M., Besnard, J., & Durand, G. (1998) · Journal of Nutrition · doi:10.1093/jn/128.12.2512 · Cited by 286 · see citing works
Mocking, R. J. T., Harmsen, I. M., Assies, J., Koeter, M. W. J., Ruhé, H. G., & Schene, A. H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.29 · Cited by 280 · see citing works
McNamara, R. K., Hahn, C.-G., Jandacek, R. J., Rider, T., Tso, P., Stanford, K. E., & Richtand, N. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.026 · Cited by 261 · see citing works
Serotoninergic neurotransmission is affected by n‐3 polyunsaturated fatty acids in the rat
Kodas, E., Galineau, L., Bodard, S., Vancassel, S., Guilloteau, D., Besnard, J., & Chalon, S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02401.x · Cited by 244 · see citing works
The use of behavioral test batteries, II: Effect of test interval
Paylor, R. E., Spencer, C. M., Yuva‐Paylor, L. A., & Pieke-Dahl, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.09.002 · Cited by 243 · see citing works
Siuciak, J. A., Boylan, C. B., Fritsche, M., Altar, C. A., & Lindsay, R. M. (1996) · Brain Research · doi:10.1016/0006-8993(95)01289-3 · Cited by 236 · see citing works
Quesseveur, G., David, D. J., Gaillard, M. C., Pla, P., Wu, M. V., Nguyen, H. T., Nicolas, V, Auregan, G., David, I., Dranovsky, A., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.30 · Cited by 235 · see citing works
Self-citationHorrobin, D. F., & Bennett, C. N. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.1999.0037 · Cited by 222 · see citing works
Jazayeri, S., Tehrani‐Doost, M., Keshavarz, S. A., Hosseini, M., Djazayery, A., Amini, H., Jalali, M., & Peet, M. (2008) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670701827275 · Cited by 215 · see citing works
MacQUEEN, G. M., Ramakrishman, K., Croll, S. D., Siuciak, J. A., Yu, G., Young, T., & Fahnestock, M. L. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.5.1145 · Cited by 212 · see citing works
Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression
Silvers, K. M., Woolley, C. C., Hamilton, F. C., Watts, P. M., & Watson, R. A. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.11.004 · Cited by 207 · see citing works
Warensjö, E., Rosell, M., Hellénius, M.-L., Vessby, B. O., Fairé, U. D., & Risérus, U. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-37 · Cited by 206 · see citing works
Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes
Kalueff, A. V., Olivier, J. D. A., Nonkes, L. J. P., & Homberg, J. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.003 · Cited by 203 · see citing works
Randomized dose‐ranging pilot trial of omega‐3 fatty acids for postpartum depression
Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Brumbach, B. H., Watchman, M., & Gelenberg, A. J. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00660.x · Cited by 199 · see citing works
Vriese, S. R. D., Christophe, A., & Maes, M. H. J. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.02.001 · Cited by 199 · see citing works
Gardier, A. M., Malagié, I., Trillat, A., Jacquot, C., & Artigas, F. (1996) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1996.tb00145.x · Cited by 198 · see citing works
Balu, D. T., Hoshaw, B. A., Malberg, J. E., Rosenzweig-Lipson, S., Schechter, L. E., & Lucki, I. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.023 · Cited by 194 · see citing works
Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids
Calder, P. C. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000400002 · Cited by 187 · see citing works
Lepack, A. E., Bang, E., Lee, B., Dwyer, J. M., & Duman, R. S. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.011 · Cited by 174 · see citing works
Venna, V. R., Deplanque, D., Allet, C., Bélarbi, K., Hamdane, M., & Bordet, R. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.025 · Cited by 171 · see citing works
Xu, D., Lian, D., Wu, J., Liu, Y., Zhu, M., Sun, J., He, D., & Li, L. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0930-6 · Cited by 163 · see citing works
Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder
Gertsik, L., Poland, R. E., Bresee, C., & Rapaport, M. H. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31823f3b5f · Cited by 162 · see citing works
Yuan, P., Zhou, R., Wang, Y., Li, X., Li, J., Chen, G., Guitart, X., & Manji, H. K. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.017 · Cited by 160 · see citing works
Hibbeln, J. R., Ferguson, T. A., & Blasbalg, T. L. (2006) · International Review of Psychiatry · doi:10.1080/09540260600582967 · Cited by 159 · see citing works
Polyunsaturated fatty acid deficit in patients with bipolar mania
Chiu, C.-C., Huang, S., Su, K., Lu, M., Huang, M., Chen, C., & Shen, W. W. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00130-x · Cited by 151 · see citing works
Blondeau, N., Nguemeni, C., Debruyne, D. N., Piens, M., Wu, X., Pan, H., Hu, X., Gandin, C., Lipsky, R. H., Plumier, J.-C., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.84 · Cited by 148 · see citing works
Autocrine Action of BDNF on Dendrite Development of Adult-Born Hippocampal Neurons
Wang, L., Chang, X., She, L., Xu, D., Huang, W., & Poo, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4682-14.2015 · Cited by 143 · see citing works
Kolbeck, R., Bartke, I., Eberle, W., & Barde, Y. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721930.x · Cited by 141 · see citing works
Delion, S., Chalon, S., Guilloteau, D., Lejeune, B., Besnard, J., & Durand, G. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37235-7 · Cited by 124 · see citing works
Fourrier, C., Rémus-Borel, J., Greenhalgh, A. D., Guichardant, M., Bernoud‐Hubac, N., Lagarde, M., Joffre, C., & Layé, S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0939-x · Cited by 124 · see citing works
Vines, A., Delattre, A. M., Lima, M. M. S., Rodrigues, L. S., Suchecki, D., Machado, R. B., Tufik, S., Pereira, S. I. R., Zanata, S. M., & Ferraz, A. C. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.017 · Cited by 115 · see citing works
Moranis, A., Delpech, J.-C., Smedt, V. D., Aubert, A., Guesnet, P., Lavialle, M., Joffre, C., & Layé, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.001 · Cited by 110 · see citing works
Larrieu, T., Madore, C., Joffre, C., & Layé, S. (2012) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0179-6 · Cited by 108 · see citing works
Ibargüen-Vargas, Y., Surget, A., Vourc’h, P., Leman, S., Andres, C. R., Gardier, A. M., & Belzung, C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.040 · Cited by 107 · see citing works
Delpech, J.-C., Thomazeau, A., Madore, C., Bosch‐Bouju, C., Larrieu, T., Lacabanne, C., Rémus-Borel, J., Aubert, A., Joffre, C., Nadjar, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.127 · Cited by 104 · see citing works
Wu, Y., Dang, R.-L., Tang, M., Cai, H., Huan-de, L., Liao, D., He, X., Cao, L.-J., Xue, Y., & Jiang, P. (2016) · Nutrients · doi:10.3390/nu8040243 · Cited by 104 · see citing works
Omega-3 fatty acids for bipolar disorder
Montgomery, P., & Richardson, A. J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005169.pub2 · Cited by 101 · see citing works
McNamara, R. K., Able, J. A., Liu, Y., Jandacek, R. J., Rider, T., Tso, P., & Lipton, J. W. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.09.011 · Cited by 95 · see citing works
The role of fatty acids in the development and treatment of mood disorders
Owen, C., Rees, A.-M., & Parker, G. B. (2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3282f29841 · Cited by 90 · see citing works
A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior
Qi, X., Lin, W., Wang, D., Pan, Y., Wang, W., & Sun, M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.051 · Cited by 84 · see citing works
Quesseveur, G., Portal, B., Basile, J.-A., Ezan, P., Mathou, A., Halley, H., Leloup, C., Fioramonti, X., Déglon, N., Giaume, C., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00490 · Cited by 77 · see citing works
Self-citationDietary n‐3 Fatty Acid Deficiency in Mice Enhances Anxiety Induced by Chronic Mild Stress
Harauma, A., & Moriguchi, T. (2011) · Lipids · doi:10.1007/s11745-010-3523-z · Cited by 76 · see citing works
Feng, P., Guan, Z., Yang, X., & Fang, J. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.018 · Cited by 71 · see citing works
Rousseau‐Ralliard, D., Héliès‐Toussaint, C., Moreau, D., Raederstorff, D., & Grynberg, A. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00651.2002 · Cited by 70 · see citing works
Self-citationHalade, G. V., Ma, Y., Ramirez, T. A., Zhang, J., Dai, Q., Hensler, J. G., Lopez, E. F., Ghasemi, O., Jin, Y.-F., & Lindsey, M. L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00224.2013 · Cited by 69 · see citing works
Luellen, B. A., Bianco, L. E., Schneider, L., & Andrews, A. M. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00279.x · Cited by 68 · see citing works
Daws, L. C., Munn, J. L., Valdez, M. S., Frosto‐Burke, T., & Hensler, J. G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04392.x · Cited by 66 · see citing works
Neuropharmacology of anxiety: perspectives and prospects
Hamon, M. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90104-x · Cited by 66 · see citing works
Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype
Guiard, B. P., David, D. J. P., Deltheil, T., Chenu, F., Maître, E. L., Renoir, T., Leroux‐Nicollet, I., Sokoloff, P., Lanfumey, L., Hamon, M., et al. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007857 · Cited by 65 · see citing works
Self-citationDietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice
Pietropaolo, S., Goubran, M., Joffre, C., Aubert, A., Lemaire-Mayo, V., Crusio, W. E., & Layé, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.002 · Cited by 63 · see citing works
Antidepressant-like effect of n-3 PUFAs in CUMS rats: role of tPA/PAI-1 system
Tang, M., Jiang, P., Huan-de, L., Cai, H., Liu, Y., Gong, H., & Zhang, L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.054 · Cited by 60 · see citing works
Prescribing patterns for depression and anxiety worldwide.
Lecrubier, Y. (2001) · PubMed · Cited by 56 · see citing works
Deltheil, T., Tanaka, K. F., Repérant, C., Hen, R., David, D. J. P., & Gardier, A. M. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000017 · Cited by 55 · see citing works
Park, Y., Moon, H.-J., & Kim, S. H. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.04.018 · Cited by 53 · see citing works
Pudell, C., Vicente, B. A., Delattre, A. M., Carabelli, B., Mori, M., Suchecki, D., Machado, R. B., Zanata, S. M., Visentainer, J. V., Santos, O. D. O., et al. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12406 · Cited by 52 · see citing works
Omega-3 fatty acids have antidepressant activity in forced swimming test in Wistar rats.
Lakhwani, L. K., Tongia, S. K., Pal, V. S., et al. (2007) · PubMed · Cited by 51 · see citing works
Naveen, S., Siddalingaswamy, M., Singsit, D., & Khanum, F. (2013) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12100 · Cited by 49 · see citing works
Mathieu, G., Oualian, C., Denis, I., Lavialle, M., Gisquet-Verrier, P., & Vancassel, S. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.07.001 · Cited by 49 · see citing works
Long-term ω-3 fatty acid supplementation induces anti-stress effects and improves learning in rats
Pérez, M. Á., Terreros, G., & Dagnino‐Subiabre, A. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-25 · Cited by 47 · see citing works
The role of brain‐derived neurotrophic factor in experimental inflammation of mouse gut
Yang, J., Yu, Y., Yu, H., Zuo, X., Liu, C., Gao, L., Chen, Z., & Li, Y. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2009.10.007 · Cited by 40 · see citing works
Laino, C. H., Fonseca, C., Sterin-Speziale, N. B., Slobodianik, N., & Reinés, A. G. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.08.047 · Cited by 35 · see citing works
Choi, J.-E., & Park, Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.07.012 · Cited by 29 · see citing works
Jin, Y., & Park, Y. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.005 · Cited by 28 · see citing works
Ferreira, C. F., Bernardi, J. R., Krolow, R., Arcego, D. M., Fries, G. R., de Aguiar, B. W., Senter, G., Kapczinski, F. P., Silveira, P. P., & Dalmaz, C. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.03.006 · Cited by 27 · see citing works
Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice
Sakakibara, Y., Kasahara, Y., Hall, F. S., Lesch, K., Murphy, D. L., Uhl, G. R., & Sora, I. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3554-x · Cited by 25 · see citing works
Able, J. A., Liu, Y., Jandacek, R. J., Rider, T., Tso, P., & McNamara, R. K. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.11.008 · Cited by 24 · see citing works
Laino, C. H., Garcia, P., Podestá, M. F., Höcht, C., Slobodianik, N., & Reinés, A. G. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24123 · Cited by 20 · see citing works
Grundy, T., Toben, C. G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00399 · Cited by 20 · see citing works
Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitis
Javeri, S., Rodi, M., Tary‐Lehmann, M., Lehmann, P., Addicks, K., & Küerten, S. (2010) · Clinical Immunology · doi:10.1016/j.clim.2010.08.001 · Cited by 14 · see citing works
McCall, N. M., Mahadevia, D., Corriveau, J. A., & Glenn, M. J. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.004 · Cited by 11 · see citing works
Hou, Y., & Lai, C. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12373 · Cited by 1 · see citing works
Supplements such as fish oils improve antidepressant effectiveness, review finds
Mayor, S. (2016) · BMJ · doi:10.1136/bmj.i2418 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The menace of obesity to depression and anxiety prevalence
Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441 · see citing works
“Several reports link higher n-3 consumption with lower prevalence and severity of mood disturbances in humans [45] and demonstrate that n-3 supplementation dampens neuroinflammation and attenuates behavioral indices of mood deficits in rodents [46,47].”
BackgroundSelf-citationDemers, G., Roy, J., Machuca-Parra, A. I., Dashtehei pour, Z., Bairamian, D., Daneault, C., Rosiers, C. D., Ferreira, G., Alquier, T., Fulton, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0623-6 · Cited by 53 · see citing works
- Authors
- Zemdegs, J., Rainer, Q., Grossmann, C. P., Rousseau-Ralliard, D., Grynberg, A., Ribeiro, E., & Guiard, B. P.
- Affiliations
- Université Paris-Sud (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Guiard, Bruno P.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-12-21
- Volume
- 12
- Pages
- 974-974
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC6308198
- OpenAlex
- W2904253189
- Cited by
- 23
- References
- 113
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 2
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- omega-3 fatty acids, brain-derived neurotrophic factor, BDNF knockout mice, antidepressant-like effects, anxiolytic-like effects, ERK activation, serotonin transporter, hippocampal serotonin, dentate gyrus neurogenesis, treatment-resistant depression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
