Dietary Omega-3 Fatty Acids Normalize BDNF Levels, Reduce Oxidative Damage, and Counteract Learning Disability after Traumatic Brain Injury in Rats

Wu, Aiguo; Ying, Zhe; Gomez-Pinilla, Fernando

doi:10.1089/neu.2004.21.1457

Cited by 518Fatty Acid Research and HealthTraumatic Brain Injury and Neurovascular DisturbancesNerve injury and regeneration

Dietary Omega-3 Fatty Acids Normalize BDNF Levels, Reduce Oxidative Damage, and Counteract Learning Disability after Traumatic Brain Injury in Rats

Wu, Aiguo, Ying, Zhe, Gomez-Pinilla, Fernando·2004·Journal of Neurotrauma

DOI 10.1089/neu.2004.21.1457

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Abstract

Omega-3 fatty acids (i.e., docosahexaenoic acid; DHA) regulate signal transduction and gene expression, and protect neurons from death. In this study we examined the capacity of dietary omega3 fatty acids supplementation to help the brain to cope with the effects of traumatic injury. Rats were fed a regular diet or an experimental diet supplemented with omega-3 fatty acids, for 4 weeks before a mild fluid percussion injury (FPI) was performed. FPI increased oxidative stress, and impaired learning ability in the Morris water maze. This type of lesion also reduced levels of brain-derived neurotrophic factor (BDNF), synapsin I, and cAMP responsive element-binding protein (CREB). It is known that BDNF facilitates synaptic transmission and learning ability by modulating synapsin I and CREB. Supplementation of omega-3 fatty acids in the diet counteracted all of the studied effects of FPI, that is, normalized levels of BDNF and associated synapsin I and CREB, reduced oxidative damage, and counteracted learning disability. The reduction of oxidative stress indicates a benevolent effect of this diet on mechanisms that maintain neuronal function and plasticity. These results imply that omega-3 enriched dietary supplements can provide protection against reduced plasticity and impaired learning ability after traumatic brain injury.

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Dietary restriction or addition of supplementary substances such as omega-3 fatty acids or resveratrol can induce an increase in BDNF levels and reduce cognitive impairment in animal models.
“dietary restriction (i.e., the maintenance of a balanced diet) or addition of supplementary substances (e.g., omega-3 fatty acids; resveratrol) can induce an increase in BDNF levels and reduce cognitive impairment in animal models [224–226].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [226]

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Authors: Wu, A., Ying, Z., & Gomez-Pinilla, F.
Affiliations: University of California, Los Angeles (US)
Department of Physiological Science, University of California at Los Angeles.
ORCID: Ying, Zhe
Venue: Journal of Neurotrauma
Publisher: SAGE Publications
Published: 2004-10
Volume: 21
Issue: 10
Pages: 1457-1467
ISSN: 0897-7151 (ISSN-L)
1557-9042
DOI: 10.1089/neu.2004.21.1457
OpenAlex: W1973418455
Cited by: 518
References: 67
Citations by year: 2026: 7 · 2025: 13 · 2024: 25 · 2023: 18 · 2022: 27 · 2021: 21 · 2020: 19 · 2019: 25 · 2018: 37 · 2017: 33 · 2016: 35 · 2015: 41 · 2014: 36 · 2013: 39 · 2012: 24
FWCI: 6.60
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Journal of Neurotrauma (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns038978-03)
National Institute of Neurological Disorders and Stroke (NS 39522, NS-38978, R01NS039522)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: omega-3 fatty acids, docosahexaenoic acid, traumatic brain injury, fluid percussion injury, brain-derived neurotrophic factor, synapsin I, CREB, oxidative stress, learning disabilities, dietary supplementation, neuroprotection, synaptic plasticity
MeSH terms: Animals, Brain Injuries, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Learning Disabilities, Neuronal Plasticity, Blotting, Western, Fatty Acids, Omega-3, Synapsins, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Oxidative Stress, Maze Learning, Brain-Derived Neurotrophic Factor, Rats

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Dietary Omega-3 Fatty Acids Normalize BDNF Levels, Reduce Oxidative Damage, and Counteract Learning Disability after Traumatic Brain Injury in Rats

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