The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
Iron in Neurodegeneration – Cause or Consequence?
Open accessAbstract
Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions. Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron overload in the basal ganglia. High iron levels and iron related pathogenic triggers have also been implicated in sporadic neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple system atrophy (MSA). Iron-induced dyshomeostasis within vulnerable brain regions is still insufficiently understood. Here, we summarize the modes of action by which iron might act as primary or secondary disease trigger in neurodegenerative disorders. In addition, available treatment options targeting brain iron dysregulation and the use of iron as biomarker in prodromal stages are critically discussed to address the question of cause or consequence.
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Cites
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Vanzulli, I., Papanikolaou, M., De-La-Rocha, I. C., Pieropan, F., Rivera, A. D., Gomez-Nicola, D., Verkhratsky, A., Rodríguez, J. J., & Butt, A. M. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.05.016 · Cited by 130
A proteogenomic view of Parkinson’s disease causality and heterogeneity
Kaiser, S., Zhang, L., Mollenhauer, B., Jacob, J., Longerich, S., Del-Aguila, J., Marcus, J., Raghavan, N., Stone, D., Fagboyegun, O., et al. (2023) · npj Parkinson's Disease · doi:10.1038/s41531-023-00461-9 · Cited by 68
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis
Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2020) · doi:10.1101/2020.06.27.175679 · Cited by 414
Metadata
- Authors
- Ndayisaba, A., Kaindlstorfer, C., & Wenning, G. K.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-03-01
- Volume
- 13
- Pages
- 180-180
- ISSN
- 1662-453X (ISSN-L)
- OpenAlex
- W2920373067
- Cited by
- 298
- References
- 226
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- gold
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