Cited by 69Parkinson's Disease Mechanisms and TreatmentsGut microbiota and healthNeuroinflammation and Neurodegeneration Mechanisms

Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson’s Disease

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Chen, Tian-Jiao, Feng, Ya, Liu, Te, Wu, Ting-Ting, Chen, Ya-Jing, Li, Xuan, Li, Qing, Wu, Yun-Cheng·2020·Frontiers in Neuroscience

Abstract

Previous studies have reported the anti-oxidant, anti-inflammatory, and anti-cancer effects of fisetin. However, the therapeutic efficacy of fisetin in Parkinson’s disease (PD) is unclear. In this study, we demonstrated that fisetin could markedly alleviate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in mice. To confirm the reported correlation between gut microbiota and PD, the bacterial DNA in the fresh feces of mice from each group was subjected to 16S rRNA (V3 and V4 regions) sequencing. The results revealed that fisetin changed the number, diversity, and distribution of gut microbiota in MPTP-induced mice model of PD. The alpha and beta diversity analyses showed that the fisetin intervented MPTP group gut microbiota exhibited a significantly higher abundance of Lachnospiraceae and a significantly lower abundance of uncultured_bacterium_g_Escherichia-Shigella and uncultured_bacterium_g_Bacillus than the MPTP group gut microbiota. These findings indicated that fisetin exerts a neuroprotective effect on neurodegeneration by altering the composition and diversity of gut microbiota. Thus, fisetin could be a potential novel therapeutic for PD.

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Authors
Chen, T.-J., Feng, Y., Liu, T., Wu, T.-T., Chen, Y.-J., Li, X., Li, Q., & Wu, Y.-C.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Shanghai University of Traditional Chinese Medicine (CN)
  • Shanghai Medical College of Fudan University (CN)
Corresponding author
Wu, Yun-Cheng
Venue
Frontiers in Neuroscience
Published
2020-12-14
Volume
14
Pages
549037-549037
ISSN
1662-453X (ISSN-L)
OpenAlex
W3111961371
Cited by
69
References
50
Citations by year
2026: 12 · 2025: 13 · 2024: 17 · 2023: 9 · 2022: 11 · 2021: 7
FWCI
2.92
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81671251, 81971185)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
fisetin, Parkinson's disease, gut microbiota, neuroprotection, MPTP-induced neurotoxicity, dopaminergic neuron loss, Lachnospiraceae, gut-brain axis, microbiome diversity, flavonoids

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