Cited by 159Parkinson's Disease Mechanisms and TreatmentsProbiotics and Fermented FoodsNeuroinflammation and Neurodegeneration Mechanisms

Lactobacillus Plantarum PS128 Alleviates Neurodegenerative Progression in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Models of Parkinson’s Disease

Open access
Liao, Jian-Fu, Cheng, Yun-Fang, You, Shu-Ting, Kuo, Wen-Chun, Huang, Chi-Wei, Chiou, Jen-Jie, Hsu, Chih-Chieh, Hsieh-Li, Hsiu-Mei +2 more·2020·Brain, Behavior, and Immunity

Abstract

Evidence suggests that the Parkinson's disease (PD) pathogenesis is strongly associated with bidirectional pathways in the microbiota-gut-brain axis (MGBA), and psychobiotics may inhibit PD progression. We previously reported that the novel psychobiotic strain, Lactobacillus plantarum PS128 (PS128), ameliorated abnormal behaviors and modulated neurotransmissions in dopaminergic pathways in rodent models. Here, we report that orally administering PS128 for 4 weeks significantly alleviated the motor deficits, elevation in corticosterone, nigrostriatal dopaminergic neuronal death, and striatal dopamine reduction in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP)-induced PD mouse models. PS128 ingestion suppressed glial cell hyperactivation and increased norepinephrine and neurotrophic factors in the striatum of the PD-model mice. PS128 administration also attenuated MPTP-induced oxidative stress and neuroinflammation in the nigrostriatal pathway. Fecal analysis showed that PS128 modulated the gut microbiota. L. plantarum abundance was significantly increased along with methionine biosynthesis-related microbial modules. PS128 also suppressed the increased family Enterobacteriaceae and lipopolysaccharide and peptidoglycan biosynthesis-related microbial modules caused by MPTP. In conclude, PS128 ingestion alleviated MPTP-induced motor deficits and neurotoxicity.PS128 supplementation inhibited neurodegenerative processes in PD-model mice and may help prevent PD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2020.07.036

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Serotonergic dysfunction is implicated in Alzheimer's disease and Parkinson's disease progression, but probiotic interventions have shown inconsistent effects on serotonin levels in Parkinson's disease.

    “In a recent randomized controlled trial (RCT), no significant changes in serum serotonin levels were observed following a 3-month adjunctive probiotic Bifidobacterium animalis subsp. lactis treatment in PD patients receiving conventional regimen (Benserazide and dopamine agonists).491 Furthermore, the administration of L. plantarum PS128 was ineffective in restoring MPTP-induced serotonin”
  • Probiotics protect neurons by preventing a decline in TH in dopaminergic neurons and boosting DA expression.

    “Liao et al. demonstrated that probiotics protect neurons by preventing a decline in TH in dopaminergic neurons and boosting DA expression [7].”
  • MPTP induction may increase occurrence of certain pathogenic bacteria and impair antioxidant and anti-inflammatory capabilities.

    “According to previous studies, MPTP induction may increase the occurrence of certain pathogenic bacteria and significantly impair the antioxidant and anti-inflammatory capabilities of the body [7,65], corroborating our findings.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Liao, J.-F., Cheng, Y.-F., You, S.-T., Kuo, W.-C., Huang, C.-W., Chiou, J.-J., Hsu, C.-C., Hsieh-Li, H.-M., Wang, S., & Tsai, Y.-C.
Affiliations
  • National Yang Ming University (TW)
  • National Taiwan Normal University (TW)
Corresponding author
  • Wang, Sabrina
  • Tsai, Ying-Chieh
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2020-11
Volume
90
Pages
26-46
ISSN
0889-1591 (ISSN-L)
OpenAlex
W3045932291
Cited by
159
References
130
Citations by year
2026: 25 · 2025: 29 · 2024: 32 · 2023: 27 · 2022: 28 · 2021: 17 · 2020: 1
FWCI
7.90
Type
journal article
Language
en
Open access
Locations
  • Brain Behavior and Immunity (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Ministry of Science and Technology, Taiwan (105\u20132320-B-010\u2013009)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Parkinson's disease, psychobiotics, microbiota-gut-brain axis, MPTP-induced neurotoxicity, nigrostriatal dopaminergic neurons, motor impairment, neuroinflammation, oxidative stress, gut microbiota, methionine biosynthesis, Enterobacteriaceae, lipopolysaccharide, peptidoglycan, norepinephrine, neurotrophic factors, corticosterone
MeSH terms
Animals, Disease Models, Animal, Mice, Inbred C57BL, Parkinson Disease, Pyrrolidines, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neuroprotective Agents, Lactiplantibacillus plantarum, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review