The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease
Open accessAbstract
Dynamic metabolic changes occurring in neurons are critically important in directing brain plasticity and cognitive function. In other tissue types, disruptions to metabolism and the resultant changes in cellular oxidative state, such as increased reactive oxygen species (ROS) or induction of hypoxia, are associated with cellular stress. In the brain however, where drastic metabolic shifts occur to support physiological processes, subsequent changes to cellular oxidative state and induction of transcriptional sensors of oxidative stress likely play a significant role in regulating physiological neuronal function. Understanding the role of metabolism and metabolically-regulated genes in neuronal function will be critical in elucidating how cognitive functions are disrupted in pathological conditions where neuronal metabolism is affected. Here, we discuss known mechanisms regulating neuronal metabolism as well as the role of hypoxia and oxidative stress during normal and disrupted neuronal function. We also summarize recent studies implicating a role for metabolism in regulating neuronal plasticity as an emerging neuroscience paradigm.
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Cited by
Wei, Y., Miao, Q., Zhang, Q., Mao, S., Li, M., Xu, X., Xia, X., Wei, K., Fan, Y., Zheng, X., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01476-4 · Cited by 153
Sutinen, A., Paffenholz, D., Nguyen, G. T. T., Ruskamo, S., Torda, A. E., & Kursula, P. (2023) · PLOS ONE · doi:10.1371/journal.pone.0284532 · Cited by 8
Sutinen, A., Jones, N. C., Hoffmann, S. V., Ruskamo, S., & Kursula, P. (2023) · Biophysical Chemistry · doi:10.1016/j.bpc.2023.107113 · Cited by 3
Sutinen, A., Paffenholz, D., Nguyen, G. T. T., Ruskamo, S., Torda, A. E., & Kursula, P. (2022) · doi:10.1101/2022.09.09.507262
Metadata
- Authors
- Watts, M. E., Pocock, R., & Claudianos, C.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-06-22
- Volume
- 11
- Pages
- 216-216
- ISSN
- 1662-5099 (ISSN-L)
- OpenAlex
- W2807705809
- Cited by
- 411
- References
- 29
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- gold
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