Executive functions and prefrontal cortex: a matter of persistence?
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Executive function is thought to originates from the dynamics of frontal cortical networks. We examined the dynamic properties of the blood oxygen level dependent time-series measured with functional MRI (fMRI) within the prefrontal cortex (PFC) to test the hypothesis that temporally persistent neural activity underlies performance in three tasks of executive function. A numerical estimate of signal persistence, the Hurst exponent, postulated to represent the coherent firing of cortical networks, was determined and correlated with task performance. Increasing persistence in the lateral PFC was shown to correlate with improved performance during an n-back task. Conversely, we observed a correlation between persistence and increasing commission error - indicating a failure to inhibit a prepotent response - during a Go/No-Go task. We propose that persistence within the PFC reflects dynamic network formation and these findings underline the importance of frequency analysis of fMRI time-series in the study of executive functions.
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The prefrontal cortex is involved in executive function and is an important substrate in the reward circuitry associated with development of alcohol dependence.
“The PFC is involved in executive function and is an important substrate in the reward circuitry associated with development of alcohol dependence (19) .”
From Single cell transcriptome profiling of the human alcohol-dependent brain (2020) · cites this paper as [19]
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Focal Cortical Blood Flow Activation Is Regulated by Intrinsic Cortical Cholinergic Neurons
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- Authors
- Ball, G., Stokes, P. R., Rhodes, R. A., Bose, S. K., Rezek, I., Wink, A.-M., Lord, L.-D., Mehta, M. A., Grasby, P. M., & Turkheimer, F. E.
- Affiliations
- Hammersmith Hospital (GB)
- Imperial College London (GB)
- King's College London (GB)
- Corresponding author
- Turkheimer, Federico E.
- Venue
- Frontiers in Systems Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 5
- Pages
- 3-3
- ISSN
- 1662-5137 (ISSN-L)
- PMC
- PMC3031025
- OpenAlex
- W2137901952
- Cited by
- 50
- References
- 116
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 5 · 2013: 1 · 2012: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Systems Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Minerva Access (University of Melbourne) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Engineering and Physical Sciences Research Council (EP/E049451/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- executive function, prefrontal cortex, signal persistence, Hurst exponent, long-range temporal correlations, lateral prefrontal cortex, n-back task, go/no-go task, response inhibition, commission errors, cortical network dynamics
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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