Cited by 806Neural dynamics and brain functionOptical Imaging and Spectroscopy TechniquesNeuroscience and Neuropharmacology Research

Hemodynamic Signals Correlate Tightly with Synchronized Gamma Oscillations

Niessing, Jörn, Ebisch, Boris, Schmidt, Kerstin E., Niessing, Michael, Singer, Wolf, Galuske, Ralf A. W.·2005·Science

Abstract

Functional imaging methods monitor neural activity by measuring hemodynamic signals. These are more closely related to local field potentials (LFPs) than to action potentials. We simultaneously recorded electrical and hemodynamic responses in the cat visual cortex. Increasing stimulus strength enhanced spiking activity, high-frequency LFP oscillations, and hemodynamic responses. With constant stimulus intensity, the hemodynamic response fluctuated; these fluctuations were only loosely related to action potential frequency but tightly correlated to the power of LFP oscillations in the gamma range. These oscillations increase with the synchrony of synaptic events, which suggests a close correlation between hemodynamic responses and neuronal synchronization.

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Crossref · 10.1126/science.1110948

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Authors
Niessing, J., Ebisch, B., Schmidt, K. E., Niessing, M., Singer, W., & Galuske, R. A. W.
Affiliations
  • Max Planck Institute for Brain Research, 60528 Frankfurt/M., Germany.
  • Technische Universität Darmstadt (DE)
Corresponding author
Galuske, Ralf A. W.
Venue
Science
Published
2005-08-05
Volume
309
Issue
5736
Pages
948-951
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2065459990
Cited by
806
References
32
Citations by year
2026: 16 · 2025: 19 · 2024: 29 · 2023: 23 · 2022: 34 · 2021: 28 · 2020: 30 · 2019: 33 · 2018: 22 · 2017: 33 · 2016: 43 · 2015: 39 · 2014: 40 · 2013: 42 · 2012: 60
FWCI
23.89
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hemodynamic response, gamma oscillations, local field potentials, neuronal synchronization, visual cortex, cats, stimulus strength, spiking activity, functional imaging, neural oscillations
MeSH terms
Action Potentials, Animals, Brain Mapping, Cats, Electric Stimulation, Electroencephalography, Evoked Potentials, Visual, Hemodynamics, Neurons, Oxygen, Photic Stimulation, Visual Cortex

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