Hemodynamic Signals Correlate Tightly with Synchronized Gamma Oscillations
Abstract
Functional imaging methods monitor neural activity by measuring hemodynamic signals. These are more closely related to local field potentials (LFPs) than to action potentials. We simultaneously recorded electrical and hemodynamic responses in the cat visual cortex. Increasing stimulus strength enhanced spiking activity, high-frequency LFP oscillations, and hemodynamic responses. With constant stimulus intensity, the hemodynamic response fluctuated; these fluctuations were only loosely related to action potential frequency but tightly correlated to the power of LFP oscillations in the gamma range. These oscillations increase with the synchrony of synaptic events, which suggests a close correlation between hemodynamic responses and neuronal synchronization.
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The association between fast gamma oscillations and whole-brain vascular hyperactivity has also been observed under anesthesia in previous EEG-fMRI and intrinsic optical signal (IOS)-fMRI studies.
“which was also observed under anesthesia in previous EEG-fMRI and intrinsic optical signal (IOS)-fMRI studies35,36.”
From Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep (2018) · cites this paper as [36]
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- Authors
- Niessing, J., Ebisch, B., Schmidt, K. E., Niessing, M., Singer, W., & Galuske, R. A. W.
- Affiliations
- Max Planck Institute for Brain Research, 60528 Frankfurt/M., Germany.
- Technische Universität Darmstadt (DE)
- Corresponding author
- Galuske, Ralf A. W.
- Venue
- Science
- Published
- 2005-08-05
- Volume
- 309
- Issue
- 5736
- Pages
- 948-951
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065459990
- Cited by
- 806
- References
- 32
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 29 · 2023: 23 · 2022: 34 · 2021: 28 · 2020: 30 · 2019: 33 · 2018: 22 · 2017: 33 · 2016: 43 · 2015: 39 · 2014: 40 · 2013: 42 · 2012: 60
- FWCI
- 23.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hemodynamic response, gamma oscillations, local field potentials, neuronal synchronization, visual cortex, cats, stimulus strength, spiking activity, functional imaging, neural oscillations
- MeSH terms
- Action Potentials, Animals, Brain Mapping, Cats, Electric Stimulation, Electroencephalography, Evoked Potentials, Visual, Hemodynamics, Neurons, Oxygen, Photic Stimulation, Visual Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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