The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further
Open accessAbstract
The genome of gut microbes encodes a collection of enzymes whose metabolic functions contribute to the bioavailability and bioactivity of unabsorbed (poly)phenols. Datasets from high throughput sequencing, metabolome measurements, and other omics have expanded the understanding of the different modes of actions by which (poly)phenols modulate the microbiome conferring health benefits to the host. Progress have been made to identify direct prebiotic effects of (poly)phenols; albeit up to date, these compounds are not recognized as prebiotics sensu stricto. Interestingly, certain probiotics strains have an enzymatic repertoire, such as tannase, α-L-rhamnosidase, and phenolic acid reductase, involved in the transformation of different (poly)phenols into bioactive phenolic metabolites. In vivo studies have demonstrated that these (poly)phenol-transforming bacteria thrive when provided with phenolic substrates. However, other taxonomically distinct gut symbionts of which a phenolic-metabolizing activity has not been demonstrated are still significantly promoted by (poly)phenols. This is the case of Akkermansia muciniphila, a so-called antiobesity bacterium, which responds positively to (poly)phenols and may be partially responsible for the health benefits formerly attributed to these molecules. We surmise that (poly)phenols broad antimicrobial action free ecological niches occupied by competing bacteria, thereby allowing the bloom of beneficial gut bacteria. This review explores the capacity of (poly)phenols to promote beneficial gut bacteria through their direct and collaborative bacterial utilization and their inhibitory action on potential pathogenic species. We propose the term duplibiotic, to describe an unabsorbed substrate modulating the gut microbiota by both antimicrobial and prebiotic modes of action. (Poly)phenol duplibiotic effect could participate in blunting metabolic disturbance and gut dysbiosis, positioning these compounds as dietary strategies with therapeutic potential.
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“Consistent with these findings, polyphenols have been postulated as being duplibiotic and as agents capable of promoting beneficial microbial species through both antimicrobial and prebiotic effects [14].”
From Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Placebo-Controlled Trial—A Pilot Study (2025) · cites this paper as [14]
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Cited by
Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14061137 · Cited by 255
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Kattah, F. M., Figueiredo, N., Bezerra, K. K., Oliveira, E. S., Melo, C. C. D., Lima, G. B., Cavalcante, J. P. R., Benetti, B. B. D. C., Lima, G. C., Mota, J. F., et al. (2025) · Nutrients · doi:10.3390/nu17132064 · Cited by 6
Murphy, B., Latimer, C., Dobani, S., Pourshahidi, L. K., Fontana, M., Ternan, N. G., McDougall, G. J., Rowland, I., Pereira-Caro, G., Tuohy, K., et al. (2023) · doi:10.20944/preprints202308.0755.v1 · Cited by 1
Murphy, B. Ó., Latimer, C., Dobani, S., Pourshahidi, L. K., Fontana, M., Ternan, N. G., McDougall, G., Rowland, I., Pereira-Caro, G., Tuohy, K. M., et al. (2024) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2024.2397055
Metadata
- Authors
- Rodríguez-Daza, M. C., Pulido-Mateos, E. C., Lupien-Meilleur, J., Guyonnet, D., Desjardins, Y., & Roy, D.
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2021-06-28
- Volume
- 8
- Pages
- 689456-689456
- ISSN
- 2296-861X (ISSN-L)
- OpenAlex
- W3173330931
- Cited by
- 474
- References
- 29
- FWCI
- 16.57
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
