Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders
Abstract
Depression is a debilitating psychiatric ailment which exerts disastrous effects on one's mental and physical health. Depression is accountable for augmentation of various life-threatening maladies such as neurodegenerative anomalies, cardiovascular diseases and diabetes. Depressive episodes are recurrent, pose a negative impact on life quality, decline life expectancy and enhance suicidal tendencies. Anti-depression chemotherapy displays marked adverse effects and frequent relapses. Thus, newer therapeutic interventions to prevent or combat depression are desperately required. Discovery of gut microbes as our mutualistic partner was made a long time ago and it is surprising that their functions still continue to expand and as of yet many are still to be uncovered. Experimental studies have revealed astonishing role of gut commensals in gut-brain signaling, immune homeostasis and hormonal regulation. Now, it is a well-established fact that gut microbes can alleviate stress or depression associated symptoms by modulating brain functions. Here in, we provide an overview of physiological alleyways involved in cross-talk between gut and brain, part played by probiotics in regulation of these pathways and use of probiotic bacteria as psychobiotics in various mental or depressive disorders.
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Psychobiotics exert antidepressant effects by altering emotional, cognitive, and neuronal indices.
“These act through the brain-gut axis, and exert antidepressant effects by altering emotional, cognitive, and neuronal indices [236,239].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [239]
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Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions
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Neuroinflammation, Microbiota-Gut-Brain Axis, and Depression: The Vicious Circle
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Arora, R., & Chandel, A. K. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113425 · Cited by 18 · see citing works
An insight into the health beneficial of probiotics dairy products: a critical review
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Potential role of gut microbiota in major depressive disorder: A review
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Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
Jiang, Y., Chen, Y., Chen, Y., Gong, X., Chen, Z., & Zhang, X. (2025) · Foods · doi:10.3390/foods14071215 · Cited by 15 · see citing works
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Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation
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The Human Superorganism: Using Microbes for Freedom vs. Fear
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The role of probiotics in nutritional health: probiotics as nutribiotics
Chávarri, M., Diez-Gutiérrez, L., Marañón, I., Villarán, M. C., & Barrón, L. J. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00018-0 · Cited by 10 · see citing works
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A PRISMA Systematic Review of Sexual Dysfunction and Probiotics with Pathophysiological Mechanisms
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The Maneuver of Psychobiotics in the Medical Aid of Clinical Depression
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The Intestinal Neuro-immune Axis
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Causality Between Irritable Bowel Syndrome and Suicide Attempt: A Mendelian Randomization Study
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The Intestinal Neuro-immune Axis
Ibrahim, I., Krishnan, S. S., & Ayariga, J. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-60006-7_28
Huang, D., Gao, Y., Hao, K., Hu, C., Zhang, S., Gong, W., Qin, X., Du, G., Li, H., & Zhou, Y. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101674
- Authors
- Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G.
- Affiliations
- Sharda University (IN)
- Corresponding author
- Chouhan, Garima
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 137
- Pages
- 109489
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W3038366553
- Cited by
- 42
- References
- 219
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 1
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- gut microbiota, depression, probiotics, psychobiotics, gut-brain axis, depressive disorders, stress, immune homeostasis, hormonal regulation, antidepressant side effects, neurodegenerative diseases
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Brain, Depressive Disorder, Humans, Probiotics
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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