Cited by 42Probiotics and Fermented FoodsGut microbiota and healthTryptophan and brain disorders

Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders

Tyagi, Priya, Tasleem, Mohd, Prakash, Shweta, Chouhan, Garima·2020·Food Research International

Abstract

Depression is a debilitating psychiatric ailment which exerts disastrous effects on one's mental and physical health. Depression is accountable for augmentation of various life-threatening maladies such as neurodegenerative anomalies, cardiovascular diseases and diabetes. Depressive episodes are recurrent, pose a negative impact on life quality, decline life expectancy and enhance suicidal tendencies. Anti-depression chemotherapy displays marked adverse effects and frequent relapses. Thus, newer therapeutic interventions to prevent or combat depression are desperately required. Discovery of gut microbes as our mutualistic partner was made a long time ago and it is surprising that their functions still continue to expand and as of yet many are still to be uncovered. Experimental studies have revealed astonishing role of gut commensals in gut-brain signaling, immune homeostasis and hormonal regulation. Now, it is a well-established fact that gut microbes can alleviate stress or depression associated symptoms by modulating brain functions. Here in, we provide an overview of physiological alleyways involved in cross-talk between gut and brain, part played by probiotics in regulation of these pathways and use of probiotic bacteria as psychobiotics in various mental or depressive disorders.

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Crossref · 10.1016/j.foodres.2020.109489

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218 of 218 references verified0 citation errors · 0 not checkable

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Authors
Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G.
Affiliations
Sharda University (IN)
Corresponding author
Chouhan, Garima
Venue
Food Research International
Publisher
Elsevier BV
Published
2020-11
Volume
137
Pages
109489
ISSN
0963-9969 (ISSN-L)
OpenAlex
W3038366553
Cited by
42
References
219
Citations by year
2026: 1 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 1
FWCI
3.57
Type
journal article
Language
en
Open access
closed
Locations
  • Food Research International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
gut microbiota, depression, probiotics, psychobiotics, gut-brain axis, depressive disorders, stress, immune homeostasis, hormonal regulation, antidepressant side effects, neurodegenerative diseases
MeSH terms
Gastrointestinal Microbiome, Bacteria, Brain, Depressive Disorder, Humans, Probiotics

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