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Recent Advances in Nanoplatforms for the Treatment of Osteosarcoma

Wu, Kunzhe, Yu, Beibei, Li, Di, Tian, Yangyang, Liu, Yan, Jiang, Jinlan·2022·Frontiers in Oncology
DOI 10.3389/fonc.2022.805978PMC PMC8885548
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Abstract

Osteosarcoma (OS) is the most common primary bone tumor in children and young people. Traditional surgical excision combined with chemotherapy presents many limitations, such as resistance and systemic side effects of chemotherapy drugs, postoperative recurrence, and bone defects. Given these limitations, novel therapeutic modalities for OS treatment using nanometer-sized platform-based chemotherapeutic delivery have emerged as a promising alternative therapy. This form of therapy offers multiple advantages, such as accurate delivery of the drug to the tumor site and repair of limited bone defects after tumor resection. In this review, we briefly summarize nanoplatforms, including liposomes, polymeric nanoparticles, inorganic nanoparticles, nanomicelles, dendrimers, nanocapsules, and exosomes. The essential shortcomings involved in these nanoplatforms, such as poor stability, immunogenicity, insufficient circulation, and drug leakage are also discussed, and related solutions are briefly proposed. Finally, the application prospects of nanoplatforms in the treatment of OS are discussed.

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Figure 1 Chol-SS-mPEG/HA-L designed for long circulation in vivo followed by receptor-mediated endocytosis and GSH-triggered cytoplasmic DOX release. Reproduced from (10) with permission from J Control Release.
Figure 1 Chol-SS-mPEG/HA-L designed for long circulation in vivo followed by receptor-mediated endocytosis and GSH-triggered cytoplasmic DOX release. Reproduced from (10) with permission from J Control Release.CC BY · PubMed Central
Figure 2 3DP scaffolds containing DMPC and DMPG formed liposomes loated with curcumin. In the presence of a buffer medium or an extracellular medium, liposome released, followed by curcumin released from the liposome. Reproduced from (12) with permission from ACS Appl Mater Interfaces.
Figure 2 3DP scaffolds containing DMPC and DMPG formed liposomes loated with curcumin. In the presence of a buffer medium or an extracellular medium, liposome released, followed by curcumin released from the liposome. Reproduced from (12) with permission from ACS Appl Mater Interfaces.CC BY · PubMed Central
Figure 3 Under 808 nm near-infrared (NIR) irradiation, SP@MX-TOB/GelMA multifunctional implants can effectively kill OS cells in conjunction with photothermal effect. In addition, SP@MX-TOB/GelMA loaded TOB showed good antibacterial properties. More importantly, the multifunctional implant has excellent cellular compatibility and osteogenic ability. Reproduced from (13) with permission from Curr Med Chem.
Figure 3 Under 808 nm near-infrared (NIR) irradiation, SP@MX-TOB/GelMA multifunctional implants can effectively kill OS cells in conjunction with photothermal effect. In addition, SP@MX-TOB/GelMA loaded TOB showed good antibacterial properties. More importantly, the multifunctional implant has excellent cellular compatibility and osteogenic ability. Reproduced from (13) with permission from Curr Med Chem.CC BY · PubMed Central
Figure 4 MCSC scaffolds were composed of M-type ferrite particles and mesoporous calcium silicate microspheres dispersed in chitosan membrane. The scaffolds showed good drug delivery performance under NIR laser irradiation, and the MCSC scaffolds also had excellent ability to promote new bone regeneration. Reproduced from (15) with permission from Sci Rep.
Figure 4 MCSC scaffolds were composed of M-type ferrite particles and mesoporous calcium silicate microspheres dispersed in chitosan membrane. The scaffolds showed good drug delivery performance under NIR laser irradiation, and the MCSC scaffolds also had excellent ability to promote new bone regeneration. Reproduced from (15) with permission from Sci Rep.CC BY · PubMed Central
Figure 5 PEG-GOFA/ICG nanoplatform is absorbed by OS cells through FA receptor-mediated endocytosis. Under NIR irradiation, PEG-GOFA/ICG nanoplatform has CHEMO-PDT synergistic effect to promote intracellular ROS production and release MTH1 inhibitor TH287 to enhance apoptosis induction of OS cells. Reproduced from (16) with permission from Acta Biomater.
Figure 5 PEG-GOFA/ICG nanoplatform is absorbed by OS cells through FA receptor-mediated endocytosis. Under NIR irradiation, PEG-GOFA/ICG nanoplatform has CHEMO-PDT synergistic effect to promote intracellular ROS production and release MTH1 inhibitor TH287 to enhance apoptosis induction of OS cells. Reproduced from (16) with permission from Acta Biomater.CC BY · PubMed Central

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Metadata

Authors
Wu, K., Yu, B., Li, D., Tian, Y., Liu, Y., & Jiang, J.
Venue
Frontiers in Oncology
Publisher
Frontiers Media SA
Published
2022-02-15
Volume
12
ISSN
2234-943X
DOI
10.3389/fonc.2022.805978
PMC
PMC8885548
Cited by
39
References
5
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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