The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Glutathione: new roles in redox signaling for an old antioxidant
Open accessAbstract
The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
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Cites
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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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“N-acetylcysteine, an efficient thiol antioxidant and GSH precursor, was able to inhibit ATG by impeding the lipidation process of LC3 mediated by ATG4, the activity of which is modulated by hydrogen peroxide (Scherz-Shouval et al., 2007).”
BackgroundOxidized Redox State of Glutathione in the Endoplasmic Reticulum
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Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252
Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update
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Metabolic Responses to Reductive Stress
Xiao, W., & Loscalzo, J. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7803 · Cited by 462
Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment
Zhang, C., Wang, X., Du, J., Gu, Z., & Zhao, Y. (2021) · Advanced Science · doi:10.1002/advs.202002797 · Cited by 401
Dan, Z., Mao, X., Liu, Q., Guo, M., Zhuang, Y., Liu, Z., Chen, K., Chen, J., Xu, R., Tang, J., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1747329 · Cited by 350
Metadata
- Authors
- Aquilano, K., Baldelli, S., & Ciriolo, M. R.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2014-08-26
- Volume
- 5
- Pages
- 196-196
- ISSN
- 1663-9812 (ISSN-L)
- OpenAlex
- W2012645913
- Cited by
- 865
- References
- 133
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
